{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:06:31Z","timestamp":1791975991356,"version":"4.4.0"},"reference-count":123,"publisher":"Springer Science and Business Media LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1007\/s11095-008-9575-6","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T20:32:44Z","timestamp":1214425964000},"page":"1967-1990","source":"Crossref","is-referenced-by-count":71,"title":["Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids"],"prefix":"10.1007","volume":"25","author":[{"given":"Stephen P.","family":"Cape","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T. S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung-Horng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Sievers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,26]]},"reference":[{"key":"9575_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(00)00423-3","volume":"203","author":"W. Wang","year":"2000","unstructured":"W. Wang. Lyophilization and development of solid protein pharmaceuticals. Int J Pharm. 203:1\u201360 (2000) doi: 10.1016\/S0378-5173(00)00423-3 .","journal-title":"Int J Pharm"},{"key":"9575_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-4615-0557-0_6","volume-title":"Rational Design of Stable Protein Formulations: Theory and Practice, Pharmaceutical Biotechnology, Volume 13","author":"G. Lee","year":"2002","unstructured":"G. Lee. Spray-drying of Proteins. In J. F. Carpenter, and M. C. Manning (eds.), Rational Design of Stable Protein Formulations: Theory and Practice, Pharmaceutical Biotechnology, Volume 13, Kluwer Academic\/Plenum Publishers, New York, 2002, pp. 135\u2013158."},{"key":"9575_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(97)00506-1","volume":"26","author":"K. A. Johnson","year":"1997","unstructured":"K. A. Johnson. Preparation of peptide and protein powders for inhalation. Adv Drug Delivery Rev. 26:3\u201315 (1997) doi: 10.1016\/S0169-409X(97)00506-1 .","journal-title":"Adv Drug Delivery Rev"},{"key":"9575_CR4","first-page":"831","volume":"45","author":"K. Corkery","year":"2000","unstructured":"K. Corkery. Inhalable drugs for systemic therapy. Respir Care. 45:831\u2013835 (2000).","journal-title":"Respir Care"},{"key":"9575_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-8446(01)00064-X","volume":"20","author":"J. Jung","year":"2001","unstructured":"J. Jung, and M. Perrut. Particle design using supercritical fluids: Literature and patent survey. J Supercrit Fluids. 20:179\u2013219 (2001) doi: 10.1016\/S0896-8446(01)00064-X .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR6","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1023\/B:PHAM.0000048185.09483.e7","volume":"21","author":"N. Jovanovic","year":"2004","unstructured":"N. Jovanovic, A. Bouchard, G. W. Hofland, G. J. Witkamp, D. J. A. Crommelin, and W. Jiskoot. Stabilization of proteins in dry powder formulations using supercritical fluid technology. Pharm Res. 21:1955\u20131969 (2004) doi: 10.1023\/B:PHAM.0000048185.09483.e7 .","journal-title":"Pharm Res"},{"key":"9575_CR7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.addr.2006.07.010","volume":"58","author":"S. A. Shoyele","year":"2006","unstructured":"S. A. Shoyele, and S. Cawthorne. Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Delivery Rev. 58:1009\u20131029 (2006) doi: 10.1016\/j.addr.2006.07.010 .","journal-title":"Adv Drug Delivery Rev"},{"key":"9575_CR8","unstructured":"R. E. Sievers, and U. Karst. Methods for fine particle formation. US Pat. 5,639,441, June 17, 1997."},{"key":"9575_CR9","doi-asserted-by":"crossref","unstructured":"R. E. Sievers, and U. Karst. Methods and apparatus for fine particle formation. Eur. Pat. EP 0 677 332 B1, 27 February 2002.","DOI":"10.1017\/S0361233300001101"},{"key":"9575_CR10","unstructured":"R. E. Sievers, S. P. Sellers, and J. F. Carpenter. Supercritical fluid-assisted nebulization and bubble drying. Chinese Pat. CN1368875, September 11, 2002."},{"key":"9575_CR11","unstructured":"R. E. Sievers, S. P. Sellers, and J. F. Carpenter. Supercritical fluid-assisted nebulization and bubble drying. US Pat. 6,630,121 B1, October 7, 2003."},{"key":"9575_CR12","unstructured":"R. E. Sievers, S. P. Sellers, and J. F. Carpenter. Supercritical fluid-assisted nebulization and bubble drying. Australian Pat. AU782916, September 8 2005."},{"key":"9575_CR13","first-page":"1257","volume":"25","author":"D. E. Yocum","year":"1998","unstructured":"D. E. Yocum, A. M. Solinger, J. Tesser, O. Gluck, M. Cornett, F. O\u2019Sullivan, K. Nordensson, B. Dallaire, C. D. Shen, and J. Lipani. Clinical and immunologic effects of a PRIMATIZED (R) anti-CD4 monoclonal antibody in active rheumatoid arthritis: Results of a phase I, single dose, dose escalating trial. J Rheumatol. 25:1257\u20131262 (1998).","journal-title":"J Rheumatol"},{"key":"9575_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1056\/NEJMra010772","volume":"346","author":"R. W. Carrell","year":"2002","unstructured":"R. W. Carrell, and D. A. Lomas. Alpha1-antitrypsin deficiency\u2014a model for conformational diseases. N Engl J Med. 346:45\u201353 (2002) doi: 10.1056\/NEJMra010772 .","journal-title":"N Engl J Med"},{"key":"9575_CR15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1050-3862(99)00022-4","volume":"15","author":"A. Colman","year":"1999","unstructured":"A. Colman. Dolly, Polly and other \u2018ollys\u2019: likely impact of cloning technology on biomedical uses of livestock. Genet Anal-Biomol Eng. 15:167\u2013173 (1999) doi: 10.1016\/S1050-3862(99)00022-4 .","journal-title":"Genet Anal-Biomol Eng"},{"key":"9575_CR16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1099-0496(199911)28:5<363::AID-PPUL9>3.0.CO;2-#","volume":"28","author":"G. Doring","year":"1999","unstructured":"G. Doring. Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis. Pediatr Pulmonol. 28:363\u2013375 (1999) doi:10.1002\/(SICI)1099-0496(199911)28:5<363::AID-PPUL9>3.0.CO;2-#.","journal-title":"Pediatr Pulmonol"},{"key":"9575_CR17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1098\/rspl.1879.0054","volume":"29","author":"J. B. Hannay","year":"1879","unstructured":"J. B. Hannay, and J. Hogarth. On the solubility of solids in gases. Proc R Soc London. 29:324 (1879) doi: 10.1098\/rspl.1879.0054 .","journal-title":"Proc R Soc London"},{"key":"9575_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-011-2138-5_1","volume-title":"Extraction of Natural Products Using Near-Critical Solvents","author":"M. B. King","year":"1993","unstructured":"M. B. King, and T. R. Bott. Introduction. In M. B. King, and T. R. Bott (eds.), Extraction of Natural Products Using Near-Critical Solvents, Blackie Academic & Professional, Glasgow, 1993, pp. 1\u201333."},{"key":"9575_CR19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0006-3495(93)81120-2","volume":"65","author":"S. J. Prestrelski","year":"1993","unstructured":"S. J. Prestrelski, N. Tedeschi, T. Arakawa, and J. F. Carpenter. Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers. Biophys J. 65:661\u2013671 (1993).","journal-title":"Biophys J"},{"key":"9575_CR20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1021\/bk-1994-0567.ch010","volume":"567","author":"S. J. Prestrelski","year":"1994","unstructured":"S. J. Prestrelski, T. Arakawa, and J. F. Carpenter. Structure of proteins in lyophilized formulations using fourier-transform infrared-spectroscopy. ACS Symp Ser. 567:148\u2013169 (1994).","journal-title":"ACS Symp Ser"},{"key":"9575_CR21","doi-asserted-by":"crossref","first-page":"10969","DOI":"10.1073\/pnas.92.24.10969","volume":"92","author":"K. Griebenow","year":"1995","unstructured":"K. Griebenow, and A. M. Klibanov. Lyophilization-induced reversible changes in the secondary structure of proteins. Proc Natl Acad Sci USA. 92:10969\u201310976 (1995) doi: 10.1073\/pnas.92.24.10969 .","journal-title":"Proc Natl Acad Sci USA"},{"key":"9575_CR22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/abbi.1993.1309","volume":"303","author":"J. F. Carpenter","year":"1993","unstructured":"J. F. Carpenter, S. J. Prestrelski, and T. Arakawa. Separation of Freezing-induced and drying-induced denaturation of lyophilized proteins using stress-specific stabilization.1. Enzyme-activity and calorimetric studies. Arch Biochem Biophys. 303:456\u2013464 (1993) doi: 10.1006\/abbi.1993.1309 .","journal-title":"Arch Biochem Biophys"},{"key":"9575_CR23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/abbi.1993.1310","volume":"303","author":"S. J. Prestrelski","year":"1993","unstructured":"S. J. Prestrelski, T. Arakawa, and J. F. Carpenter. Separation of freezing-induced and drying-induced denaturation of lyophilized proteins using stress-specific stabilization.2. Structural studies using infrared-spectroscopy. Arch Biochem Biophys. 303:465\u2013473 (1993) doi: 10.1006\/abbi.1993.1310 .","journal-title":"Arch Biochem Biophys"},{"key":"9575_CR24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/abbi.1998.0948","volume":"360","author":"L. Kreilgaard","year":"1998","unstructured":"L. Kreilgaard, S. Frokjaer, J. M. Flink, T. W. Randolph, and J. F. Carpenter. Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. Arch Biochem Biophys. 360:121\u2013134 (1998) doi: 10.1006\/abbi.1998.0948 .","journal-title":"Arch Biochem Biophys"},{"key":"9575_CR25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0378-5173(99)00127-1","volume":"185","author":"A. Engwicht","year":"1999","unstructured":"A. Engwicht, U. Girreser, and B. W. Muller. Critical properties of lactide-co-glycolide polymers for the use in microparticle preparation by the Aerosol Solvent Extraction System. Int J Pharm. 185:61\u201372 (1999) doi: 10.1016\/S0378-5173(99)00127-1 .","journal-title":"Int J Pharm"},{"key":"9575_CR26","unstructured":"R. T. Bustami, H. K. Chan, F. Dehghani, and N. R. Foster. Generation of protein micro-particles using high pressure modified carbon dioxide. Proceedings of the 5th International Symposium on Supercritical Fluids, 8\u201312 April, Atlanta, GA, USA (2000)."},{"key":"9575_CR27","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1023\/A:1007551006782","volume":"17","author":"R. T. Bustami","year":"2000","unstructured":"R. T. Bustami, H. K. Chan, F. Dehghani, and N. R. Foster. Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide. Pharm Res. 17:1360\u20131366 (2000) doi: 10.1023\/A:1007551006782 .","journal-title":"Pharm Res"},{"key":"9575_CR28","unstructured":"R. Sloan, M. Tservistas, M. E. Hollowood, L. Sarup, G. O. Humphreys, P. York, W. Ashraf, and M. Hoare. Controlled particle formation of biological material using supercritical fluids. Proceedings of the 6th Meeting on Supercritical Fluids: Chemistry and Materials, M. Poliakoff, M.W. George, and S.M. Howdle (eds.), 10\u201313 April, Nottingham (UK), pp. 169\u2013174 (1999)."},{"key":"9575_CR29","first-page":"101","volume":"78","author":"L. Sarup","year":"2000","unstructured":"L. Sarup, M. T. Servistas, R. Sloan, M. Hoare, and G. O. Humphreys. Investigation of supercritical fluid technology to produce dry particulate formulations of antibody fragments. Trans Inst Chem Eng, C. 78:101\u2013104 (2000) doi: 10.1205\/096030800532815 .","journal-title":"Trans Inst Chem Eng, C"},{"key":"9575_CR30","unstructured":"M. Hanna, and P. York. Method and apparatus for the formation of particles. US Pat. 5,851,453, December 22, 1998."},{"key":"9575_CR31","unstructured":"M. Hanna, and P. York. Method and apparatus for the formation of particles. US Pat. US 6,063,138, May 16, 2000."},{"key":"9575_CR32","unstructured":"P. Pallado, L. Benedetti, and L. Callegaro. Nanospheres comprising a biocompatible polysaccharide. US Pat. US 6,214,384 B1, April 10, 2001."},{"key":"9575_CR33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/bk-1992-0514.ch019","volume":"514","author":"J. W. Tom","year":"1993","unstructured":"J. W. Tom, G. B. Lim, P. G. Debenedetti, and R. K. Prudhomme. Applications of supercritical fluids in the controlled release of drugs. ACS Symp Ser. 514:238\u2013257 (1993).","journal-title":"ACS Symp Ser"},{"key":"9575_CR34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0168-3659(93)90166-3","volume":"24","author":"P. G. Debenedetti","year":"1993","unstructured":"P. G. Debenedetti, J. W. Tom, S. D. Yeo, and G. B. Lim. Application of supercritical fluids for the production of sustained delivery devices. J Controlled Release. 24:27\u201344 (1993) doi: 10.1016\/0168-3659(93)90166-3 .","journal-title":"J Controlled Release"},{"key":"9575_CR35","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1021\/bp0255513","volume":"19","author":"M. Sarkari","year":"2003","unstructured":"M. Sarkari, I. Darrat, and B. L. Knutson. CO2 and fluorinated solvent-based technologies for protein microparticle precipitation from aqueous solutions. Biotechnol Progr. 19:448\u2013454 (2003) doi: 10.1021\/bp0255513 .","journal-title":"Biotechnol Progr"},{"key":"9575_CR36","unstructured":"N. Elvassore, A. Bertucco, and P. Caliceti. Production of protein-polymer micro-capsules by supercritical anti-solvent techniques. Proceedings of the 5th International Symposium on Supercritical Fluids, 8\u201312 April, Atlanta, GA, USA (2000)."},{"key":"9575_CR37","unstructured":"M. C. Manning, T. W. Randolph, E. Shefter, and R. F. Falk. Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the same. US Pat. US 5,770,559, June 23, 1998."},{"key":"9575_CR38","unstructured":"M. C. Manning, T. W. Randolph, E. Shefter, and R. F. Falk. Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the same. US Pat. US 5,981,474, November 9, 1999."},{"key":"9575_CR39","unstructured":"P. Pallado, L. Benedetti, and L. Callegaro. Nanospheres comprising a biocompatible polysaccharide. Eur. Pat. EP 0 817 620 B1, 30 January 2002."},{"key":"9575_CR40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/(SICI)1097-0290(20000220)67:4<457::AID-BIT9>3.0.CO;2-K","volume":"67","author":"D. P. Nesta","year":"2000","unstructured":"D. P. Nesta, J. S. Elliott, and J. P. Warr. Supercritical fluid precipitation of recombinant human immunoglobulin from aqueous solutions. Biotechnol Bioeng. 67:457\u2013464 (2000) doi: 10.1002\/(SICI)1097-0290(20000220)67:4<457::AID-BIT9>3.0.CO;2-K .","journal-title":"Biotechnol Bioeng"},{"key":"9575_CR41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/bit.260410308","volume":"41","author":"S. D. Yeo","year":"1993","unstructured":"S. D. Yeo, G. B. Lim, P. G. Debenedetti, and H. Bernstein. Formation of microparticulate protein powders using a supercritical fluid antisolvent. Biotechnol Bioeng. 41:341\u2013346 (1993) doi: 10.1002\/bit.260410308 .","journal-title":"Biotechnol Bioeng"},{"key":"9575_CR42","unstructured":"R. Thiering, F. Dehghani, and N. R. Foster. Micronization of model proteins using compressed carbon dioxide. Proceedings of the 5th International Symposium on Supercritical Fluids, 8\u201312 April, Atlanta, GA, USA (2000)."},{"key":"9575_CR43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1097-4660(200001)75:1<29::AID-JCTB172>3.0.CO;2-E","volume":"75","author":"R. Thiering","year":"2000","unstructured":"R. Thiering, F. Dehghani, A. Dillow, and N. R. Foster. The influence of operating conditions on the dense gas precipitation of model proteins. J Chem Technol Biotechnol. 75:29\u201341 (2000) doi: 10.1002\/(SICI)1097-4660(200001)75:1<29::AID-JCTB172>3.0.CO;2-E .","journal-title":"J Chem Technol Biotechnol"},{"key":"9575_CR44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1097-4660(200001)75:1<42::AID-JCTB173>3.0.CO;2-C","volume":"75","author":"R. Thiering","year":"2000","unstructured":"R. Thiering, F. Dehghani, A. Dillow, and N. R. Foster. Solvent effects on the controlled dense gas precipitation of model proteins. J Chem Technol Biotechnol. 75:42\u201353 (2000) doi: 10.1002\/(SICI)1097-4660(200001)75:1<42::AID-JCTB173>3.0.CO;2-C .","journal-title":"J Chem Technol Biotechnol"},{"key":"9575_CR45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/js950482q","volume":"85","author":"M. A. Winters","year":"1996","unstructured":"M. A. Winters, B. L. Knutson, P. G. Debenedetti, H. G. Sparks, T. M. Przybycien, C. L. Stevenson, and S. J. Prestrelski. Precipitation of proteins in supercritical carbon dioxide. J Pharm Sci. 85:586\u2013594 (1996) doi: 10.1021\/js950482q .","journal-title":"J Pharm Sci"},{"key":"9575_CR46","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1023\/A:1012112503590","volume":"14","author":"M. A. Winters","year":"1997","unstructured":"M. A. Winters, P. G. Debenedetti, J. Carey, H. G. Sparks, S. U. Sane, and T. M. Przybycien. Long-term and high-temperature storage of supercritically-processed microparticulate protein powders. Pharm Res. 14:1370\u20131378 (1997) doi: 10.1023\/A:1012112503590 .","journal-title":"Pharm Res"},{"key":"9575_CR47","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/jps.1113","volume":"90","author":"N. Elvassore","year":"2001","unstructured":"N. Elvassore, A. Bertucco, and P. Caliceti. Production of insulin-loaded poly(ethylene glycol)\/poly(l-lactide) (PEG\/PLA) nanoparticles by gas antisolvent techniques. J Pharm Sci. 90:1628\u20131636 (2001) doi: 10.1002\/jps.1113 .","journal-title":"J Pharm Sci"},{"key":"9575_CR48","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1021\/ie0004904","volume":"40","author":"N. Elvassore","year":"2001","unstructured":"N. Elvassore, A. Bertucco, and P. Caliceti. Production of protein-loaded polymeric microcapsules by compressed CO2 in a mixed solvent. Ind Eng Chem Res. 40:795\u2013800 (2001) doi: 10.1021\/ie0004904 .","journal-title":"Ind Eng Chem Res"},{"key":"9575_CR49","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/jps.10193","volume":"91","author":"W. K. Snavely","year":"2002","unstructured":"W. K. Snavely, B. Subramaniam, R. A. Rajewski, and M. R. Defelippis. Micronization of insulin from halogenated alcohol solution using supercritical carbon dioxide as an antisolvent. J Pharm Sci. 91:2026\u20132039 (2002) doi: 10.1002\/jps.10193 .","journal-title":"J Pharm Sci"},{"key":"9575_CR50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1021\/bp0256317","volume":"19","author":"G. Muhrer","year":"2003","unstructured":"G. Muhrer, and M. Mazzotti. Precipitation of lysozyme nanoparticles from dimethyl sulfoxide using carbon dioxide as antisolvent. Biotechnol Progr. 19:549\u2013556 (2003) doi: 10.1021\/bp0256317 .","journal-title":"Biotechnol Progr"},{"key":"9575_CR51","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/aic.690480207","volume":"48","author":"P. Chattopadhyay","year":"2002","unstructured":"P. Chattopadhyay, and R. B. Gupta. Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer. AlChE J. 48:235\u2013244 (2002) doi: 10.1002\/aic.690480207 .","journal-title":"AlChE J"},{"key":"9575_CR52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0928-0987(00)00108-1","volume":"11","author":"S. Moshashaee","year":"2000","unstructured":"S. Moshashaee, M. Bisrat, R. T. Forbes, H. Nyqvist, and P. York. Supercritical fluid processing of proteins I: Lysozyme precipitation from organic solution. Eur J Pharm Sci. 11:239\u2013245 (2000) doi: 10.1016\/S0928-0987(00)00108-1 .","journal-title":"Eur J Pharm Sci"},{"key":"9575_CR53","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0032-5910(02)00045-1","volume":"126","author":"L. S. Tu","year":"2002","unstructured":"L. S. Tu, F. Dehghani, and N. R. Foster. Micronisation and micro encapsulation of pharmaceuticals using a carbon dioxide antisolvent. Powder Technol. 126:134\u2013149 (2002) doi: 10.1016\/S0032-5910(02)00045-1 .","journal-title":"Powder Technol"},{"key":"9575_CR54","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejps.2005.11.003","volume":"27","author":"N. Jovanovic","year":"2006","unstructured":"N. Jovanovic, A. Bouchard, G. W. Hofland, G. J. Witkamp, D. J. A. Crommelin, and W. Jiskott. Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying. Eur J Pharm Sci. 27:336\u2013345 (2006) doi: 10.1016\/j.ejps.2005.11.003 .","journal-title":"Eur J Pharm Sci"},{"key":"9575_CR55","unstructured":"N. R. Foster, H. K. Chan, R. T. Bustami, and F. Dehghani. Effect of Nozzle Design on Protein Microparticles in the ASES Process. Proceedings of the Sixth Conference on Supercritical Fluids and Their Applications, E. Reverchon (ed.), Maiori, Italy, pp. 359\u2013364 (2001)."},{"key":"9575_CR56","unstructured":"R. T. Forbes, R. Sloan, I. Kibria, M. E. Hollowood, G. O. Humphreys, and P. York. Production of Stable Protein Particles: A Comparison of Freeze, Spray and Supercritical Drying. Proceedings of the World Congress on Particle Technology 3, 7\u20139 July, Brighton, UK (1998)."},{"key":"9575_CR57","unstructured":"R. Sloan, M. E. Hollowood, G. O. Humphreys, W. Ashraf, and P. York. Supercritical fluid processing: preparation of stable protein particles. Proceedings of the 5th Meeting on Supercritical Fluids, M. Perrut and P. Subra (eds.), 23\u201325 March, Nice, France, pp. 301\u2013306 (1998)."},{"key":"9575_CR58","unstructured":"D. J. Gilbert, S. Palakodaty, R. Sloan, and P. York. Particle Engineering for Pharmaceutical Applications \u2014 A Process Scale Up. Proceedings of the 5th International Symposium on Supercritical Fluids, 8\u201312 April, Atlanta, GA, USA (2000)."},{"key":"9575_CR59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1211\/002235702504","volume":"55","author":"S. Moshashaee","year":"2003","unstructured":"S. Moshashaee, M. Bisrat, R. T. Forbes, E. A. Quinn, H. Nyqvist, and P. York. Supercritical fluid processing of proteins: lysozyme precipitation from aqueous solution. J Pharm Pharmacol. 55:185\u2013192 (2003) doi: 10.1211\/002235702504 .","journal-title":"J Pharm Pharmacol"},{"key":"9575_CR60","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0939-6411(98)00005-8","volume":"45","author":"J. F. Carpenter","year":"1998","unstructured":"J. F. Carpenter, S. J. Prestrelski, and A. Dong. Application of infrared spectroscopy to development of stable lyophilized protein formulations. Eur J Pharm Biopharm. 45:231\u2013238 (1998) doi: 10.1016\/S0939-6411(98)00005-8 .","journal-title":"Eur J Pharm Biopharm"},{"key":"9575_CR61","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1389-1723(01)80051-7","volume":"91","author":"H. Ogino","year":"2001","unstructured":"H. Ogino, and H. Ishikawa. Enzymes which are stable in the presence of organic solvents. J Biosci Bioeng. 91:109\u2013116 (2001) doi: 10.1263\/jbb.91.109 .","journal-title":"J Biosci Bioeng"},{"key":"9575_CR62","unstructured":"T. P. Castor, and G. T. Hong. Method for size reduction of proteins. US Pat. 6,051,694, April 18, 2000."},{"key":"9575_CR63","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1021\/js980237h","volume":"88","author":"T. J. Young","year":"1999","unstructured":"T. J. Young, K. P. Johnston, K. Mishima, and H. Tanaka. Encapsulation of lysozyme in a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent. J Pharm Sci. 88:640\u2013650 (1999) doi: 10.1021\/js980237h .","journal-title":"J Pharm Sci"},{"key":"9575_CR64","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/aic.690460418","volume":"46","author":"K. Mishima","year":"2000","unstructured":"K. Mishima, K. Matsuyama, D. Tanabe, S. Yamauchi, T. J. Young, and K. P. Johnston. Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent. AlChE J. 46:857\u2013865 (2000) doi: 10.1002\/aic.690460418 .","journal-title":"AlChE J"},{"key":"9575_CR65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-5173(02)00149-7","volume":"242","author":"I. R. Dos Santos","year":"2002","unstructured":"I. R. Dos Santos, J. Richard, B. Pech, C. Thies, and J. P. Benoit. Microencapsulation of protein particles within lipids using a novel supercritical fluid process. Int J Pharm. 242:69\u201378 (2002) doi: 10.1016\/S0378-5173(02)00149-7 .","journal-title":"Int J Pharm"},{"key":"9575_CR66","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/02652040309178053","volume":"20","author":"I. R. Dos Santos","year":"2003","unstructured":"I. R. Dos Santos, J. Richard, C. Thies, B. Pech, and J. P. Benoit. A supercritical fluid-based coating technology. 3: Preparation and characterization of bovine serum albumin particles coated with lipids. J Microencapsulation. 20:110\u2013128 (2003) doi: 10.1080\/02652040210162630 .","journal-title":"J Microencapsulation"},{"key":"9575_CR67","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1021\/bk-2006-0924.ch016","volume":"924","author":"J. Richard","year":"2006","unstructured":"J. Richard, F. Deschamps, A. M. De Conti, and O. Thomas. Using a supercritical fluid-based process: Application to injectable sustained-release formulations of biomolecules. ACS Symp Ser. 924:250\u2013261 (2006).","journal-title":"ACS Symp Ser"},{"key":"9575_CR68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jconrel.2004.07.017","volume":"101","author":"M. J. Whitaker","year":"2005","unstructured":"M. J. Whitaker, J. Y. Hao, O. R. Davies, G. Serhatkulu, S. Stolnik-Trenkic, S. M. Howdle, and K. M. Shakesheff. The production of protein-loaded microparticles by supercritical fluid enhanced mixing and spraying. J Controlled Release. 101:85\u201392 (2005) doi: 10.1016\/j.jconrel.2004.07.017 .","journal-title":"J Controlled Release"},{"key":"9575_CR69","unstructured":"R. E. Sievers, B. P. Quinn, S. P. Cape, J. A. Searles, C. S. Braun, P. A. Bhagwat, L. G. Rebits, D. H. McAdams, J.L. Burger, J.A. Best, L. Lindsay, M.T. Hernandez, T. Iacovangelo, D. Kristensen, and D. Chen. Near-critical Fluid Micronization of Stabilized Vaccines, Antibiotics, and Anti-virals. Proceedings of the 8th Conference on Supercritical Fluids and Their Applications: Chemical Reactivity and Material Processing in Supercritical Fluids, 28\u201331 May, Ischia, Italy, pp. 407\u2013412 (2006)."},{"key":"9575_CR70","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.supflu.2007.03.001","volume":"42","author":"R. E. Sievers","year":"2007","unstructured":"R. E. Sievers, B. P. Quinn, S. P. Cape, J. A. Searles, C. S. Braun, P. Bhagwat, L. G. Rebits, D. H. McAdams, J. L. Burger, J. A. Best, L. Lindsay, M. T. Hernandez, K. O. Kisich, T. Iacovangelo, D. Kristensen, and D. Chen. Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals. J Supercrit Fluids. 42:385\u2013391 (2007) doi: 10.1016\/j.supflu.2007.03.001 .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR71","unstructured":"R. E. Sievers, D. J. Bennett, S. P. Cape, C. S. Braun, J. A. Best, A. L. Morin, C. A. Pelzmann, B. P. Quinn, P. Pathak, J. A. Searles, P. A. Bhagwat, L. G. Rebits, J. L. Burger, and D. H. McAdams. Micronization of measles vaccine and siRNA by CAN-BD for aerosol delivery by air expansion of powders with a PuffHaler\u2122. Proceedings of the RDD Europe 2007, R.N. Dalby, P.R. Byron, J. Peart, and J.D. Suman (eds.), April 17\u201320, Paris, France, pp. 231\u2013234 (2007)."},{"key":"9575_CR72","first-page":"198","volume":"20","author":"S. P. Cape","year":"2007","unstructured":"S. P. Cape, C. S. Braun, J. A. Best, J. L. Burger, D. H. McAdams, P. A. Bhagwat, L. G. Rebits, P. Pathak, D. J. Bennett, and R. E. Sievers. Formulation and inhalable powder preparation of live virus measles vaccine by CAN-BD. J Aerosol Med. 20:198\u2013199 (2007).","journal-title":"J Aerosol Med"},{"key":"9575_CR73","first-page":"217","volume":"20","author":"R. E. Sievers","year":"2007","unstructured":"R. E. Sievers. Stabilization, micronization, and rapid gentle drying by CAN-BD of fine particle aerosols for respiratory delivery of vaccines, antibiotics and anti-virals. J Aerosol Med. 20:217 (2007).","journal-title":"J Aerosol Med"},{"key":"9575_CR74","doi-asserted-by":"crossref","unstructured":"J. L. Burger, S. P. Cape, C. S. Braun, D. H. McAdams, J. A. Best, P. A. Bhagwat, P. Pathak, L. G. Rebits, and R. E. Sievers. Stabilizing formulations for inhalable powders of live attenuated measles virus vaccine. J Aerosol Med. 21:25\u201334 (2008) doi: 10.1089\/jamp.2007.0658 .","DOI":"10.1089\/jamp.2007.0658"},{"key":"9575_CR75","unstructured":"R. E. Sievers, S. P. Cape, K. O. Kisich, D. J. Bennett, C. S. Braun, J. L. Burger, J. A. Best, D. H. McAdams, N. A. Wolters, B. P. Quinn, J. A. Searles, D. M. Krank, P. Pathak, P. A. Bhagwat, and L. G. Rebits. Challenges of Developing a Stable Dry Powder Live Viral Vaccine. Proceedings of the Respiratory Drug Delivery 2008, R.N. Dalby, P.R. Byron, J. Peart, and J.D. Suman (eds.), May 11\u201315, Scottsdale, AZ (USA), pp. 281\u2013290 (2008)."},{"key":"9575_CR76","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/jps.20859","volume":"96","author":"A. M. Abdul-Fattah","year":"2007","unstructured":"A. M. Abdul-Fattah, V. Truong-Le, L. Yee, L. Nguyen, D. S. Kalonia, M. T. Cicerone, and M. J. Pikal. Drying-induced variations in physico-chemical properties of amorphous pharmaceuticals and their impact on stability (I): Stability of a monoclonal antibody. J Pharm Sci. 96:1983\u20132008 (2007) doi: 10.1002\/jps.20859 .","journal-title":"J Pharm Sci"},{"key":"9575_CR77","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s11095-006-9191-2","volume":"24","author":"A. M. Abdul-Fattah","year":"2007","unstructured":"A. M. Abdul-Fattah, V. Truong-Le, L. Yee, E. Pan, Y. Ao, D. S. Kalonia, and M. J. Pikal. Drying-induced variations in physico-chemical properties of amorphous pharmaceuticals and their impact on stability II: Stability of a vaccine. Pharm Res. 24:715\u2013727 (2007) doi: 10.1007\/s11095-006-9191-2 .","journal-title":"Pharm Res"},{"key":"9575_CR78","unstructured":"V. Truong-Le, and B. Pham. Preservation of bioactive materials by spray drying. US Pat. App. US 2003\/0215515 A1, Nov. 20 2003."},{"key":"9575_CR79","unstructured":"V. Truong-Le, and T. Scherer. High pressure spray-dry of bioactive materials. US Pat. App. US 2004\/185091 A1, Sep. 23, 2004."},{"key":"9575_CR80","unstructured":"V. Truong-Le, and T. Scherer. High pressure spray-dry of bioactive materials. US Pat. App. US 2006\/002862 A1, Jan. 5, 2006."},{"key":"9575_CR81","unstructured":"V. Truong-Le, and B. Pham. Preservation of bioactive materials by spray drying. US Pat. US 7,258,873, Nov. 20 2007."},{"key":"9575_CR82","unstructured":"B. Y. Shekunov, P. Chattopadhyay, and J. S. Seitzinger. Lyophilization method and apparatus for producing particles. US Pat. 6,931,888, August 23, 2005."},{"key":"9575_CR83","unstructured":"V. Truong-Le, B. V. Pham, J. F. Carpenter, R. Seid, and T. W. Randolph. Spray Freeze Dry of Compositions for Pulmonary Administration. US Pat. App. US 2004\/0042971 A1, Mar. 4 2004."},{"key":"9575_CR84","unstructured":"V. Truong-Le, B. V. Pham, J. F. Carpenter, R. Seid, and T. W. Randolph. Spray Freeze Dry of Compositions for Intranasal Administration. US Pat. App. US 2004\/0042972 A1, Mar. 4 2004."},{"key":"9575_CR85","unstructured":"B. Y. Shekunov, P. Chattopadhyay, and J. Seitzinger. Production of respirable particles using spray-freeze-drying with compressed CO2. Proceedings of the Respiratory Drug Delivery IX, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and S.J. Farr (eds.), April 25\u201329, Palm Desert, CA (USA), pp. 489\u2013491 (2004)."},{"key":"9575_CR86","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1021\/ie010943k","volume":"41","author":"E. Reverchon","year":"2002","unstructured":"E. Reverchon. Supercritical-assisted atomization to produce micro- and\/or nanoparticles of controlled size and distribution. Ind Eng Chem Res. 41:2405\u20132411 (2002) doi: 10.1021\/ie010943k .","journal-title":"Ind Eng Chem Res"},{"key":"9575_CR87","unstructured":"E. Reverchon. Process for the production of micro and\/or nano particles. Intl. Pat. App. WO 03\/004142 A1, 16 January 2003."},{"key":"9575_CR88","unstructured":"E. Reverchon. Process for the production of micro and\/or nano particles. US Pat. App. US 2004\/0178529 A1, September 16, 2004."},{"key":"9575_CR89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/713834046","volume":"30","author":"R. E. Sievers","year":"1999","unstructured":"R. E. Sievers, U. Karst, P. D. Milewski, S. P. Sellers, B. A. Miles, J. D. Schaefer, C. R. Stoldt, and C. Y. Xu. Formation of aqueous small droplet aerosols assisted by supercritical carbon dioxide. Aerosol Sci Technol. 30:3\u201315 (1999) doi: 10.1080\/027868299304840 .","journal-title":"Aerosol Sci Technol"},{"key":"9575_CR90","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/ie000190m","volume":"39","author":"R. E. Sievers","year":"2000","unstructured":"R. E. Sievers, P. D. Milewski, S. P. Sellers, B. A. Miles, B. J. Korte, K. D. Kusek, G. S. Clark, B. Mioskowski, and J. A. Villa. Supercritical and near-critical carbon dioxide assisted low-temperature bubble drying. Ind Eng Chem Res. 39:4831\u20134836 (2000) doi: 10.1021\/ie000190m .","journal-title":"Ind Eng Chem Res"},{"key":"9575_CR91","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jps.1032","volume":"90","author":"S. P. Sellers","year":"2001","unstructured":"S. P. Sellers, G. S. Clark, R. E. Sievers, and J. F. Carpenter. Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO2-assisted aerosolization. J Pharm Sci. 90:785\u2013797 (2001) doi: 10.1002\/jps.1032 .","journal-title":"J Pharm Sci"},{"key":"9575_CR92","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1351\/pac200173081299","volume":"73","author":"R. E. Sievers","year":"2001","unstructured":"R. E. Sievers, E. T. S. Huang, J. A. Villa, J. K. Kawamoto, M. M. Evans, and P. R. Brauer. Low-temperature manufacturing of fine pharmaceutical powders with supercritical fluid aerosolization in a Bubble Dryer (R). Pure Appl Chem. 73:1299\u20131303 (2001) doi: 10.1351\/pac200173081299 .","journal-title":"Pure Appl Chem"},{"key":"9575_CR93","unstructured":"E. T. S. Huang, H. Y. Chang, S. P. Cape, L. Rinner, B. P. Quinn, and R. E. Sievers. Nanoparticle and microparticle generation with super- or near-critical carbon dioxide. Proceedings of the 6th International Symposium on Supercritical Fluids, 28\u201330 April, Versailles, France, pp. 1695\u20131700 (2003)."},{"key":"9575_CR94","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-8446(02)00188-2","volume":"26","author":"R. E. Sievers","year":"2003","unstructured":"R. E. Sievers, E. T. S. Huang, J. A. Villa, G. Engling, and P. R. Brauer. Micronization of water-soluble or alcohol-soluble pharmaceuticals and model compounds with a low-temperature Bubble Dryer\u00ae. J Supercrit Fluids. 26:9\u201316 (2003) doi: 10.1016\/S0896-8446(02)00188-2 .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR95","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/027868290964432","volume":"39","author":"J. A. Villa","year":"2005","unstructured":"J. A. Villa, E. T. S. Huang, S. P. Cape, and R. E. Sievers. Synthesis of composite microparticles with a mixing cross. Aerosol Sci Technol. 39:473\u2013484 (2005).","journal-title":"Aerosol Sci Technol"},{"key":"9575_CR96","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/js980321x","volume":"88","author":"M. Adler","year":"1999","unstructured":"M. Adler, and G. Lee. Stability and surface activity of lactate dehydrogenase in spray-dried trehalose. J Pharm Sci. 88:199\u2013208 (1999) doi: 10.1021\/js980321x .","journal-title":"J Pharm Sci"},{"key":"9575_CR97","unstructured":"R. E. Sievers, E. T. S. Huang, J. A. Villa, and T. R. Walsh. CAN-BD Process for Rapidly Forming and Drying Fine Particles. Proceedings of the 8th Meeting on Supercritical Fluids: Chemical Reactivity and Material Processing in Supercritical Fluids, M. Besnard and F. Cansell (eds.), 14\u201317 April, Bordeaux (France), pp. 73\u201378 (2002)."},{"key":"9575_CR98","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0896-8446(01)00090-0","volume":"21","author":"R. Thiering","year":"2001","unstructured":"R. Thiering, F. Dehghani, and N.R. Foster. Current issues relating to anti-solvent micronisation techniques and their extension to industrial scales. J Supercrit Fluids. 21:159\u2013177 (2001) doi: 10.1016\/S0896-8446(01)00090-0 .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR99","unstructured":"R. E. Sievers, P. D. Milewski, C. Y. Xu, U. Karst, J. Rusic-Pavletic, K. D. Kusek, T. Mandal, W. C. Andersen, C. R. Stoldt, J. D. Schaefer, and B. A. Miles. Supercritical Fluid Emulsions with Aqueous Solutions for Forming Fine Particles of Pharmaceuticals and Metal Oxides. Proceedings of the 5th Meeting on Supercritical Fluids, M. Perrut and P. Subra (eds.), 23\u201325 March, Nice, France, pp. 273\u2013274 (1998)."},{"key":"9575_CR100","doi-asserted-by":"crossref","first-page":"S1271","DOI":"10.1016\/S0021-8502(98)90818-7","volume":"29","author":"R. E. Sievers","year":"1998","unstructured":"R. E. Sievers, P. D. Milewski, S. P. Sellers, K. D. Kusek, P. G. Kleutz, and B. A. Miles. Supercritical CO2-Assisted Methods for the Production and Pulmonary Administration of Pharmaceutical Aerosols. J Aerosol Sci. 29:S1271\u2013S1272 (1998) doi: 10.1016\/S0021-8502(98)90818-7 .","journal-title":"J Aerosol Sci"},{"key":"9575_CR101","unstructured":"R. E. Sievers, S. P. Cape, B. P. Quinn, J. A. Searles, J. A. Best, J. L. Burger, D. H. McAdams, and L. G. Rebits. Stabilization, Nebulization, and Near-ambient Temperature Drying of Measles Vaccine, IgG Antibody, TB Antibiotics, and Zanamivir. Proceedings of the Respiratory Drug Delivery X, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and S.J. Farr (eds.), April 23\u201327, Boca Raton, FL (USA), pp. 401\u2013404 (2006)."},{"key":"9575_CR102","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1021\/ie034111t","volume":"43","author":"E. Reverchon","year":"2004","unstructured":"E. Reverchon, and A. Spada. Crystalline microparticles of controlled size produced by supercritical-assisted atomizatione. Ind Eng Chem Res. 43:1460\u20131465 (2004) doi: 10.1021\/ie034111t .","journal-title":"Ind Eng Chem Res"},{"key":"9575_CR103","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ceat.200300005","volume":"26","author":"E. Reverchon","year":"2003","unstructured":"E. Reverchon, and G. Della Porta. Particle design using supercritical fluids. Chem Eng Technol. 26:840\u2013845 (2003) doi: 10.1002\/ceat.200300005 .","journal-title":"Chem Eng Technol"},{"key":"9575_CR104","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1211\/0022357022043","volume":"55","author":"E. Reverchon","year":"2003","unstructured":"E. Reverchon, G. Della Porta, and A. Spada. Ampicillin micronization by supercritical assisted atomization. J Pharm Pharmacol. 55:1465\u20131471 (2003) doi: 10.1211\/0022357022043 .","journal-title":"J Pharm Pharmacol"},{"key":"9575_CR105","unstructured":"S. P. Cape, J. A. Villa, E. T. S. Huang, L. V. Rinner, S. M. Hibbard, J. A. Madsen, T. L. Piester, D. K. Alargov, B. P. Quinn, and R. E. Sievers. Manufacturing and coating nanoparticles and microparticles with dense carbon dioxide nebulization in mixing tees and crosses in a Bubble Dryer\u00ae. Proceedings of the International Congress for Particle Technology, PARTEC 2004, March 16\u201318, Nuremberg, Germany (2004)."},{"key":"9575_CR106","first-page":"213","volume":"16","author":"R. E. Sievers","year":"2003","unstructured":"R. E. Sievers, G. Clark, J. A. Villa, D. Alargov, L. Rinner, S. P. Cape, and E. T. S. Huang. Micronization of inhalable drugs with liquid carbon dioxide at near ambient conditions. J Aerosol Med. 16:213 (2003).","journal-title":"J Aerosol Med"},{"key":"9575_CR107","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.powtec.2004.02.017","volume":"141","author":"E. Reverchon","year":"2004","unstructured":"E. Reverchon, and A. Spada. Erythromycin micro-particles produced by supercritical fluid atomization. Powder Technol. 141:100\u2013108 (2004) doi: 10.1016\/j.powtec.2004.02.017 .","journal-title":"Powder Technol"},{"key":"9575_CR108","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1211\/0022357044751","volume":"56","author":"E. Reverchon","year":"2004","unstructured":"E. Reverchon, G. Della Porta, A. Spada, and A. Antonacci. Griseofulvin micronization and dissolution rate improvement by supercritical assisted atomization. J Pharm Pharmacol. 56:1379\u20131387 (2004) doi: 10.1211\/0022357044751 .","journal-title":"J Pharm Pharmacol"},{"key":"9575_CR109","doi-asserted-by":"crossref","first-page":"E421","DOI":"10.1208\/pt060352","volume":"6","author":"G. Della Porta","year":"2005","unstructured":"G. Della Porta, C. De Vittori, and E. Reverchon. Supercritical assisted atomization: A novel technology for microparticles preparation of an asthma-controlling drug. AAPS PharmSciTech. 6:E421\u2013E428 (2005) doi: 10.1208\/pt060352 .","journal-title":"AAPS PharmSciTech"},{"key":"9575_CR110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1021\/bk-2003-0860.ch021","volume":"860","author":"E. T. S. Huang","year":"2003","unstructured":"E. T. S. Huang, H. Y. Chang, C. D. Liang, and R. E. Sievers. Fine particle pharmaceutical manufacturing using dense carbon dioxide mixed with aqueous or alcoholic solutions. ACS Symp Ser. 860:324\u2013338 (2003).","journal-title":"ACS Symp Ser"},{"key":"9575_CR111","first-page":"312","volume-title":"Green Chemistry: Frontiers in Benign Chemical Synthesis and Processes","author":"C. Y. Xu","year":"1998","unstructured":"C. Y. Xu, R. E. Sievers, U. Karst, B. A. Watkins, C. M. Karbiwnyk, W. C. Andersen, J. D. Schaefer, and C. R. Stoldt. Supercritical carbon dioxide assisted aerosolization for thin film deposition, fine powder generation, and drug delivery. In P.T. Anastas, and T.C. Williamson (eds.), Green Chemistry: Frontiers in Benign Chemical Synthesis and Processes, Oxford University Press, Oxford, 1998, pp. 312\u2013335."},{"key":"9575_CR112","unstructured":"R. E. Sievers, J. A. Villa, S. P. Cape, D. K. Alargov, L. Rinner, E. T. S. Huang, and B. P. Quinn. Synthesis and coating respirable particles with a low volume mixing cross or tee. Proceedings of the Respiratory Drug Delivery IX, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and S.J. Farr (eds.), April 25\u201329, Palm Desert, CA (USA), pp. 765\u2013767 (2004)."},{"key":"9575_CR113","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.supflu.2004.10.010","volume":"35","author":"E. Reverchon","year":"2005","unstructured":"E. Reverchon, R. Adami, I. De Marco, C. G. Laudani, and A. Spada. Pigment Red 60 micronization using supercritical fluids based techniques. J Supercrit Fluids. 35:76\u201382 (2005) doi: 10.1016\/j.supflu.2004.10.010 .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR114","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-8446(02)00162-6","volume":"26","author":"E. Reverchon","year":"2003","unstructured":"E. Reverchon, and G. Della Porta. Micronization of antibiotics by supercritical assisted atomization. J Supercrit Fluids. 26:243\u2013252 (2003) doi: 10.1016\/S0896-8446(02)00162-6 .","journal-title":"J Supercrit Fluids"},{"key":"9575_CR115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(03)00024-3","volume":"258","author":"E. Reverchon","year":"2003","unstructured":"E. Reverchon, and G. Della Porta. Terbutaline microparticles suitable for aerosol delivery produced by supercritical assisted atomization. Int J Pharm. 258:1\u20139 (2003) doi: 10.1016\/S0378-5173(03)00024-3 .","journal-title":"Int J Pharm"},{"key":"9575_CR116","unstructured":"R. E. Sievers, E. T. S. Huang, J. A. Villa, T. R. Walsh, H. V. Meresman, C. D. Liang, and S. P. Cape. Rapid Gentle Drying using Dense Carbon Dioxide to Form Fine Dry Powders. Proceedings of the Respiratory Drug Delivery VIII, R.N. Dalby, P.R. Byron, J. Peart, and S.J. Farr (eds.), May 12\u201316, Tucson, AZ (USA), pp. 675\u2013677 (2002)."},{"key":"9575_CR117","unstructured":"J. A. Villa, R. E. Sievers, and E. T. S. Huang. Bubble Drying To Form Fine Particles From Solutes In Aqueous Solutions. Proceedings of the 7th Meeting on Supercritical Fluids: Particle Design\u2014Materials and Natural Products Processing, M. Perrut and E. Reverchon (eds.), 6\u20138 December, Antibes\/Juan-Les-Pins (France), pp. 83\u201388 (2000)."},{"key":"9575_CR118","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1381-1177(99)00084-3","volume":"9","author":"A. Giessauf","year":"2000","unstructured":"A. Giessauf, and T. Gamse. A simple process for increasing the specific activity of porcine pancreatic lipase by supercritical carbon dioxide treatment. J Mol Catal B: Enzym. 9:57\u201364 (2000) doi: 10.1016\/S1381-1177(99)00084-3 .","journal-title":"J Mol Catal B: Enzym"},{"key":"9575_CR119","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0076-6879(94)32047-0","volume":"232","author":"A. Dong","year":"1994","unstructured":"A. Dong, and W.S. Caughey. Infrared methods for study of hemoglobin reactions and structures. Methods Enzymol. 232:139\u2013175 (1994) doi: 10.1016\/0076-6879(94)32047-0 .","journal-title":"Methods Enzymol"},{"key":"9575_CR120","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1021\/bi00465a022","volume":"29","author":"A. Dong","year":"1990","unstructured":"A. Dong, P. Huang, and W. S. Caughey. Protein secondary structures in water from second-derivative amide I infrared spectra. Biochemistry. 29:3303\u20133308 (1990) doi: 10.1021\/bi00465a022 .","journal-title":"Biochemistry"},{"key":"9575_CR121","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jps.2600840407","volume":"84","author":"A. Dong","year":"1995","unstructured":"A. Dong, S. J. Prestrelski, S. D. Allison, and J. F. Carpenter. Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation. J Pharm Sci. 84:415\u2013424 (1995) doi: 10.1002\/jps.2600840407 .","journal-title":"J Pharm Sci"},{"key":"9575_CR122","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0076-6879(81)80057-2","volume":"80","author":"J. Travis","year":"1981","unstructured":"J. Travis, and D. Johnson. Human alpha-1-proteinase inhibitor. Methods Enzymol. 80:754\u2013765 (1981) doi: 10.1016\/S0076-6879(81)80057-2 .","journal-title":"Methods Enzymol"},{"key":"9575_CR123","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/js980011e","volume":"88","author":"S. T. Tzannis","year":"1999","unstructured":"S. T. Tzannis, and S. J. Prestrelski. Activity-stability considerations of trypsinogen during spray drying: Effects of sucrose. J Pharm Sci. 88:351\u2013359 (1999) doi: 10.1021\/js980011e .","journal-title":"J Pharm Sci"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-008-9575-6.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T16:33:19Z","timestamp":1588782799000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-008-9575-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,26]]},"references-count":123,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["9575"],"URL":"https:\/\/doi.org\/10.1007\/s11095-008-9575-6","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,26]]}}}