{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:08:09Z","timestamp":1789564089553,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Funda\u00e7\u00e3o CAPES minist\u00e9rio da educa\u00e7\u00e3o"},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s11095-017-2118-2","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T10:30:38Z","timestamp":1487673038000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ocular safety of Intravitreal Clindamycin Hydrochloride Released by PLGA Implants"],"prefix":"10.1007","volume":"34","author":[{"given":"Gabriella M.","family":"Fernandes-Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Lig\u00f3rio","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Rodrigues","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Silva-Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Behar-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"issue":"4","key":"2118_CR1","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1167\/iovs.15-18127","volume":"57","author":"JB Saliba","year":"2016","unstructured":"Saliba JB, Vieira L, Fernandes-Cunha GM, Silva GR, Fialho SL, Silva-Cunha A, et al. Anti-inflammatory effect of dexamethasone controlled released from anterior suprachoroidal polyurethane implants on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2016;57(4):1671\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2118_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.addr.2011.09.001","volume":"64","author":"A Elsaesser","year":"2012","unstructured":"Elsaesser A, Howard CV. Toxicology of nanoparticles. Adv Drug Deliv Rev. 2012;64(2):129\u201337.","journal-title":"Adv Drug Deliv Rev"},{"key":"2118_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF00130002","volume":"12","author":"GA Peyman","year":"1988","unstructured":"Peyman GA, Charles HC, Liu KR, Khoobehi B, Niesman M. Intravitreal liposome-encapsulated drugs: a preliminary human report. Int Ophthalmol. 1988;12:175\u201382.","journal-title":"Int Ophthalmol"},{"key":"2118_CR4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3928\/1542-8877-20010501-03","volume":"32","author":"K Kishore","year":"2001","unstructured":"Kishore K et al. Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis. Ophthalmic Surg Lasers. 2001;32:183\u201392.","journal-title":"Ophthalmic Surg Lasers"},{"key":"2118_CR5","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1097\/IAE.0b013e31804b3f0d","volume":"27","author":"L Sobrin","year":"2007","unstructured":"Sobrin L, Kump LI, Foster CS. Intravitreal clindamycin for toxoplasmic retinochoroiditis. Retina. 2007;27:952\u20137.","journal-title":"Retina"},{"key":"2118_CR6","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/j.ophtha.2010.01.028","volume":"117","author":"AF Lasave","year":"2010","unstructured":"Lasave AF, D\u00edaz-Llopis M, Muccioli C, Belfort R, Arevalo JF. Intravitreal clindamycin and dexamethasone for zone 1 toxoplasmic retinochoroiditis at 24 months. Ophthalmology. 2010;117:1831\u20138.","journal-title":"Ophthalmology"},{"key":"2118_CR7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ophtha.2010.04.020","volume":"118","author":"M Soheilian","year":"2011","unstructured":"Soheilian M, Ramezani A, Azimzadeh A, Sadoughi MM, Dehghan MH, Shahghdami R, et al. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. Ophthalmology. 2011;118:134\u201341.","journal-title":"Ophthalmology"},{"key":"2118_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0161-6420(80)35268-8","volume":"87","author":"KF Tabbara","year":"1980","unstructured":"Tabbara KF, O\u2019Connor GR. Treatment of ocular toxoplasmosis with clin- damycin and sulfadiazine. Ophthalmology. 1980;87:129\u201334.","journal-title":"Ophthalmology"},{"key":"2118_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.preteyeres.2013.12.005","volume":"39","author":"M Maenz","year":"2014","unstructured":"Maenz M, Schl\u00fcter D, Liesenfeld O, Schares G, Gross U, Pleyer A. Ocular toxoplasmosis past, present and new aspects of an old disease. Prog Retin Eye Res. 2014;39:77\u2013106.","journal-title":"Prog Retin Eye Res"},{"key":"2118_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/infdis\/135.Supplement.S120","volume":"135","author":"HC Neu","year":"1977","unstructured":"Neu HC, Pnnce A, Neu CO, Garvey GJ. Incidence of diarrhea and colitis associated with clindamycim therapy. Infect Dis. 1977;135:120\u20135.","journal-title":"Infect Dis"},{"issue":"5","key":"2118_CR11","first-page":"615","volume":"9","author":"GA Stainer","year":"1977","unstructured":"Stainer GA, Peyman GA, Meisels H, Fishman G. Toxicity of selected antibiotics in vitreous replacement fluid. Ann Ophthalmol. 1977;9(5):615\u20138.","journal-title":"Ann Ophthalmol"},{"issue":"1","key":"2118_CR12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1023\/A:1006968608825","volume":"19","author":"P Walter","year":"1999","unstructured":"Walter P, L\u00fcke C, Sickel W. Antibiotics and light responses in superfused bovine retina. Cell Mol Neurobiol. 1999;19(1):87\u201392.","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"2118_CR13","doi-asserted-by":"publisher","DOI":"10.17795\/jjnpp-16414","volume":"9","author":"L Tamaddon","year":"2014","unstructured":"Tamaddon L, Mostafavi A, Riazi-esfahani M, Karkhane R, Aghazadeh S, Rafiee-Tehrani M, et al. Development, characterizations and biocompatibility evaluations of intravitreal lipid implants. Jundishapur J Nat Pharm Prod. 2014;9(2), e16414.","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"2118_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jpba.2014.08.023","volume":"102","author":"GM Fernandes-Cunha","year":"2015","unstructured":"Fernandes-Cunha GM, Gouvea DR, Fulg\u00eancio GO, Rezende CMF, Da Silva GR, Bretas JM, et al. Development of a method to quantify clindamycin in vitreous humor of rabbits\u2019 eyes by UPLC\u2013MS\/MS: application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation. J Pharm Biomed Anal. 2015;102:346\u201352.","journal-title":"J Pharm Biomed Anal"},{"key":"2118_CR15","doi-asserted-by":"publisher","unstructured":"Fernandes-Cunha GM, Rezende CMF, Mussel WN, Da Silva GR, Gomes ECL, Yoshida MI, et al. Anti-toxoplasma activity and impact evaluation of lyophilization, hot molding process, and gamma-irradiation techniques on CLH-PLGA intravitreal implants. J Mater Sci Mater Med. 2016;27(10). doi: 10.1007\/s10856-015-5621-1 .","DOI":"10.1007\/s10856-015-5621-1"},{"issue":"2","key":"2118_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/10717540590921432","volume":"12","author":"SL Fialho","year":"2005","unstructured":"Fialho SL, Silva-Cunha A. Manufacturing techniques of biodegradable implants intended for intraocular application. Drug Deliv. 2005;12(2):109\u201316.","journal-title":"Drug Deliv"},{"key":"2118_CR17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejps.2015.03.003","volume":"73","author":"GR Silva Da","year":"2015","unstructured":"Da Silva GR, Lima TH, Or\u00e9fice RL, Fernandes-Cunha GM, Silva-Cunha A, Zhao M, et al. In vitro and in vivo ocular biocompatibility of electrospun poly(e-caprolactone) nanofibers. Eur J Pharm Sci. 2015;73:9\u201319.","journal-title":"Eur J Pharm Sci"},{"key":"2118_CR18","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1096\/fj.09-154344","volume":"24","author":"M Zhao","year":"2010","unstructured":"Zhao M, Valamanesh F, Celerier I, Savoldelli M, Jonet L, Jeanny JC, et al. The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Muller glial cells. FASEB J. 2010;24:3405\u201315.","journal-title":"FASEB J"},{"issue":"7","key":"2118_CR19","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1172\/JCI61427","volume":"122","author":"M Zhao","year":"2012","unstructured":"Zhao M, C\u00e9l\u00e9rier I, Bousquet E, Jeanny JC, Jonet L, Savoldelli M, et al. Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy. J Clin Invest. 2012;122(7):2672\u20139.","journal-title":"J Clin Invest"},{"key":"2118_CR20","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.micron.2012.04.006","volume":"43","author":"M Hezel","year":"2012","unstructured":"Hezel M, Ebrahimi F, Kocha M, Dehghani F. Propidium iodide staining: a new application in fluorescence microscopy for analysis of cytoarchitecture in adult and developing rodent brain. Micron. 2012;43:1031\u20138.","journal-title":"Micron"},{"issue":"3","key":"2118_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/1091581813484500","volume":"32","author":"WJ Brock","year":"2013","unstructured":"Brock WJ, Somps CJ, Torti V, Render JA, Jamison J, Rivera MI. Ocular toxicity assessment from systemically administered xenobiotics: considerations in drug development. Int J Toxicol. 2013;32(3):171\u201388.","journal-title":"Int J Toxicol"},{"issue":"8","key":"2118_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105359","volume":"9","author":"E S\u00f6derstjerna","year":"2014","unstructured":"S\u00f6derstjerna E, Bauer P, Cedervall T, Abdshill H, Johansson F, Johansson UE. Silver and gold nanoparticles exposure to in vitro cultured retina\u2014studies on nanoparticle internalization, apoptosis, oxidative stress, glial- and microglial activity. Plos One. 2014;9(8), e105359.","journal-title":"Plos One"},{"key":"2118_CR23","doi-asserted-by":"crossref","unstructured":"Siqueira RC, dos Santos WF, Scott IU, Messias A, Rosa MN, Fernandes Cunha GM, et al. Neuroprotective effects of intravitreal triamcinolone acetonide and dexamethasone implant in rabbit retinas after pars plana vitrectomy and silicone oil injection. Retina. 2014;1\u20137.","DOI":"10.1097\/IAE.0000000000000284"},{"issue":"2","key":"2118_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000312817","volume":"44","author":"FM Penha","year":"2010","unstructured":"Penha FM, Rodrigues EB, Maia M, Dib E, Fiod Costa E, Furlani BA, et al. Retinal and ocular toxicity in ocular application of drugs and chemicals\u2014part I: animal models and toxicity assays. Ophthalmic Res. 2010;44(2):82\u2013104.","journal-title":"Ophthalmic Res"},{"key":"2118_CR25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","volume":"25","author":"A Bringmann","year":"2006","unstructured":"Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, et al. M\u00fcller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25:397\u2013424.","journal-title":"Prog Retin Eye Res"},{"key":"2118_CR26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exer.2013.07.009","volume":"123","author":"C Chiba","year":"2014","unstructured":"Chiba C. The retinal pigment epithelium: an important player of retinal disorders and regeneration. Exp Eye Res. 2014;123:107\u201314.","journal-title":"Exp Eye Res"},{"issue":"8","key":"2118_CR27","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1167\/iovs.06-0166","volume":"47","author":"Y Luo","year":"2006","unstructured":"Luo Y, Zhuo Y, Fukuhara M, Rizzolo LJ. Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line. Invest Ophthalmol Vis Sci. 2006;47(8):3644\u201355.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2118_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0306-4522(99)00313-9","volume":"95","author":"M Dubois-Dauphin","year":"2000","unstructured":"Dubois-Dauphin M, Poitry-Yamate C, de Bilbao F, Julliard A, Jourdan F, Donati G. Early postnatal M\u00fcller cell death leads to retinal but not optic nerve degeneration in transgenic mice. Neuroscience. 2000;95:9\u201321.","journal-title":"Neuroscience"},{"issue":"2","key":"2118_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3844\/ajptsp.2007.89.97","volume":"2","author":"GA Ramadan","year":"2007","unstructured":"Ramadan GA. Sorbitol-induced diabetic-like retinal lesions in rats: microscopic study. Am J Pharmacol Toxicol. 2007;2(2):89\u201397.","journal-title":"Am J Pharmacol Toxicol"},{"key":"2118_CR30","first-page":"329","volume":"9","author":"R Maddala","year":"2003","unstructured":"Maddala R, Reddy VN, Epstein DL, Rao V. Growth fator induced activation of Rho and RacGTPases and actin cytoskeletal reorganization in human lens epithelial cells. Mol Vis. 2003;9:329\u201336.","journal-title":"Mol Vis"},{"key":"2118_CR31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.279.5350.509","volume":"279","author":"A Hall","year":"1998","unstructured":"Hall A. Rho GTPases and the actin cytoskeleton. Science. 1998;279:509\u201314.","journal-title":"Science"},{"key":"2118_CR32","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1006\/exer.2002.1188","volume":"74","author":"J Winkler","year":"2002","unstructured":"Winkler J, Hagelstein S, Rohde M, Laqua H. Cellular and cytoskeletal dynamics within organ cultures of porcine neuroretina. Exp Eye Res. 2002;74:777\u201388.","journal-title":"Exp Eye Res"},{"issue":"6","key":"2118_CR33","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/adt.2006.4.695","volume":"4","author":"ME Verdugo-Gazdik","year":"2006","unstructured":"Verdugo-Gazdik ME, Simic D, Opsahl AC, Tengowski MW. Investigating cytoskeletal alterations as a potential marker of retinal and lens drug-related toxicity. Assay Drug Dev Technol. 2006;4(6):695\u2013707.","journal-title":"Assay Drug Dev Technol"},{"issue":"3","key":"2118_CR34","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1189\/jlb.0208138","volume":"84","author":"S Ebert","year":"2008","unstructured":"Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, et al. Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype. J Leukoc Biol. 2008;84(3):736\u201340.","journal-title":"J Leukoc Biol"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-017-2118-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-017-2118-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-017-2118-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T10:22:02Z","timestamp":1658658122000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-017-2118-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["2118"],"URL":"https:\/\/doi.org\/10.1007\/s11095-017-2118-2","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]},"assertion":[{"value":"30 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}