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However, the effectiveness of cognitive interventions varies greatly among studies and more comprehensive studies are required. We aimed to evaluate whether the current evidence shows that cognitive interventions are effective at improving cognition, neuropsychiatric symptoms, depression, quality of life, and basic activities of daily living among individuals with possible or probable AD. Randomized controlled trials of all types of cognitive intervention were identified for inclusion in pairwise and network meta-analyses. There was a moderate and statistically significant post-intervention improvement in global cognition among individuals with AD for all types of cognitive intervention compared to control interventions (39 studies, g = 0.43, 95% CI: 0.28 to 0.58,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01; Q = 102.27, df = 38,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01; I\n                    <jats:sup>2<\/jats:sup>\n                    = 61.97%, \u03c4\n                    <jats:sup>2<\/jats:sup>\n                    = 0.13). Regarding the specific types of cognitive intervention, combined interventions had the highest surface under the cumulative ranking curve (SUCRA) value (90.7%), followed by CT (67.8%), CS (53.4%), and lastly CR (28.9%). Significant effects of cognitive interventions were also found for working memory, verbal memory, verbal fluency, confrontation naming, attention, neuropsychiatric symptoms, basic activities of daily living, and quality of life.\n                  <\/jats:p>","DOI":"10.1007\/s11065-023-09584-5","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T20:21:34Z","timestamp":1679862094000},"page":"402-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparison of Cognitive Intervention Strategies for Individuals With Alzheimer\u2019s Disease: A Systematic Review and Network Meta-analysis"],"prefix":"10.1007","volume":"34","author":[{"given":"Chunchen","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"issue":"16","key":"9584_CR1","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1001\/jama.2019.4782","volume":"322","author":"Z Arvanitakis","year":"2019","unstructured":"Arvanitakis, Z., Shah, R. 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