{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:14:20Z","timestamp":1772921660611,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1007\/s11095-004-7672-8","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T14:21:48Z","timestamp":1108477308000},"page":"2207-2212","source":"Crossref","is-referenced-by-count":10,"title":["Prophylactic Role of Liposomized Chloroquine Against Murine Cryptococcosis Less Susceptible to Fluconazole"],"prefix":"10.1007","volume":"21","author":[{"given":"Masood A.","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rukhsana","family":"Jabeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owais","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1086\/323895","volume":"33","author":"N. Singh","year":"2001","unstructured":"1. N. Singh. Trends in the epidemiology of oppotunistic fungal infections: predisposing factors and the impact of antimicrobial use practices. Clin. Infect. Dis. 33:1692?1696 (2001).","journal-title":"Clin. Infect. Dis."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/clinids\/17.5.837","volume":"17","author":"W. G. Powderly","year":"1993","unstructured":"2. W. G. Powderly. Cryptococcal meningitis and AIDS. Clin. Infect. Dis. 17:837?842 (1993).","journal-title":"Clin. Infect. Dis."},{"key":"CR3","doi-asserted-by":"crossref","unstructured":"3. S. M. Levitz, Nong, Shu-Hua., K.F. Seetoo, T. S. Harrison, R. A. Speizer, and E.R. Simons. Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages. Infect. Immun. 67:885?890 (1999).","DOI":"10.1128\/IAI.67.2.885-890.1999"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/AAC.13.6.914","volume":"13","author":"W. C. Chen","year":"1978","unstructured":"4. W. C. Chen, D. L. Chou, and D. S. Feingold. Dissociation between ion permeability and the lethal action of polyene antibiotics on C. albicans. Antimicrob. Agents Chemother. 13:914?917 (1978).","journal-title":"Antimicrob. Agents Chemother."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/clinids\/7.5.646","volume":"7","author":"R. Horn","year":"1985","unstructured":"5. R. Horn, B. Wong, T.E. Kiehn, and D. Armstrong. Fungemia in a cancer hospital: changing frequency, earlier onset and results of therapy. Rev. Infect. Dis. 7:646?655 (1985).","journal-title":"Rev. Infect. Dis."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.4049\/jimmunol.160.3.1290","volume":"160","author":"U. E. Schaible","year":"1998","unstructured":"6. U. E. Schaible, S. Sturgill-Koszycki, P. H. Schlesinger, and D. G. Russell. Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J. Immunol. 160:1290?1296 (1998).","journal-title":"J. Immunol."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/315416a0","volume":"315","author":"L. D. Sibley","year":"1985","unstructured":"7. L. D. Sibley, E. Weidner, and J. L. Krahenbuhl. Phagosome acidification blocked by intracellular Toxoplasma gondii. Nature 315:416?419 (1985).","journal-title":"Nature"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1083\/jcb.99.6.1936","volume":"99","author":"M. A. Horwitz","year":"1984","unstructured":"8. M. A. Horwitz and F. R. Maxfield. Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J. Cell Biol. 99:1936?1943 (1984).","journal-title":"J. Cell Biol."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1056\/NEJM198708273170905","volume":"317","author":"D. J. Krogstad","year":"1987","unstructured":"9. D. J. Krogstad and P. H. Schlesinger. Acid-vesicle function, intracellular pathogens and action of chloroquine against Plasmodium falciparum. N. Engl. J. Med. 317:542?549 (1987).","journal-title":"N. Engl. J. Med."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1172\/JCI115301","volume":"88","author":"T. F. Byrd","year":"1991","unstructured":"10. T. F. Byrd and M. A. Horwitz. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of the iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens. J. Clin. Invest. 88:351?357 (1991).","journal-title":"J. Clin. Invest."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1172\/JCI117119","volume":"93","author":"S. L. Newman","year":"1994","unstructured":"11. S. L. Newman, L. Gootee, G. Brunner, and G. S. Deepe Jr. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of the intracellular iron and is therapeutic in murine model of histoplasmosis. J. Clin. Invest. 93:1422?1429 (1994).","journal-title":"J. Clin. Invest."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/IAI.63.4.1478-1483.1995","volume":"63","author":"A. H. Fortier","year":"1995","unstructured":"12. A. H. Fortier, D. A. Leiby, R. B. Narayan, E. Asafodjei, R. M. Crawford, C. A. Nansy, and M. A. Mitzer. Growth of Francisella tulerensis LVS in macrophages: the acidic intracellular environment provides essential intracellular iron required for growth. Infect. Immun. 63:1478?1483 (1995).","journal-title":"Infect. Immun."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1172\/JCI119688","volume":"100","author":"S. M. Levitz","year":"1997","unstructured":"13. S. M. Levitz, S. T. Harrison, T. Abdulmoneim, and L. Xiuping. Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation. J. Clin. Invest. 100:1640?1646 (1997).","journal-title":"J. Clin. Invest."},{"issue":"1","key":"CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01875551","volume":"17","author":"J. J. Bergers","year":"1995","unstructured":"14. J. J. Bergers, T. L. ten Hagen, E. W. Van Etten, and I. A. Bakker-Woudenberg. Liposomes as delivery systems in the prevention and treatment of infectious diseases. Pharm. World Sci. 17(1):1?11 (1995).","journal-title":"Pharm. World Sci."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02558256","volume":"42","author":"W. S. Singleton","year":"1965","unstructured":"15. W. S. Singleton, M. S. Gray, and M. L. Brown. A method for adsorbent fractionation of cottonseed oil for experimental intravenous fat emulsions. J. Am. Oil Chem. Soc. 42:53?56 (1965).","journal-title":"J. Am. Oil Chem. Soc."},{"issue":"1","key":"CR16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1128\/AAC.39.1.180","volume":"39","author":"M. Owais","year":"1995","unstructured":"16. M. Owais, G. C. Varshney, A. Choudhury, S. Chandra, and C. M. Gupta. Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice. Antimicrob. Agents Chemother. 39(1):180?184 (1995).","journal-title":"Antimicrob. Agents Chemother."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1046\/j.1432-1327.2000.01447.x","volume":"267","author":"M. Owais","year":"2000","unstructured":"17. M. Owais and C. M. Gupta. Liposome mediated cytosolic delivery of macromolecules and its possible role in vaccine development. Eur. J. Biochem. 267:3946?3956 (2000).","journal-title":"Eur. J. Biochem."},{"key":"CR18","volume-title":"Reference Method for broth dilution antifungal susceptibility testing for yeasts","author":"National Committee for Clinical Laboratory Standards","year":"1995","unstructured":"18. National Committee for Clinical Laboratory Standards. Reference Method for broth dilution antifungal susceptibility testing for yeasts. Approved standard M 27-A. National Committee for Clinical Laboratory Standards, Villanova, PA, 1995."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10611860290022615","volume":"10","author":"M. A. Khan","year":"2002","unstructured":"19. M. A. Khan, S. M. Faisal, W. Haque, and M. Owais. Immunomodulator tuftsin augments antifungal activity of Amp B against experimental murine candidiasis. J. Drug Targetting. 10:185?192 (2002).","journal-title":"J. Drug Targetting."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/315649","volume":"182","author":"T. Harrison","year":"2000","unstructured":"20. T. Harrison, G. Griffin, and S. Levitz. Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans. J. Infect. Dis. 182:283?289 (2000).","journal-title":"J. Infect. Dis."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1128\/AAC.41.4.802","volume":"41","author":"R. Mazzolla","year":"1997","unstructured":"21. R. Mazzolla, R. Barluzzi, A. Brozzetti, J. R. Boelaert, T. Luna, S. Saleppico, F. Bistoni, and E. Blasi. Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis. Antimicrob. Agents Chemother. 41:802?807 (1997).","journal-title":"Antimicrob. Agents Chemother."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1126\/science.276.5320.1857","volume":"276","author":"J. M. Orenstein","year":"1997","unstructured":"22. J. M. Orenstein, C. Fox, and S. M. Wahl. Macrophages as a source of HIV during opportunistic infections. Science 276:1857?1861 (1997).","journal-title":"Science"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1086\/319259","volume":"183","author":"S. M. Weber","year":"2001","unstructured":"23. S. M. Weber and S. M. Levitz. Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome. J. Infect. Dis. 183:935?942 (2001).","journal-title":"J. Infect. Dis."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-004-7672-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-004-7672-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-004-7672-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T05:08:56Z","timestamp":1683004136000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-004-7672-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["7672"],"URL":"https:\/\/doi.org\/10.1007\/s11095-004-7672-8","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}