{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:30:42Z","timestamp":1789212642535,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1007\/s11095-006-9046-x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T23:08:18Z","timestamp":1155078498000},"page":"2030-2035","source":"Crossref","is-referenced-by-count":18,"title":["Predicting Plutonium Decorporation Efficacy after Intravenous Administration of DTPA Formulations: Study of Pharmacokinetic\u2013Pharmacodynamic Relationships in Rats"],"prefix":"10.1007","volume":"23","author":[{"given":"Guillaume","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Robert","family":"Deverre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Fattal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"B\u00e9nech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"9046_CR1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/00004032-196212000-00031","volume":"8","author":"W. D. Norwood","year":"1962","unstructured":"W. D. Norwood. Therapeutic removal of plutonium in humans. Health Phys. 8:747\u2013750 (1962).","journal-title":"Health Phys."},{"key":"9046_CR2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.rpd.a032979","volume":"87","author":"R. Wood","year":"2000","unstructured":"R. Wood, C. Sharp, P. Gourmelon, B. Le Guen, G. N. Stradling, D. M. Taylor, and M.-H. Heng\u00e9-Napoli. Decorporation treatment\u2014medical overview. Radiat. Prot. Dosim. 87:51\u201357 (2000).","journal-title":"Radiat. Prot. Dosim."},{"key":"9046_CR3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.rpd.a032975","volume":"87","author":"D. M. Taylor","year":"2000","unstructured":"D. M. Taylor, G. N. Stradling, and M.-H. Heng\u00e9-Napoli. The scientific background to decorporation. Radiat. Prot. Dosim. 87:11\u201317 (2000).","journal-title":"Radiat. Prot. Dosim."},{"key":"9046_CR4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/oxfordjournals.rpd.a032445","volume":"79","author":"P. W. Durbin","year":"1998","unstructured":"P. W. Durbin, B. Kullgren, J. Xu, and K. N. Raymond. Development of decorporation agents for the actinides. Radiat. Prot. Dosim. 79:433\u2013443 (1998).","journal-title":"Radiat. Prot. Dosim."},{"key":"9046_CR5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0047-0740(79)90061-5","volume":"6","author":"F. E. H. Crawley","year":"1979","unstructured":"F. E. H. Crawley and J. W. Haines. The dosimetry of carbon-14 labelled compounds: the metabolism of diethylenetriamine pentaacetic acid (DTPA) in the rat. Int. J. Nucl. Med. Biol. 6:9\u201315 (1979).","journal-title":"Int. J. Nucl. Med. Biol."},{"key":"9046_CR6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2307\/3574913","volume":"75","author":"W. Stevens","year":"1978","unstructured":"W. Stevens, F. W. Bruenger, and D. R. Atherton. The retention and distribution of 241Am and 65Zn, given as DTPA chelates in rats and of [14C]DTPA in rats and beagles. Radiat. Res. 75:397\u2013409 (1978).","journal-title":"Radiat. Res."},{"key":"9046_CR7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00004032-198301000-00006","volume":"44","author":"J. W. Stather","year":"1983","unstructured":"J. W. Stather, H. Smith, and M. R. Bailey. The retention of 14C-DPTA in human volunteers after inhalation or intravenous injection. Health Phys. 44:45\u201352 (1983).","journal-title":"Health Phys."},{"key":"9046_CR8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1126\/science.180.4083.300","volume":"180","author":"Y. E. Rahman","year":"1973","unstructured":"Y. E. Rahman, M. W. Rosenthal, and E. A. Cerny. Intracellular plutonium: removal by liposome-encapsulated chelating agent. Science 180:300\u2013302 (1973).","journal-title":"Science"},{"key":"9046_CR9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/09553000410001702300","volume":"80","author":"G. Phan","year":"2004","unstructured":"G. Phan, B. Ramounet-Le Gall, J. Manceau, M. Fanet, H. Benech, P. Fritsch, E. Fattal, and J.-R. Deverre. Targeting of diethylene triamine pentaacetic acid encapsulated in liposomes to rat liver: an effective strategy to prevent bone deposition and increase urine elimination of plutonium in rats. Int. J. Radiat. Biol. 80:413\u2013422 (2004).","journal-title":"Int. J. Radiat. Biol."},{"key":"9046_CR10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2005.09.029","volume":"110","author":"G. Phan","year":"2005","unstructured":"G. Phan, A. Herbet, S. Cholet, H. Benech, J.-R. Deverre, and E. Fattal. Pharmacokinetics of DTPA entrapped in conventional and long-circulating liposomes of different size for plutonium decorporation. J. Control. Release 110:177\u2013188 (2005).","journal-title":"J. Control. Release"},{"key":"9046_CR11","volume-title":"Pharmacocin\u00e9tique. Principes fondamentaux","author":"J. P. Labaune","year":"1988","unstructured":"J. P. Labaune. Pharmacocin\u00e9tique. Principes fondamentaux, 2nd ed. Masson, Paris, 1988.","edition":"2"},{"key":"9046_CR12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00004032-197303000-00007","volume":"24","author":"G. B. Schofield","year":"1973","unstructured":"G. B. Schofield and J. C. Lynn. A measure of the effectiveness of DTPA chelation therapy in cases of plutonium inhalation and plutonium wounds. Health Phys. 24:317\u2013326 (1973).","journal-title":"Health Phys."},{"key":"9046_CR13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00004032-197406000-00008","volume":"26","author":"G. B. Schofield","year":"1974","unstructured":"G. B. Schofield, H. Howells, and F. Ward. Assessment and management of a plutonium contaminated wound case. Health Phys. 26:541\u2013554 (1974).","journal-title":"Health Phys."},{"key":"9046_CR14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00004032-197209000-00007","volume":"23","author":"L. Jolly Jr.","year":"1972","unstructured":"L. Jolly Jr., H. A. McClearen, G. A. Poda, and W. P. Walke. Treatment and evaluation of a plutonium-238 nitrate contaminated puncture wound. A two-year case history. Health Phys. 23:333\u2013341 (1972).","journal-title":"Health Phys."},{"key":"9046_CR15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00004032-196212000-00033","volume":"8","author":"W. H. Langham","year":"1962","unstructured":"W. H. Langham, J. N. P. Lawrence, J. McClelland, and L. H. Hempelmann. The Los Alamos Scientific Laboratory's experience with plutonium in mans. Health Phys. 8:753\u2013760 (1962).","journal-title":"Health Phys."},{"key":"9046_CR16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00004032-197805000-00001","volume":"34","author":"R. M. Hall","year":"1978","unstructured":"R. M. Hall, G. A. Poda, R. R. Fleming, and J. A. Smith. A mathematical model for estimation of plutonium in the human body from urine data influenced by DTPA therapy. Health Phys. 34:419\u2013431 (1978).","journal-title":"Health Phys."},{"key":"9046_CR17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF01065658","volume":"13","author":"M. E. Wise","year":"1985","unstructured":"M. E. Wise. Negative power functions of time in pharmacokinetics and their implications. J. Pharmacokinet. Biopharm. 13:309\u2013346 (1985).","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"9046_CR18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02459967","volume":"51","author":"M. E. Wise","year":"1989","unstructured":"M. E. Wise and G. J. J. M. Borsboom. Two exceptional sets of physiological clearance curves and their mathematical form: test cases? Bull. Math. Biol. 51:579\u2013596 (1989).","journal-title":"Bull. Math. Biol."},{"key":"9046_CR19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1016031129053","volume":"13","author":"P. Macheras","year":"1996","unstructured":"P. Macheras. A fractal approach to heterogeneous drug distribution: calcium pharmacokinetics. Pharm. Res. 13:663\u2013670 (1996).","journal-title":"Pharm. Res."},{"key":"9046_CR20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/00004032-198512000-00007","volume":"49","author":"R. W. Leggett","year":"1985","unstructured":"R. W. Leggett. A model of the retention, translocation and excretion of systemic Pu. Health Phys. 49:1115\u20131137 (1985).","journal-title":"Health Phys."},{"key":"9046_CR21","unstructured":"The metabolism of plutonium and related elements. International Commission on Radiological Protection. A report of a Task Group of Committee 2. Annals of the ICRP 16: i\u2013vi, 1\u201398 (1986)."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-006-9046-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-006-9046-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-006-9046-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T05:38:54Z","timestamp":1559367534000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-006-9046-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["9046"],"URL":"https:\/\/doi.org\/10.1007\/s11095-006-9046-x","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,9]]}}}