{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:59:38Z","timestamp":1773471578358,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s11095-016-1936-y","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T17:07:29Z","timestamp":1462554449000},"page":"1998-2009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Saquinavir Loaded Acetalated Dextran Microconfetti \u2013 a Long Acting Protease Inhibitor Injectable"],"prefix":"10.1007","volume":"33","author":[{"given":"Michael A.","family":"Collier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Gallovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Bachelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig D.","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kashuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy M.","family":"Ainslie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"1936_CR1","unstructured":"Organization WH. HIV\/AIDS. Available from: http:\/\/www.who.int\/hiv\/en\/ ."},{"key":"1936_CR2","unstructured":"Aids.gov. HIV Basics. Available from: https:\/\/www.aids.gov\/ ."},{"issue":"2\u20133","key":"1936_CR3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.antiviral.2006.05.007","volume":"71","author":"R Pauwels","year":"2006","unstructured":"Pauwels R. Aspects of successful drug discovery and development. Antivir Res. 2006;71(2\u20133):77\u201389.","journal-title":"Antivir Res"},{"issue":"23","key":"1936_CR4","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1001\/jama.282.23.2220","volume":"282","author":"B Ledergerber","year":"1999","unstructured":"Ledergerber B, Egger M, Erard V, Weber R, Hirschel B, Furrer H, et al. AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study. JAMA. 1999;282(23):2220\u20136.","journal-title":"JAMA"},{"issue":"9","key":"1936_CR5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/QAD.0b013e32832ba8ec","volume":"23","author":"EM Gardner","year":"2009","unstructured":"Gardner EM, Burman WJ, Steiner JF, Anderson PL, Bangsberg DR. Antiretroviral medication adherence and the development of class-specific antiretroviral resistance. AIDS. 2009;23(9):1035\u201346.","journal-title":"AIDS"},{"issue":"8","key":"1936_CR6","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1177\/135965350801300820","volume":"13","author":"N Hentig von","year":"2008","unstructured":"von Hentig N, Nisius G, Lennemann T, Khaykin P, Stephan C, Babacan E, et al. Pharmacokinetics, safety and efficacy of saquinavir\/ ritonavir 1,000\/100 mg twice daily as HIV type-1 therapy and transmission prophylaxis in pregnancy. Antivir Ther. 2008;13(8):1039\u201346.","journal-title":"Antivir Ther"},{"issue":"10","key":"1936_CR7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1056\/NEJMra025195","volume":"350","author":"F Clavel","year":"2004","unstructured":"Clavel F, Hance AJ. HIV drug resistance. N Engl J Med. 2004;350(10):1023\u201335.","journal-title":"N Engl J Med"},{"key":"1936_CR8","unstructured":"Prevention CfDCa. Initiation of and adherence to treatment as prevention 2013."},{"issue":"5","key":"1936_CR9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/135965350601100510","volume":"11","author":"J Ananworanich","year":"2006","unstructured":"Ananworanich J, Hirschel B, Sirivichayakul S, Ubolyam S, Jupimai T, Prasithsirikul W, et al. Absence of resistance mutations in antiretroviral-naive patients treated with ritonavir-boosted saquinavir. Antivir Ther. 2006;11(5):631\u20135.","journal-title":"Antivir Ther"},{"issue":"1","key":"1936_CR10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jac\/dkn187","volume":"62","author":"L Dickinson","year":"2008","unstructured":"Dickinson L, Boffito M, Khoo SH, Schutz M, Aarons LJ, Pozniak AL, et al. Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing. J Antimicrob Chemother. 2008;62(1):161\u20137.","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"1936_CR11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12325-009-0039-0","volume":"26","author":"DE Kemp","year":"2009","unstructured":"Kemp DE, Canan F, Goldstein BI, McIntyre RS. Long-acting risperidone: a review of its role in the treatment of bipolar disorder. Adv Ther. 2009;26(6):588\u201399.","journal-title":"Adv Ther"},{"key":"1936_CR12","first-page":"CD005214","volume":"3","author":"BH Draper","year":"2006","unstructured":"Draper BH, Morroni C, Hoffman M, Smit J, Beksinska M, Hapgood J, et al. Depot medroxyprogesterone versus norethisterone oenanthate for long-acting progestogenic contraception. Cochrane Database Syst Rev. 2006;3:CD005214.","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"1936_CR13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1046\/j.1365-2265.1999.00881.x","volume":"51","author":"E Nieschlag","year":"1999","unstructured":"Nieschlag E, Buchter D, Von Eckardstein S, Abshagen K, Simoni M, Behre HM. Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men. Clin Endocrinol. 1999;51(6):757\u201363.","journal-title":"Clin Endocrinol"},{"issue":"5","key":"1936_CR14","first-page":"15","volume":"67","author":"JP McEvoy","year":"2006","unstructured":"McEvoy JP. Risks versus benefits of different types of long-acting injectable antipsychotics. J Clin Psychiatry. 2006;67(5):15\u20138.","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"1936_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archinternmed.2009.432","volume":"170","author":"L Elzi","year":"2010","unstructured":"Elzi L, Marzolini C, Furrer H, Ledergerber B, Cavassini M, Hirschel B, et al. Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008. Arch Intern Med. 2010;170(1):57\u201365.","journal-title":"Arch Intern Med"},{"key":"1936_CR16","unstructured":"Info A. Guidelines for the use of antiretroviral agents in HIV-1-Infected Adults and Adolescents. In.; 2015."},{"issue":"11","key":"1936_CR17","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1089\/aid.2008.0083","volume":"24","author":"LS Robison","year":"2008","unstructured":"Robison LS, Westfall AO, Mugavero MJ, Kempf MC, Cole SR, Allison JJ, et al. Short-term discontinuation of HAART regimens more common in vulnerable patient populations. AIDS Res Hum Retrovir. 2008;24(11):1347\u201355.","journal-title":"AIDS Res Hum Retrovir"},{"issue":"6","key":"1936_CR18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/COH.0000000000000002","volume":"8","author":"WR Spreen","year":"2013","unstructured":"Spreen WR, Margolis DA, Pottage Jr JC. Long-acting injectable antiretrovirals for HIV treatment and prevention. Curr Opin HIV AIDS. 2013;8(6):565\u201371.","journal-title":"Curr Opin HIV AIDS"},{"issue":"9","key":"1936_CR19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd1494","volume":"3","author":"BE Rabinow","year":"2004","unstructured":"Rabinow BE. Nanosuspensions in drug delivery. Nat Rev Drug Discov. 2004;3(9):785\u201396.","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"1936_CR20","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1128\/AAC.01529-09","volume":"54","author":"G Klooster van\u2019t","year":"2010","unstructured":"van\u2019t Klooster G, Hoeben E, Borghys H, Looszova A, Bouche MP, van Velsen F, et al. Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation. Antimicrob Agents Chemother. 2010;54(5):2042\u201350.","journal-title":"Antimicrob Agents Chemother"},{"key":"1936_CR21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1477-3155-11-43","volume":"11","author":"HW Fung","year":"2013","unstructured":"Fung HW, Mikasa TJ, Vergara J, Sivananthan SJ, Guderian JA, Duthie MS, et al. Optimizing manufacturing and composition of a TLR4 nanosuspension: physicochemical stability and vaccine adjuvant activity. J Nanobiotechnol. 2013;11:43.","journal-title":"J Nanobiotechnol"},{"issue":"1\u20132","key":"1936_CR22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2012.04.043","volume":"431","author":"N Kanthamneni","year":"2012","unstructured":"Kanthamneni N, Sharma S, Meenach SA, Billet B, Zhao JC, Bachelder EM, et al. Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions. Int J Pharm. 2012;431(1\u20132):101\u201310.","journal-title":"Int J Pharm"},{"issue":"8","key":"1936_CR23","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/am3008888","volume":"4","author":"KJ Kauffman","year":"2012","unstructured":"Kauffman KJ, Do C, Sharma S, Gallovic MD, Bachelder EM, Ainslie KM. Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product. ACS Appl Mater Interfaces. 2012;4(8):4149\u201355.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"32","key":"1936_CR24","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1021\/ja803947s","volume":"130","author":"EM Bachelder","year":"2008","unstructured":"Bachelder EM, Beaudette TT, Broaders KE, Dashe J, Frechet JM. Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications. J Am Chem Soc. 2008;130(32):10494\u20135.","journal-title":"J Am Chem Soc"},{"issue":"25","key":"1936_CR25","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/la400541e","volume":"29","author":"HM Borteh","year":"2013","unstructured":"Borteh HM, Gallovic MD, Sharma S, Peine KJ, Miao S, Brackman DJ, et al. Electrospun acetalated dextran scaffolds for temporal release of therapeutics. Langmuir. 2013;29(25):7957\u201365.","journal-title":"Langmuir"},{"key":"1936_CR26","doi-asserted-by":"crossref","unstructured":"Khorshidi S, Solouk A, Mirzadeh H, Mazinani S, Lagaron JM, Sharifi S, et al. A review of key challenges of electrospun scaffolds for tissue-engineering applications. J Tissue Eng Regen Med. 2015.","DOI":"10.1002\/term.1978"},{"issue":"1","key":"1936_CR27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0168-3659(01)00245-0","volume":"73","author":"N Passerini","year":"2001","unstructured":"Passerini N, Craig DQ. An investigation into the effects of residual water on the glass transition temperature of polylactide microspheres using modulated temperature DSC. J Control Release: Off J Control Release Soc. 2001;73(1):111\u20135.","journal-title":"J Control Release: Off J Control Release Soc"},{"issue":"13","key":"1936_CR28","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.biomaterials.2003.09.040","volume":"25","author":"L Singh","year":"2004","unstructured":"Singh L, Kumar V, Ratner BD. Generation of porous microcellular 85\/15 poly (DL-lactide-co-glycolide) foams for biomedical applications. Biomaterials. 2004;25(13):2611\u20137.","journal-title":"Biomaterials"},{"issue":"10","key":"1936_CR29","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/bmc.865","volume":"21","author":"BH Jung","year":"2007","unstructured":"Jung BH, Rezk NL, Bridges AS, Corbett AH, Kashuba AD. Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry. Biomed Chromatogr: BMC. 2007;21(10):1095\u2013104.","journal-title":"Biomed Chromatogr: BMC"},{"key":"1936_CR30","unstructured":"Horn T. Transmitted HIV drug resistance on the rise in U.S. AIDSMEDS. 2012."},{"issue":"3","key":"1936_CR31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ajic.2012.02.001","volume":"40","author":"WR Jarvis","year":"2012","unstructured":"Jarvis WR, Jarvis AA, Chinn RY. National prevalence of methicillin-resistant Staphylococcus aureus in inpatients at United States health care facilities, 2010. Am J Infect Control. 2012;40(3):194\u2013200.","journal-title":"Am J Infect Control"},{"issue":"2","key":"1936_CR32","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1093\/infdis\/jiu816","volume":"211","author":"H Salamon","year":"2015","unstructured":"Salamon H, Yamaguchi KD, Cirillo DM, Miotto P, Schito M, Posey J, et al. Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis. J Infect Dis. 2015;211(2):S50\u201357.","journal-title":"J Infect Dis"},{"key":"1936_CR33","doi-asserted-by":"crossref","unstructured":"Md. Fazley Elahi* WL, Guoping G, Khan F. Core-shell fibers for biomedical applications-a review. Bioeng Biomed Sci. 2013;3(1).","DOI":"10.4172\/2155-9538.1000121"},{"issue":"3","key":"1936_CR34","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/mp3005098","volume":"10","author":"AD Duong","year":"2013","unstructured":"Duong AD, Sharma S, Peine KJ, Gupta G, Satoskar AR, Bachelder EM, et al. Electrospray encapsulation of toll-like receptor agonist resiquimod in polymer microparticles for the treatment of visceral leishmaniasis. Mol Pharm. 2013;10(3):1045\u201355.","journal-title":"Mol Pharm"},{"issue":"1","key":"1936_CR35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijpharm.2014.11.045","volume":"478","author":"S Seif","year":"2015","unstructured":"Seif S, Franzen L, Windbergs M. Overcoming drug crystallization in electrospun fibers - Elucidating key parameters and developing strategies for drug delivery. Int J Pharm. 2015;478(1):390\u20137.","journal-title":"Int J Pharm"},{"issue":"15","key":"1936_CR36","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.jacc.2011.05.050","volume":"58","author":"PW Serruys","year":"2011","unstructured":"Serruys PW, Onuma Y, Dudek D, Smits PC, Koolen J, Chevalier B, et al. Evaluation of the second generation of a bioresorbable everolimus-eluting vascular scaffold for the treatment of de novo coronary artery stenosis: 12-month clinical and imaging outcomes. J Am Coll Cardiol. 2011;58(15):1578\u201388.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"1936_CR37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0975-7406.148777","volume":"7","author":"B Yerragunta","year":"2015","unstructured":"Yerragunta B, Jogala S, Chinnala KM, Aukunuru J. Development of a novel 3-month drug releasing risperidone microspheres. J Pharm Bioallied Sci. 2015;7(1):37\u201344.","journal-title":"J Pharm Bioallied Sci"},{"key":"1936_CR38","unstructured":"Insert VP. Naltraxone for extended-release injectable suspension. 2015."},{"key":"1936_CR39","unstructured":"Reach V. Keeping the cold chain cold. 2014."},{"issue":"2","key":"1936_CR40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/515642","volume":"178","author":"CF Perno","year":"1998","unstructured":"Perno CF, Newcomb FM, Davis DA, Aquaro S, Humphrey RW, Calio R, et al. Relative potency of protease inhibitors in monocytes\/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis. 1998;178(2):413\u201322.","journal-title":"J Infect Dis"},{"issue":"2","key":"1936_CR41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/AAC.46.2.402-408.2002","volume":"46","author":"DA Davis","year":"2002","unstructured":"Davis DA, Read-Connole E, Pearson K, Fales HM, Newcomb FM, Moskovitz J, et al. Oxidative modifications of kynostatin-272, a potent human immunodeficiency virus type 1 protease inhibitor: potential mechanism for altered activity in monocytes\/macrophages. Antimicrob Agents Chemother. 2002;46(2):402\u20138.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"1936_CR42","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2174\/157016210791330356","volume":"8","author":"SD Mahajan","year":"2010","unstructured":"Mahajan SD, Roy I, Xu G, Yong KT, Ding H, Aalinkeel R, et al. Enhancing the delivery of anti retroviral drug \u201cSaquinavir\u201d across the blood brain barrier using nanoparticles. Curr HIV Res. 2010;8(5):396\u2013404.","journal-title":"Curr HIV Res"},{"key":"1936_CR43","unstructured":"Prakashan N. Mechanical operations: fundamental principles and applications; 2007."},{"issue":"13","key":"1936_CR44","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1073\/pnas.0600997103","volume":"103","author":"JA Champion","year":"2006","unstructured":"Champion JA, Mitragotri S. Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A. 2006;103(13):4930\u20134.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1936_CR45","unstructured":"Hrkach J. Targeted polymeric nanotherapeutics. In frontiers of engineering: reports on leading-edge engineering from the 2008 Symposium. 2008."},{"issue":"4","key":"1936_CR46","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1517\/17425241003602259","volume":"7","author":"Y Fu","year":"2010","unstructured":"Fu Y, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin Drug Deliv. 2010;7(4):429\u201344.","journal-title":"Expert Opin Drug Deliv"},{"issue":"6","key":"1936_CR47","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/jac\/dkh487","volume":"54","author":"J Ford","year":"2004","unstructured":"Ford J, Khoo SH, Back DJ. The intracellular pharmacology of antiretroviral protease inhibitors. J Antimicrob Chemother. 2004;54(6):982\u201390.","journal-title":"J Antimicrob Chemother"},{"issue":"7\u20138","key":"1936_CR48","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/ten.2005.11.1077","volume":"11","author":"BB Crow","year":"2005","unstructured":"Crow BB, Borneman AF, Hawkins DL, Smith GM, Nelson KD. Evaluation of in vitro drug release, pH change, and molecular weight degradation of poly(L-lactic acid) and poly(D, L-lactide-co-glycolide) fibers. Tissue Eng. 2005;11(7\u20138):1077\u201384.","journal-title":"Tissue Eng"},{"issue":"1","key":"1936_CR49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0022-3565(24)37962-5","volume":"288","author":"YS Lin","year":"1999","unstructured":"Lin YS, Nguyen C, Mendoza JL, Escandon E, Fei D, Meng YG, et al. Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther. 1999;288(1):371\u20138.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"1936_CR50","first-page":"299","volume":"29","author":"JW Holladay","year":"2001","unstructured":"Holladay JW, Dewey MJ, Michniak BB, Wiltshire H, Halberg DL, Weigl P, et al. Elevated alpha-1-acid glycoprotein reduces the volume of distribution and systemic clearance of saquinavir. Drug Metab Dispos: Biol Fate Chem. 2001;29(3):299\u2013303.","journal-title":"Drug Metab Dispos: Biol Fate Chem"},{"key":"1936_CR51","unstructured":"AIDSinfo. Invirase Drug Database. Available from: https:\/\/aidsinfo.nih.gov\/drugs\/164\/invirase\/0\/professional ."},{"issue":"7","key":"1936_CR52","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/AAC.00267-13","volume":"57","author":"N Gautam","year":"2013","unstructured":"Gautam N, Roy U, Balkundi S, Puligujja P, Guo D, Smith N, et al. Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy. Antimicrob Agents Chemother. 2013;57(7):3110\u201320.","journal-title":"Antimicrob Agents Chemother"},{"key":"1936_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2014.11.020","volume":"199","author":"J Meeus","year":"2015","unstructured":"Meeus J, Scurr DJ, Amssoms K, Wuyts K, Annaert P, Davies MC, et al. In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor. J Control Release: Off J Control Release Soc. 2015;199:1\u20139.","journal-title":"J Control Release: Off J Control Release Soc"},{"key":"1936_CR54","first-page":"103","volume":"2","author":"NK Saksena","year":"2010","unstructured":"Saksena NK, Wang B, Zhou L, Soedjono M, Ho YS, Conceicao V. HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites. HIV\/AIDS. 2010;2:103\u201322.","journal-title":"HIV\/AIDS"},{"issue":"1","key":"1936_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00498250110085845","volume":"32","author":"VA Eagling","year":"2002","unstructured":"Eagling VA, Wiltshire H, Whitcombe IW, Back DJ. CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica; Fate Foreign Compounds Biol Syst. 2002;32(1):1\u201317.","journal-title":"Xenobiotica; Fate Foreign Compounds Biol Syst"},{"issue":"4","key":"1936_CR56","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/modpathol.3880538","volume":"15","author":"LK Diaz","year":"2002","unstructured":"Diaz LK, Murphy RL, Phair JP, Variakojis D. The AIDS autopsy spleen: a comparison of the pre-anti-retroviral and highly active anti-retroviral therapy eras. Modern Pathol: Off J U S Can Acad Pathol Inc. 2002;15(4):406\u201312.","journal-title":"Modern Pathol: Off J U S Can Acad Pathol Inc"},{"issue":"10","key":"1936_CR57","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/AAC.00419-09","volume":"53","author":"M Mascio Di","year":"2009","unstructured":"Di Mascio M, Srinivasula S, Bhattacharjee A, Cheng L, Martiniova L, Herscovitch P, et al. Antiretroviral tissue kinetics: in vivo imaging using positron emission tomography. Antimicrob Agents Chemother. 2009;53(10):4086\u201395.","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"1936_CR58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1523-1755.2005.67096.x","volume":"67","author":"E Daugas","year":"2005","unstructured":"Daugas E, Rougier JP, Hill G. HAART-related nephropathies in HIV-infected patients. Kidney Int. 2005;67(2):393\u2013403.","journal-title":"Kidney Int"},{"issue":"5","key":"1936_CR59","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1046\/j.1523-1755.2003.00901.x","volume":"63","author":"NJ Weiner","year":"2003","unstructured":"Weiner NJ, Goodman JW, Kimmel PL. The HIV-associated renal diseases: current insight into pathogenesis and treatment. Kidney Int. 2003;63(5):1618\u201331.","journal-title":"Kidney Int"},{"issue":"4","key":"1936_CR60","first-page":"393","volume":"21","author":"N Tanji","year":"2006","unstructured":"Tanji N, Ross MD, Tanji K, Bruggeman LA, Markowitz GS, Klotman PE, et al. Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reaction. Histol Histopathol. 2006;21(4):393\u2013401.","journal-title":"Histol Histopathol"},{"issue":"3","key":"1936_CR61","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/AAC.41.3.654","volume":"41","author":"DJ Kempf","year":"1997","unstructured":"Kempf DJ, Marsh KC, Kumar G, Rodrigues AD, Denissen JF, McDonald E, et al. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents Chemother. 1997;41(3):654\u201360.","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"1936_CR62","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.2165\/00003495-200363120-00007","volume":"63","author":"GL Plosker","year":"2003","unstructured":"Plosker GL, Scott LJ. Saquinavir: a review of its use in boosted regimens for treating HIV infection. Drugs. 2003;63(12):1299\u2013324.","journal-title":"Drugs"},{"issue":"3","key":"1936_CR63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.0306-5251.2001.01452.x","volume":"52","author":"N Buss","year":"2001","unstructured":"Buss N, Snell P, Bock J, Hsu A, Jorga K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. Br J Clin Pharmacol. 2001;52(3):255\u201364.","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"1936_CR64","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1158\/0008-5472.CAN-09-4362","volume":"70","author":"K Shahani","year":"2010","unstructured":"Shahani K, Swaminathan SK, Freeman D, Blum A, Ma L, Panyam J. Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res. 2010;70(11):4443\u201352.","journal-title":"Cancer Res"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-016-1936-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-016-1936-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-016-1936-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:22:44Z","timestamp":1748913764000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-016-1936-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,6]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1936"],"URL":"https:\/\/doi.org\/10.1007\/s11095-016-1936-y","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,6]]}}}