{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:35:00Z","timestamp":1793032500832,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s11095-013-1005-8","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:19:49Z","timestamp":1369322389000},"page":"2549-2559","source":"Crossref","is-referenced-by-count":137,"title":["Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"30","author":[{"given":"Rongqin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinning","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,24]]},"reference":[{"issue":"32","key":"1005_CR1","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.2174\/138161211798194495","volume":"17","author":"A Stefano Di","year":"2011","unstructured":"Di Stefano A, Sozio P, Cerasa LS, Iannitelli A. L-Dopa prodrugs: an overview of trends for improving Parkinson\u2019s disease treatment. Curr Pharm Des. 2011;17(32):3482\u201393.","journal-title":"Curr Pharm Des."},{"issue":"2","key":"1005_CR2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1586\/ern.11.203","volume":"12","author":"H Reichmann","year":"2012","unstructured":"Reichmann H, Emre M. Optimizing levodopa therapy to treat wearing-off symptoms in Parkinson\u2019s disease: focus on levodopa\/carbidopa\/entacapone. Expert Rev Neurother. 2012;12(2):119\u201331.","journal-title":"Expert Rev Neurother."},{"issue":"2","key":"1005_CR3","doi-asserted-by":"crossref","first-page":"2ps2","DOI":"10.1126\/scitranslmed.3000350","volume":"1","author":"A Bj\u00f6rklund","year":"2009","unstructured":"Bj\u00f6rklund A, Bj\u00f6rklund T, Kirik D. Gene therapy for dopamine replacement in Parkinson\u2019s disease. Sci Transl Med. 2009;1(2):2ps2.","journal-title":"Sci Transl Med."},{"issue":"1\u20132","key":"1005_CR4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jns.2009.09.032","volume":"290","author":"RQ Huang","year":"2010","unstructured":"Huang RQ, Ke WL, Liu Y, Wu DD, Feng LY, Jiang C, et al. Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci. 2010;290(1\u20132):123\u201330.","journal-title":"J Neurol Sci."},{"key":"1005_CR5","doi-asserted-by":"crossref","first-page":"296151","DOI":"10.1155\/2011\/296151","volume":"2011","author":"RJ Boado","year":"2011","unstructured":"Boado RJ, Pardridge WM. The Trojan horse liposome technology for nonviral gene transfer across the blood-brain barrier. J Drug Deliv. 2011;2011:296151.","journal-title":"J Drug Deliv."},{"issue":"3","key":"1005_CR6","doi-asserted-by":"crossref","first-page":"e32568","DOI":"10.1371\/journal.pone.0032568","volume":"7","author":"S Wagner","year":"2012","unstructured":"Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, et al. Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. PLoS One. 2012;7(3):e32568.","journal-title":"PLoS One."},{"issue":"4","key":"1005_CR7","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/j.1471-4159.2008.05492.x","volume":"106","author":"M Demeule","year":"2008","unstructured":"Demeule M, Currie JC, Bertrand Y, Ch\u00e9 C, Nguyen T, R\u00e9gina A, et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J Neurochem. 2008;106(4):1534\u201344.","journal-title":"J Neurochem."},{"issue":"36","key":"1005_CR8","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1016\/j.biomaterials.2009.08.049","volume":"30","author":"WL Ke","year":"2009","unstructured":"Ke WL, Shao K, Huang RQ, Han L, Liu Y, Li JF, et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials. 2009;30(36):6976\u201385.","journal-title":"Biomaterials."},{"issue":"26","key":"1005_CR9","doi-asserted-by":"crossref","first-page":"265101","DOI":"10.1088\/0957-4484\/21\/26\/265101","volume":"21","author":"RQ Huang","year":"2010","unstructured":"Huang RQ, Liu SH, Shao K, Han L, Ke WL, Liu Y, et al. Evaluation and mechanism studies of PEGylated dendrigraft poly-L-lysines as novel gene delivery vectors. Nanotechnology. 2010;21(26):265101.","journal-title":"Nanotechnology."},{"issue":"9","key":"1005_CR10","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.biomaterials.2010.11.079","volume":"32","author":"RQ Huang","year":"2011","unstructured":"Huang RQ, Ke WL, Han L, Li JF, Liu SH, Jiang C. Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration. Biomaterials. 2011;32(9):2399\u2013406.","journal-title":"Biomaterials."},{"issue":"1\u20132","key":"1005_CR11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2005.03.005","volume":"105","author":"Y Xie","year":"2005","unstructured":"Xie Y, Ye LY, Zhang XB, Cui W, Lou JN, Nagai T, et al. Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: In vitro and in vivo studies. J Control Release. 2005;105(1\u20132):106\u201319.","journal-title":"J Control Release."},{"issue":"3","key":"1005_CR12","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/jnr.20971","volume":"84","author":"LM Canzoniero","year":"2006","unstructured":"Canzoniero LM, Adornetto A, Secondo A, Magi S, Dell\u2019aversano C, Scorziello A, et al. Involvement of the nitric oxide\/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells. J Neurosci Res. 2006;84(3):692\u20137.","journal-title":"J Neurosci Res."},{"issue":"9","key":"1005_CR13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jgm.1361","volume":"11","author":"RQ Huang","year":"2009","unstructured":"Huang RQ, Han L, Li JH, Ren FL, Ke WL, Jiang C, et al. Neuroprotection in a 6-OHDA-lesioned Parkinson model using Lactoferrin-modified Nanoparticles. J Gene Med. 2009;11(9):754\u201363.","journal-title":"J Gene Med."},{"issue":"2","key":"1005_CR14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biomaterials.2007.09.024","volume":"29","author":"RQ Huang","year":"2008","unstructured":"Huang RQ, Ke WL, Liu Y, Jiang C, Pei YY. The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain. Biomaterials. 2008;29(2):238\u201346.","journal-title":"Biomaterials."},{"key":"1005_CR15","doi-asserted-by":"crossref","first-page":"469679","DOI":"10.1155\/2011\/469679","volume":"2011","author":"C Spuch","year":"2011","unstructured":"Spuch C, Navarro C. Liposomes for targeted delivery of active agents against neurodegenerative diseases (Alzheimer\u2019s disease and Parkinson\u2019s disease). J Drug Deliv. 2011;2011:469679.","journal-title":"J Drug Deliv."},{"issue":"1","key":"1005_CR16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2010.06.018","volume":"147","author":"K Shao","year":"2010","unstructured":"Shao K, Huang RQ, Li JF, Han L, Ye LY, Lou JN, et al. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J Control Release. 2010;147(1):118\u201326.","journal-title":"J Control Release."},{"issue":"1","key":"1005_CR17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0166-4328(02)00180-8","volume":"136","author":"M Alam","year":"2002","unstructured":"Alam M, Schmidt WJ. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res. 2002;136(1):317\u201324.","journal-title":"Behav Brain Res."},{"issue":"2","key":"1005_CR18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2007.01.056","volume":"146","author":"S Samantaray","year":"2007","unstructured":"Samantaray S, Knaryan VH, Guyton MK, Matzelle DD, Ray SK, Banik NL. The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats. Neuroscience. 2007;146(2):741\u201355.","journal-title":"Neuroscience."},{"key":"1005_CR19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-7091-0643-3_6","volume":"65","author":"EC Hirsch","year":"2003","unstructured":"Hirsch EC, H\u00f6glinger G, Rousselet E, Breidert T, Parain K, Feger J, et al. Animal models of Parkinson\u2019s disease in rodents induced by toxins: an update. J Neural Transm Suppl. 2003;65:89\u2013100.","journal-title":"J Neural Transm Suppl."},{"issue":"2","key":"1005_CR20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(03)00172-1","volume":"341","author":"TB Sherer","year":"2003","unstructured":"Sherer TB, Betarbet R, Kim JH, Greenamyre JT. Selective microglial activation in the rat rotenone model of Parkinson\u2019s disease. Neurosci Lett. 2003;341(2):87\u201390.","journal-title":"Neurosci Lett."},{"key":"1005_CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-1-61779-536-7_30","volume":"846","author":"G Mercanti","year":"2012","unstructured":"Mercanti G, Bazzu G, Giusti P. A 6-hydroxydopamine in vivo model of Parkinson\u2019s disease. Methods Mol Biol. 2012;846:355\u201364.","journal-title":"Methods Mol Biol."},{"issue":"39","key":"1005_CR22","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1002\/adma.201101899","volume":"23","author":"JF Li","year":"2011","unstructured":"Li JF, Zhou L, Ye DY, Huang SX, Shao K, Huang RQ, et al. Choline-derivate-modified nanoparticles for brain-targeting gene delivery. Adv Mater. 2011;23(39):4516\u201320.","journal-title":"Adv Mater."},{"issue":"19","key":"1005_CR23","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.biomaterials.2012.03.031","volume":"33","author":"SH Liu","year":"2012","unstructured":"Liu SH, Guo YB, Huang RQ, Li JF, Huang SX, Kuang YY, et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012;33(19):4907\u201316.","journal-title":"Biomaterials."},{"issue":"10","key":"1005_CR24","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1021\/bm700668w","volume":"8","author":"I Tsogas","year":"2007","unstructured":"Tsogas I, Theodossiou T, Sideratou Z, Paleos CM, Collet H, Rossi JC, et al. Interaction and transport of poly(L-lysine) dendrigrafts through liposomal and cellular membranes: the role of generation and surface functionalization. Biomacromolecules. 2007;8(10):3263\u201370.","journal-title":"Biomacromolecules."},{"issue":"4","key":"1005_CR25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/08977194.2012.691478","volume":"30","author":"EP Duarte","year":"2012","unstructured":"Duarte EP, Curcio M, Canzoniero LM, Duarte CB. Neuroprotection by GDNF in the ischemic brain. Growth Factors. 2012;30(4):242\u201357.","journal-title":"Growth Factors."},{"issue":"2","key":"1005_CR26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.expneurol.2006.06.006","volume":"202","author":"HA Boger","year":"2006","unstructured":"Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, et al. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Exp Neurol. 2006;202(2):336\u201347.","journal-title":"Exp Neurol."},{"issue":"12","key":"1005_CR27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1089\/104303403322168019","volume":"14","author":"C Jiang","year":"2003","unstructured":"Jiang C, Koyabu N, Yonemitsu Y, Shimazoe T, Watanabe S, Naito M, et al. In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells. Hum Gene Ther. 2003;14(12):1181\u201391.","journal-title":"Hum Gene Ther."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-013-1005-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-013-1005-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-013-1005-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T01:54:32Z","timestamp":1559354072000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-013-1005-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["1005"],"URL":"https:\/\/doi.org\/10.1007\/s11095-013-1005-8","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,24]]}}}