{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:57:19Z","timestamp":1792112239009,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s11095-015-1752-9","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T16:01:52Z","timestamp":1437580912000},"page":"3927-3936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery"],"prefix":"10.1007","volume":"32","author":[{"given":"Margreke J.","family":"Brill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"van Rongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van Ramshorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Hazebroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Darwich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Rostami-Hodjegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherijne A.","family":"Knibbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"1752_CR1","unstructured":"Shields M, Carroll MD, Ogden CL. Adult obesity prevalence in Canada and the United States. In: Services usdohah, editor. Hyattsville, MD: NCHS Data Brief; 2011."},{"key":"1752_CR2","unstructured":"IASO. International Association for the Study of Obesity. In: IASO."},{"key":"1752_CR3","unstructured":"Hautvast J. Overgewicht en obesitas. In: Health Council of the Netherlands; 2003."},{"key":"1752_CR4","unstructured":"Craig RMJ, et al. Cardiovascular disease and risk factors in adults. London: The Information Centre for Health and Social Care. In: Health Survey for England 2006; 2008."},{"issue":"7","key":"1752_CR5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.puhe.2006.11.016","volume":"121","author":"T Andreyeva","year":"2007","unstructured":"Andreyeva T, Michaud PC, van Soest A. Obesity and health in Europeans aged 50 years and older. Public Health. 2007;121(7):497\u2013509.","journal-title":"Public Health"},{"issue":"14","key":"1752_CR6","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1001\/jama.292.14.1724","volume":"292","author":"H Buchwald","year":"2004","unstructured":"Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724\u201337.","journal-title":"JAMA"},{"issue":"26","key":"1752_CR7","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1056\/NEJMoa035622","volume":"351","author":"L Sjostrom","year":"2004","unstructured":"Sjostrom L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683\u201393.","journal-title":"N Engl J Med"},{"issue":"4","key":"1752_CR8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11695-012-0864-0","volume":"23","author":"H Buchwald","year":"2013","unstructured":"Buchwald H, Oien DM. Metabolic\/bariatric surgery worldwide 2011. Obes Surg. 2013;23(4):427\u201336.","journal-title":"Obes Surg"},{"issue":"1","key":"1752_CR9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1345\/aph.1Q414","volume":"46","author":"A Edwards","year":"2012","unstructured":"Edwards A, Ensom MH. Pharmacokinetic effects of bariatric surgery. Ann Pharmacother. 2012;46(1):130\u20136.","journal-title":"Ann Pharmacother"},{"issue":"8","key":"1752_CR10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ncpendmet0563","volume":"3","author":"JG Kral","year":"2007","unstructured":"Kral JG, Naslund E. Surgical treatment of obesity. Nat Clin Pract Endocrinol Metab. 2007;3(8):574\u201383.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"8","key":"1752_CR11","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1381\/0960892055002248","volume":"15","author":"A Baltasar","year":"2005","unstructured":"Baltasar A, Serra C, Perez N, Bou R, Bengochea M, Ferri L. Laparoscopic sleeve gastrectomy: a multi-purpose bariatric operation. Obes Surg. 2005;15(8):1124\u20138.","journal-title":"Obes Surg"},{"issue":"11","key":"1752_CR12","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1467-789X.2011.00901.x","volume":"12","author":"KM Horner","year":"2011","unstructured":"Horner KM, Byrne NM, Cleghorn GJ, Naslund E, King NA. The effects of weight loss strategies on gastric emptying and appetite control. Obes Rev. 2011;12(11):935\u201351.","journal-title":"Obes Rev"},{"issue":"6","key":"1752_CR13","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/SLA.0b013e3182774522","volume":"258","author":"J Melissas","year":"2013","unstructured":"Melissas J, Leventi A, Klinaki I, Perisinakis K, Koukouraki S, de Bree E, et al. Alterations of global gastrointestinal motility after sleeve gastrectomy: a prospective study. Ann Surg. 2013;258(6):976\u201382.","journal-title":"Ann Surg"},{"issue":"1","key":"1752_CR14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","volume":"138","author":"UM Zanger","year":"2013","unstructured":"Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138(1):103\u201341.","journal-title":"Pharmacol Ther"},{"issue":"4","key":"1752_CR15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1517\/17425255.1.4.629","volume":"1","author":"KW Renton","year":"2005","unstructured":"Renton KW. Regulation of drug metabolism and disposition during inflammation and infection. Expert Opin Drug Metab Toxicol. 2005;1(4):629\u201340.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"5","key":"1752_CR16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI200525102","volume":"115","author":"KE Wellen","year":"2005","unstructured":"Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111\u20139.","journal-title":"J Clin Invest"},{"issue":"5","key":"1752_CR17","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","volume":"115","author":"G Fantuzzi","year":"2005","unstructured":"Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115(5):911\u20139. quiz 920.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"1752_CR18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/clpt.2009.311","volume":"87","author":"P Mathieu","year":"2010","unstructured":"Mathieu P, Lemieux I, Despres JP. Obesity, inflammation, and cardiovascular risk. Clin Pharmacol Ther. 2010;87(4):407\u201316.","journal-title":"Clin Pharmacol Ther"},{"key":"1752_CR19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.46.120604.141059","volume":"46","author":"AE Aitken","year":"2006","unstructured":"Aitken AE, Richardson TA, Morgan ET. Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol. 2006;46:123\u201349.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3","key":"1752_CR20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2010.06.003","volume":"197","author":"J Yang","year":"2010","unstructured":"Yang J, Hao C, Yang D, Shi D, Song X, Luan X, et al. Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes. Toxicol Lett. 2010;197(3):219\u201326.","journal-title":"Toxicol Lett"},{"issue":"2","key":"1752_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jhep.2013.09.012","volume":"60","author":"H Immonen","year":"2014","unstructured":"Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, et al. Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients. J Hepatol. 2014;60(2):377\u201383.","journal-title":"J Hepatol"},{"issue":"8","key":"1752_CR22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00011-012-0473-3","volume":"61","author":"SR Rao","year":"2012","unstructured":"Rao SR. Inflammatory markers and bariatric surgery: a meta-analysis. Inflamm Res. 2012;61(8):789\u2013807.","journal-title":"Inflamm Res"},{"issue":"3","key":"1752_CR23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00008571-200004000-00001","volume":"10","author":"DS Streetman","year":"2000","unstructured":"Streetman DS, Bertino Jr JS, Nafziger AN. Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes. Pharmacogenetics. 2000;10(3):187\u2013216.","journal-title":"Pharmacogenetics"},{"key":"1752_CR24","unstructured":"Flockhart A. Cytochrome P450 drug interaction table. Available from: http:\/\/www.greenbridgemed.com\/wp-content\/uploads\/2011\/09\/Drugs-using-P450-Hepatic-metabolism.pdf ."},{"issue":"10","key":"1752_CR25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s40262-014-0166-x","volume":"53","author":"MJ Brill","year":"2014","unstructured":"Brill MJ, van Rongen A, Houwink AP, Burggraaf J, van Ramshorst B, Wiezer RJ, et al. Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers. Clin Pharmacokinet. 2014;53(10):931\u201341.","journal-title":"Clin Pharmacokinet"},{"issue":"8","key":"1752_CR26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1056\/NEJMoa066254","volume":"357","author":"L Sjostrom","year":"2007","unstructured":"Sjostrom L, Narbro K, Sjostrom CD, Karason K, Larsson B, Wedel H, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741\u201352.","journal-title":"N Engl J Med"},{"issue":"10","key":"1752_CR27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.2107138","volume":"166","author":"CN Sessler","year":"2002","unstructured":"Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O\u2019Neal PV, Keane KA, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002;166(10):1338\u201344.","journal-title":"Am J Respir Crit Care Med"},{"key":"1752_CR28","unstructured":"Beal S, Sheiner LB, Boeckmann A, Bauer RJ. NONMEM User\u2019s Guides. (1988\u20132011) Ellicott City, MD, USA; 2011."},{"key":"1752_CR29","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1007\/s11095-006-9067-5","volume":"23","author":"K Brendel","year":"2006","unstructured":"Brendel K, Comets E, Laffont CM, Laveille C, Mentr\u00e9 F. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide. Pharm Res. 2006;23:2036\u201349.","journal-title":"Pharm Res"},{"issue":"5","key":"1752_CR30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10928-007-9066-0","volume":"34","author":"RM Savic","year":"2007","unstructured":"Savic RM, Jonker DM, Kerbusch T, Karlsson MO. Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies. J Pharmacokinet Pharmacodyn. 2007;34(5):711\u201326.","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"10","key":"1752_CR31","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2165\/00003088-200544100-00004","volume":"44","author":"S Janmahasatian","year":"2005","unstructured":"Janmahasatian S, Duffull SB, Ash S, Ward LC, Byrne NM, Green B. Quantification of lean bodyweight. Clin Pharmacokinet. 2005;44(10):1051\u201365.","journal-title":"Clin Pharmacokinet"},{"issue":"6","key":"1752_CR32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/SLA.0b013e3181dbb572","volume":"251","author":"LN Bell","year":"2010","unstructured":"Bell LN, Temm CJ, Saxena R, Vuppalanchi R, Schauer P, Rabinovitz M, et al. Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content. Ann Surg. 2010;251(6):1041\u20138.","journal-title":"Ann Surg"},{"issue":"2","key":"1752_CR33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/SLA.0b013e31827a0e82","volume":"258","author":"S Tandra","year":"2013","unstructured":"Tandra S, Chalasani N, Jones DR, Mattar S, Hall SD, Vuppalanchi R. Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients. Ann Surg. 2013;258(2):262\u20139.","journal-title":"Ann Surg"},{"issue":"1","key":"1752_CR34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00000542-198461010-00006","volume":"61","author":"DJ Greenblatt","year":"1984","unstructured":"Greenblatt DJ, Abernethy DR, Locniskar A, Harmatz JS, Limjuco RA, Shader RI. Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology. 1984;61(1):27\u201335.","journal-title":"Anesthesiology"},{"issue":"5","key":"1752_CR35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0009-9236(96)90177-0","volume":"59","author":"KE Thummel","year":"1996","unstructured":"Thummel KE, O\u2019Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD, et al. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin Pharmacol Ther. 1996;59(5):491\u2013502.","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"1752_CR36","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0006-2952(94)90543-6","volume":"47","author":"JC Gorski","year":"1994","unstructured":"Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA. Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol. 1994;47(9):1643\u201353.","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"1752_CR37","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1067\/mcp.2002.129068","volume":"72","author":"JI Lee","year":"2002","unstructured":"Lee JI, Chaves-Gnecco D, Amico JA, Kroboth PD, Wilson JW, Frye RF. Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping. Clin Pharmacol Ther. 2002;72(6):718\u201328.","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"1752_CR38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2125.2009.03559.x","volume":"69","author":"SS Shord","year":"2010","unstructured":"Shord SS, Chan LN, Camp JR, Vasquez EM, Jeong HY, Molokie RE, et al. Effects of oral clotrimazole troches on the pharmacokinetics of oral and intravenous midazolam. Br J Clin Pharmacol. 2010;69(2):160\u20136.","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"1752_CR39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/clpt.1992.84","volume":"51","author":"JW Mandema","year":"1992","unstructured":"Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clin Pharmacol Ther. 1992;51(6):715\u201328.","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1752_CR40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2125.1997.t01-1-00613.x","volume":"44","author":"JM Gerven van","year":"1997","unstructured":"van Gerven JM, Roncari G, Schoemaker RC, Massarella J, Keesmaat P, Kooyman H, et al. Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997;44(5):487\u201393.","journal-title":"Br J Clin Pharmacol"},{"issue":"1\u20132","key":"1752_CR41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.lfs.2011.05.005","volume":"89","author":"R Ghose","year":"2011","unstructured":"Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, et al. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011;89(1\u20132):57\u201364.","journal-title":"Life Sci"},{"issue":"1","key":"1752_CR42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/138920011794520035","volume":"12","author":"C Buechler","year":"2011","unstructured":"Buechler C, Weiss TS. Does hepatic steatosis affect drug metabolizing enzymes in the liver? Curr Drug Metab. 2011;12(1):24\u201334.","journal-title":"Curr Drug Metab"},{"issue":"6","key":"1752_CR43","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/ar.20715","volume":"291","author":"GC Farrell","year":"2008","unstructured":"Farrell GC, Teoh NC, McCuskey RS. Hepatic microcirculation in fatty liver disease. Anat Rec (Hoboken). 2008;291(6):684\u201392.","journal-title":"Anat Rec (Hoboken)"},{"issue":"5","key":"1752_CR44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0009-9236(99)70009-3","volume":"66","author":"SM Tsunoda","year":"1999","unstructured":"Tsunoda SM, Velez RL, von Moltke LL, Greenblatt DJ. Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole. Clin Pharmacol Ther. 1999;66(5):461\u201371.","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"1752_CR45","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/JCP.0b013e3182905ffb","volume":"33","author":"JL Roerig","year":"2013","unstructured":"Roerig JL, Steffen KJ, Zimmerman C, Mitchell JE, Crosby RD, Cao L. A comparison of duloxetine plasma levels in postbariatric surgery patients versus matched nonsurgical control subjects. J Clin Psychopharmacol. 2013;33(4):479\u201384.","journal-title":"J Clin Psychopharmacol"},{"issue":"8","key":"1752_CR46","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1365-2036.2011.04812.x","volume":"34","author":"A Ardila-Hani","year":"2011","unstructured":"Ardila-Hani A, Soffer EE. Review article: the impact of bariatric surgery on gastrointestinal motility. Aliment Pharmacol Ther. 2011;34(8):825\u201331.","journal-title":"Aliment Pharmacol Ther"},{"issue":"11","key":"1752_CR47","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s11695-009-9954-z","volume":"19","author":"I Braghetto","year":"2009","unstructured":"Braghetto I, Davanzo C, Korn O, Csendes A, Valladares H, Herrera E, et al. Scintigraphic evaluation of gastric emptying in obese patients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg. 2009;19(11):1515\u201321.","journal-title":"Obes Surg"},{"issue":"2","key":"1752_CR48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1208\/s12248-009-9099-y","volume":"11","author":"M Jamei","year":"2009","unstructured":"Jamei M, Turner D, Yang J, Neuhoff S, Polak S, Rostami-Hodjegan A, et al. Population-based mechanistic prediction of oral drug absorption. AAPS J. 2009;11(2):225\u201337.","journal-title":"AAPS J"},{"issue":"7","key":"1752_CR49","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.2042-7158.2012.01538.x","volume":"64","author":"AS Darwich","year":"2012","unstructured":"Darwich AS, Pade D, Ammori BJ, Jamei M, Ashcroft DM, Rostami-Hodjegan A. A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution. J Pharm Pharmacol. 2012;64(7):1008\u201324.","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"1752_CR50","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","volume":"283","author":"MF Paine","year":"1997","unstructured":"Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, et al. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther. 1997;283(3):1552\u201362.","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"1752_CR51","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/oby.2002.56","volume":"10","author":"L Busetto","year":"2002","unstructured":"Busetto L, Tregnaghi A, De Marchi F, Segato G, Foletto M, Sergi G, et al. Liver volume and visceral obesity in women with hepatic steatosis undergoing gastric banding. Obes Res. 2002;10(5):408\u201311.","journal-title":"Obes Res"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-015-1752-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-015-1752-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-015-1752-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:37:24Z","timestamp":1748533044000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-015-1752-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1752"],"URL":"https:\/\/doi.org\/10.1007\/s11095-015-1752-9","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,23]]}}}