{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:54:58Z","timestamp":1791035698775,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T00:00:00Z","timestamp":1174694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T00:00:00Z","timestamp":1174694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1007\/s11095-007-9287-3","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T13:48:14Z","timestamp":1174657694000},"page":"1590-1598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":217,"title":["Cellular Uptake of Cationic Polymer-DNA Complexes Via Caveolae Plays a Pivotal Role in Gene Transfection in COS-7 Cells"],"prefix":"10.1007","volume":"24","author":[{"given":"M. A. E. M.","family":"van der Aa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. S.","family":"Huth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"H\u00e4fele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Oosting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mastrobattista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. E.","family":"Hennink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Peschka-S\u00fcss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J. A.","family":"Crommelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,3,24]]},"reference":[{"key":"9287_CR1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1211\/002235703765951311","volume":"55","author":"Y. W. Cho","year":"2003","unstructured":"Y. W. Cho, J. D. Kim, and K. Park. Polycation gene delivery systems: escape from endosomes to cytosol. J. Pharm. Pharmacol.\n                           55:721\u2013734 (2003).","journal-title":"J. Pharm. Pharmacol."},{"key":"9287_CR2","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.addr.2004.12.008","volume":"57","author":"D. Lechardeur","year":"2005","unstructured":"D. Lechardeur, A. S. Verkman, and G. L. Lukacs. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv. Drug Deliv. Rev.\n                           57:755\u2013767 (2005).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9287_CR3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.addr.2004.10.004","volume":"57","author":"M. Belting","year":"2005","unstructured":"M. Belting, S. Sandgren, and A. Wittrup. Nuclear delivery of macromolecules: barriers and carriers. Adv. Drug Deliv. Rev.\n                           57:505\u2013527 (2005).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9287_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1124\/pr.58.1.8","volume":"58","author":"I. A. Khalil","year":"2006","unstructured":"I. A. Khalil, K. Kogure, H. Akita, and H. Harashima. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev.\n                           58:32\u201345 (2006).","journal-title":"Pharmacol. Rev."},{"key":"9287_CR5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0962-8924(01)02082-7","volume":"11","author":"K. Takeiand","year":"2001","unstructured":"K. Takeiand and V. Haucke. Clathrin-mediated endocytosis: membrane factors pull the trigger. Trends Cell Biol.\n                           11:385\u2013391 (2001).","journal-title":"Trends Cell Biol."},{"key":"9287_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev.biochem.67.1.199","volume":"67","author":"R. G. Anderson","year":"1998","unstructured":"R. G. Anderson. The caveolae membrane system. Annu. Rev. Biochem.\n                           67:199\u2013225 (1998).","journal-title":"Annu. Rev. Biochem."},{"key":"9287_CR7","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1242\/jcs.00327","volume":"116","author":"P. U. Le","year":"2003","unstructured":"P. U. Le and I. R. Nabi. Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum. J. Cell Sci.\n                           116:1059\u20131071 (2003).","journal-title":"J. Cell Sci."},{"key":"9287_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1083\/jcb.200302028","volume":"161","author":"I. R. Nabi","year":"2003","unstructured":"I. R. Nabi and P. U. Le. Caveolae\/raft-dependent endocytosis. J. Cell Biol.\n                           161:673\u2013677 (2003).","journal-title":"J. Cell Biol."},{"key":"9287_CR9","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/35074539","volume":"3","author":"L. Pelkmans","year":"2001","unstructured":"L. Pelkmans, J. Kartenbeck, and A. Helenius. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat. Cell Biol.\n                           3:473\u2013483 (2001).","journal-title":"Nat. Cell Biol."},{"key":"9287_CR10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1046\/j.1462-5822.2002.00230.x","volume":"4","author":"M. J. Duncan","year":"2002","unstructured":"M. J. Duncan, J. S. Shin, and S. N. Abraham. Microbial entry through caveolae: variations on a theme. Cell. Microbiol.\n                           4:783\u2013791 (2002).","journal-title":"Cell. Microbiol."},{"key":"9287_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0167-4889(99)00070-1","volume":"1450","author":"W. I. Lencer","year":"1999","unstructured":"W. I. Lencer, T. R. Hirst, and R. K. Holmes. Membrane traffic and the cellular uptake of cholera toxin. Biochim. Biophys. Acta\n                           1450:177\u2013190 (1999).","journal-title":"Biochim. Biophys. Acta"},{"key":"9287_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1034\/j.1600-0854.2002.30501.x","volume":"3","author":"L. Pelkmans","year":"2002","unstructured":"L. Pelkmans and A. Helenius. Endocytosis via caveolae. Traffic\n                           3:311\u2013320 (2002).","journal-title":"Traffic"},{"key":"9287_CR13","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S0962-8924(00)89101-1","volume":"5","author":"J. A. Swanson","year":"1995","unstructured":"J. A. Swanson and C. Watts. Macropinocytosis. Trends Cell Biol.\n                           5:424\u2013428 (1995).","journal-title":"Trends Cell Biol."},{"key":"9287_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/cyto.a.10105","volume":"57","author":"U. Huth","year":"2004","unstructured":"U. Huth, A. Wieschollek, Y. Garini, R. Schubert, and R. Peschka-Suss. Fourier transformed spectral bio-imaging for studying the intracellular fate of liposomes. Cytometry A\n                           57:10\u201321 (2004).","journal-title":"Cytometry A"},{"key":"9287_CR15","doi-asserted-by":"publisher","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","volume":"92","author":"O. Boussif","year":"1995","unstructured":"O. Boussif, F. Lezoualc\u2019h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA.\n                           92:7297\u20137301 (1995).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9287_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0168-3659(97)00059-X","volume":"49","author":"P. van de Wetering","year":"1997","unstructured":"P. van de Wetering, J. Y. Cherng, H. Talsma, and W. E. Hennink. Relation between transfection efficiency and cytotoxicity of poly(2-dimethylamino)ethyl methacrylate\/plasmid complexes. J. Control. Release\n                           49:59\u201369 (1997).","journal-title":"J. Control. Release"},{"key":"9287_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3109\/10611860009009209","volume":"8","author":"N. J. Zuidam","year":"2000","unstructured":"N. J. Zuidam, G. Posthuma, E. T. de Vries, D. J. Crommelin, W. E. Hennink, and G. Storm. Effects of physicochemical characteristics of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes on cellular association and internalization. J. Drug Target.\n                           8:51\u201366 (2000).","journal-title":"J. Drug Target."},{"key":"9287_CR18","doi-asserted-by":"publisher","first-page":"5177","DOI":"10.1073\/pnas.96.9.5177","volume":"96","author":"W. T. Godbey","year":"1999","unstructured":"W. T. Godbey, K. K. Wu, and A. G. Mikos. Tracking the intracellular path of poly(ethylenimine)\/DNA complexes for gene delivery. Proc. Natl. Acad. Sci. U. S. A.\n                           96:5177\u20135181 (1999).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9287_CR19","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0168-3659(02)00129-3","volume":"82","author":"T. Bieber","year":"2002","unstructured":"T. Bieber, W. Meissner, S. Kostin, A. Niemann, and H. Elsasser. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. J. Control. Release\n                           82:441 (2002).","journal-title":"J. Control. Release"},{"key":"9287_CR20","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/jgm.696","volume":"7","author":"A. Akinc","year":"2004","unstructured":"A. Akinc, M. Thomas, A. M. Klibanov, and R. Langer. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J. Gene Med.\n                           7:657\u2013663 (2004).","journal-title":"J. Gene Med."},{"key":"9287_CR21","doi-asserted-by":"publisher","first-page":"44826","DOI":"10.1074\/jbc.M308643200","volume":"278","author":"N. D. Sonawane","year":"2003","unstructured":"N. D. Sonawane, F. C. Szoka, Jr., and A. S. Verkman. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem.\n                           278:44826\u201344831 (2003).","journal-title":"J. Biol. Chem."},{"key":"9287_CR22","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/jgm.577","volume":"6","author":"S. Huth","year":"2004","unstructured":"S. Huth, J. Lausier, S. W. Gersting, C. Rudolph, C. Plank, U. Welsch, and J. Rosenecker. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J. Gene Med.\n                           6:923\u2013936 (2004).","journal-title":"J. Gene Med."},{"key":"9287_CR23","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.ymthe.2005.03.038","volume":"12","author":"J. Rejman","year":"2005","unstructured":"J. Rejman, A. Bragonzi, and M. Conese. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Mol. Ther.\n                           12:468\u2013474 (2005).","journal-title":"Mol. Ther."},{"key":"9287_CR24","doi-asserted-by":"crossref","unstructured":"S. Grosse, Y. Aron, G. Thevenot, D. Francois, M. Monsigny, and I. Fajac. Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycations. J. Gene. Med. (2005).","DOI":"10.1002\/jgm.772"},{"key":"9287_CR25","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1023\/A:1016054623543","volume":"13","author":"J. Y. Cherng","year":"1996","unstructured":"J. Y. Cherng, P. van de Wetering, H. Talsma, D. J. Crommelin, and W. E. Hennink. Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles. Pharm. Res.\n                           13:1038\u20131042 (1996).","journal-title":"Pharm. Res."},{"key":"9287_CR26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jgm.643","volume":"7","author":"M. A. van der Aa","year":"2004","unstructured":"M. A. van der Aa, G. A. Koning, C. d\u2019Oliveira, R. S. Oosting, K. J. Wilschut, W. E. Hennink, and D. J. Crommelin. An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems. J. Gene Med.\n                           7:208\u2013217 (2004).","journal-title":"J. Gene Med."},{"key":"9287_CR27","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1023\/A:1015096302720","volume":"16","author":"C. Arigita","year":"1999","unstructured":"C. Arigita, N. J. Zuidam, D. J. Crommelin, and W. E. Hennink. Association and dissociation characteristics of polymer\/DNA complexes used for gene delivery. Pharm. Res.\n                           16:1534\u20131541 (1999).","journal-title":"Pharm. Res."},{"key":"9287_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0092-8674(87)90295-9","volume":"49","author":"S. Rothenberger","year":"1987","unstructured":"S. Rothenberger, B. J. Iacopetta, and L. C. Kuhn. Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site. Cell\n                           49:423\u2013431 (1987).","journal-title":"Cell"},{"key":"9287_CR29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1242\/jcs.103.1.211","volume":"103","author":"I. Killisch","year":"1992","unstructured":"I. Killisch, P. Steinlein, K. Romisch, R. Hollinshead, H. Beug, and G. Griffiths. Characterization of early and late endocytic compartments of the transferrin cycle. Transferrin receptor antibody blocks erythroid differentiation by trapping the receptor in the early endosome. J. Cell Sci.\n                           103:211\u2013232 (1992).","journal-title":"J. Cell Sci."},{"key":"9287_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.cellbio.18.011502.142107","volume":"18","author":"K. Sandvig","year":"2002","unstructured":"K. Sandvig, and B. van Deurs. Membrane traffic exploited by protein toxins. Annu. Rev. Cell Dev. Biol.\n                           18:1\u201324 (2002).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"9287_CR31","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/ncb1103","volume":"6","author":"O. O. Glebov","year":"2004","unstructured":"O. O. Glebov and B. J. Nichols. Lipid raft proteins have a random distribution during localized activation of the T-cell receptor. Nat. Cell Biol.\n                           6:238\u2013243 (2004).","journal-title":"Nat. Cell Biol."},{"key":"9287_CR32","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1083\/jcb.200407078","volume":"168","author":"M. Kirkham","year":"2005","unstructured":"M. Kirkham, A. Fujita, R. Chadda, S. J. Nixon, T. V. Kurzchalia, D. K. Sharma, R. E. Pagano, J. F. Hancock, S. Mayor, and R. G. Parton. Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. J. Cell Biol.\n                           168:465\u2013476 (2005).","journal-title":"J. Cell Biol."},{"issue":"3","key":"9287_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.jconrel.2005.10.018","volume":"110","author":"U. Huth","year":"2006","unstructured":"U. Huth, R. Schubert, and R. Peschka-Suss. Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging. J. Control. Release\n                           110(3):490\u2013504 (2006).","journal-title":"J. Control. Release"},{"key":"9287_CR34","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1083\/jcb.135.5.1249","volume":"135","author":"N. Araki","year":"1996","unstructured":"N. Araki, M. T. Johnson, and J. A. Swanson. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol.\n                           135:1249\u20131260 (1996).","journal-title":"J. Cell Biol."},{"key":"9287_CR35","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1083\/jcb.132.4.595","volume":"132","author":"H. Shpetner","year":"1996","unstructured":"H. Shpetner, M. Joly, D. Hartley, and S. Corvera. Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J. Cell Biol.\n                           132:595\u2013605 (1996).","journal-title":"J. Cell Biol."},{"key":"9287_CR36","doi-asserted-by":"publisher","first-page":"17250","DOI":"10.1074\/jbc.270.29.17250","volume":"270","author":"E. P. Kilsdonk","year":"1995","unstructured":"E. P. Kilsdonk, P. G. Yancey, G. W. Stoudt, F. W. Bangerter, W. J. Johnson, M. C. Phillips, and G. H. Rothblat. Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem.\n                           270:17250\u201317256 (1995).","journal-title":"J. Biol. Chem."},{"key":"9287_CR37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1091\/mbc.10.4.961","volume":"10","author":"S. K. Rodal","year":"1999","unstructured":"S. K. Rodal, G. Skretting, O. Garred, F. Vilhardt, B. van Deurs, and K. Sandvig. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol. Biol. Cell\n                           10:961\u2013974 (1999).","journal-title":"Mol. Biol. Cell"},{"key":"9287_CR38","doi-asserted-by":"publisher","first-page":"6775","DOI":"10.1073\/pnas.96.12.6775","volume":"96","author":"A. Subtil","year":"1999","unstructured":"A. Subtil, I. Gaidarov, K. Kobylarz, M. A. Lampson, J. H. Keen, and T. E. McGraw. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc. Natl. Acad. Sci. U. S. A.\n                           96:6775\u20136780 (1999).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9287_CR39","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1083\/jcb.127.5.1199","volume":"127","author":"R. G. Parton","year":"1994","unstructured":"R. G. Parton, B. Joggerst, and K. Simons. Regulated internalization of caveolae. J. Cell Biol.\n                           127:1199\u20131215 (1994).","journal-title":"J. Cell Biol."},{"key":"9287_CR40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1083\/jcb.131.1.69","volume":"131","author":"H. Damke","year":"1995","unstructured":"H. Damke, T. Baba, A. M. van der Bliek, and S. L. Schmid. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J. Cell Biol.\n                           131:69\u201380 (1995).","journal-title":"J. Cell Biol."},{"key":"9287_CR41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ncb787","volume":"4","author":"B. J. Nichols","year":"2002","unstructured":"B. J. Nichols. A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex. Nat. Cell Biol.\n                           4:374\u2013378 (2002).","journal-title":"Nat. Cell Biol."},{"key":"9287_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1042\/BJ20031253","volume":"377","author":"J. Rejman","year":"2004","unstructured":"J. Rejman, V. Oberle, I. S. Zuhorn, and D. Hoekstra. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J.\n                           377:159\u2013169 (2004).","journal-title":"Biochem. J."},{"key":"9287_CR43","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ymthe.2004.05.023","volume":"10","author":"C. Goncalves","year":"2004","unstructured":"C. Goncalves, E. Mennesson, R. Fuchs, J. P. Gorvel, P. Midoux, and C. Pichon. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells. Mol. Ther.\n                           10:373\u2013385 (2004).","journal-title":"Mol. Ther."},{"key":"9287_CR44","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/jgm.173","volume":"3","author":"A. Kichler","year":"2001","unstructured":"A. Kichler, C. Leborgne, E. Coeytaux, and O. Danos. Polyethylenimine-mediated gene delivery: a mechanistic study. J. Gene Med.\n                           3:135\u2013144 (2001).","journal-title":"J. Gene Med."},{"key":"9287_CR45","doi-asserted-by":"publisher","first-page":"7972","DOI":"10.1073\/pnas.85.21.7972","volume":"85","author":"E. J. Bowman","year":"1988","unstructured":"E. J. Bowman, A. Siebers, and K. Altendorf. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc. Natl. Acad. Sci. USA.\n                           85:7972\u20137976 (1988).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9287_CR46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1006\/excr.1996.0133","volume":"224","author":"C. Mineo","year":"1996","unstructured":"C. Mineo and R. G. Anderson. A vacuolar-type proton ATPase mediates acidification of plasmalemmal vesicles during potocytosis. Exp. Cell Res.\n                           224:237\u2013242 (1996).","journal-title":"Exp. Cell Res."},{"key":"9287_CR47","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/jgm.558","volume":"6","author":"I. Kopatz","year":"2004","unstructured":"I. Kopatz, J. S. Remy, and J. P. Behr. A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin. J. Gene Med.\n                           6:769\u2013776 (2004).","journal-title":"J. Gene Med."},{"key":"9287_CR48","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.ymthe.2006.07.006","volume":"14","author":"K. von Gersdorff","year":"2006","unstructured":"K. von Gersdorff, N. N. Sanders, R. Vandenbroucke, S. C. De Smedt, E. Wagner, and M. Ogris. The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type. Mol. Ther.\n                           14:745\u2013753 (2006).","journal-title":"Mol. Ther."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9287-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-007-9287-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9287-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9287-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T19:14:28Z","timestamp":1630437268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-007-9287-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,24]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["9287"],"URL":"https:\/\/doi.org\/10.1007\/s11095-007-9287-3","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,24]]},"assertion":[{"value":"5 January 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}