{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:25:31Z","timestamp":1791231931350,"version":"4.1.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1007\/s11095-007-9347-8","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T17:54:20Z","timestamp":1190742860000},"page":"500-511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Natural and Synthetic Polymers as Inhibitors of Drug Efflux Pumps"],"prefix":"10.1007","volume":"25","author":[{"given":"Martin","family":"Werle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"9347_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","volume":"455","author":"R. L. Juliano","year":"1976","unstructured":"R. L. Juliano and V. Ling. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 455:152\u2013162 (1976).","journal-title":"Biochim. Biophys. Acta"},{"key":"9347_CR2","doi-asserted-by":"publisher","first-page":"7735","DOI":"10.1073\/pnas.84.21.7735","volume":"84","author":"F. Thiebaut","year":"1987","unstructured":"F. Thiebaut, T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, and M. C. Willingham. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U. S. A. 84:7735\u20137738 (1987).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9347_CR3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/38.9.1974900","volume":"38","author":"C. Cordon-Cardo","year":"1990","unstructured":"C. Cordon-Cardo, J. P. O\u2019Brien, J. Boccia, D. Casals, J. R. Bertino, and M. R. Melamed. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38:1277\u20131287 (1990).","journal-title":"J. Histochem. Cytochem."},{"key":"9347_CR4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.31887\/DCNS.2006.8.3\/fgirardin","volume":"8","author":"F. Girardin","year":"2006","unstructured":"F. Girardin. Membrane transporter proteins: a challenge for CNS drug development. Dialogues Clin. Neurosci. 8:311\u2013321 (2006).","journal-title":"Dialogues Clin. Neurosci."},{"key":"9347_CR5","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.addr.2004.02.006","volume":"56","author":"S. Majumdar","year":"2004","unstructured":"S. Majumdar, S. Duvvuri, and A. K. Mitra. Membrane transporter\/receptor-targeted prodrug design: strategies for human and veterinary drug development. Adv. Drug Deliv. Rev. 56:1437\u20131452 (2004).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9347_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.cbpa.2006.06.015","volume":"10","author":"M. V. Varma","year":"2006","unstructured":"M. V. Varma, O. P. Perumal, and R. Panchagnula. Functional role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery. Curr. Opin. Chem. Biol. 10:367\u2013373 (2006).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"9347_CR7","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/00007691-199810000-00024","volume":"20","author":"A. Tsuji","year":"1998","unstructured":"A. Tsuji. P-glycoprotein-mediated efflux transport of anticancer drugs at the blood-brain barrier. Ther. Drug Monit. 20:588\u2013590 (1998).","journal-title":"Ther. Drug Monit."},{"key":"9347_CR8","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/S0006-291X(88)80073-1","volume":"152","author":"H. Goldberg","year":"1988","unstructured":"H. Goldberg, V. Ling, P. Y. Wong, and K. Skorecki. Reduced cyclosporin accumulation in multidrug-resistant cells. Biochem. Biophys. Res. Commun. 152:552\u2013558 (1988).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9347_CR9","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0021-9258(19)85010-X","volume":"264","author":"C. P. Yang","year":"1989","unstructured":"C. P. Yang, S. G. DePinho, L. M. Greenberger, R. J. Arceci, and S. B. Horwitz. Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus. J. Biol. Chem. 264:782\u2013788 (1989).","journal-title":"J. Biol. Chem."},{"key":"9347_CR10","first-page":"5002","volume":"49","author":"K. Yusa","year":"1989","unstructured":"K. Yusa and T. Tsuruo. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562\/ADM cells. Cancer Res. 49:5002\u20135006 (1989).","journal-title":"Cancer Res."},{"key":"9347_CR11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1476-5381.1993.tb13914.x","volume":"110","author":"J. Karlsson","year":"1993","unstructured":"J. Karlsson, S. M. Kuo, J. Ziemniak, and P. Artursson. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110:1009\u20131016 (1993).","journal-title":"Br. J. Pharmacol."},{"key":"9347_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/0006-291X(92)91593-F","volume":"189","author":"I. A. de Lannoy","year":"1992","unstructured":"I. A. de Lannoy and M. Silverman. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. 189:551\u2013557 (1992).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9347_CR13","first-page":"331","volume":"15","author":"D. Leveque","year":"1995","unstructured":"D. Leveque and F. Jehl. P-glycoprotein and pharmacokinetics. Anticancer Res. 15:331\u2013336 (1995).","journal-title":"Anticancer Res."},{"key":"9347_CR14","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/10915810600746023","volume":"25","author":"S. Choudhuri","year":"2006","unstructured":"S. Choudhuri and C. D. Klaassen. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int. J. Toxicol. 25:231\u2013259 (2006).","journal-title":"Int. J. Toxicol."},{"key":"9347_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/00001813-200102000-00003","volume":"12","author":"M. Mazel","year":"2001","unstructured":"M. Mazel, P. Clair, C. Rousselle, P. Vidal, J. M. Scherrmann, D. Mathieu, and J. Temsamani. Doxorubicin\u2013peptide conjugates overcome multidrug resistance. Anticancer Drugs 12:107\u2013116 (2001).","journal-title":"Anticancer Drugs"},{"key":"9347_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/mp0500871","volume":"3","author":"T. J. Raub","year":"2006","unstructured":"T. J. Raub. P-glycoprotein recognition of substrates and circumvention through rational drug design. Mol. Pharmacol. 3:3\u201325 (2006).","journal-title":"Mol. Pharmacol."},{"key":"9347_CR17","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S1043-6618(03)00158-0","volume":"48","author":"M. V. Varma","year":"2003","unstructured":"M. V. Varma, Y. Ashokraj, C. S. Dey, and R. Panchagnula. P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol. Res. 48:347\u2013359 (2003).","journal-title":"Pharmacol. Res."},{"key":"9347_CR18","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ejps.2005.04.003","volume":"25","author":"M. V. Varma","year":"2005","unstructured":"M. V. Varma and R. Panchagnula. Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo. Eur. J. Pharm. Sci. 25:445\u2013453 (2005).","journal-title":"Eur. J. Pharm. Sci."},{"key":"9347_CR19","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/(SICI)1520-6017(200004)89:4<429::AID-JPS1>3.0.CO;2-J","volume":"89","author":"B. J. Aungst","year":"2000","unstructured":"B. J. Aungst. Intestinal permeation enhancers. J. Pharm. Sci. 89:429\u2013442 (2000).","journal-title":"J. Pharm. Sci."},{"key":"9347_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-3659(97)00204-6","volume":"52","author":"A. Bernkop-Schn\u00fcrch","year":"1998","unstructured":"A. Bernkop-Schn\u00fcrch. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release 52:1\u201316 (1998).","journal-title":"J. Control. Release"},{"key":"9347_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0168-3659(96)01536-2","volume":"45","author":"H. L. Luessen","year":"1997","unstructured":"H. L. Luessen, C. O. Rentel, A. F. Kotz\u00e9, C.-M. Lehr, A. G. deBoer, J. C. Verhoef, and H. E. Junginger. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control. Release 45:15\u201323 (1997).","journal-title":"J. Control. Release"},{"key":"9347_CR22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v22.i5.10","volume":"22","author":"S. A. Galindo-Rodriguez","year":"2005","unstructured":"S. A. Galindo-Rodriguez, E. Allemann, H. Fessi, and E. Doelker. Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies. Crit. Rev. Ther. Drug Carr. Syst. 22:419\u2013464 (2005).","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"9347_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1023\/A:1022286422439","volume":"20","author":"J. S. Woo","year":"2003","unstructured":"J. S. Woo, C. H. Lee, C. K. Shim, and S. J. Hwang. Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031. Pharmacol. Res. 20:24\u201330 (2003).","journal-title":"Pharmacol. Res."},{"key":"9347_CR24","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/S0024-3205(00)00786-4","volume":"67","author":"S. K. Banerjee","year":"2000","unstructured":"S. K. Banerjee, C. Jagannath, R. L. Hunter, and A. Dasgupta. Bioavailability of tobramycin after oral delivery in FVB mice using CRL-1605 copolymer, an inhibitor of P-glycoprotein. Life Sci. 67:2011\u20132016 (2000).","journal-title":"Life Sci."},{"key":"9347_CR25","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511570216","volume-title":"Introduction to the Blood-Brain Barrier. Methodology, Biology and Pathology","author":"W. M. Pardridge","year":"1998","unstructured":"W. M. Pardridge. Introduction to the Blood-Brain Barrier. Methodology, Biology and Pathology, Cambridge University Press, Cambridge, 1998."},{"key":"9347_CR26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0022-3565(24)38781-6","volume":"296","author":"E. V. Batrakova","year":"2001","unstructured":"E. V. Batrakova, D. W. Miller, S. Li, V. Alakhov, A. V. Kabanov, and W. F. Elmquist. Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies. J. Pharmacol. Exp. Ther. 296:551\u2013557 (2001).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"9347_CR27","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S0006-291X(88)81321-4","volume":"153","author":"W. T. Beck","year":"1988","unstructured":"W. T. Beck, M. C. Cirtain, C. J. Glover, R. L. Felsted, and A. R. Safa. Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine. Biochem. Biophys. Res. Commun. 153:959\u2013966 (1988).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9347_CR28","first-page":"1967","volume":"41","author":"T. Tsuruo","year":"1981","unstructured":"T. Tsuruo, H. Iida, S. Tsukagoshi, and Y. Sakurai. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 41:1967\u20131972 (1981).","journal-title":"Cancer Res."},{"key":"9347_CR29","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/bjc.1997.530","volume":"76","author":"J. van Asperen","year":"1997","unstructured":"J. van Asperen, O. van Tellingen, A. Sparreboom, A. H. Schinkel, P. Borst, W. J. Nooijen, and J. H. Beijnen. Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. Br. J. Cancer 76:1181\u20131183 (1997).","journal-title":"Br. J. Cancer"},{"key":"9347_CR30","first-page":"4416","volume":"6","author":"H. A. Bardelmeijer","year":"2000","unstructured":"H. A. Bardelmeijer, J. H. Beijnen, K. R. Brouwer, H. Rosing, W. J. Nooijen, J. H. Schellens, and O. van Tellingen. Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein. Clin. Cancer Res. 6:4416\u20134421 (2000).","journal-title":"Clin. Cancer Res."},{"key":"9347_CR31","first-page":"297","volume":"2","author":"E. Friche","year":"1990","unstructured":"E. Friche, P. B. Jensen, M. Sehested, E. J. Demant, and N. N. Nissen. The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor. Cancer Commun. 2:297\u2013303 (1990).","journal-title":"Cancer Commun."},{"key":"9347_CR32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1021\/bc950093n","volume":"7","author":"V. Alakhov","year":"1996","unstructured":"V. Alakhov, E. Y. Moskaleva, E. V. Batrakova, and A. V. Kabanov. Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer. Bioconjug. Chem. 7:209\u2013216 (1996).","journal-title":"Bioconjug. Chem."},{"key":"9347_CR33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0167-4889(01)00175-6","volume":"1542","author":"J. Jodoin","year":"2002","unstructured":"J. Jodoin, M. Demeule, and R. Beliveau. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta 1542:149\u2013159 (2002).","journal-title":"Biochim. Biophys. Acta"},{"key":"9347_CR34","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/sj.bjp.0706008","volume":"143","author":"Y. Honda","year":"2004","unstructured":"Y. Honda, F. Ushigome, N. Koyabu, S. Morimoto, Y. Shoyama, T. Uchiumi, M. Kuwano, H. Ohtani, and Y. Sawada. Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br. J. Pharmacol. 143:856\u2013864 (2004).","journal-title":"Br. J. Pharmacol."},{"key":"9347_CR35","unstructured":"B. Carreno-Gomez and R. Duncan. Compositions with enhanced oral bioavailability. USP 20030211072 (2002)."},{"key":"9347_CR36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0378-5173(03)00271-0","volume":"260","author":"A. Bernkop-Schn\u00fcrch","year":"2003","unstructured":"A. Bernkop-Schn\u00fcrch, M. Hornof, and T. Zoidl. Thiolated polymers\u2013thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int. J. Pharm. 260:229\u2013237 (2003).","journal-title":"Int. J. Pharm."},{"key":"9347_CR37","doi-asserted-by":"crossref","unstructured":"B. M. Johnson, W. N. Charman, and C. J. H. Porter. An in vitro examination of the impact of polyehtylene glycol 400, pluronic P 85 and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on p-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. AAPS PharmSci. 4(4) (2002).","DOI":"10.1208\/ps040440"},{"key":"9347_CR38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijpharm.2006.01.020","volume":"313","author":"Q. Shen","year":"2006","unstructured":"Q. Shen, Y. Lin, T. Handa, M. Doi, M. Sugie, K. Wakayama, N. Okada, T. Fujita, and A. Yamamoto. Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int. J. Pharm. 313:49\u201356 (2006).","journal-title":"Int. J. Pharm."},{"key":"9347_CR39","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/jps.10175","volume":"91","author":"E. D. Hugger","year":"2002","unstructured":"E. D. Hugger, K. L. Audus, and R. T. Borchardt. Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers. J. Pharm. Sci. 91:1980\u20131990 (2002).","journal-title":"J. Pharm. Sci."},{"key":"9347_CR40","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/jps.10176","volume":"91","author":"E. D. Hugger","year":"2002","unstructured":"E. D. Hugger, B. L. Novak, P. S. Burton, K. L. Audus, and R. T. Borchardt. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J. Pharm. Sci. 91:1991\u20132002 (2002).","journal-title":"J. Pharm. Sci."},{"key":"9347_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ijpharm.2004.05.014","volume":"280","author":"J. S. Choi","year":"2004","unstructured":"J. S. Choi and B. W. Jo. Enhanced paclitaxel bioavailability after oral administration of pegylated paclitaxel prodrug for oral delivery in rats. Int. J. Pharm. 280:221\u2013227 (2004).","journal-title":"Int. J. Pharm."},{"key":"9347_CR42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jconrel.2005.11.005","volume":"111","author":"E. M. Collnot","year":"2006","unstructured":"E. M. Collnot, C. Baldes, M. F. Wempe, J. Hyatt, L. Navarro, K. J. Edgar, U. F. Schaefer, and C.-M. Lehr. Influence of vitamin E TPGS poly(ethlyene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J. Control. Release 111:35\u201340 (2006).","journal-title":"J. Control. Release"},{"key":"9347_CR43","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/jps.20017","volume":"93","author":"Y. Shono","year":"2004","unstructured":"Y. Shono, H. Nishihara, Y. Matsuda, S. Furukawa, N. Okada, T. Fujita, and A. Yamamoto. Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. J. Pharm. Sci. 93:877\u2013885 (2004).","journal-title":"J. Pharm. Sci."},{"key":"9347_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0168-3659(03)00163-9","volume":"90","author":"Y. L. Lo","year":"2003","unstructured":"Y. L. Lo. Relationships between the hydrophilic\u2013lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. J. Control. Release 90:37\u201348 (2003).","journal-title":"J. Control. Release"},{"key":"9347_CR45","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1007\/BF02976689","volume":"26","author":"H. Zhang","year":"2003","unstructured":"H. Zhang, M. Yao, R. A. Morrison, and S. Chong. Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats. Arch. Pharm. Res. 26:768\u2013772 (2003).","journal-title":"Arch. Pharm. Res."},{"key":"9347_CR46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0928-0987(02)00055-6","volume":"16","author":"B. D. Rege","year":"2002","unstructured":"B. D. Rege, J. P. Kao, and J. E. Polli. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 16:237\u2013226 (2002).","journal-title":"Eur. J. Pharm. Sci."},{"key":"9347_CR47","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/03639040500388573","volume":"32","author":"C. Liu","year":"2006","unstructured":"C. Liu, J. Wu, B. Shi, Y. Zhang, T. Gao, and Y. Pei. Enhancing the bioavailability of cyclosporine a using solid dispersion containing polyoxyethylene (40) stearate. Drug Dev. Ind. Pharm. 32:115\u2013123 (2006).","journal-title":"Drug Dev. Ind. Pharm."},{"key":"9347_CR48","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.1016\/j.biomaterials.2006.08.004","volume":"27","author":"F. F\u00f6ger","year":"2006","unstructured":"F. F\u00f6ger, H. Hoyer, K. Kafedjiiski, M. Thaurer, and A. Bernkop-Schn\u00fcrch. In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials 27:5855\u20135860 (2006).","journal-title":"Biomaterials"},{"key":"9347_CR49","first-page":"95","volume":"10","author":"R. L. Hunter","year":"1994","unstructured":"R. L. Hunter, J. McNicholl, and A. A. Lal. Mechanisms of action of nonionic block copolymer adjuvants. AIDS Res. Hum. Retrovir. 10:95\u201398 (1994).","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"9347_CR50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0002-9610(76)90293-2","volume":"132","author":"G. Rodeheaver","year":"1976","unstructured":"G. Rodeheaver, V. Turnbull, M. T. Edgerton, L. Kurtz, and R. F. Edlich. Pharmacokinetics of a new skin wound cleanser. Am. J. Surg. 132:67\u201374 (1976).","journal-title":"Am. J. Surg."},{"key":"9347_CR51","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0022-3565(24)29254-5","volume":"299","author":"E. V. Batrakova","year":"2001","unstructured":"E. V. Batrakova, S. Li, S. V. Vinogradov, V. Alakhov, D. W. Miller, and A. V. Kabanov. Mechanism of pluronic effect on p-glycoprotein efflux system in blood brain barrier: contributions of energy depletion and membrane fluidization. Pharmacol. Exp. Ther. 299:483\u2013493 (2001).","journal-title":"Pharmacol. Exp. Ther."},{"key":"9347_CR52","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1021\/bc970118d","volume":"8","author":"D. W. Miller","year":"1997","unstructured":"D. W. Miller, E. V. Batrakova, D. O. Waltner, V. Alakhov, and A. V. Kabanov. Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence for two potential pathways for drug absorption. Bioconjug. Chem. 8:649\u2013657 (1997).","journal-title":"Bioconjug. Chem."},{"key":"9347_CR53","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/S0024-3205(99)00111-3","volume":"64","author":"C. Jagannath","year":"1999","unstructured":"C. Jagannath, A. Wells, M. Mshvildadze, M. Olsen, E. Sepulveda, M. Emanuele, R. L. J. Hunter, and A. Dasgupta. Significantly improved oral uptake of amikacin in FVB mice in the presence of CRL-1605 copolymer. Life Sci. 64:1733\u20131738 (1999).","journal-title":"Life Sci."},{"issue":"1","key":"9347_CR54","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0169-409X(02)00176-X","volume":"55","author":"A. V. Kabanov","year":"2003","unstructured":"A. V. Kabanov, E. V. Batrakova, and D. W. Miller. Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv. Drug Deliv. Rev. 55(1):151\u2013164 (2003).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9347_CR55","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1023\/A:1018990706838","volume":"16","author":"E. V. Batrakova","year":"1999","unstructured":"E. V. Batrakova, S. Li, D. W. Miller, and A. V. Kabanov. Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers. Pharm. Res. 16:1366\u20131372 (1999).","journal-title":"Pharm. Res."},{"key":"9347_CR56","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0169-409X(02)00047-9","volume":"54","author":"A. V. Kabanov","year":"2002","unstructured":"A. V. Kabanov, E. V. Batrakova, and V. Y. Alakhov. Pluronic block copolymers for overcoming drug resistance in cancer. Adv. Drug Deliv. Rev. 54:759\u2013779 (2002).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9347_CR57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0939-6411(00)00075-8","volume":"50","author":"J. Kopecek","year":"2000","unstructured":"J. Kopecek, P. Kopeckova, T. Minko, and Z. Lu. HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur. J. Pharm. Biopharm. 50:61\u201381 (2000).","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"9347_CR58","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0168-3659(01)00330-3","volume":"74","author":"J. Kopecek","year":"2001","unstructured":"J. Kopecek, P. Kopeckova, T. Minko, Z. R. Lu, and C. M. Peterson. Water soluble polymers in tumor targeted delivery. J. Control. Release 74:147\u2013158 (2001).","journal-title":"J. Control. Release"},{"key":"9347_CR59","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0927-7765(99)00064-8","volume":"16","author":"V. Alakhov","year":"1999","unstructured":"V. Alakhov, E. Klinksi, S. Li, G. Pietrzynski, A. Venne, E. Batrakova, T. Bronitch, and A. V. Kabanov. Block co-polymer based formulation of doxorubicin. From cell screen to clinical trials. Colloids Surf., B Biointerfaces 16:113\u2013134 (1999).","journal-title":"Colloids Surf., B Biointerfaces"},{"issue":"16","key":"9347_CR60","first-page":"3626","volume":"56","author":"A. Venne","year":"1996","unstructured":"A. Venne, S. Li, R. Mandeville, A. V. Kabanov, and V. Alakhov. Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells. Cancer Res. 56(16):3626\u20133629 (1996, Aug 15).","journal-title":"Cancer Res."},{"key":"9347_CR61","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1023\/A:1018942823676","volume":"16","author":"E. Batrakova","year":"1999","unstructured":"E. Batrakova, S. Lee, S. Li, A. Venne, V. Alakhov, and A. V. Kabanov. Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells. Pharm. Res. 16:1373\u20131379 (1999).","journal-title":"Pharm. Res."},{"key":"9347_CR62","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1054\/bjoc.2000.1260","volume":"83","author":"R. Evers","year":"2000","unstructured":"R. Evers, M. Kool, A. J. Smith, L. van Deemter, M. de Haas, and P. Borst. Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport. Br. J. Cancer 83:366\u2013374 (2000).","journal-title":"Br. J. Cancer"},{"key":"9347_CR63","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1023\/A:1011964213024","volume":"15","author":"E. V. Batrakova","year":"1998","unstructured":"E. V. Batrakova, H. Y. Han, V. Alakhov, D. W. Miller, and A. V. Kabanov. Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm. Res. 15:850\u2013855 (1998).","journal-title":"Pharm. Res."},{"key":"9347_CR64","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1007\/s11095-004-7675-5","volume":"21","author":"E. V. Batrakova","year":"2004","unstructured":"E. V. Batrakova, S. Li, Y. Li, V. Y. Alakhov, and A. V. Kabanov. Effect of pluronic P85 on ATPase activity of drug efflux transporters. Pharm. Res. 21:2226\u20132233 (2004).","journal-title":"Pharm. Res."},{"key":"9347_CR65","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-1978-24702","volume":"2","author":"E. Buhleier","year":"1978","unstructured":"E. Buhleier, W. Wehner, and F. V\u00f6gtle. \u201cCascade\u201d- and \u201cnonskid-chain-like\u201d syntheses of molecular cavity topologies. Synthesis 2:155\u2013158 (1978).","journal-title":"Synthesis"},{"key":"9347_CR66","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1359-6446(04)03276-3","volume":"10","author":"E. R. Gillies","year":"2005","unstructured":"E. R. Gillies and J. M. Frechet. Dendrimers and dendritic polymers in drug delivery. Drug Discov. Today 10:35\u201343 (2005).","journal-title":"Drug Discov. Today"},{"key":"9347_CR67","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1016\/j.addr.2005.09.017","volume":"57","author":"C. Dufes","year":"2005","unstructured":"C. Dufes, I. F. Uchegbu, and A. G. Schatzlein. Dendrimers in gene delivery. Adv. Drug Deliv. Rev. 57:2177\u2013202 (2005).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9347_CR68","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1021\/mp050019e","volume":"2","author":"V. J. Venditto","year":"2005","unstructured":"V. J. Venditto, C. A. Regino, and M. W. Brechbiel. PAMAM dendrimer based macromolecules as improved contrast agents. Mol. Pharm. 2:302\u2013311 (2005).","journal-title":"Mol. Pharm."},{"key":"9347_CR69","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jconrel.2003.12.006","volume":"95","author":"A. D\u2019Emanuele","year":"2004","unstructured":"A. D\u2019Emanuele, R. Jevprasesphant, J. Penny, and D. Attwood. The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J. Control. Release 95:447\u2013453 (2004).","journal-title":"J. Control. Release"},{"key":"9347_CR70","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.addr.2005.07.002","volume":"57","author":"A. Bernkop-Schn\u00fcrch","year":"2004","unstructured":"A. Bernkop-Schn\u00fcrch. Thiomers: a new generation of mucoadhesive polymers. Adv. Drug Deliv. Rev. 57:1569\u20131582 (2004).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9347_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jconrel.2005.11.011","volume":"111","author":"M. Werle","year":"2006","unstructured":"M. Werle and M. Hoffer. Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. J. Control. Release 111:41\u201346 (2006).","journal-title":"J. Control. Release"},{"issue":"1","key":"9347_CR72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0168-3659(96)01536-2","volume":"45","author":"H. L. Luessen","year":"1997","unstructured":"H. L. Luessen, C. O. Rentel, A. F. Kotz\u00e9, C.-M. Lehr, A. B. G. de Boer, J. C. Verhoef, and H. E. Junginger. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control. Release 45(1):15\u201323 (1997).","journal-title":"J. Control. Release"},{"key":"9347_CR73","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1211\/0022357011775659","volume":"53","author":"L. Bromberg","year":"2001","unstructured":"L. Bromberg. Interactions among proteins and hydrophobically modified polyelectrolytes. J. Pharm. Pharmacol. 53:541\u2013547 (2001).","journal-title":"J. Pharm. Pharmacol."},{"key":"9347_CR74","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0168-3659(94)90078-7","volume":"29","author":"H. L. Luessen","year":"1994","unstructured":"H. L. Luessen, C.-M. Lehr, C.-O. Rentel, A. B. J. Noach, A. G. de Boer, J. C. Verhoef, and H. E. Junginger. Bioadhesive polymers for the peroral delivery of peptide drugs. J. Control. Release 29:329\u2013338 (1994).","journal-title":"J. Control. Release"},{"key":"9347_CR75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0168-3659(02)00419-4","volume":"88","author":"L. Bromberg","year":"2003","unstructured":"L. Bromberg and V. Alakhov. Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers. J. Control. Release 88:11\u201322 (2003).","journal-title":"J. Control. Release"},{"key":"9347_CR76","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1016\/j.biomaterials.2006.03.033","volume":"27","author":"F. F\u00f6ger","year":"2006","unstructured":"F. F\u00f6ger, T. Schmitz, and A. Bernkop-Schn\u00fcrch. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 27:4250\u20134255 (2006).","journal-title":"Biomaterials"},{"key":"9347_CR77","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1080\/10611860601140798","volume":"15","author":"F. F\u00f6ger","year":"2006","unstructured":"F. F\u00f6ger, K. Kafedjiiski, H. Hoyer, B. Loretz, and A. Bernkop-Schn\u00fcrch. Enhanced transport of P-glycoprotein substrate saquinavir in presence of thiolated chitosan. J. Drug Target. 15:132\u2013139 (2006).","journal-title":"J. Drug Target."},{"key":"9347_CR78","unstructured":"V. Grabovac and A. Bernkop-Schn\u00fcrch. Thiolated polymers as effective inhibitors of intestinal Mrp2 efflux pump transporters. Sci. Pharm. 74 (2006)."},{"key":"9347_CR79","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<729::AID-IJC19>3.0.CO;2-Z","volume":"76","author":"L. Jette","year":"1998","unstructured":"L. Jette, G. F. Murphy, and R. Beliveau. Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment. Int. J. Cancer 76:729\u201337 (1998).","journal-title":"Int. J. Cancer"},{"key":"9347_CR80","doi-asserted-by":"publisher","first-page":"10594","DOI":"10.1073\/pnas.94.20.10594","volume":"94","author":"S. Dey","year":"1977","unstructured":"S. Dey, M. Ramachandra, I. Pastan, M. M. Gottesman, and S. V. Ambudkar. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc. Natl. Acad. Sci. U. S. A. 94:10594\u201310599 (1997).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"9347_CR81","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3330351","volume":"333","author":"C. Pascaud","year":"1998","unstructured":"C. Pascaud, M. Garrigos, and S. Orlowski. Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents. Biochem. J. 333:351\u2013358 (1998).","journal-title":"Biochem. J."},{"issue":"3","key":"9347_CR82","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1046\/j.1432-1327.1999.00098.x","volume":"259","author":"A. B. Shapiro","year":"1999","unstructured":"A. B. Shapiro, K. Fox, P. Lam, and V. Ling. Stimulation of P-glycoprotein mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur. J. Biochem. 259(3):841\u2013850 (1999).","journal-title":"Eur. J. Biochem."},{"key":"9347_CR83","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1021\/bi0485326","volume":"44","author":"M. R. Lugo","year":"2005","unstructured":"M. R. Lugo and F. J. Sharom. Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site. Biochemisrtry 44:643\u2013655 (2005).","journal-title":"Biochemisrtry"},{"key":"9347_CR84","doi-asserted-by":"publisher","first-page":"44332","DOI":"10.1074\/jbc.M208433200","volume":"277","author":"T. W. Loo","year":"2002","unstructured":"T. W. Loo and D. M. Clarke. Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein. J. Biol. Chem. 277:44332\u201344338 (2002).","journal-title":"J. Biol. Chem."},{"issue":"16","key":"9347_CR85","doi-asserted-by":"publisher","first-page":"13603","DOI":"10.1074\/jbc.C300073200","volume":"278","author":"T. W. Loo","year":"2003","unstructured":"T. W. Loo, M. C. Bartlett, and D. M. Clarke. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding. J. Biol. Chem. 278(16):13603\u201313606 (2003).","journal-title":"J. Biol. Chem."},{"key":"9347_CR86","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1021\/mp050071a","volume":"3","author":"P. Crivori","year":"2006","unstructured":"P. Crivori, B. Reinach, D. Pezzetta, and I. Poggesi. Computational models for identifying potential P-glycoprotein substrates and inhibitors. Mol. Pharm. 3:33\u201344 (2006).","journal-title":"Mol. Pharm."},{"key":"9347_CR87","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.tips.2006.02.008","volume":"27","author":"R. A. Shilling","year":"2006","unstructured":"R. A. Shilling, H. Venter, S. Velamakanni, A. Bapna, B. Woebking, S. Shahi, and H. W. van Veen. New light on multidrug binding by an ATP-binding-cassette transporter. Trends Pharmacol. Sci. 27:195\u2013203 (2006).","journal-title":"Trends Pharmacol. Sci."},{"key":"9347_CR88","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1124\/mol.61.5.964","volume":"61","author":"S. Ekins","year":"2002","unstructured":"S. Ekins, R. B. Kim, B. F. Leake, A. H. Dantzig, E. G. Schuetz, L. B. Lan, K. Yasuda, R. L. Shepard, M. A. Winter, J. D. Schuetz, J. H. Wikel, and S. A. Wrighton. Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol. Pharm. Pharmacol. 61:964\u2013973 (2002).","journal-title":"Mol. Pharm. Pharmacol."},{"key":"9347_CR89","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2165\/00137696-200604040-00008","volume":"4","author":"A. Bernkop-Schn\u00fcrch","year":"2006","unstructured":"A. Bernkop-Schn\u00fcrch and V. Grabovac. Polymeric efflux pump inhibitors in oral drug delivery. Am. J. Drug Deliv. 4:263\u2013272 (2006).","journal-title":"Am. J. Drug Deliv."},{"issue":"3","key":"9347_CR90","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1021\/mp060121r","volume":"4","author":"E. M. Collnot","year":"2007","unstructured":"E. M. Collnot, C. Baldes, M. F. Wempe, R. Kappl, J. Huttermann, J. A. Hyatt, K. J. Edgar, U. F. Schaefer, and C. M. Lehr. Mechanism of inhibition of p-glycoprotein mediated efflux by vitamin e TPGS: influence on ATPase activity and membrane fluidity. Mol. Pharm. 4(3):465\u2013474 (2007).","journal-title":"Mol. Pharm."},{"key":"9347_CR91","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jconrel.2004.03.022","volume":"97","author":"R. Jevprasesphant","year":"2004","unstructured":"R. Jevprasesphant, J. Penny, D. Attwood, and A. D\u2019Emanuele. Transport of dendrimer nanocarriers through epithelial cells via the transcellular route. J. Control. Release 97:259\u2013267 (2004).","journal-title":"J. Control. Release"},{"key":"9347_CR92","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1046\/j.1432-1327.2000.01046.x","volume":"267","author":"J. Ferte","year":"2000","unstructured":"J. Ferte. Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane. Eur. J. Biochem. 267:277\u2013294 (2000).","journal-title":"Eur. J. Biochem."},{"key":"9347_CR93","first-page":"23","volume":"28","author":"Y. Takehisa","year":"1997","unstructured":"Y. Takehisa, S. Takaharu, T. Eiji, and N. Osamu. Disposition of polycarbophil calcium (HSR-237) in rats and dogs. Iyakuhin Kenkyu 28:23\u201332 (1997).","journal-title":"Iyakuhin Kenkyu"},{"key":"9347_CR94","first-page":"1","volume":"7","author":"S. Muranishi","year":"1990","unstructured":"S. Muranishi. Absorption enhancers. Crit. Rev. Ther. Drug Carr. Syst. 7:1\u201333 (1990).","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"9347_CR95","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.CIR.94.3.298","volume":"94","author":"G. L. Schaer","year":"1996","unstructured":"G. L. Schaer, L. J. Spaccavento, K. F. Browne, K. A. Krueger, D. Krichbaum, J. M. Phelan, W. O. Fletcher, C. L. Grines, S. Edwards, M. K. Jolly, and R. J. Gibbons. Beneficial effects of RheothRx injection in patients receiving thrombolytic therapy for acute myocardial infarction. Results of a randomized, double-blind, placebo-controlled trial. Circulation 94:298\u2013307 (1996).","journal-title":"Circulation"},{"key":"9347_CR96","first-page":"117","volume":"17","author":"K. Toth","year":"1997","unstructured":"K. Toth, L. Bogar, I. Juricskay, M. Keltai, S. Yusuf, L. J. Haywood, and H. J. Meiselman. The effect of RheothRx Injection on the hemorheological parameters in patients with acute myocardial infarction. Clin. Hemorheol. Microcirc. 17:117\u2013125 (1997).","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"9347_CR97","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0927-7765(99)00064-8","volume":"16","author":"V. Alakhov","year":"1999","unstructured":"V. Alakhov, E. Klinksi, S. Li, G. Pietrzynski, A. Venne, E. Batrakova, T. Bronitch, and A. V. Kabanov. Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloids Surf., B Biointerfaces 16:113\u2013134 (1999).","journal-title":"Colloids Surf., B Biointerfaces"},{"key":"9347_CR98","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0024-3205(99)00495-6","volume":"65","author":"J. M. Blonder","year":"1999","unstructured":"J. M. Blonder, L. Baird, J. C. Fulfs, and G. J. Rosenthal. Dose-dependent hyperlipidemia in rabbits following administration of poloxamer 407 gel. Life Sci. 65:261\u2013266 (1999).","journal-title":"Life Sci."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9347-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-007-9347-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9347-8.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-007-9347-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:49:19Z","timestamp":1737420559000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-007-9347-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,26]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["9347"],"URL":"https:\/\/doi.org\/10.1007\/s11095-007-9347-8","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,26]]},"assertion":[{"value":"4 April 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}