{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:28:15Z","timestamp":1773664095531,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1007\/s11095-009-9834-1","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T21:03:55Z","timestamp":1234213435000},"page":"1149-1154","source":"Crossref","is-referenced-by-count":35,"title":["Selective Adhesion of Nanoparticles to Inflamed Tissue in Gastric Ulcers"],"prefix":"10.1007","volume":"26","author":[{"given":"Saad","family":"Hasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Pellequer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alf","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"9834_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/00365529609094526","volume":"215","author":"J. E. Crabtree","year":"1996","unstructured":"J. E. Crabtree. Immune and inflammatory responses to Helicobacter pylori infection. Scand. J. Gastroenterol. Suppl. 215:3\u201310 (1996). doi: 10.3109\/00365529609094526 .","journal-title":"Scand. J. Gastroenterol. Suppl."},{"issue":"Suppl 1","key":"9834_CR2","first-page":"S37","volume":"19","author":"P. Correa","year":"1995","unstructured":"P. Correa. Helicobacter pylori and gastric carcinogenesis. Am. J. Surg. Pathol. 19(Suppl 1):S37\u2013S43 (1995).","journal-title":"Am. J. Surg. Pathol."},{"key":"9834_CR3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BFb0043062","volume":"94","author":"Y. Tabata","year":"1990","unstructured":"Y. Tabata, and Y. Ikada. Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci. 94:107\u2013141 (1990). doi: 10.1007\/BFb0043062 .","journal-title":"Adv. Polym. Sci."},{"key":"9834_CR4","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1023\/A:1011032328064","volume":"18","author":"A. Lamprecht","year":"2001","unstructured":"A. Lamprecht, U. Sch\u00e4fer, and C. M. Lehr. Size dependent targeting of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm. Res. 18:788\u2013793 (2001). doi: 10.1023\/A:1011032328064 .","journal-title":"Pharm. Res."},{"key":"9834_CR5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0022-3565(24)29290-9","volume":"299","author":"A. Lamprecht","year":"2001","unstructured":"A. Lamprecht, N. Ubrich, H. Yamamoto, U. Sch\u00e4fer, H. Takeuchi, P. Maincent, Y. Kawashima, and C. M. Lehr. Biodegradable nanoparticles for the targeted drug delivery in the treatment of inflammatory bowel disease. J. Pharmacol. Exp. Ther. 299:775\u2013781 (2001).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"9834_CR6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1124\/jpet.105.088146","volume":"315","author":"A. Lamprecht","year":"2005","unstructured":"A. Lamprecht, H. Yamamoto, H. Takeuchi, and Y. Kawashima. Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J. Pharmacol. Exp. Ther. 315:196\u2013202 (2005). doi: 10.1124\/jpet.105.088146 .","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"9834_CR7","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1208\/pt050232","volume":"5","author":"R. B. Umamaheshwari","year":"2004","unstructured":"R. B. Umamaheshwari, S. Ramteke, and N. K. Jain. Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model. AAPS PharmSciTech. 5:E32 (2004). doi: 10.1208\/pt050232 .","journal-title":"AAPS PharmSciTech."},{"key":"9834_CR8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijpharm.2007.07.041","volume":"349","author":"K. Dillen","year":"2008","unstructured":"K. Dillen, C. Bridts, P. Van der Veken, P. Cos, J. Vandervoort, K. Augustyns, W. Stevens, and A. Ludwig. Adhesion of PLGA or Eudragit\/PLGA nanoparticles to Staphylococcus and Pseudomonas. Int. J. Pharm. 349:234\u2013240 (2008). doi: 10.1016\/j.ijpharm.2007.07.041 .","journal-title":"Int. J. Pharm."},{"key":"9834_CR9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ijpharm.2007.11.001","volume":"352","author":"Y. I. Jeong","year":"2008","unstructured":"Y. I. Jeong, H. S. Na, D. H. Seo, D. G. Kim, H. C. Lee, M. K. Jang, S. K. Na, S. H. Roh, S. I. Kim, and J. W. Nah. Ciprofloxacin-encapsulated poly(DL-lactide-co-glycolide) nanoparticles and its antibacterial activity. Int. J. Pharm. 352:317\u2013323 (2008). doi: 10.1016\/j.ijpharm.2007.11.001 .","journal-title":"Int. J. Pharm."},{"key":"9834_CR10","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"J. E. Krawisz","year":"1984","unstructured":"J. E. Krawisz, P. Sharon, and W. F. Stenson. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology. 87:1344\u20131350 (1984).","journal-title":"Gastroenterology"},{"key":"9834_CR11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1018858409737","volume":"16","author":"M. Demoy","year":"1999","unstructured":"M. Demoy, J. P. Andreux, C. Weingarten, B. Gouritin, V. Guilloux, and P. Couvreur. Spleen capture of nanoparticles: influence of animal species and surface characteristics. Pharm. Res. 16:37\u201341 (1999). doi: 10.1023\/A:1018858409737 .","journal-title":"Pharm. Res."},{"key":"9834_CR12","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1248\/bpb.28.1321","volume":"28","author":"S. Okabe","year":"2005","unstructured":"S. Okabe, and K. Amagase. An overview of acetic acid ulcer models\u2014the history and state of the art of peptic ulcer research. Biol. Pharm. Bull. 28:1321\u20131341 (2005). doi: 10.1248\/bpb.28.1321 .","journal-title":"Biol. Pharm. Bull."},{"key":"9834_CR13","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0016-5085(89)90904-9","volume":"96","author":"G. P. Morris","year":"1989","unstructured":"G. P. Morris, P. L. Beck, M. S. Herridge, W. T. Depew, M. R. Szewczuk, and J. L. Wallace. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroeneterology. 96:795\u2013803 (1989).","journal-title":"Gastroeneterology"},{"key":"9834_CR14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0022-3565(25)12260-X","volume":"276","author":"G. Yue","year":"1996","unstructured":"G. Yue, F. F. Sun, C. Dunn, K. Yin, and P. Y. K. Wong. The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease in rats. J. Pharmacol. Exp. Ther. 276:265\u2013270 (1996).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"9834_CR15","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1023\/A:1016085108889","volume":"13","author":"M. P. Desai","year":"1996","unstructured":"M. P. Desai, V. Labhasetwar, G. L. Amidon, and R. J. Levy. Gastrointestinal uptake of biodegradable microparticles: effects of particle size. Pharm. Res. 13:1838\u20131845 (1996). doi: 10.1023\/A:1016085108889 .","journal-title":"Pharm. Res."},{"key":"9834_CR16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.2042-7158.1989.tb06377.x","volume":"41","author":"P. U. Jani","year":"1989","unstructured":"P. U. Jani, G. W. Halbert, J. Langridge, and A. T. Florence. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J. Pharm. Pharmacol. 41:809\u2013821 (1989).","journal-title":"J. Pharm. Pharmacol."},{"key":"9834_CR17","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.2042-7158.1990.tb07033.x","volume":"42","author":"P. U. Jani","year":"1990","unstructured":"P. U. Jani, G. W. Halbert, J. Langridge, and A. T. Florence. Nanoparticle uptake by the ratgastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42:821\u2013826 (1990).","journal-title":"J. Pharm. Pharmacol."},{"key":"9834_CR18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-5173(98)00346-9","volume":"177","author":"S. Sakuma","year":"1999","unstructured":"S. Sakuma, R. Sudo, N. Suzuki, H. Kikuchi, M. Akashi, and M. Hayashi. Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract. Int. J. Pharm. 177:161\u2013172 (1999). doi: 10.1016\/S0378-5173(98)00346-9 .","journal-title":"Int. J. Pharm."},{"key":"9834_CR19","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","volume":"104","author":"S. K. Lai","year":"2007","unstructured":"S. K. Lai, D. E. O\u2019Hanlon, S. Harrold, S. T. Man, Y. Y. Wang, R. Cone, and J. Hanes. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. 104:1482\u20131487 (2007). doi: 10.1073\/pnas.0608611104 .","journal-title":"Proc. Natl. Acad. Sci."},{"key":"9834_CR20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/js9703380","volume":"87","author":"B. Tirosh","year":"1998","unstructured":"B. Tirosh, and A. Rubinstein. Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions. J. Pharm. Sci. 87:453\u2013456 (1998). doi: 10.1021\/js9703380 .","journal-title":"J. Pharm. Sci."},{"key":"9834_CR21","first-page":"117","volume":"3","author":"R. Nagashima","year":"1981","unstructured":"R. Nagashima. Mechanisms of action of sulcrafate. J. Clin. Gastroenterol. 3:117\u2013127 (1981).","journal-title":"J. Clin. Gastroenterol."},{"key":"9834_CR22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-3659(99)00012-7","volume":"60","author":"M. Polakovic","year":"1999","unstructured":"M. Polakovic, T. G\u00f6rner, R. Gref, and E. Dellacherie. Lidocaine loaded biodegradable nanospheres. II. Modelling of drug release. J. Control. Release. 60:169\u2013177 (1999). doi: 10.1016\/S0168-3659(99)00012-7 .","journal-title":"J. Control. Release"},{"key":"9834_CR23","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1016\/j.biomaterials.2008.08.009","volume":"29","author":"B. Moulari","year":"2008","unstructured":"B. Moulari, D. Pertuit, Y. Pellequer, and A. Lamprecht. The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis. Biomaterials. 29:4554\u20134560 (2008). doi: 10.1016\/j.biomaterials.2008.08.009 .","journal-title":"Biomaterials"},{"key":"9834_CR24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jconrel.2007.08.008","volume":"123","author":"D. Pertuit","year":"2007","unstructured":"D. Pertuit, B. Moulari, T. Betz, A. Nadaradjane, D. Neumann, L. Isma\u00efli, B. Refouvelet, Y. Pellequer, and A. Lamprecht. 5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease. J. Control. Release. 123:211\u2013218 (2007). doi: 10.1016\/j.jconrel.2007.08.008 .","journal-title":"J. Control. Release"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-009-9834-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-009-9834-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-009-9834-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:14:49Z","timestamp":1738941289000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-009-9834-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,10]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["9834"],"URL":"https:\/\/doi.org\/10.1007\/s11095-009-9834-1","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,10]]}}}