{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:56:04Z","timestamp":1790459764652,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s11095-010-0331-3","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T20:52:15Z","timestamp":1291063935000},"page":"702-711","source":"Crossref","is-referenced-by-count":9,"title":["Positive Correlation Between the Generation of Reactive Oxygen Species and Activation\/Reactivation of Transgene Expression After Hydrodynamic Injections into Mice"],"prefix":"10.1007","volume":"28","author":[{"given":"Naomi","family":"Takiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiya","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daihi","family":"Oushiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kiyose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,30]]},"reference":[{"key":"331_CR1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.gt.3300947","volume":"6","author":"F Liu","year":"1999","unstructured":"Liu F, Song YK, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 1999;6:1258\u201366.","journal-title":"Gene Ther"},{"key":"331_CR2","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1089\/10430349950017734","volume":"10","author":"G Zhang","year":"1999","unstructured":"Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther. 1999;10:1735\u20137.","journal-title":"Hum Gene Ther"},{"key":"331_CR3","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1349-7006.2008.00774.x","volume":"99","author":"M Nishikawa","year":"2008","unstructured":"Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic considerations regarding non-viral cancer gene therapy. Cancer Sci. 2008;99:856\u201362.","journal-title":"Cancer Sci"},{"key":"331_CR4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0022-3565(24)29608-7","volume":"297","author":"N Kobayashi","year":"2001","unstructured":"Kobayashi N, Kuramoto T, Yamaoka K, Hashida M, Takakura Y. Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures. J Pharmacol Exp Ther. 2001;297:853\u201360.","journal-title":"J Pharmacol Exp Ther"},{"key":"331_CR5","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/sj.gt.3302970","volume":"14","author":"H Ochiai","year":"2007","unstructured":"Ochiai H, Fujimuro M, Yokosawa H, Harashima H, Kamiya H. Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression. Gene Ther. 2007;14:1152\u20139.","journal-title":"Gene Ther"},{"key":"331_CR6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/hum.2008.020","volume":"19","author":"M Nishikawa","year":"2008","unstructured":"Nishikawa M, Nakayama A, Takahashi Y, Fukuhara Y, Takakura Y. Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution. Hum Gene Ther. 2008;19:1009\u201320.","journal-title":"Hum Gene Ther"},{"key":"331_CR7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.gt.3302865","volume":"14","author":"T Suda","year":"2007","unstructured":"Suda T, Gao X, Stolz DB, Liu D. Structural impact of hydrodynamic injection on mouse liver. Gene Ther. 2007;14:129\u201337.","journal-title":"Gene Ther"},{"key":"331_CR8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.canlet.2008.02.028","volume":"266","author":"A Galanis","year":"2008","unstructured":"Galanis A, Pappa A, Giannakakis A, Lanitis E, Dangaj D, Sandaltzopoulos R. Reactive oxygen species and HIF-1 signalling in cancer. Cancer Lett. 2008;266:12\u201320.","journal-title":"Cancer Lett"},{"key":"331_CR9","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","volume":"275","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. Reactive oxygen species generated at mitochondrial Complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275:25130\u20138.","journal-title":"J Biol Chem"},{"key":"331_CR10","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.lfs.2004.02.030","volume":"75","author":"M Taniguchi","year":"2004","unstructured":"Taniguchi M, Takeuchi T, Nakatsuka R, Watanabe T, Sato K. Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 2004;75:1539\u201349.","journal-title":"Life Sci"},{"key":"331_CR11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1096\/fasebj.10.4.8647340","volume":"10","author":"R Taub","year":"1996","unstructured":"Taub R. Transcriptional control of liver regeneration. FASEB J. 1996;10:413\u201327.","journal-title":"FASEB J"},{"key":"331_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","volume":"174","author":"N Rooijenand Van","year":"1994","unstructured":"Van Rooijenand N, Sanders A. Liposome mediated depletion of macropbages: mechanism of action, preparation of liposomes and applications. J Immunol Methods. 1994;174:83\u201393.","journal-title":"J Immunol Methods"},{"key":"331_CR13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/sj.gt.3301460","volume":"8","author":"F Sakurai","year":"2001","unstructured":"Sakurai F, Nishioka T, Saito H, Baba T, Okuda A, Matsumoto O, et al. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther. 2001;8:677\u201386.","journal-title":"Gene Ther"},{"key":"331_CR14","unstructured":"Kiyose K, Hanaoka K, Oushiki D, Nakamura T, Kajimura M, Suematsu M, et al. Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. J Am Chem Soc: in press."},{"key":"331_CR15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","volume":"213","author":"GK Michalopoulos","year":"2007","unstructured":"Michalopoulos GK. Liver regeneration. J Cell Physiol. 2007;213:286\u2013300.","journal-title":"J Cell Physiol"},{"key":"331_CR16","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1016\/S0021-9258(19)38899-4","volume":"265","author":"SP Srivastava","year":"1990","unstructured":"Srivastava SP, Chen N, Holtzman JL. The in vitro NADPH-dependent inhibition by CCl4 of the ATP-dependent calcium uptake of hepatic microsomes from male rats. Studies on the mechanism of the inactivation of the hepatic microsomal calcium pump by the CCl3 radical. J Biol Chem. 1990;265:8392\u20139.","journal-title":"J Biol Chem"},{"key":"331_CR17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1440-169X.2007.00910.x","volume":"49","author":"S Hata","year":"2007","unstructured":"Hata S, Namae M, Nishina H. Liver development and regeneration: from laboratory study to clinical therapy. Dev Growth Differ. 2007;49:163\u201370.","journal-title":"Dev Growth Differ"},{"key":"331_CR18","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","volume":"274","author":"DE Cressman","year":"1996","unstructured":"Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6- deficient mice. Science. 1996;274:1379\u201383.","journal-title":"Science"},{"key":"331_CR19","doi-asserted-by":"crossref","unstructured":"Zimmermann A. Regulation of liver regeneration. Nephrol Dial Transplant. 2004;19.","DOI":"10.1093\/ndt\/gfh1034"},{"key":"331_CR20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00042737-199901000-00011","volume":"11","author":"Y Yamada","year":"1999","unstructured":"Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Eur J Gastroenerol Hepatol. 1999;11:51.","journal-title":"Eur J Gastroenerol Hepatol"},{"key":"331_CR21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/08941930390205773","volume":"16","author":"H Jaeschke","year":"2003","unstructured":"Jaeschke H. Role of reactive oxygen species in hepatic ischemia-reperfusion injury and preconditioning. J Investig Surg. 2003;16:127\u201340.","journal-title":"J Investig Surg"},{"key":"331_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-5849(02)01167-X","volume":"34","author":"C Loguercio","year":"2003","unstructured":"Loguercio C, Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radic Biol Med. 2003;34:1\u201310.","journal-title":"Free Radic Biol Med"},{"key":"331_CR23","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/sj.gt.3302210","volume":"11","author":"G Zhang","year":"2004","unstructured":"Zhang G, Gao X, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, et al. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther. 2004;11:675\u201382.","journal-title":"Gene Ther"},{"key":"331_CR24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00534-002-0720-z","volume":"10","author":"S Arii","year":"2003","unstructured":"Arii S, Teramoto K, Kawamura T. Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver. J Hepatobiliary Pancreat Surg. 2003;10:189\u201394.","journal-title":"J Hepatobiliary Pancreat Surg"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-010-0331-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-010-0331-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-010-0331-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T08:43:25Z","timestamp":1740732205000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-010-0331-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,30]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["331"],"URL":"https:\/\/doi.org\/10.1007\/s11095-010-0331-3","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,30]]}}}