{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:59:31Z","timestamp":1790470771965,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2012-39148-C03-01"],"award-info":[{"award-number":["SAF2012-39148-C03-01"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2015-70368-R"],"award-info":[{"award-number":["SAF2015-70368-R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERNED"],"award-info":[{"award-number":["CIBERNED"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008054","name":"Fundaci\u00f3n Ram\u00f3n Areces","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s11095-017-2312-2","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T20:45:28Z","timestamp":1517949928000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-\u03b2 Levels in Primary Neurons from an Alzheimer\u2019s Disease Transgenic Model"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-7774","authenticated-orcid":false,"given":"Lara","family":"Ord\u00f3\u00f1ez-Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Benito-Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"F\u00e1brias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Wandosell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"issue":"1","key":"2312_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-2001-3111","volume":"3","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis. 2001;3(1):75\u201380.","journal-title":"J Alzheimers Dis"},{"issue":"5580","key":"2312_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297(5580):353\u20136.","journal-title":"Science"},{"issue":"2","key":"2312_CR3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001;81(2):741\u201366.","journal-title":"Physiol Rev"},{"key":"2312_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40035-017-0077-5","volume":"6","author":"P Sweeney","year":"2017","unstructured":"Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, et al. Protein misfolding in neurodegenerative diseases: implications and strategies. Trans Neurodegener. 2017;6:6.","journal-title":"Trans Neurodegener"},{"issue":"2","key":"2312_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jnc.13772","volume":"139","author":"CL Ugalde","year":"2016","unstructured":"Ugalde CL, Finkelstein DI, Lawson VA, Hill AF. Pathogenic mechanisms of prion protein, amyloid-beta and alpha-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers. J Neurochem. 2016;139(2):162\u201380.","journal-title":"J Neurochem"},{"key":"2312_CR6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1042\/bse0550153","volume":"55","author":"T Wileman","year":"2013","unstructured":"Wileman T. Autophagy as a defence against intracellular pathogens. Essays Biochem. 2013;55:153\u201363.","journal-title":"Essays Biochem"},{"issue":"11","key":"2312_CR7","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1111\/cmi.12357","volume":"16","author":"ST Shibutani","year":"2014","unstructured":"Shibutani ST, Yoshimori T. Autophagosome formation in response to intracellular bacterial invasion. Cell Microbiol. 2014;16(11):1619\u201326.","journal-title":"Cell Microbiol"},{"issue":"1","key":"2312_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10059-013-0140-8","volume":"36","author":"SW Ryter","year":"2013","unstructured":"Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells. 2013;36(1):7\u201316.","journal-title":"Mol Cells"},{"issue":"4","key":"2312_CR9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.33549\/physiolres.932684","volume":"63","author":"Z Papackova","year":"2014","unstructured":"Papackova Z, Cahova M. Important role of autophagy in regulation of metabolic processes in health, disease and aging. Physiol Res. 2014;63(4):409\u201320.","journal-title":"Physiol Res"},{"issue":"4","key":"2312_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1515\/revneuro-2014-0076","volume":"26","author":"A Zare-Shahabadi","year":"2015","unstructured":"Zare-Shahabadi A, Masliah E, Johnson GV, Rezaei N. Autophagy in Alzheimer's disease. Rev Neurosci. 2015;26(4):385\u201395.","journal-title":"Rev Neurosci"},{"issue":"2","key":"2312_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","volume":"44","author":"JH Son","year":"2012","unstructured":"Son JH, Shim JH, Kim KH, Ha JY, Han JY. Neuronal autophagy and neurodegenerative diseases. Exp Mol Med. 2012;44(2):89\u201398.","journal-title":"Exp Mol Med"},{"issue":"2","key":"2312_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/jnen\/64.2.113","volume":"64","author":"RA Nixon","year":"2005","unstructured":"Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol. 2005;64(2):113\u201322.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"2312_CR13","doi-asserted-by":"publisher","first-page":"e9979","DOI":"10.1371\/journal.pone.0009979","volume":"5","author":"P Spilman","year":"2010","unstructured":"Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010;5(4):e9979.","journal-title":"PLoS One"},{"issue":"17","key":"2312_CR14","doi-asserted-by":"publisher","first-page":"13107","DOI":"10.1074\/jbc.M110.100420","volume":"285","author":"A Caccamo","year":"2010","unstructured":"Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem. 2010;285(17):13107\u201320.","journal-title":"J Biol Chem"},{"issue":"5","key":"2312_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10495-015-1102-8","volume":"20","author":"C Tommasino","year":"2015","unstructured":"Tommasino C, Marconi M, Ciarlo L, Matarrese P, Malorni W. Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids. Apoptosis: Int J Program Cell Death. 2015;20(5):645\u201357.","journal-title":"Apoptosis: Int J Program Cell Death"},{"issue":"1","key":"2312_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1194\/jlr.R031278","volume":"54","author":"MM Young","year":"2013","unstructured":"Young MM, Kester M, Wang HG. Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res. 2013;54(1):5\u201319.","journal-title":"J Lipid Res"},{"issue":"7503","key":"2312_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nature13475","volume":"510","author":"M Maceyka","year":"2014","unstructured":"Maceyka M, Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature. 2014;510(7503):58\u201367.","journal-title":"Nature"},{"issue":"2","key":"2312_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.bbagen.2016.11.033","volume":"1861","author":"M Casasampere","year":"2017","unstructured":"Casasampere M, Ordonez YF, Casas J, Fabrias G. Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms. Biochim Biophys Acta. 2017;1861(2):264\u201375.","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"2312_CR19","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1128\/MCB.00226-13","volume":"33","author":"MM Siddique","year":"2013","unstructured":"Siddique MM, Li Y, Wang L, Ching J, Mal M, Ilkayeva O, et al. Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol. 2013;33(11):2353\u201369.","journal-title":"Mol Cell Biol"},{"issue":"15","key":"2312_CR20","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1096\/fj.03-0292fje","volume":"17","author":"F Scarlatti","year":"2003","unstructured":"Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J: Off Publ Fed Am Soc Exp Biol. 2003;17(15):2339\u201341.","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"issue":"5\u20136","key":"2312_CR21","first-page":"263","volume":"29","author":"G Sala","year":"2003","unstructured":"Sala G, Minutolo F, Macchia M, Sacchi N, Ghidoni R. Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells. Drugs Exp Clin Res. 2003;29(5\u20136):263\u20139.","journal-title":"Drugs Exp Clin Res"},{"issue":"2","key":"2312_CR22","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.brainresrev.2006.04.004","volume":"52","author":"TS Anekonda","year":"2006","unstructured":"Anekonda TS. Resveratrol--a boon for treating Alzheimer's disease? Brain Res Rev. 2006;52(2):316\u201326.","journal-title":"Brain Res Rev"},{"issue":"6","key":"2312_CR23","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/cmdc.200700325","volume":"3","author":"JM Munoz-Olaya","year":"2008","unstructured":"Munoz-Olaya JM, Matabosch X, Bedia C, Egido-Gabas M, Casas J, Llebaria A, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008;3(6):946\u201353.","journal-title":"ChemMedChem"},{"issue":"6","key":"2312_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001;17(6):157\u201365.","journal-title":"Biomol Eng"},{"issue":"6286","key":"2312_CR25","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","volume":"352","author":"S Hong","year":"2016","unstructured":"Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352(6286):712\u20136.","journal-title":"Science"},{"key":"2312_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-59745-019-5_17","volume":"633","author":"D Kramer","year":"2010","unstructured":"Kramer D, Minichiello L. Cell culture of primary cerebellar granule cells. Methods Mol Biol. 2010;633:233\u20139.","journal-title":"Methods Mol Biol"},{"issue":"4","key":"2312_CR27","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1046\/j.1471-4159.2003.02051.x","volume":"87","author":"MT Moreno-Flores","year":"2003","unstructured":"Moreno-Flores MT, Martin-Aparicio E, Martin-Bermejo MJ, Agudo M, McMahon S, Avila J, et al. Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture. J Neurochem. 2003;87(4):879\u201390.","journal-title":"J Neurochem"},{"issue":"9","key":"2312_CR28","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1007\/s11064-016-1950-9","volume":"41","author":"H Deng","year":"2016","unstructured":"Deng H, Mi MT. Resveratrol Attenuates Abeta25-35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway. Neurochem Res. 2016;41(9):2367\u201379.","journal-title":"Neurochem Res"},{"key":"2312_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.02.027","volume":"348","author":"H Zhao","year":"2017","unstructured":"Zhao H, Chen S, Gao K, Zhou Z, Wang C, Shen Z, et al. Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1\/AMPK signaling pathway. Neuroscience. 2017;348:241\u201351.","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"2312_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1\u20132):55\u201363.","journal-title":"J Immunol Methods"},{"issue":"6","key":"2312_CR31","first-page":"763","volume":"59","author":"VS Gasparov","year":"1994","unstructured":"Gasparov VS, Degtiar VG. [Protein determination by binding with the dye Coomassie brilliant blue G-250]. Biokhimiia. 1994;59(6):763\u201377.","journal-title":"Biokhimiia"},{"issue":"11","key":"2312_CR32","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1080\/15548627.2016.1213927","volume":"12","author":"S Hernandez-Tiedra","year":"2016","unstructured":"Hernandez-Tiedra S, Fabrias G, Davila D, Salanueva IJ, Casas J, Montes LR, et al. Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016;12(11):2213\u201329.","journal-title":"Autophagy"},{"issue":"9","key":"2312_CR33","doi-asserted-by":"publisher","first-page":"e74768","DOI":"10.1371\/journal.pone.0074768","volume":"8","author":"MW Holliday Jr","year":"2013","unstructured":"Holliday MW Jr, Cox SB, Kang MH, Maurer BJ. C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. PLoS One. 2013;8(9):e74768.","journal-title":"PLoS One"},{"issue":"23","key":"2312_CR34","doi-asserted-by":"publisher","first-page":"16718","DOI":"10.1074\/jbc.M700647200","volume":"282","author":"JM Kraveka","year":"2007","unstructured":"Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, et al. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem. 2007;282(23):16718\u201328.","journal-title":"J Biol Chem"},{"key":"2312_CR35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/978-1-59745-157-4_11","volume":"445","author":"G Lavieu","year":"2008","unstructured":"Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, et al. Sphingolipids in macroautophagy. Methods Mol Biol. 2008;445:159\u201373.","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2312_CR36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.4161\/auto.4586","volume":"3","author":"CD Pacheco","year":"2007","unstructured":"Pacheco CD, Lieberman AP. Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease. Autophagy. 2007;3(5):487\u20139.","journal-title":"Autophagy"},{"issue":"12","key":"2312_CR37","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/hmg\/ddm100","volume":"16","author":"CD Pacheco","year":"2007","unstructured":"Pacheco CD, Kunkel R, Lieberman AP. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum Mol Genet. 2007;16(12):1495\u2013503.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2312_CR38","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.canlet.2009.03.020","volume":"282","author":"P Signorelli","year":"2009","unstructured":"Signorelli P, Munoz-Olaya JM, Gagliostro V, Casas J, Ghidoni R, Fabrias G. Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett. 2009;282(2):238\u201343.","journal-title":"Cancer Lett"},{"key":"2312_CR39","doi-asserted-by":"publisher","first-page":"e1245","DOI":"10.1038\/cddis.2014.215","volume":"5","author":"Y Li","year":"2014","unstructured":"Li Y, Li S, Qin X, Hou W, Dong H, Yao L, et al. The pleiotropic roles of sphingolipid signaling in autophagy. Cell Death Dis. 2014;5:e1245.","journal-title":"Cell Death Dis"},{"issue":"23","key":"2312_CR40","doi-asserted-by":"publisher","first-page":"7988","DOI":"10.1523\/JNEUROSCI.0777-14.2014","volume":"34","author":"A Caccamo","year":"2014","unstructured":"Caccamo A, De Pinto V, Messina A, Branca C, Oddo S. Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. J Neurosci: Off J Soc Neurosci. 2014;34(23):7988\u201398.","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"7","key":"2312_CR41","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.chembiol.2010.05.023","volume":"17","author":"CR Vieira","year":"2010","unstructured":"Vieira CR, Munoz-Olaya JM, Sot J, Jimenez-Baranda S, Izquierdo-Useros N, Abad JL, et al. Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chem Biol. 2010;17(7):766\u201375.","journal-title":"Chem Biol"},{"issue":"5","key":"2312_CR42","doi-asserted-by":"publisher","first-page":"a006270","DOI":"10.1101\/cshperspect.a006270","volume":"2","author":"C Haass","year":"2012","unstructured":"Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med. 2012;2(5):a006270.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"8","key":"2312_CR43","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.bbalip.2010.03.007","volume":"1801","author":"KS Vetrivel","year":"2010","unstructured":"Vetrivel KS, Thinakaran G. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Biophys Acta. 2010;1801(8):860\u20137.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"2312_CR44","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/85064","volume":"4","author":"H Cai","year":"2001","unstructured":"Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, et al. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci. 2001;4(3):233\u20134.","journal-title":"Nat Neurosci"},{"issue":"6761","key":"2312_CR45","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/990114","volume":"402","author":"S Sinha","year":"1999","unstructured":"Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999;402(6761):537\u201340.","journal-title":"Nature"},{"issue":"5440","key":"2312_CR46","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286(5440):735\u201341.","journal-title":"Science"},{"issue":"6","key":"2312_CR47","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/bies.201400002","volume":"36","author":"P Nilsson","year":"2014","unstructured":"Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer's disease Abeta peptide. Bioessays: News Rev Mol Cell Dev Biol. 2014;36(6):570\u20138.","journal-title":"Bioessays: News Rev Mol Cell Dev Biol"},{"issue":"2","key":"2312_CR48","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3233\/JAD-2010-101080","volume":"22","author":"SD Ginsberg","year":"2010","unstructured":"Ginsberg SD, Mufson EJ, Counts SE, Wuu J, Alldred MJ, Nixon RA, et al. Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. J Alzheimer's Dis: JAD. 2010;22(2):631\u20139.","journal-title":"J Alzheimer's Dis: JAD"},{"issue":"5","key":"2312_CR49","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","volume":"161","author":"RH Takahashi","year":"2002","unstructured":"Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, et al. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol. 2002;161(5):1869\u201379.","journal-title":"Am J Pathol"},{"issue":"5","key":"2312_CR50","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.bbalip.2013.09.005","volume":"1841","author":"W Jiang","year":"2014","unstructured":"Jiang W, Ogretmen B. Autophagy paradox and ceramide. Biochim Biophys Acta. 2014;1841(5):783\u201392.","journal-title":"Biochim Biophys Acta"},{"issue":"44","key":"2312_CR51","doi-asserted-by":"publisher","first-page":"38069","DOI":"10.1074\/jbc.M111.297994","volume":"286","author":"CM Devlin","year":"2011","unstructured":"Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, et al. Dihydroceramide-based response to hypoxia. J Biol Chem. 2011;286(44):38069\u201378.","journal-title":"J Biol Chem"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-017-2312-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-017-2312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-017-2312-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T00:07:22Z","timestamp":1660435642000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-017-2312-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["2312"],"URL":"https:\/\/doi.org\/10.1007\/s11095-017-2312-2","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,6]]},"assertion":[{"value":"10 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"49"}}