{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:49:43Z","timestamp":1790707783950,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s11095-016-2080-4","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T16:09:18Z","timestamp":1482163758000},"page":"492-505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival"],"prefix":"10.1007","volume":"34","author":[{"given":"Luis P. B.","family":"Guerzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-0637","authenticated-orcid":false,"given":"Angelina","family":"Angelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"2080_CR1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","volume":"16","author":"J Brettschneider","year":"2015","unstructured":"Brettschneider J, DelTredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci. 2015;16:109\u201320.","journal-title":"Nat Rev Neurosci"},{"key":"2080_CR2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","volume":"4","author":"MV Chao","year":"2003","unstructured":"Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci. 2003;4:299\u2013309.","journal-title":"Nat Rev Neurosci"},{"key":"2080_CR3","first-page":"57","volume":"2014","author":"A Mariga","year":"2014","unstructured":"Mariga A, Zavadil J, Ginsberg SD, Chao MV. Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function. Dev Neurobiol. 2014;2014:57\u201364.","journal-title":"Dev Neurobiol"},{"key":"2080_CR4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s13311-014-0327-5","volume":"12","author":"AF Teich","year":"2015","unstructured":"Teich AF, Nicholls RE, Puzzo D, Fiorito J, Purgatorio R, Fa\u2019 M, et al. SYNAPTIC therapy in ALZHEIMER\u2019S disease: a CREB-centric approach. Neurotherapeutics. 2015;12:29\u201341.","journal-title":"Neurotherapeutics"},{"key":"2080_CR5","doi-asserted-by":"crossref","first-page":"2406e2413","DOI":"10.1016\/j.neurobiolaging.2015.04.014","volume":"36","author":"E Rosa","year":"2015","unstructured":"Rosa E, Fahnestock M. CREB expression mediates amyloid \u03b2-induced basal BDNF downregulation. Neurobiol Aging. 2015;36:2406e2413.","journal-title":"Neurobiol Aging"},{"key":"2080_CR6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/157488471003150820151532","volume":"10","author":"Y Pan","year":"2015","unstructured":"Pan Y, Khalil H, Nicolazzo JA. The impact of docosahexaenoic acid on Alzheimer\u2019s disease: is there a role of the blood-brain barrier? Curr Clin Pharmacol. 2015;10:222\u201341.","journal-title":"Curr Clin Pharmacol"},{"key":"2080_CR7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11095-011-0572-9","volume":"29","author":"SRK Vaka","year":"2012","unstructured":"Vaka SRK, Murthy SN. Delivery of brain-derived neurotrophic factor via nose-to-brain pathway. Pharm Res. 2012;29:441\u20137.","journal-title":"Pharm Res"},{"key":"2080_CR8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1097-0185(199806)253:3<79::AID-AR4>3.0.CO;2-9","volume":"253","author":"JB Hutchins","year":"1998","unstructured":"Hutchins JB, Barger SW. Why neurons die: cell death in the nervous system. Anat Rec. 1998;253:79\u201390.","journal-title":"Anat Rec"},{"key":"2080_CR9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2012.01.006","volume":"134","author":"S Balaratnasingam","year":"2012","unstructured":"Balaratnasingam S, Janca A. Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders. Pharmacol Ther. 2012;134:116\u201324.","journal-title":"Pharmacol Ther"},{"key":"2080_CR10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrd3366","volume":"10","author":"AH Nagahara","year":"2011","unstructured":"Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011;10:209\u201319.","journal-title":"Nat Rev Drug Discov"},{"key":"2080_CR11","first-page":"8","volume":"6","author":"F Fumagalli","year":"2006","unstructured":"Fumagalli F, Racagni G, Riva MA. The expanding role of BDNF: a therapeutic target for Alzheimer\u2019s disease? Pharm J. 2006;6:8\u201315.","journal-title":"Pharm J"},{"key":"2080_CR12","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","volume":"361","author":"LF Reichardt","year":"2006","unstructured":"Reichardt LF. Neurotrophin-regulated signaling pathways. Philos Trans R Soc Lond Ser B Biol Sci. 2006;361:1545\u201364.","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"2080_CR13","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1110\/ps.8.12.2589","volume":"8","author":"RC Robinson","year":"1999","unstructured":"Robinson RC, Radziejewski C, Spraggon G, Greenwald J, Kostura MR, Burtnick LD, et al. The structures of the neurotrophin-4 homodimer and the brain-derived neurotrophic factor\/neurotrophin-4 heterodimer reveal a common Trk-binding site. Protein Sci. 1999;8:2589\u201397.","journal-title":"Protein Sci"},{"key":"2080_CR14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11095-009-0009-x","volume":"27","author":"JP Bertram","year":"2010","unstructured":"Bertram JP, Rauch MF, Chang K, Lavik EB. Using polymer chemistry to modulate the delivery of neurotrophic factors from degradable microspheres: delivery of BDNF. Pharm Res. 2010;27:82\u201391.","journal-title":"Pharm Res"},{"key":"2080_CR15","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1021\/pr5006982","volume":"13","author":"G Zhang","year":"2014","unstructured":"Zhang G, Bowling H, Hom N, Kirshenbaum K, Klann E, Chao MV, et al. In-depth quantitative proteomic analysis of de novo protein synthesis induced by brain-derived neurotrophic factor. J Proteome Res. 2014;13:5707\u201314.","journal-title":"J Proteome Res"},{"key":"2080_CR16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1523\/JNEUROSCI.2641-14.2015","volume":"35","author":"M Genheden","year":"2015","unstructured":"Genheden M, Kenney JW, Johnston HE, Manousopoulou A, Garbis SD, Proud CG. BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1. J Neurosci. 2015;35:972\u201384.","journal-title":"J Neurosci"},{"key":"2080_CR17","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1046\/j.1471-4159.1996.66062279.x","volume":"66","author":"C Gaiddon","year":"1996","unstructured":"Gaiddon C, Loeffler JP, Larmet Y. Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. J Neurochem. 1996;66:2279\u201386.","journal-title":"J Neurochem"},{"key":"2080_CR18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","volume":"5","author":"C Zuccato","year":"2009","unstructured":"Zuccato C, Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol. 2009;5:311\u201322.","journal-title":"Nat Rev Neurol"},{"key":"2080_CR19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"MP Mattson","year":"2004","unstructured":"Mattson MP. Pathways towards and away from Alzheimer\u2019s disease. Nature. 2004;430:631\u20139.","journal-title":"Nature"},{"key":"2080_CR20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0301-0082(00)00014-9","volume":"63","author":"MG Murer","year":"2001","unstructured":"Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer\u2019s disease and Parkinson\u2019s disease. Prog Neurobiol. 2001;63:71\u2013124.","journal-title":"Prog Neurobiol"},{"key":"2080_CR21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF03033829","volume":"8","author":"RL Nosheny","year":"2005","unstructured":"Nosheny RL, Mocchetti I, Bachis A. Brain-derived neurotrophic factor as a prototype neuroprotective factor against HIV-1-associated neuronal degeneration. Neurotox Res. 2005;8:187\u201398.","journal-title":"Neurotox Res"},{"key":"2080_CR22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm.1912","volume":"15","author":"AH Nagahara","year":"2009","unstructured":"Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer\u2019s disease. Nat Med. 2009;15:331\u20137.","journal-title":"Nat Med"},{"key":"2080_CR23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tins.2010.11.001","volume":"34","author":"L Aron","year":"2011","unstructured":"Aron L, Klein R. Repairing the parkinsonian brain with neurotrophic factors. Trends Neurosci. 2011;34:88\u2013100.","journal-title":"Trends Neurosci"},{"key":"2080_CR24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.drudis.2013.07.010","volume":"18","author":"A Angelova","year":"2013","unstructured":"Angelova A, Angelov B, Drechsler M, Lesieur S. Neurotrophin delivery using nanotechnology. Drug Discov Today. 2013;18:1263\u201371.","journal-title":"Drug Discov Today"},{"key":"2080_CR25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/dneu.20758","volume":"70","author":"E Castren","year":"2010","unstructured":"Castren E, Rantamaki T. The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol. 2010;70:289\u201397.","journal-title":"Dev Neurobiol"},{"key":"2080_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2003.08.096","volume":"480","author":"O Guillin","year":"2003","unstructured":"Guillin O, Griffon N, Bezard E, Leriche L, Diaz J, Gross C, et al. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson\u2019s disease. Eur J Pharmacol. 2003;480:89\u201395.","journal-title":"Eur J Pharmacol"},{"key":"2080_CR27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0896-6273(00)80395-5","volume":"19","author":"S Finkbeiner","year":"1997","unstructured":"Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. CREB: a major mediator of neuronal neurotrophin responses. Neuron. 1997;19:1031\u201347.","journal-title":"Neuron"},{"key":"2080_CR28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1046\/j.1460-9568.2001.01432.x","volume":"13","author":"RA Bender","year":"2001","unstructured":"Bender RA, Lauterborn JC, Gall CM, Cariaga W, Baram TZ. Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation. Eur J Neurosci. 2001;13:679\u201386.","journal-title":"Eur J Neurosci"},{"key":"2080_CR29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuint.2015.10.009","volume":"91","author":"S Nakajima","year":"2015","unstructured":"Nakajima S, Numakawa T, Adachi N, Ooshima Y, Odaka H, Yoshimura A, et al. Self-amplified BDNF transcription is a regulatory system for synaptic aturation in cultured cortical neurons. Neurochem Int. 2015;91:55\u201361.","journal-title":"Neurochem Int"},{"key":"2080_CR30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nn1381","volume":"8","author":"Y Ji","year":"2005","unstructured":"Ji Y, Pang PT, Feng L, Lu B. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci. 2005;8:164\u201372.","journal-title":"Nat Neurosci"},{"key":"2080_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","volume":"116","author":"K Sakamoto","year":"2011","unstructured":"Sakamoto K, Karelina K, Obrietan K. CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem. 2011;116:1\u20139.","journal-title":"J Neurochem"},{"key":"2080_CR32","doi-asserted-by":"crossref","first-page":"546e554","DOI":"10.1016\/j.neurobiolaging.2010.03.019","volume":"33","author":"M Fahnestock","year":"2012","unstructured":"Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, et al. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012;33:546e554.","journal-title":"Neurobiol Aging"},{"key":"2080_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2009.10.003","volume":"492","author":"JPE Spencer","year":"2009","unstructured":"Spencer JPE, Vauzour D, Rendeiro C. Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys. 2009;492:1\u20139.","journal-title":"Arch Biochem Biophys"},{"key":"2080_CR34","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1073\/pnas.061020198","volume":"98","author":"FS Lee","year":"2001","unstructured":"Lee FS, Chao MV. Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc Natl Acad Sci U S A. 2001;98:3555\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2080_CR35","first-page":"1207","volume":"25","author":"M Domeniconi","year":"2010","unstructured":"Domeniconi M, Chao MV. Transactivation of Trk receptors in spinal motor neurons. Histol Histopathol. 2010;25:1207\u201313.","journal-title":"Histol Histopathol"},{"key":"2080_CR36","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI41356","volume":"120","author":"SM Massa","year":"2010","unstructured":"Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Investig. 2010;120:1774\u201385.","journal-title":"J Clin Investig"},{"key":"2080_CR37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrd4024","volume":"12","author":"FM Longo","year":"2013","unstructured":"Longo FM, Massa SM. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov. 2013;12:507\u201325.","journal-title":"Nat Rev Drug Discov"},{"key":"2080_CR38","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/814068","volume":"2015","author":"R Venkatesan","year":"2015","unstructured":"Venkatesan R, Ji E, Kim SY. Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review. BioMed Research International. 2015;2015, 814068.","journal-title":"BioMed Research International"},{"key":"2080_CR39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1021\/cn400213r","volume":"5","author":"FI Baptista","year":"2014","unstructured":"Baptista FI, Henriques AG, Silva AMS, Wiltfang J, da Cruze Silva OAB. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer\u2019s disease. ACS Chem Neurosci. 2014;5:83\u201392.","journal-title":"ACS Chem Neurosci"},{"key":"2080_CR40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2011.09.010","volume":"52","author":"RJ Williams","year":"2012","unstructured":"Williams RJ, Spencer JPE. Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med. 2012;52:35\u201345.","journal-title":"Free Radic Biol Med"},{"key":"2080_CR41","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0197-4580(02)00024-6","volume":"23","author":"S Bastianetto","year":"2002","unstructured":"Bastianetto S, Quirion R. Natural extracts as possible protective agents of brain aging. Neurobiol Aging. 2002;23:891\u20137.","journal-title":"Neurobiol Aging"},{"key":"2080_CR42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.mrfmmm.2005.03.023","volume":"579","author":"MA Soobrattee","year":"2005","unstructured":"Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res Fundam Mol Mech Mutagen. 2005;579:200\u201313.","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"2080_CR43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/acs.molpharmaceut.5b00611","volume":"13","author":"G Djioken Paka","year":"2016","unstructured":"Djioken Paka G, Doggui S, Zaghmi A, Safar R, Dao L, Reisch A, et al. Neuronal uptake and neuroprotective properties of curcumin-loaded nanoparticles on SK-N-SH cell line: role of poly(lactide-co-glycolide) polymeric matrix composition. Mol Pharm. 2016;13:391\u2013403.","journal-title":"Mol Pharm"},{"key":"2080_CR44","doi-asserted-by":"crossref","first-page":"27571","DOI":"10.1074\/jbc.M114.562561","volume":"289","author":"X Liu","year":"2014","unstructured":"Liu X, Obianyo O, Chan CB, Huang J, Xue S, Yang J, et al. Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor. J Biol Chem. 2014;289:27571\u201384.","journal-title":"J Biol Chem"},{"key":"2080_CR45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuint.2015.07.021","volume":"89","author":"X Du","year":"2015","unstructured":"Du X, Hill RA. 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders. Neurochem Int. 2015;89:170\u201380.","journal-title":"Neurochem Int"},{"key":"2080_CR46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2008.01.104","volume":"1210","author":"R Wang","year":"2008","unstructured":"Wang R, Li YB, Li YH, Xu Y, Wu HL, Li XJ. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res. 2008;1210:84\u201391.","journal-title":"Brain Res"},{"key":"2080_CR47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-7847.99898","volume":"6","author":"GP Kumar","year":"2012","unstructured":"Kumar GP, Khanum F. Neuroprotective potential of phytochemicals. Pharmacogn Rev. 2012;6:81\u201390.","journal-title":"Pharmacogn Rev"},{"key":"2080_CR48","doi-asserted-by":"crossref","first-page":"e59843","DOI":"10.1371\/journal.pone.0059843","volume":"8","author":"J Wu","year":"2013","unstructured":"Wu J, Li Q, Wang X, Yu S, Li L, Wu X, et al. Neuroprotection by curcumin in ischemic brain injury involves the Akt\/Nrf2 pathway. PLoS One. 2013;8:e59843.","journal-title":"PLoS One"},{"key":"2080_CR49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nlm.2013.08.001","volume":"106","author":"JB Hoppe","year":"2013","unstructured":"Hoppe JB, Coradini K, Frozza RL, Oliveira CM, Meneghetti AB, Bernardi A, et al. Free and nanoencapsulated curcumin suppress beta-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt\/GSK-3beta signaling pathway. Neurobiol Learn Mem. 2013;106:134\u201344.","journal-title":"Neurobiol Learn Mem"},{"key":"2080_CR50","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","volume":"21","author":"GP Lim","year":"2001","unstructured":"Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21:8370\u20137.","journal-title":"J Neurosci"},{"key":"2080_CR51","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","volume":"280","author":"F Yang","year":"2005","unstructured":"Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005;280:5892\u2013903.","journal-title":"J Biol Chem"},{"key":"2080_CR52","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/cn500323q","volume":"6","author":"D Mastroeni","year":"2015","unstructured":"Mastroeni D, Khdour OM, Arce PM, Hecht SM, Coleman PD. Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function. ACS Chem Neurosci. 2015;6:588\u201398.","journal-title":"ACS Chem Neurosci"},{"key":"2080_CR53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/archneur.60.2.203","volume":"60","author":"JA Luchsinger","year":"2003","unstructured":"Luchsinger JA, Tang MX, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol. 2003;60:203\u20138.","journal-title":"Arch Neurol"},{"key":"2080_CR54","doi-asserted-by":"crossref","first-page":"485102","DOI":"10.1088\/0957-4484\/25\/48\/485102","volume":"25","author":"R Pangeni","year":"2014","unstructured":"Pangeni R, Sharma S, Mustafa G, Javed A, Baboota S. Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson\u2019s disease by reducing oxidative stress. Nanotechnology. 2014;25:485102.","journal-title":"Nanotechnology"},{"key":"2080_CR55","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00394-008-0703-1","volume":"47","author":"W Kou","year":"2008","unstructured":"Kou W, Luchtman D, Song C. Eicosapentaenoic acid (EPA) increases cell viability and expression of neurotrophin receptors in retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cells. Eur J Nutr. 2008;47:104\u201313.","journal-title":"Eur J Nutr"},{"key":"2080_CR56","doi-asserted-by":"crossref","first-page":"35215","DOI":"10.1074\/jbc.M004446200","volume":"275","author":"H-Y Kim","year":"2000","unstructured":"Kim H-Y, Akbar M, Lau A, Lisa E. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). J Biol Chem. 2000;275:35215\u201323.","journal-title":"J Biol Chem"},{"key":"2080_CR57","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/pharmaceutics5010127","volume":"5","author":"C G\u00e9ral","year":"2013","unstructured":"G\u00e9ral C, Angelova A, Lesieur S. From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics. 2013;5:127\u201367.","journal-title":"Pharmaceutics"},{"key":"2080_CR58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/9781118336632.ch11","volume-title":"Self-assembled supramolecular architectures: lyotropic liquid crystals","author":"C G\u00e9ral","year":"2012","unstructured":"G\u00e9ral C, Angelova A, Angelov B, Nicolas V, Lesieur S. Chapter 11: multicompartment lipid nanocarriers for targeting of cells expressing brain receptors. In: Garti N, Somasundaran P, Mezzenga R, editors. Self-assembled supramolecular architectures: lyotropic liquid crystals. New Jersey: Wiley; 2012. p. 319\u201355."},{"key":"2080_CR59","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10904-014-0143-8","volume":"25","author":"A Angelova","year":"2015","unstructured":"Angelova A, Angelov B, Mutafchieva R, Lesieur S. Biocompatible mesoporous and soft nanoarchitectures. J Inorg Organomet Polym. 2015;25:214\u201332.","journal-title":"J Inorg Organomet Polym"},{"key":"2080_CR60","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrn3505","volume":"14","author":"B Lu","year":"2013","unstructured":"Lu B, Nagappan G, Guan X, Nathan PJ, Wren P. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci. 2013;14:401\u201316.","journal-title":"Nat Rev Neurosci"},{"key":"2080_CR61","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/pr.111.005108","volume":"64","author":"AE Autry","year":"2012","unstructured":"Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev. 2012;64:238\u201358.","journal-title":"Pharmacol Rev"},{"key":"2080_CR62","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","volume":"76","author":"G Leal","year":"2014","unstructured":"Leal G, Comprido D, Duarte CB. BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology. 2014;76:639\u201356.","journal-title":"Neuropharmacology"},{"issue":"Pt C","key":"2080_CR63","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuropharm.2013.04.054","volume":"76","author":"K Deinhardt","year":"2014","unstructured":"Deinhardt K, Chao MV. Shaping neurons: long and short range effects of mature and proBDNF signaling upon neuronal structure. Neuropharmacology. 2014;76(Pt C):603\u20139.","journal-title":"Neuropharmacology"},{"key":"2080_CR64","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ejpb.2011.10.012","volume":"80","author":"H Wu","year":"2012","unstructured":"Wu H, Li J, Zhang Q, Yan X, Guo L, Gao X, et al. A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-b25\u201335-treated rats following intranasal administration. Eur J Pharm Biopharm. 2012;80:368\u201378.","journal-title":"Eur J Pharm Biopharm"},{"key":"2080_CR65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jconrel.2010.11.033","volume":"152","author":"JK Sahni","year":"2011","unstructured":"Sahni JK, Doggui S, Ali J, Baboota S, Dao L, Ramassamy C. Neurotherapeutic applications of nanoparticles in Alzheimer\u2019s disease. J Control Release. 2011;152:208\u201331.","journal-title":"J Control Release"},{"key":"2080_CR66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/157488912798842241","volume":"7","author":"MR Micheli","year":"2012","unstructured":"Micheli MR, Bova R, Magini A, Polidoro M, Emiliani C. Lipid-based nanocarriers for CNS-targeted drug delivery. Recent Pat CNS Drug Discov. 2012;7:71\u201386.","journal-title":"Recent Pat CNS Drug Discov"},{"key":"2080_CR67","first-page":"2677","volume":"9","author":"E Herran","year":"2014","unstructured":"Herran E, Requejo C, Ruiz-Ortega JA, Aristieta A, Igartua M, Bengoetxea H, et al. Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson\u2019s disease. Int J Nanomed. 2014;9:2677\u201387.","journal-title":"Int J Nanomed"},{"key":"2080_CR68","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.addr.2011.10.007","volume":"64","author":"HL Wong","year":"2014","unstructured":"Wong HL, Wu XY, Bendayan R. Nanotechnological advances for the delivery of CNS therapeutics. Adv Drug Deliv Rev. 2014;64:686\u2013700.","journal-title":"Adv Drug Deliv Rev"},{"key":"2080_CR69","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1773-2247(05)50013-3","volume":"15","author":"A Angelova","year":"2005","unstructured":"Angelova A, Angelov B, Papahadjopoulos-Sternberg B, Ollivon M, Bourgaux C. Structural organisation of proteocubosome carriers involving medium- and large-size proteins. J Drug Deliv Sci Technol. 2005;15:108\u201312.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2080_CR70","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1021\/jp044216p","volume":"109","author":"A Angelova","year":"2005","unstructured":"Angelova A, Angelov B, Papahadjopoulos-Sternberg B, Bourgaux C, Couvreur P. Protein driven patterning of self-assembled cubosomic nanostructures: long oriented nanoridges. J Phys Chem B. 2005;109:3089\u201393.","journal-title":"J Phys Chem B"},{"key":"2080_CR71","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1098\/rsif.2007.1351","volume":"5","author":"Z Almsherqi","year":"2008","unstructured":"Almsherqi Z, Hyde S, Ramachandran M, Deng Y. Cubic membranes: a structure-based design for DNA uptake. J R Soc Interface. 2008;5:1023\u20139.","journal-title":"J R Soc Interface"},{"key":"2080_CR72","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/jz400857z","volume":"4","author":"B Angelov","year":"2013","unstructured":"Angelov B, Angelova A, Filippov SK, Narayanan T, Drechsler M, \u0160t\u011bp\u00e1nek P, et al. DNA\/fusogenic lipid nanocarrier assembly: millisecond structural dynamics. J Phys Chem Lett. 2013;4:1959\u201364.","journal-title":"J Phys Chem Lett"},{"key":"2080_CR73","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0006-8993(95)00261-N","volume":"680","author":"CE Krewson","year":"1995","unstructured":"Krewson CE, Klarman ML, Saltzman WM. Distribution of nerve growth factor following direct delivery to brain interstitium. Brain Res. 1995;680:196\u2013206.","journal-title":"Brain Res"},{"key":"2080_CR74","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.colsurfb.2013.09.030","volume":"113","author":"S Sood","year":"2014","unstructured":"Sood S, Jain K, Gowthamarajan K. Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment. Colloid Surf B. 2014;113:330\u20137.","journal-title":"Colloid Surf B"},{"key":"2080_CR75","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2011.08.026","volume":"157","author":"M Rogers","year":"2012","unstructured":"Rogers M, Rush R. Non-viral gene therapy for neurological diseases, with an emphasis on targeted gene delivery. J Control Release. 2012;157:183\u20139.","journal-title":"J Control Release"},{"key":"2080_CR76","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijpharm.2009.06.019","volume":"379","author":"A Mistry","year":"2009","unstructured":"Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm. 2009;379:146\u201357.","journal-title":"Int J Pharm"},{"key":"2080_CR77","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.biomaterials.2005.06.034","volume":"27","author":"JA Burdick","year":"2006","unstructured":"Burdick JA, Ward M, Liang E, Young MJ, Langer R. Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels. Biomaterials. 2006;27:452\u20139.","journal-title":"Biomaterials"},{"key":"2080_CR78","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","volume":"19","author":"XY Zhuang","year":"2011","unstructured":"Zhuang XY, Xiang XY, Grizzle W, Sun DM, Zhang SQ, Axtell RC, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011;19:1769\u201379.","journal-title":"Mol Ther"},{"key":"2080_CR79","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ijpharm.2013.06.006","volume":"454","author":"A Angelova","year":"2013","unstructured":"Angelova A, Angelov B, Drechsler M, Garamus VM, Lesieur S. Protein entrapment in PEGylated lipid nanoparticles. Int J Pharm. 2013;454:625\u201332.","journal-title":"Int J Pharm"},{"key":"2080_CR80","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1039\/c1sm06447a","volume":"7","author":"B Angelov","year":"2011","unstructured":"Angelov B, Angelova A, Filippov SK, Karlsson G, Terrill N, Lesieur S, et al. Topology and internal structure of PEGylated lipid nanocarriers for neuronal transfection: synchrotron radiation SAXS and cryo-TEM studies. Soft Matter. 2011;7:9714\u201320.","journal-title":"Soft Matter"},{"key":"2080_CR81","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejps.2009.02.019","volume":"37","author":"J Shaikh","year":"2009","unstructured":"Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MNVR. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci. 2009;37:223\u201330.","journal-title":"Eur J Pharm Sci"},{"key":"2080_CR82","first-page":"3623","volume":"9","author":"YM Wei","year":"2014","unstructured":"Wei YM, Guo JM, Zheng XL, Wu J, Zhou Y, Yu Y, et al. Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes. Int J Nanomed. 2014;9:3623\u201330.","journal-title":"Int J Nanomed"},{"key":"2080_CR83","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/cncr.21300","volume":"104","author":"L Li","year":"2005","unstructured":"Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin - In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005;104:1322\u201331.","journal-title":"Cancer"},{"key":"2080_CR84","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/j.msec.2013.08.017","volume":"33","author":"E Esposito","year":"2013","unstructured":"Esposito E, Ravani L, Mariani P, Contado C, Drechsler M, Puglia C, et al. Curcumin containing monoolein aqueous dispersions: a preformulative study. Mat Sci Eng C Mater. 2013;33:4923\u201334.","journal-title":"Mat Sci Eng C Mater"},{"key":"2080_CR85","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijpharm.2011.08.023","volume":"420","author":"JJ Zhang","year":"2011","unstructured":"Zhang JJ, Lv HX, Jiang K, Gao Y. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011;420:180\u20138.","journal-title":"Int J Pharm"},{"key":"2080_CR86","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ejps.2012.07.006","volume":"47","author":"JF Hao","year":"2012","unstructured":"Hao JF, Wang FG, Wang XD, Zhang DR, Bi YP, Gao YS, et al. Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. Eur J Pharm Sci. 2012;47:497\u2013505.","journal-title":"Eur J Pharm Sci"},{"key":"2080_CR87","doi-asserted-by":"crossref","first-page":"16647","DOI":"10.1021\/la302721n","volume":"28","author":"B Angelov","year":"2012","unstructured":"Angelov B, Angelova A, Garamus VM, Drechsler M, Willumeit R, Mutafchieva R, et al. Earliest stage of the tetrahedral nanochannel formation in cubosome particles from unilamellar nanovesicles. Langmuir. 2012;28:16647\u201355.","journal-title":"Langmuir"},{"key":"2080_CR88","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1039\/C5TB01193K","volume":"3","author":"Y Chen","year":"2015","unstructured":"Chen Y, Angelova A, Angelov B, Drechsler M, Garamus VM, Willumeit-R\u00f6mer R, et al. Sterically stabilized spongosomes for multi-drug delivery of anticancer nanomedicines. J Mater Chem B. 2015;3:7734\u201344.","journal-title":"J Mater Chem B"},{"key":"2080_CR89","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1039\/C5SM00169B","volume":"11","author":"B Angelov","year":"2015","unstructured":"Angelov B, Angelova A, Drechsler M, Garamus VM, Mutafchieva R, Lesieur S. Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging. Soft Matter. 2015;11:3686\u201392.","journal-title":"Soft Matter"},{"key":"2080_CR90","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/la047590p","volume":"21","author":"J Barauskas","year":"2005","unstructured":"Barauskas J, Johnsson M, Joabsson F, Tiberg F. Cubic phase nanoparticles (Cubosome): principles for controlling size, structure, and stability. Langmuir. 2005;21:2569\u201377.","journal-title":"Langmuir"},{"key":"2080_CR91","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1471-4159.2000.0750991.x","volume":"75","author":"M Encinas","year":"2000","unstructured":"Encinas M, Iglesias M, Liu YH, Wang HY, Muhaisen A, Cena V, et al. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem. 2000;75:991\u20131003.","journal-title":"J Neurochem"},{"key":"2080_CR92","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0896-6273(93)90187-V","volume":"11","author":"DR Kaplan","year":"1993","unstructured":"Kaplan DR, Matsumoto K, Lucarelli E, Thiele CJ. Induction of Trkb by retinoic acid mediates biologic responsiveness to Bdnf and differentiation of human neuroblastoma cells. Neuron. 1993;11:321\u201331.","journal-title":"Neuron"},{"key":"2080_CR93","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/jnc.12243","volume":"126","author":"C Eggeling","year":"2013","unstructured":"Eggeling C, Willig KI, Barrantes FJ. STED microscopy of living cells \u2013 new frontiers in membrane and neurobiology. J Neurochem. 2013;126:203\u201312.","journal-title":"J Neurochem"},{"key":"2080_CR94","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00232-010-9261-6","volume":"235","author":"JJ Wenz","year":"2010","unstructured":"Wenz JJ, Borroni V, Barrantes FJ. Statistical analysis of high-resolution light microscope images reveals effects of cytoskeleton-disrupting drugs on the membrane organization of the nicotinic acetylcholine receptor. J Membr Biol. 2010;235:163\u201375.","journal-title":"J Membr Biol"},{"key":"2080_CR95","doi-asserted-by":"crossref","unstructured":"Zhang SH, Zhou X, Rush RA. Extraction and quantification of the neurotrophins. In: Neurotrophin Protocols. Totowa, USA: Humana Press; 2001. p. 31\u201341.","DOI":"10.1385\/1-59259-060-8:31"},{"key":"2080_CR96","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.foodchem.2014.09.016","volume":"172","author":"RA Silva-Buzanello","year":"2015","unstructured":"Silva-Buzanello RA, Ferro AC, Bona E, Cardozo-Filho L, Araujo PH, Leimann FV, et al. Validation of an ultraviolet-visible (UV-Vis) technique for the quantitative determination of curcumin in poly(L-lactic acid) nanoparticles. Food Chem. 2015;172:99\u2013104.","journal-title":"Food Chem"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-016-2080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-016-2080-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-016-2080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T14:40:03Z","timestamp":1568644803000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-016-2080-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["2080"],"URL":"https:\/\/doi.org\/10.1007\/s11095-016-2080-4","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}