{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:33:41Z","timestamp":1791005621791,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"DOI":"10.1007\/s11095-015-1640-3","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T23:17:20Z","timestamp":1424215040000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion"],"prefix":"10.1007","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Z.","family":"Benet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Okochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"issue":"15\u201316","key":"1640_CR1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.drudis.2011.05.010","volume":"16","author":"DB Kell","year":"2011","unstructured":"Kell DB, Dobson PD, Oliver SG. Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discov Today. 2011;16(15\u201316):704\u201314.","journal-title":"Drug Discov Today"},{"issue":"5\u20136","key":"1640_CR2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drudis.2012.11.008","volume":"18","author":"DB Kell","year":"2013","unstructured":"Kell DB, Dobson PD, Bilsland E, Oliver SG. The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discov Today. 2013;18(5\u20136):218\u201339.","journal-title":"Drug Discov Today"},{"issue":"8","key":"1640_CR3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrd3187","volume":"9","author":"K Sugano","year":"2010","unstructured":"Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, Di L, et al. Coexistence of passive and carrier-mediated processes in drug transport. Nat Rev Drug Discov. 2010;9(8):597\u2013614.","journal-title":"Nat Rev Drug Discov"},{"issue":"15\u201316","key":"1640_CR4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.drudis.2012.03.015","volume":"17","author":"L Di","year":"2012","unstructured":"Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, et al. Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. Drug Discov Today. 2012;17(15\u201316):905\u201312.","journal-title":"Drug Discov Today"},{"issue":"1","key":"1640_CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-004-9004-4","volume":"22","author":"CY Wu","year":"2005","unstructured":"Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport\/absorption\/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005;22(1):11\u201323.","journal-title":"Pharm Res"},{"issue":"6","key":"1640_CR6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.addr.2007.08.043","volume":"60","author":"JM Custodio","year":"2008","unstructured":"Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption\/elimination\/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev. 2008;60(6):717\u201333.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"1640_CR7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1476-5381.1968.tb07949.x","volume":"34","author":"AM Barrett","year":"1968","unstructured":"Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol. 1968;34(1):43\u201355.","journal-title":"Br J Pharmacol"},{"issue":"4","key":"1640_CR8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/BF00736064","volume":"339","author":"K Stoschitzky","year":"1989","unstructured":"Stoschitzky K, Lindner W, Rath M, Leitner C, Uray G, Zernig G, et al. Stereoselective hemodynamic effects of (R)-and (S)-propranolol in man. Naunyn Schmiedeberg\u2019s Arch Pharmacol. 1989;339(4):474\u20138.","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"5","key":"1640_CR9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1023\/A:1012121632357","volume":"14","author":"H Lennernas","year":"1997","unstructured":"Lennernas H, Nylander S, Ungell AL. Jejunal permeability: a comparison between the ussing chamber technique and the single-pass perfusion in humans. Pharm Res. 1997;14(5):667\u201371.","journal-title":"Pharm Res"},{"issue":"5","key":"1640_CR10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1023\/A:1007508714259","volume":"17","author":"JJ Yang","year":"2000","unstructured":"Yang JJ, Kim KJ, Lee VH. Role of P-glycoprotein in restricting propranolol transport in cultured rabbit conjunctival epithelial cell layers. Pharm Res. 2000;17(5):533\u20138.","journal-title":"Pharm Res"},{"issue":"3","key":"1640_CR11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/chir.20753","volume":"22","author":"Y Wang","year":"2010","unstructured":"Wang Y, Cao J, Wang X, Zeng S. Stereoselective transport and uptake of propranolol across human intestinal Caco-2 cell monolayers. Chirality. 2010;22(3):361\u20138.","journal-title":"Chirality"},{"issue":"3","key":"1640_CR12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jconrel.2003.12.006","volume":"95","author":"A D\u2019Emanuele","year":"2004","unstructured":"D\u2019Emanuele A, Jevprasesphant R, Penny J, Attwood D. The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Controll Release. 2004;95(3):447\u201353.","journal-title":"J Controll Release"},{"issue":"4","key":"1640_CR13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1208\/s12248-011-9290-9","volume":"13","author":"LZ Benet","year":"2011","unstructured":"Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. AAPS J. 2011;13(4):519\u201347.","journal-title":"AAPS J"},{"issue":"11","key":"1640_CR14","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1007\/s11095-008-9658-4","volume":"25","author":"T Nishimura","year":"2008","unstructured":"Nishimura T, Kato Y, Amano N, Ono M, Kubo Y, Kimura Y, et al. Species difference in intestinal absorption mechanism of etoposide and digoxin between cynomolgus monkey and rat. Pharm Res. 2008;25(11):2467\u201376.","journal-title":"Pharm Res"},{"issue":"7","key":"1640_CR15","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s11095-012-0699-3","volume":"29","author":"W Liu","year":"2012","unstructured":"Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharm Res. 2012;29(7):1768\u201374.","journal-title":"Pharm Res"},{"key":"1640_CR16","first-page":"231","volume":"5","author":"DB Kell","year":"2014","unstructured":"Kell DB, Oliver SG. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Front Pharmacol. 2014;5:231. doi: 10.3389\/fphar.2014.00231 .","journal-title":"Front Pharmacol"},{"issue":"3","key":"1640_CR17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd2438","volume":"7","author":"PD Dobson","year":"2008","unstructured":"Dobson PD, Kell DB. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov. 2008;7(3):205\u201320.","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"1640_CR18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/156802609787521616","volume":"9","author":"PD Dobson","year":"2009","unstructured":"Dobson PD, Lanthaler K, Oliver SG, Kell DB. Implications of the dominant role of transporters in drug uptake by cells. Curr Top Med Chem. 2009;9(2):163\u201381.","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"1640_CR19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jps.23359","volume":"102","author":"LZ Benet","year":"2013","unstructured":"Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci. 2013;102(1):34\u201342.","journal-title":"J Pharm Sci"},{"issue":"3","key":"1640_CR20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11095-012-0926-y","volume":"30","author":"Y Kubo","year":"2013","unstructured":"Kubo Y, Kusagawa Y, Tachikawa M, Akanuma S, Hosoya K. Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier. Pharm Res. 2013;30(3):847\u201356.","journal-title":"Pharm Res"},{"issue":"9","key":"1640_CR21","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1002\/jps.23535","volume":"102","author":"Y Kubo","year":"2013","unstructured":"Kubo Y, Shimizu Y, Kusagawa Y, Akanuma S, Hosoya K. Propranolol transport across the inner blood-retinal barrier: potential involvement of a novel organic cation transporter. J Pharm Sci. 2013;102(9):3332\u201342.","journal-title":"J Pharm Sci"},{"issue":"1","key":"1640_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.bjp.0703518","volume":"131","author":"AJ Dudley","year":"2000","unstructured":"Dudley AJ, Bleasby K, Brown CD. The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000;131(1):71\u20139.","journal-title":"Br J Pharmacol"},{"issue":"6","key":"1640_CR23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/chir.22178","volume":"25","author":"XL Zheng","year":"2013","unstructured":"Zheng XL, Yu QQ, Wang Y, Zeng S. Stereoselective accumulation of propranolol enantiomers in K562 and K562\/ADR cells. Chirality. 2013;25(6):361\u20134.","journal-title":"Chirality"},{"issue":"3","key":"1640_CR24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","volume":"9","author":"C International Transporter","year":"2010","unstructured":"International Transporter C, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, et al. Membrane transporters in drug development. Nat Rev Drug Discov. 2010;9(3):215\u201336.","journal-title":"Nat Rev Drug Discov"},{"issue":"20","key":"1640_CR25","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.2174\/092986708785132870","volume":"15","author":"SF Zhou","year":"2008","unstructured":"Zhou SF, Wang LL, Di YM, Xue CC, Duan W, Li CG, et al. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem. 2008;15(20):1981\u20132039.","journal-title":"Curr Med Chem"},{"issue":"2\u20133","key":"1640_CR26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.mam.2012.11.003","volume":"34","author":"DE Smith","year":"2013","unstructured":"Smith DE, Clemencon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol Asp Med. 2013;34(2\u20133):323\u201336.","journal-title":"Mol Asp Med"},{"issue":"4","key":"1640_CR27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/cphy.c130008","volume":"3","author":"AP Halestrap","year":"2013","unstructured":"Halestrap AP. Monocarboxylic acid transport. J Comp Physiol. 2013;3(4):1611\u201343.","journal-title":"J Comp Physiol"},{"issue":"1","key":"1640_CR28","doi-asserted-by":"crossref","first-page":"G123","DOI":"10.1152\/ajpgi.00102.2011","volume":"302","author":"L Ma","year":"2012","unstructured":"Ma L, Juttner M, Kullak-Ublick GA, Eloranta JJ. Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2. Am J Physiol Gastr Liver Physiol. 2012;302(1):G123\u201333.","journal-title":"Am J Physiol Gastr Liver Physiol"},{"issue":"3","key":"1640_CR29","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1124\/jpet.102.041236","volume":"303","author":"RH Stephens","year":"2002","unstructured":"Stephens RH, Tanianis-Hughes J, Higgs NB, Humphrey M, Warhurst G. Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-\/-) mouse intestine. J Pharmacol Exp Ther. 2002;303(3):1095\u2013101.","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"1640_CR30","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1023\/A:1025032511040","volume":"20","author":"S Neuhoff","year":"2003","unstructured":"Neuhoff S, Ungell AL, Zamora I, Artursson P. pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003;20(8):1141\u20138.","journal-title":"Pharm Res"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-015-1640-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-015-1640-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-015-1640-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:48:12Z","timestamp":1717746492000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-015-1640-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,19]]},"references-count":30,"alternative-id":["1640"],"URL":"https:\/\/doi.org\/10.1007\/s11095-015-1640-3","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,19]]}}}