{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:52:32Z","timestamp":1761292352856},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,7,15]],"date-time":"2006-07-15T00:00:00Z","timestamp":1152921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,7,15]],"date-time":"2006-07-15T00:00:00Z","timestamp":1152921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s11095-006-9010-9","type":"journal-article","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T22:08:31Z","timestamp":1152828511000},"page":"1857-1867","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Enhanced Transscleral Iontophoretic Transport with Ion-Exchange Membrane"],"prefix":"10.1007","volume":"23","author":[{"given":"S. Kevin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honggang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I.","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,7,15]]},"reference":[{"key":"9010_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0169-409X(92)90023-J","volume":"9","author":"G. B. Kasting","year":"1992","unstructured":"G. B. Kasting. Theoretical models for iontophoretic delivery. Adv. Drug Deliv. Rev. 9:177\u2013199 (1992).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9010_CR2","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1001\/archopht.1984.01040031483028","volume":"102","author":"L. Hughes","year":"1984","unstructured":"L. Hughes and D. M. Maurice. A fresh look at iontophoresis. Arch. Ophthalmol.\n                           102:1825\u20131829 (1984).","journal-title":"Arch. Ophthalmol."},{"key":"9010_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00003226-200201000-00029","volume":"21","author":"S. H. Yoo","year":"2002","unstructured":"S. H. Yoo, D. Dursun, S. Dubovy, D. Miller, E. Alfonso, R. K. Forster, F. F. Behar-Cohen, and J. M. Parel. Iontophoresis for the treatment of paecilomyces keratitis. Cornea\n                           21:131\u2013132 (2002).","journal-title":"Cornea"},{"key":"9010_CR4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1006\/exer.1997.0364","volume":"65","author":"F. F. Behar-Cohen","year":"1997","unstructured":"F. F. Behar-Cohen, J. M. Parel, Y. Pouliquen, B. Thillaye-Goldenberg, O. Goureau, S. Heydolph, Y. Courtois, and Y. De Kozak. Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats. Exp. Eye Res.\n                           65:533\u2013545 (1997).","journal-title":"Exp. Eye Res."},{"key":"9010_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1006\/exer.2001.1098","volume":"74","author":"F. F. Behar-Cohen","year":"2002","unstructured":"F. F. Behar-Cohen, A. El Aouni, S. Gautier, G. David, J. Davis, P. Chapon, and J. M. Parel. Transscleral coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. Exp. Eye Res.\n                           74:51\u201359 (2002).","journal-title":"Exp. Eye Res."},{"key":"9010_CR6","first-page":"3299","volume":"43","author":"M. Voigt","year":"2002","unstructured":"M. Voigt, M. Kralinger, G. Kieselbach, P. Chapon, S. Anagnoste, B. Hayden, and J. M. Parel. Ocular aspirin distribution: a comparison of intravenous, topical, and coulomb-controlled iontophoresis administration. Invest. Ophthalmol. Vis Sci.\n                           43:3299\u20133306 (2002).","journal-title":"Invest. Ophthalmol. Vis Sci."},{"key":"9010_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/108076803321637672","volume":"19","author":"T. M. Parkinson","year":"2003","unstructured":"T. M. Parkinson, E. Ferguson, S. Febbraro, A. Bakhtyari, M. King, and M. Mundasad. Tolerance of ocular iontophoresis in healthy volunteers. J. Ocular Pharmacol. Ther.\n                           19:145\u2013151 (2003).","journal-title":"J. Ocular Pharmacol. Ther."},{"key":"9010_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0169-409X(92)90022-I","volume":"9","author":"J. B. Phipps","year":"1992","unstructured":"J. B. Phipps and J. R. Gyory. Transdermal ion migration. Adv. Drug Deliv. Rev.\n                           9:137\u2013176 (1992).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9010_CR9","volume-title":"Percutaneous Penetration Enhancers","author":"B. H. Sage","year":"1995","unstructured":"B. H. Sage. Iontophoresis. In: E. W. Smith and H. I. Maibach (eds.), Percutaneous Penetration Enhancers, CRC, Boca Raton, 1995, Ch 15.1."},{"key":"9010_CR10","volume-title":"Electronically Controlled Drug Delivery","author":"M. B. Delgado-Charro","year":"1998","unstructured":"M. B. Delgado-Charro and R. H. Guy. Iontophoresis of peptides. In: B. Berner and S. M. Dinh (eds.), Electronically Controlled Drug Delivery, CRC, Boca Raton, 1998, Ch 7."},{"key":"9010_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0168-3659(88)90075-2","volume":"7","author":"A. K. Banga","year":"1988","unstructured":"A. K. Banga and Y. W. Chien. Iontophoretic delivery of drugs: fundamentals, developments, and biomedical applications. J. Control. Release\n                           7:1\u201324 (1988).","journal-title":"J. Control. Release"},{"key":"9010_CR12","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1002\/jps.2600831023","volume":"83","author":"S. P. Schwendeman","year":"1994","unstructured":"S. P. Schwendeman, G. L. Amidon, V. Labhasetwar, and R. J. Levy. Modulated drug release using iontophoresis through heterogeneous cation-exchange membranes. 2. Influence of cation-exchanger content on membrane resistance and characteristic times. J. Pharm. Sci.\n                           83:1482\u20131494 (1994).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR13","unstructured":"S. A. Molokhia, Y. Zhang, W. I. Higuchi, H. S. White, and S. K. Li. Iontophoretic transport across a multiple membrane system. In preparation."},{"key":"9010_CR14","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1002\/aic.690330902","volume":"33","author":"W. M. Deen","year":"1987","unstructured":"W. M. Deen. Hindered transport of large molecules in liquid-filled pores. AIChE J.\n                           33:1409\u20131425 (1987).","journal-title":"AIChE J."},{"key":"9010_CR15","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/jps.20293","volume":"94","author":"S. K. Li","year":"2005","unstructured":"S. K. Li, Y. Zhang, H. Zhu, W. I. Higuchi, and H. S. White. Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport. J. Pharm. Sci.\n                           94:847\u2013860 (2005).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR16","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1023\/A:1018998529283","volume":"11","author":"K. D. Peck","year":"1994","unstructured":"K. D. Peck, A. H. Ghanem, and W. I. Higuchi. Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane. Pharm. Res.\n                           11:1306\u20131314 (1994).","journal-title":"Pharm. Res."},{"key":"9010_CR17","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1021\/js960479m","volume":"86","author":"S. K. Li","year":"1997","unstructured":"S. K. Li, A. H. Ghanem, K. D. Peck, and W. I. Higuchi. Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge. J. Pharm. Sci.\n                           86:680\u2013689 (1997).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR18","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1021\/js950044j","volume":"85","author":"K. D. Peck","year":"1996","unstructured":"K. D. Peck, V. Srinivasan, S. K. Li, W. I. Higuchi, and A. H. Ghanem. Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane. J. Pharm. Sci.\n                           85:781\u2013788 (1996).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0169-409X(01)00193-4","volume":"52","author":"D. H. Geroski","year":"2001","unstructured":"D. H. Geroski and H. F. Edelhauser. Transscleral drug delivery for posterior segment disease. Adv. Drug Deliv. Rev.\n                           52:37\u201348 (2001).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9010_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpharm.2005.01.041","volume":"297","author":"N. He","year":"2005","unstructured":"N. He, K. S. Warner, W. I. Higuchi, and S. K. Li. Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers. Int. J. Pharm.\n                           297:9\u201321 (2005).","journal-title":"Int. J. Pharm."},{"key":"9010_CR21","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1007\/s11095-004-7669-3","volume":"21","author":"S. K. Li","year":"2004","unstructured":"S. K. Li, S. A. Molokhia, and E. K. Jeong. Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging. Pharm. Res.\n                           21:2175\u20132184 (2004).","journal-title":"Pharm. Res."},{"key":"9010_CR22","first-page":"627","volume":"38","author":"K. M. Hamalainen","year":"1997","unstructured":"K. M. Hamalainen, K. Kananen, S. Auriola, K. Kontturi, and A. Urtti. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera. Invest. Ophthalmol. Vis Sci.\n                           38:627\u2013634 (1997).","journal-title":"Invest. Ophthalmol. Vis Sci."},{"key":"9010_CR23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0014-4835(77)90136-1","volume":"25","author":"D. M. Maurice","year":"1977","unstructured":"D. M. Maurice and J. Polgar. Diffusion across the sclera. Exp. Eye Res.\n                           25:577\u2013582 (1977).","journal-title":"Exp. Eye Res."},{"key":"9010_CR24","first-page":"1893","volume":"36","author":"T. W. Olsen","year":"1995","unstructured":"T. W. Olsen, H. F. Edelhauser, J. I. Lim and D. H. Geroski. Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Invest. Ophthalmol. Vis Sci.\n                           36:1893\u20131903 (1995).","journal-title":"Invest. Ophthalmol. Vis Sci."},{"key":"9010_CR25","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1006\/jcis.1993.1027","volume":"155","author":"S. M. Sims","year":"1993","unstructured":"S. M. Sims, W. I. Higuchi, V. Srinivasan, and K. D. Peck. Ionic partition coefficients and electroosmotic flow in cylindrical pores: comparison of the predictions of the Poisson\u2013Boltzmann equation with experiment. J. Colloid Interface Sci.\n                           155:210\u2013220 (1993).","journal-title":"J. Colloid Interface Sci."},{"key":"9010_CR26","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0168-3659(89)90042-4","volume":"8","author":"G. B. Kasting","year":"1989","unstructured":"G. B. Kasting and J. C. Keister. Application of electro-diffusion theory for a homogeneous membrane to iontophoretic transport through skin. J. Control. Release\n                           8:195\u2013210 (1989).","journal-title":"J. Control. Release"},{"key":"9010_CR27","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1021\/js9802594","volume":"87","author":"M. R. Prausnitz","year":"1998","unstructured":"M. R. Prausnitz and J. S. Noonan. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J. Pharm. Sci.\n                           87:1479\u20131488 (1998).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR28","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1021\/js980331y","volume":"88","author":"S. K. Li","year":"1999","unstructured":"S. K. Li, A. H. Ghanem, K. D. Peck, and W. I. Higuchi. Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: a study using AC iontophoresis. J. Pharm. Sci.\n                           88:419\u2013427 (1999).","journal-title":"J. Pharm. Sci."},{"key":"9010_CR29","unstructured":"D. F. Untereker, J. B. Phipps, P. T. Cahalan, and K. R. Brennen. Iontophoresis electrode. US Patent 5,395,310 (1995)."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-006-9010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-006-9010-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-006-9010-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-006-9010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T23:19:55Z","timestamp":1652570395000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-006-9010-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,15]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["9010"],"URL":"https:\/\/doi.org\/10.1007\/s11095-006-9010-9","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,15]]},"assertion":[{"value":"19 January 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}