{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:20:25Z","timestamp":1760865625409},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T00:00:00Z","timestamp":1287100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s11095-010-0290-8","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T03:48:14Z","timestamp":1287028094000},"page":"394-404","source":"Crossref","is-referenced-by-count":8,"title":["A Semi-mechanistic Gastric Emptying Model for the Population Pharmacokinetic Analysis of Orally Administered Acetaminophen in Critically Ill Patients"],"prefix":"10.1007","volume":"28","author":[{"given":"Kayode","family":"Ogungbenro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Vasist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Maclaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Dukes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Aarons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"key":"290_CR1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/00003088-197601030-00002","volume":"1","author":"WS Nimmo","year":"1976","unstructured":"Nimmo WS. Drugs, diseases and altered gastric emptying. Clin Pharmacokinet. 1976;1:189\u2013203.","journal-title":"Clin Pharmacokinet"},{"key":"290_CR2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1476-5381.1973.tb08339.x","volume":"47","author":"RC Heading","year":"1973","unstructured":"Heading RC, Nimmo J, Prescott LF, Tothill P. Dependence of paracetamol absorption on rate of gastric emptying. Br J Pharmacol. 1973;47:415\u201321.","journal-title":"Br J Pharmacol"},{"key":"290_CR3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/biomet\/90.2.327","volume":"90","author":"DAS Fraser","year":"2003","unstructured":"Fraser DAS. Likelihood for component parameters. Biometrika. 2003;90:327\u201339.","journal-title":"Biometrika"},{"key":"290_CR4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0884533609357570","volume":"25","author":"RJL Fraser","year":"2010","unstructured":"Fraser RJL, Bryant L. Current and future therapeutic prokinetic therapy to improve enteral feed intolerance in the ICU patient. Nutr Clin Pract. 2010;25:26\u201331.","journal-title":"Nutr Clin Pract"},{"key":"290_CR5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2125.1975.tb00568.x","volume":"2","author":"WS Nimmo","year":"1975","unstructured":"Nimmo WS, Heading RC, Wilson J, Tothill P, Prescott LF. Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol. 1975;2:509\u201313.","journal-title":"Br J Clin Pharmacol"},{"key":"290_CR6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(75)91687-6","volume":"1","author":"WS Nimmo","year":"1975","unstructured":"Nimmo WS, Wilson J, Prescott LF. Narcotic analgesics and delayed gastric emptying during labour. Lancet. 1975;1:890\u20133.","journal-title":"Lancet"},{"key":"290_CR7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02063957","volume":"40","author":"SG Desautels","year":"1995","unstructured":"Desautels SG, Hutson WR, Christian PE, Moore JG, Datz FL. Gastric-emptying response to variable oral erythromycin dosing in diabetic gastroparesis. Dig Dis Sci. 1995;40:141\u20136.","journal-title":"Dig Dis Sci"},{"key":"290_CR8","first-page":"A241","volume":"40","author":"WR Hutson","year":"1992","unstructured":"Hutson WR, Desautels SE, Christian PE, Moore JG, Datz FL. Gastric-emptying response to variable oral erythromycin dosing in diabetic gastroparesis. Clin Res. 1992;40:A241\u20131.","journal-title":"Clin Res"},{"key":"290_CR9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2125.1980.tb05834.x","volume":"9","author":"S Holt","year":"1980","unstructured":"Holt S, Stewart MJ, Adam RD, Heading RC. Alcohol absorption, gastric-emptying and a breathalyser. Br J Clin Pharmacol. 1980;9:205\u20138.","journal-title":"Br J Clin Pharmacol"},{"key":"290_CR10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev.ph.39.030177.001031","volume":"39","author":"LR Johnson","year":"1977","unstructured":"Johnson LR. Gastrointestinal hormones and their functions. Annu Rev Physiol. 1977;39:135\u201358.","journal-title":"Annu Rev Physiol"},{"key":"290_CR11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.ijo.0800418","volume":"21","author":"E Naslund","year":"1997","unstructured":"Naslund E, Gryback P, Hellstrom PM, Jacobsson H, Holst JJ, Theodorsson E, et al. Gastrointestinal hormones and gastric emptying 20\u00a0years after jejunoileal bypass for massive obesity. Int J Obes Relat Metab Disord. 1997;21:387\u201392.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"290_CR12","volume-title":"Human physiology: from cells to systems","author":"L Sherwood","year":"2010","unstructured":"Sherwood L. Human physiology: from cells to systems. Belmont: Brooks\/Cole; 2010."},{"key":"290_CR13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s001340050325","volume":"23","author":"MM Tarling","year":"1997","unstructured":"Tarling MM, Toner CC, Withington PS, Baxter MK, Whelpton R, Goldhill DR. A model of gastric emptying using paracetamol absorption in intensive care patients. Intensive Care Med. 1997;23:256\u201360.","journal-title":"Intensive Care Med"},{"key":"290_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/014860710803200145","volume":"32","author":"J Landzinski","year":"2008","unstructured":"Landzinski J, Kiser TH, Fish DN, Wischmeyer PE, MacLaren R. Gastric motility function in critically ill patients tolerant vs. intolerant to gastric nutrition. JPEN J Parenter Enteral Nutr. 2008;32:45\u201350.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"290_CR15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/0148607108319803","volume":"32","author":"R MacLaren","year":"2008","unstructured":"MacLaren R, Kiser TH, Fish DN, Wischmeyer PE. Erythromycin vs. metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. J Parenter Enteral Nutr. 2008;32:412\u20139.","journal-title":"J Parenter Enteral Nutr."},{"key":"290_CR16","doi-asserted-by":"crossref","first-page":"A192","DOI":"10.1097\/01.CCM.0000251508.12555.3E","volume":"35","author":"R MacLaren","year":"2007","unstructured":"MacLaren R, Kiser T, Fish D, Wischmeyer P. Erythromycin versus metoclopramide for facilitating gastric emptying and tolerance to intra-gastric nutrition. Crit Care Med. 2007;35:A192\u20132.","journal-title":"Crit Care Med"},{"key":"290_CR17","first-page":"A193","volume":"35","author":"J Landzinski","year":"2007","unstructured":"Landzinski J, Kiser T, Fish D, MacLaren R, Wischmeyer P. Gastric motility function in critically-ill patients tolerant versus intolerant to gastric nutrition. Crit Care Med. 2007;35:A193\u20133.","journal-title":"Crit Care Med"},{"key":"290_CR18","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2982.2009.01388.x","volume":"21","author":"K Verbeke","year":"2009","unstructured":"Verbeke K. Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying? Neurogastroenterol Motil. 2009;21:1013\u20136.","journal-title":"Neurogastroenterol Motil"},{"key":"290_CR19","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/cpt1978244420","volume":"24","author":"JA Clements","year":"1978","unstructured":"Clements JA, Heading RC, Nimmo WS, Prescott LF. Kinetics of acetaminophen absorption and gastric-emptying in man. Clin Pharmacol Ther. 1978;24:420\u201331.","journal-title":"Clin Pharmacol Ther"},{"key":"290_CR20","doi-asserted-by":"crossref","first-page":"P60","DOI":"10.1111\/j.2042-7158.1978.tb10767.x","volume":"30","author":"JA Clements","year":"1978","unstructured":"Clements JA, Nimmo WS, Heading RC, Prescott LF. Physiologically-based pharmacokinetic model for absorption of oral paracetamol in man. J Pharm Pharmacol. 1978;30:P60\u20130.","journal-title":"J Pharm Pharmacol"},{"key":"290_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/cs0630231","volume":"63","author":"RC Heading","year":"1982","unstructured":"Heading RC. Gastric emptying: a clinical perspective. Clin Sci (Lond). 1982;63:231\u20135.","journal-title":"Clin Sci (Lond)"},{"key":"290_CR22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/gut.23.4.292","volume":"23","author":"S Holt","year":"1982","unstructured":"Holt S, Reid J, Taylor TV, Tothill P, Heading RC. Gastric emptying of solids in man. Gut. 1982;23:292\u20136.","journal-title":"Gut"},{"key":"290_CR23","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/0016-5085(95)90202-3","volume":"108","author":"B Braden","year":"1995","unstructured":"Braden B, Adams S, Duan LP, Orth KH, Maul FD, Lembcke B, et al. The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. Gastroenterology. 1995;108:1048\u201355.","journal-title":"Gastroenterology"},{"key":"290_CR24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1440-1681.2006.04516.x","volume":"33","author":"M Sanaka","year":"2006","unstructured":"Sanaka M, Urita Y, Sugimoto M, Yamamoto T, Kuyama Y. Comparison between gastric scintigraphy and the [13C]-acetate breath test with Wagner-Nelson analysis in humans. Clin Exp Pharmacol Physiol. 2006;33:1239\u201343.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"290_CR25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000077391","volume":"69","author":"M Sanaka","year":"2004","unstructured":"Sanaka M, Yamamoto T, Ishii T, Kuyama Y. The Wagner-Nelson method can generate an accurate gastric emptying flow curve from (CO2)-C-13 data obtained by a C-13-labeled substrate breath test. Digestion. 2004;69:71\u20138.","journal-title":"Digestion"},{"key":"290_CR26","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0016-5085(97)70126-4","volume":"112","author":"MG Choi","year":"1997","unstructured":"Choi MG, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Nair KS. [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology. 1997;112:1155\u201362.","journal-title":"Gastroenterology"},{"key":"290_CR27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1365-2982.2009.01340.x","volume":"21","author":"J Keller","year":"2009","unstructured":"Keller J, Andresen V, Wolter J, Layer P, Camilleri M. Influence of clinical parameters on the results of 13C-octanoic acid breath tests: examination of different mathematical models in a large patient cohort. Neurogastroenterol Motil. 2009;21:1039\u2013e1083.","journal-title":"Neurogastroenterol Motil"},{"key":"290_CR28","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/0016-5085(93)90640-X","volume":"104","author":"YF Ghoos","year":"1993","unstructured":"Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology. 1993;104:1640\u20137.","journal-title":"Gastroenterology"},{"key":"290_CR29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10620-005-1270-4","volume":"50","author":"M Sanaka","year":"2005","unstructured":"Sanaka M, Yamamoto T, Kuyama Y. Theoretical flaws in the gastric emptying breath test: why is it dubious? Dig Dis Sci. 2005;50:15\u20137.","journal-title":"Dig Dis Sci"},{"key":"290_CR30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/clpt.1981.153","volume":"30","author":"S Holt","year":"1981","unstructured":"Holt S, Heading RC, Clements JA, Tothill P, Prescott LF. Acetaminophen absorption and metabolism in celiac disease and Crohn\u2019s disease. Clin Pharmacol Ther. 1981;30:232\u20138.","journal-title":"Clin Pharmacol Ther"},{"key":"290_CR31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0939-6411(00)00083-7","volume":"50","author":"LP Balant","year":"2000","unstructured":"Balant LP, Gex-Fabry M. Modelling during drug development. Eur J Pharm Biopharm. 2000;50:13\u201326.","journal-title":"Eur J Pharm Biopharm"},{"key":"290_CR32","unstructured":"FDA. US Department of Health and Human Services, Food and Drug Administration. Innovation or stagnation? Challenge and opportunity on the critical path to new medical products. (2004)."},{"key":"290_CR33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10928-006-9010-8","volume":"33","author":"L Zhang","year":"2006","unstructured":"Zhang L, Sinha V, Forgue S, Callies S, Ni L, Peck R, et al. Model-based drug development: the road to quantitative pharmacology. J Pharmacokinet Pharmacodyn. 2006;33:369\u201393.","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"290_CR34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0169-2607(93)90062-P","volume":"41","author":"L Aarons","year":"1993","unstructured":"Aarons L. The estimation of population pharmacokinetic parameters using an EM algorithm. Comput Methods Programs Biomed. 1993;41:9\u201316.","journal-title":"Comput Methods Programs Biomed."},{"key":"290_CR35","unstructured":"Beal S, Sheiner LB, Boeckmann A, Bauer RJ. NONMEM User\u2019s Guides. (1989\u20132009). Icon Development Solutions, Ellicott City, MD, USA (2009)."},{"key":"290_CR36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cmpb.2003.11.003","volume":"75","author":"L Lindbom","year":"2004","unstructured":"Lindbom L, Ribbing J, Jonsson EN. Perls-speaks-NONMEM (PsN)\u2013a Perl module for NONMEM related programming. Comput Methods Programs Biomed. 2004;75:85\u201394.","journal-title":"Comput Methods Programs Biomed."},{"key":"290_CR37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cmpb.2005.04.005","volume":"79","author":"L Lindbom","year":"2005","unstructured":"Lindbom L, Pihlgren P, Jonsson N. PsN-Toolkit\u2013A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed. 2005;79:241\u201357.","journal-title":"Comput Methods Programs Biomed."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-010-0290-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-010-0290-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-010-0290-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T01:54:03Z","timestamp":1559354043000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-010-0290-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,15]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["290"],"URL":"https:\/\/doi.org\/10.1007\/s11095-010-0290-8","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,15]]}}}