{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:46:36Z","timestamp":1790077596933,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s11095-014-1330-6","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:39:34Z","timestamp":1393893574000},"page":"2335-2343","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Airborne Particle Size, Acoustic Airflow and Breathing Pattern on Delivery of Nebulized Antibiotic into the Maxillary Sinuses Using a Realistic Human Nasal Replica"],"prefix":"10.1007","volume":"31","author":[{"given":"Lara","family":"Leclerc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Pourchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Leguellec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vecellio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Cottier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"1330_CR1","unstructured":"Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 2012;(23):3 p preceding table of contents, 1\u2013298."},{"key":"1330_CR2","doi-asserted-by":"crossref","unstructured":"Bhattacharyya N, Grebner J, Martinson NG. Recurrent acute rhinosinusitis: epidemiology and health care cost burden. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg. 2011.","DOI":"10.1177\/0194599811426089"},{"issue":"2","key":"1330_CR3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1152\/japplphysiol.00106.2005","volume":"99","author":"E Tarhan","year":"2005","unstructured":"Tarhan E, Coskun M, Cakmak O, \u00c7elik H, Cankurtaran M. Acoustic rhinometry in humans: accuracy of nasal passage area estimates, and ability to quantify paranasal sinus volume and ostium size. J Appl Physiol. 2005;99(2):616\u201323.","journal-title":"J Appl Physiol"},{"issue":"1","key":"1330_CR4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5530\/rjps.2012.1.4","volume":"2","author":"T Deshpande","year":"2012","unstructured":"Deshpande T, Masareddy R, Patil A. Nasal drug delivery\u2014a review. RGUHS J Pharm Sci. 2012;2(1):24\u201337.","journal-title":"RGUHS J Pharm Sci"},{"issue":"1","key":"1330_CR5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13346-012-0108-9","volume":"3","author":"PG Djupesland","year":"2013","unstructured":"Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective\u2014a review. Drug Deliv Trans Res. 2013;3(1):42\u201362.","journal-title":"Drug Deliv Trans Res"},{"issue":"6","key":"1330_CR6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1067\/mhn.2002.129738","volume":"127","author":"WC Vaughan","year":"2002","unstructured":"Vaughan WC, Carvalho G. Use of nebulized antibiotics for acute infections in chronic sinusitis. Otolaryngol Head Neck Surg. 2002;127(6):558\u201368.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1\u20132","key":"1330_CR7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijpharm.2011.01.024","volume":"407","author":"L Vecellio","year":"2011","unstructured":"Vecellio L, De Gersem R, Le Guellec S, Reychler G, Pitance L, Le Pennec D, et al. Deposition of aerosols delivered by nasal route with jet and mesh nebulizers. Int J Pharm. 2011;407(1\u20132):87\u201394.","journal-title":"Int J Pharm"},{"issue":"4","key":"1330_CR8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2500\/ajr.2008.22.3191","volume":"22","author":"R Valentine","year":"2008","unstructured":"Valentine R, Athanasiadis T, Thwin M, Singhal D, Weitzel EK, Wormald P-J. A prospective controlled trial of pulsed nasal nebulizer in maximally dissected cadavers. Am J Rhinol. 2008;22(4):390\u20134.","journal-title":"Am J Rhinol"},{"issue":"1","key":"1330_CR9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2011.09.023","volume":"421","author":"M Durand","year":"2011","unstructured":"Durand M, Pourchez J, Aubert G, Le Guellec S, Navarro L, Forest V, et al. Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: new insights into the mechanisms involved. Int J Pharm. 2011;421(1):63\u201371.","journal-title":"Int J Pharm"},{"issue":"3","key":"1330_CR10","first-page":"213","volume":"46","author":"W M\u00f6ller","year":"2008","unstructured":"M\u00f6ller W, Schuschnig U, Meyer G, Mentzel H, Keller M. Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow. Rhinology. 2008;46(3):213\u201320.","journal-title":"Rhinology"},{"issue":"1","key":"1330_CR11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11095-009-0002-4","volume":"27","author":"V Kundoor","year":"2010","unstructured":"Kundoor V, Dalby RN. Assessment of nasal spray deposition pattern in a silicone human nose model using a color-based method. Pharm Res. 2010;27(1):30\u20136.","journal-title":"Pharm Res"},{"issue":"1","key":"1330_CR12","first-page":"323","volume":"89","author":"JT Kelly","year":"2000","unstructured":"Kelly JT, Prasad AK, Wexler AS. Detailed flow patterns in the nasal cavity. J Appl Physiol Bethesda Md 1985. 2000;89(1):323\u201337.","journal-title":"J Appl Physiol Bethesda Md 1985"},{"issue":"4","key":"1330_CR13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/08942680152744640","volume":"14","author":"HM Janssens","year":"2001","unstructured":"Janssens HM, de Jongste JC, Fokkens WJ, Robben SG, Wouters K, Tiddens HA. The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants. J Aerosol Med Off J Int Soc Aerosol Med. 2001;14(4):433\u201341.","journal-title":"J Aerosol Med Off J Int Soc Aerosol Med"},{"issue":"1","key":"1330_CR14","first-page":"17","volume":"27","author":"N Hyo","year":"1989","unstructured":"Hyo N, Takano H, Hyo Y. Particle deposition efficiency of therapeutic aerosols in the human maxillary sinus. Rhinology. 1989;27(1):17\u201326.","journal-title":"Rhinology"},{"issue":"1","key":"1330_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/194589240401800101","volume":"18","author":"R Saijo","year":"2004","unstructured":"Saijo R, Majima Y, Hyo N, Takano H. Particle deposition of therapeutic aerosols in the nose and paranasal sinuses after transnasal sinus surgery: a cast model study. Am J Rhinol. 2004;18(1):1\u20137.","journal-title":"Am J Rhinol"},{"issue":"4","key":"1330_CR16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2500\/ajr.2008.22.3192","volume":"22","author":"C Hilton","year":"2008","unstructured":"Hilton C, Wiedmann T, St Martin M, Humphrey B, Schleiffarth R, Rimell F. Differential deposition of aerosols in the maxillary sinus of human cadavers by particle size. Am J Rhinol. 2008;22(4):395\u20138.","journal-title":"Am J Rhinol"},{"issue":"1","key":"1330_CR17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/08942680152007936","volume":"14","author":"M Durand","year":"2001","unstructured":"Durand M, Rusch P, Granjon D, Chantrel G, Prades JM, Dubois F, et al. Preliminary study of the deposition of aerosol in the maxillary sinuses using a plastinated model. J Aerosol Med Off J Int Soc Aerosol Med. 2001;14(1):83\u201393.","journal-title":"J Aerosol Med Off J Int Soc Aerosol Med"},{"issue":"6","key":"1330_CR18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10439-006-9094-8","volume":"34","author":"C Croce","year":"2006","unstructured":"Croce C, Fodil R, Durand M, Sbirlea-Apiou G, Caillibotte G, Papon J-F, et al. In vitro experiments and numerical simulations of airflow in realistic nasal airway geometry. Ann Biomed Eng. 2006;34(6):997\u20131007.","journal-title":"Ann Biomed Eng"},{"issue":"2","key":"1330_CR19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ar.1091940206","volume":"194","author":"GV Hagens","year":"1979","unstructured":"Hagens GV. Impregnation of soft biological specimens with thermosetting resins and elastomers. Anat Rec. 1979;194(2):247\u201355.","journal-title":"Anat Rec"},{"issue":"1","key":"1330_CR20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4193\/Rhino09.187","volume":"49","author":"M Durand","year":"2011","unstructured":"Durand M, Pourchez J, Louis B, Pouget JF, Isabey D, Coste A, et al. Plastinated nasal model: a new concept of anatomically realistic cast. Rhinology. 2011;49(1):30\u20136.","journal-title":"Rhinology"},{"issue":"1","key":"1330_CR21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/089426804322994479","volume":"17","author":"L Vecellio None","year":"2004","unstructured":"Vecellio None L, Grimbert D, Bordenave J, Benoit G, Furet Y, Fauroux B, et al. Residual gravimetric method to measure nebulizer output. J Aerosol Med Off J Int Soc Aerosol Med. 2004;17(1):63\u201371.","journal-title":"J Aerosol Med Off J Int Soc Aerosol Med"},{"issue":"7","key":"1330_CR22","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.rmed.2011.02.006","volume":"105","author":"CP Cri\u00e9e","year":"2011","unstructured":"Cri\u00e9e CP, Sorichter S, Smith HJ, Kardos P, Merget R, Heise D, et al. Body plethysmography\u2014its principles and clinical use. Respir Med. 2011;105(7):959\u201371.","journal-title":"Respir Med"},{"issue":"39","key":"1330_CR23","first-page":"46","volume":"23","author":"R Booker","year":"2009","unstructured":"Booker R. Interpretation and evaluation of pulmonary function tests. Nurs Stand R Coll Nurs G B 1987. 2009;23(39):46\u201356. quiz 58.","journal-title":"Nurs Stand R Coll Nurs G B 1987"},{"issue":"2","key":"1330_CR24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1378\/chest.11-2964","volume":"142","author":"JD Flesch","year":"2012","unstructured":"Flesch JD, Dine CJ. Lung volumes: measurement, clinical use, and coding. Chest J. 2012;142(2):506\u201310.","journal-title":"Chest J"},{"issue":"4","key":"1330_CR25","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1152\/jappl.1993.75.4.1767","volume":"75","author":"S Schreck","year":"1993","unstructured":"Schreck S, Sullivan KJ, Ho CM, Chang HK. Correlations between flow resistance and geometry in a model of the human nose. J Appl Physiol. 1993;75(4):1767\u201375.","journal-title":"J Appl Physiol"},{"issue":"7","key":"1330_CR26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2362.2006.01654.x","volume":"36","author":"M Maniscalco","year":"2006","unstructured":"Maniscalco M, Sofia M, Weitzberg E, Lundberg JO. Sounding airflow enhances aerosol delivery into the paranasal sinuses. Eur J Clin Invest. 2006;36(7):509\u201313.","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"1330_CR27","first-page":"1527","volume":"94","author":"O Cakmak","year":"2003","unstructured":"Cakmak O, Celik H, Cankurtaran M, Buyuklu F, Ozgirgin N, Ozluoglu LN. Effects of paranasal sinus ostia and volume on acoustic rhinometry measurements: a model study. J Appl Physiol Bethesda Md 1985. 2003;94(4):1527\u201335.","journal-title":"J Appl Physiol Bethesda Md 1985"},{"issue":"9","key":"1330_CR28","doi-asserted-by":"crossref","first-page":"e74991","DOI":"10.1371\/journal.pone.0074991","volume":"8","author":"W M\u00f6ller","year":"2013","unstructured":"M\u00f6ller W, Schuschnig U, Celik G, M\u00fcnzing W, Bartenstein P, H\u00e4ussinger K, et al. Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols. PLoS ONE. 2013;8(9):e74991.","journal-title":"PLoS ONE"},{"issue":"5","key":"1330_CR29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.anorl.2011.09.002","volume":"129","author":"M Durand","year":"2012","unstructured":"Durand M, Le Guellec S, Pourchez J, Dubois F, Aubert G, Chantrel G, et al. Sonic aerosol therapy to target maxillary sinuses. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129(5):244\u201350.","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"1","key":"1330_CR30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s11095-013-1157-6","volume":"31","author":"SL Guellec","year":"2014","unstructured":"Guellec SL, Pennec DL, Gatier S, Leclerc L, Cabrera M, Pourchez J, et al. Validation of anatomical models to study aerosol deposition in human nasal cavities. Pharm Res. 2014;31(1):228\u201337.","journal-title":"Pharm Res"},{"key":"1330_CR31","doi-asserted-by":"crossref","unstructured":"Leclerc L, Pourchez J, Prevot N, Vecellio L, Le Guellec S, Cottier M, et al. Assessing sinus aerosol deposition: benefits of SPECT\u2013CT imaging. Int J Pharm. 2014; 462:135\u2013141.","DOI":"10.1016\/j.ijpharm.2013.12.032"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-014-1330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-014-1330-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-014-1330-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T10:08:10Z","timestamp":1648462090000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-014-1330-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,4]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["1330"],"URL":"https:\/\/doi.org\/10.1007\/s11095-014-1330-6","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,4]]}}}