{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:24:12Z","timestamp":1772893452951,"version":"3.50.1"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11095-018-2528-9","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T17:01:57Z","timestamp":1541696517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Mycobacterium Tuberculosis and Interactions with the Host Immune System: Opportunities for Nanoparticle Based Immunotherapeutics and Vaccines"],"prefix":"10.1007","volume":"36","author":[{"given":"Raymonde B.","family":"Bekale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Mari","family":"Du Plessis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Jen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti R.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muazzam","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervin","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene D.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-6094","authenticated-orcid":false,"given":"Admire","family":"Dube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"2528_CR1","unstructured":"Global Tuberculosis Report 2017.World Health Organization,Geneva. Available from: https:\/\/reliefweb.int\/report\/world\/global-tuberculosis-report-2017."},{"key":"2528_CR2","unstructured":"Amina JM. Secretary-general\u2019s remarks at high-level meeting on tuberculosis. United Nations. Secretary-General. 2018. Available from: https:\/\/www.un.org\/sg\/en\/content\/sg\/statement\/2018-09-26\/secretary-generals-remarks-high-level-meeting-tuberculosis."},{"key":"2528_CR3","doi-asserted-by":"crossref","unstructured":"JAMA AF. Addressing the tuberculosis epidemic: 21st century research for an ancient disease. JAMA. 320(13):1315\u20136 Available from: https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2702934?preview=true&utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Am_Med_TrendMD_1.","DOI":"10.1001\/jama.2018.12852"},{"key":"2528_CR4","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/S1473-3099(18)30110-5","volume":"18","author":"S Tiberi","year":"2018","unstructured":"Tiberi S, du Plessis N, Walzl G, Vjecha MJ, Rao M, Ntoumi F, et al. Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies. Lancet Infect Dis. 2018;18:e183\u2013e198.","journal-title":"Lancet Infect Dis."},{"key":"2528_CR5","first-page":"37","volume":"5","author":"G Abate","year":"2016","unstructured":"Abate G, Hoft DF. Immunotherapy for tuberculosis: future prospects. ImmunoTargets Ther. 2016;5:37\u201345.","journal-title":"ImmunoTargets Ther"},{"issue":"1","key":"2528_CR6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.micinf.2015.09.005","volume":"18","author":"EP Amaral","year":"2016","unstructured":"Amaral EP, Lasunskaia EB, D\u2019Imp\u00e9rio-Lima MR. Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death. Microb Infect. 2016;18(1):11\u201320.","journal-title":"Microb Infect"},{"key":"2528_CR7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/2213529402666160601120759","volume":"2","author":"A Dube","year":"2016","unstructured":"Dube A, Reynolds JL. Modulation of innate immune responses using nanoparticles for infectious disease therapy. Curr Bionanotechnol. 2016;2:60\u20135.","journal-title":"Curr Bionanotechnol"},{"key":"2528_CR8","first-page":"239","volume":"114","author":"DJ Kusner","year":"2005","unstructured":"Kusner DJ. Mechanisms of mycobacterial persistence in tuberculosis. Clin ImmunolAcademic Press. 2005;114:239\u201347.","journal-title":"Clin ImmunolAcademic Press"},{"key":"2528_CR9","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nchembio.1917","volume":"11","author":"R Guler","year":"2015","unstructured":"Guler R, Brombacher F. Host-directed drug therapy for tuberculosis. Nat Chem Biol. 2015;11:748\u201351.","journal-title":"Nat Chem Biol"},{"key":"2528_CR10","first-page":"116","volume":"21","author":"F Khademi","year":"2018","unstructured":"Khademi F, Derakhshan M, Yousefi-Avarvand A, Tafaghodi M. Potential of polymeric particles as future vaccine delivery systems\/adjuvants for parenteral and non-parenteral immunization against tuberculosis: a systematic review. Iran J Basic Med Sci Mashhad University of Medical Sciences. 2018;21:116\u201323.","journal-title":"Iran J Basic Med Sci Mashhad University of Medical Sciences"},{"key":"2528_CR11","volume-title":"2015 report on tuberculosis research funding trends, 2005\u20132014: a decade of data","author":"M Frick","year":"2015","unstructured":"Frick M. 2015 report on tuberculosis research funding trends, 2005\u20132014: a decade of data. New ork: Treat Action Group; 2015."},{"key":"2528_CR12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/1469-0691.12555","volume":"20","author":"E Cambau","year":"2014","unstructured":"Cambau E, Drancourt M. Steps towards the discovery of Mycobacterium tuberculosis by Robert Koch, 1882. Clin Microbiol Infect Elsevier. 2014;20:196\u2013201.","journal-title":"Clin Microbiol Infect Elsevier"},{"key":"2528_CR13","first-page":"3","volume":"4","author":"MA Forrellad","year":"2013","unstructured":"Forrellad MA, Klepp LI, Gioffr\u00e9 A, Sabio Y Garc\u00eda J, Morbidoni HR, de la Paz Santangelo M, et al. Virulence factors of the mycobacterium tuberculosis complex. Virulence Taylor & Francis. 2013;4:3\u201366.","journal-title":"Virulence Taylor & Francis"},{"issue":"1","key":"2528_CR14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12879-016-1450-1","volume":"16","author":"P Sinha","year":"2016","unstructured":"Sinha P, Gupta A, Prakash P, Anupurba S, Tripathi R, Srivastava GN. Differentiation of mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40 and 32kD alpha antigen encoding gene fragments. BMC Infect Dis BioMed Central. 2016;16(1):123.","journal-title":"BMC Infect Dis BioMed Central"},{"key":"2528_CR15","unstructured":"Eleanor MG, Kumar AE, Dan MM. Review on Mycobacterium Tuberculosis. RRJMB. 2016. p. 2320\u20133528."},{"key":"2528_CR16","doi-asserted-by":"crossref","unstructured":"Cook GM, Berney M, Gebhard S, Heinemann M, Cox RA, Danilchanka O, et al. Physiology of mycobacteria. In: Poole RK, editor. Advances in microbial physiology. Amsterdam: Elsevier; 2009. p. 81\u2013319.","DOI":"10.1016\/S0065-2911(09)05502-7"},{"key":"2528_CR17","first-page":"109","volume":"18","author":"M Niederweis","year":"2010","unstructured":"Niederweis M, Danilchanka O, Huff J, Hoffmann C, Engelhardt H. Mycobacterial outer membranes: in search of proteins. Trends Microbiol NIH Public Access. 2010;18:109\u201316.","journal-title":"Trends Microbiol NIH Public Access"},{"key":"2528_CR18","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1021\/jacs.6b12541","volume":"139","author":"FP Rodriguez-Rivera","year":"2017","unstructured":"Rodriguez-Rivera FP, Zhou X, Theriot JA, Bertozzi CR. Visualization of mycobacterial membrane dynamics in live cells. J Am Chem Soc. 2017;139:3488\u201395.","journal-title":"J Am Chem Soc"},{"key":"2528_CR19","first-page":"67","volume":"21","author":"H Marrakchi","year":"2014","unstructured":"Marrakchi H, Lan\u00e9elle M-A, Daff\u00e9 M. Mycolic acids: structures, biosynthesis, and beyond. Chem Biol Cell Press. 2014;21:67\u201385.","journal-title":"Chem Biol Cell Press"},{"key":"2528_CR20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/MMBR.00028-07","volume":"72","author":"EC Hett","year":"2008","unstructured":"Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev American Society for Microbiology. 2008;72:126\u201356.","journal-title":"Microbiol Mol Biol Rev American Society for Microbiology"},{"key":"2528_CR21","first-page":"62","volume":"29","author":"B Merget","year":"2013","unstructured":"Merget B, Zilian D, M\u00fcller T, Sotriffer CA. MycPermCheck: the mycobacterium tuberculosis permeability prediction tool for small molecules. Bioinformatics Oxford University Press. 2013;29:62\u20138.","journal-title":"Bioinformatics Oxford University Press"},{"key":"2528_CR22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-319-48683-3_10","volume-title":"Drug resistance in bacteria, fungi, malaria, and cancer","author":"GE Louw","year":"2017","unstructured":"Louw GE, Sampson SL. Implications of chromosomal mutations for mycobacterial drug resistance. In: Arora G, Sajid A, Kalia VC, editors. Drug resistance in bacteria, fungi, malaria, and cancer. Cham: Springer International Publishing; 2017. p. 233\u201362."},{"key":"2528_CR23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1574-6976.2012.00331.x","volume":"36","author":"M Gengenbacher","year":"2012","unstructured":"Gengenbacher M, Kaufmann SHE. Mycobacterium tuberculosis\u00a0: success through dormancy. FEMS Microbiol Rev Oxford University Press. 2012;36:514\u201332.","journal-title":"FEMS Microbiol Rev Oxford University Press"},{"key":"2528_CR24","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1099\/mic.0.000288","volume":"162","author":"S Helaine","year":"2016","unstructured":"Helaine S, Holden DW, Mouton JM, Sampson SL. Elucidating population-wide mycobacterial replication dynamics at the single-cell level. Microbiology. 2016;162:966\u201378.","journal-title":"Microbiology"},{"key":"2528_CR25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.chom.2013.05.012","volume":"13","author":"ESC Rittershaus","year":"2013","unstructured":"Rittershaus ESC, Baek S-H, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe NIH Public Access. 2013;13:643\u201351.","journal-title":"Cell Host Microbe NIH Public Access"},{"key":"2528_CR26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1097(03)00856-5","volume":"230","author":"I Keren","year":"2004","unstructured":"Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K. Persister cells and tolerance to antimicrobials. FEMS Microbiol Lett. 2004;230:13\u20138.","journal-title":"FEMS Microbiol Lett"},{"key":"2528_CR27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","volume":"64","author":"K Lewis","year":"2010","unstructured":"Lewis K. Persister cells. Annu Rev Microbiol. 2010;64:357\u201372.","journal-title":"Annu Rev Microbiol"},{"issue":"1","key":"2528_CR28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.micro.55.1.139","volume":"55","author":"LG Wayne","year":"2001","unstructured":"Wayne LG, Sohaskey CD. Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol. 2001;55(1):139\u201363.","journal-title":"Annu Rev Microbiol"},{"key":"2528_CR29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12026-011-8229-7","volume":"50","author":"HP Gideon","year":"2011","unstructured":"Gideon HP, Flynn JL. Latent tuberculosis: what the host "sees"? Immunol Res NIH Public Access. 2011;50:202\u201312.","journal-title":"Immunol Res NIH Public Access"},{"key":"2528_CR30","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.rmed.2006.01.014","volume":"100","author":"BE G\u00fclbay","year":"2006","unstructured":"G\u00fclbay BE, G\u00fcrkan \u00d6U, Y\u0131ld\u0131z \u00d6A, \u00d6nen ZP, Erkekol F\u00d6, Ba\u00e7\u00e7\u0131o\u011flu A, et al. Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patients for tuberculosis. Respir Med. 2006;100:1834\u201342.","journal-title":"Respir Med"},{"key":"2528_CR31","first-page":"53","volume":"374","author":"T Smith","year":"2013","unstructured":"Smith T, Wolff KA, Nguyen L. Molecular biology of drug resistance in mycobacterium tuberculosis. Curr Top Microbiol Immunol NIH Public Access. 2013;374:53\u201380.","journal-title":"Curr Top Microbiol Immunol NIH Public Access"},{"issue":"5","key":"2528_CR32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.201712-2524OC","volume":"198","author":"GE Vel\u00e1squez","year":"2018","unstructured":"Vel\u00e1squez GE, Brooks MB, Coit JM, Pertinez H, Vargas V\u00e1squez D, S\u00e1nchez Garavito E, et al. Efficacy and safety of high-dose rifampin in pulmonary tuberculosis: a randomized controlled trial. Am J Respir Crit Care Med. 2018;198(5):657\u201366.","journal-title":"Am J Respir Crit Care Med"},{"key":"2528_CR33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/cpt.634","volume":"102","author":"R Savic","year":"2017","unstructured":"Savic R, Weiner M, MacKenzie W, Engle M, Whitworth W, Johnson J, et al. Defining the optimal dose of rifapentine for pulmonary tuberculosis: exposure-response relations from two phase II clinical trials. Clin Pharmacol Ther. 2017;102:321\u201331.","journal-title":"Clin Pharmacol Ther"},{"key":"2528_CR34","first-page":"365","volume":"5","author":"ET Helbig","year":"2013","unstructured":"Helbig ET, Opitz B, Sander LE. Adjuvant immunotherapies as a novel approach to bacterial infections. Immunotherapy. Future Medicine Ltd London, UK. 2013;5:365\u201381.","journal-title":"Future Medicine Ltd London, UK"},{"key":"2528_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/139127","volume":"2012","author":"M Silva Miranda","year":"2012","unstructured":"Silva Miranda M, Breiman A, Allain S, Deknuydt F, Altare F. The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria? Clin Dev Immunol. 2012;2012:1\u201314.","journal-title":"Clin Dev Immunol"},{"key":"2528_CR36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/imr.12439","volume":"273","author":"R Levin","year":"2016","unstructured":"Levin R, Grinstein S, Canton J. The life cycle of phagosomes: formation, maturation, and resolution. Immunol Rev Wiley\/Blackwell. 2016;273:156\u201379.","journal-title":"Immunol Rev Wiley\/Blackwell"},{"key":"2528_CR37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.it.2017.03.006","volume":"38","author":"A-M Pauwels","year":"2017","unstructured":"Pauwels A-M, Trost M, Beyaert R, Hoffmann E. Patterns, receptors, and signals: regulation of phagosome maturation. Trends Immunol. 2017;38:407\u201322.","journal-title":"Trends Immunol"},{"key":"2528_CR38","first-page":"36982","volume":"279","author":"J Chua","year":"2004","unstructured":"Chua J, Deretic V. Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. J Biol Chem American Society for Biochemistry and Molecular Biology. 2004;279:36982\u201392.","journal-title":"J Biol Chem American Society for Biochemistry and Molecular Biology"},{"key":"2528_CR39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.chom.2008.05.006","volume":"3","author":"J Pieters","year":"2008","unstructured":"Pieters J. Mycobacterium tuberculosis and the macrophage: maintaining a balance. Cell Host Microbe Cell Presss. 2008;3:399\u2013407.","journal-title":"Cell Host Microbe Cell Presss"},{"key":"2528_CR40","first-page":"37","volume":"130","author":"R Jayachandran","year":"2007","unstructured":"Jayachandran R, Sundaramurthy V, Combaluzier B, Mueller P, Korf H, Huygen K, et al. Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell Press. 2007;130:37\u201350.","journal-title":"Cell Press"},{"key":"2528_CR41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/imr.12266","volume":"264","author":"G Weiss","year":"2015","unstructured":"Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev. 2015;264:182\u2013203.","journal-title":"Immunol Rev"},{"key":"2528_CR42","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1016\/j.celrep.2017.08.101","volume":"20","author":"CJ Queval","year":"2017","unstructured":"Queval CJ, Song O-R, Carralot J-P, Saliou J-M, Bongiovanni A, Deloison G, et al. Mycobacterium tuberculosis controls phagosomal acidification by targeting CISH-mediated signaling. Cell Rep Elsevier. 2017;20:3188\u201398.","journal-title":"Cell Rep Elsevier"},{"key":"2528_CR43","doi-asserted-by":"crossref","first-page":"19371","DOI":"10.1073\/pnas.1109201108","volume":"108","author":"D Wong","year":"2011","unstructured":"Wong D, Bach H, Sun J, Hmama Z, Av-Gay Y. Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification. Proc Natl Acad Sci U S A National Academy of Sciences. 2011;108:19371\u20136.","journal-title":"Proc Natl Acad Sci U S A National Academy of Sciences"},{"key":"2528_CR44","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.4049\/jimmunol.170.6.2811","volume":"170","author":"K Hashimi","year":"2003","unstructured":"Hashimi K, Porter B, Iyer SS, Zulfiqar DJ, Malik A, Thompson CR, et al. Cutting edge: mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. J Immunol Ref. 2003;170:2811\u20135.","journal-title":"J Immunol Ref"},{"key":"2528_CR45","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","volume":"5","author":"G Arango Duque","year":"2014","unstructured":"Arango Duque G, Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol. 2014;5:491.","journal-title":"Front Immunol"},{"key":"2528_CR46","first-page":"614","volume":"5","author":"N Wang","year":"2014","unstructured":"Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol Frontiers Media SA. 2014;5:614.","journal-title":"Front Immunol Frontiers Media SA"},{"key":"2528_CR47","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1111\/j.1742-4658.2010.07666.x","volume":"277","author":"LS Meena","year":"2010","unstructured":"Meena LS. Rajni. Survival mechanisms of pathogenic mycobacterium tuberculosis H37Rv. FEBS J. 2010;277:2416\u201327.","journal-title":"FEBS J"},{"issue":"1","key":"2528_CR48","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1165\/rcmb.2010-0319OC","volume":"45","author":"S O\u2019Leary","year":"2011","unstructured":"O\u2019Leary S, O\u2019Sullivan MP, Keane J. IL-10 blocks phagosome maturation in Mycobacterium tuberculosis\u2013 infected human macrophages. Am J Respir Cell Mol Biol American Thoracic Society. 2011;45(1):172\u201380.","journal-title":"Am J Respir Cell Mol Biol American Thoracic Society"},{"key":"2528_CR49","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1146\/annurev-immunol-032712-100022","volume":"36","author":"AJ Pag\u00e1n","year":"2018","unstructured":"Pag\u00e1n AJ, Ramakrishnan L. The formation and function of granulomas. Annu Rev Immunol. 2018;36:639\u201365.","journal-title":"Annu Rev Immunol"},{"key":"2528_CR50","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nm.2299","volume":"17","author":"A Harari","year":"2011","unstructured":"Harari A, Rozot V, Enders FB, Perreau M, Stalder JM, Nicod LP, et al. Dominant TNF-\u03b1+ Mycobacterium tuberculosis\u2013specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med. 2011;17:372\u20136.","journal-title":"Nat Med"},{"key":"2528_CR51","first-page":"105","volume":"205","author":"AJ Wolf","year":"2008","unstructured":"Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, et al. Initiation of the adaptive immune response to mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med Rockefeller University Press. 2008;205:105\u201315.","journal-title":"J Exp Med Rockefeller University Press"},{"key":"2528_CR52","first-page":"5407","volume":"162","author":"BR Triebold","year":"1999","unstructured":"Triebold BR, Bloom JL, Flynn AM, Caruso N, Serbina E, Klein K, et al. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-\u03b3. Yet Succumb to Tuberculosis J Immunol. 1999;162:5407\u201316.","journal-title":"Yet Succumb to Tuberculosis J Immunol"},{"key":"2528_CR53","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.4049\/jimmunol.167.5.2734","volume":"167","author":"DH Canaday","year":"2001","unstructured":"Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH. CD4(+) and CD8(+) T cells kill intracellular mycobacterium tuberculosis by a perforin and Fas\/Fas ligand-independent mechanism. J Immunol ssociation of Immunologists. 2001;167:2734\u201342.","journal-title":"J Immunol ssociation of Immunologists"},{"key":"2528_CR54","first-page":"121","volume":"197","author":"L Tailleux","year":"2003","unstructured":"Tailleux L, Schwartz O, Herrmann J-L, Pivert E, Jackson M, Amara A, et al. DC-SIGN is the major mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med Rockefeller University Press. 2003;197:121\u20137.","journal-title":"J Exp Med Rockefeller University Press"},{"issue":"2","key":"2528_CR55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tube.2012.10.008","volume":"93","author":"KA Prendergast","year":"2013","unstructured":"Prendergast KA, Kirman JR. Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses. Tuberculosis Churchill Livingstone. 2013;93(2):115\u201322.","journal-title":"Tuberculosis Churchill Livingstone"},{"key":"2528_CR56","first-page":"3268","volume":"175","author":"T Tian","year":"2005","unstructured":"Tian T, Woodworth J, Sk\u00f6ld M, Behar SM. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to mycobacterium tuberculosis and exacerbates the outcome of infection. J Immunol American Association of Immunologists. 2005;175:3268\u201372.","journal-title":"J Immunol American Association of Immunologists"},{"key":"2528_CR57","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1172\/JCI45005","volume":"124","author":"R Keeton","year":"2014","unstructured":"Keeton R, Allie N, Dambuza I, Abel B, Hsu N-J, Sebesho B, et al. Soluble TNFRp75 regulates host protective immunity against mycobacterium tuberculosis. J Clin Invest American Society for Clinical Investigation. 2014;124:1537\u201351.","journal-title":"J Clin Invest American Society for Clinical Investigation"},{"key":"2528_CR58","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1084\/jem.20052545","volume":"203","author":"SA Khader","year":"2006","unstructured":"Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, et al. Interleukin 12p40 is required for dendritic cell migration and T cell priming after mycobacterium tuberculosis infection. J Exp Med. 2006;203:1805\u201315.","journal-title":"J Exp Med"},{"key":"2528_CR59","first-page":"258","volume":"360","author":"C Caux","year":"1992","unstructured":"Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-\u03b1 cooperate in the generation of dendritic Langerhans cells. Nature Nature Publishing Group. 1992;360:258\u201361.","journal-title":"Nature Nature Publishing Group"},{"key":"2528_CR60","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","volume":"179","author":"F Sallusto","year":"1994","unstructured":"Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179:1109\u201318.","journal-title":"J Exp Med"},{"key":"2528_CR61","first-page":"39499","volume":"6","author":"IM Dambuza","year":"2016","unstructured":"Dambuza IM, Keeton R, Hsu N-J, Allie N, Quesniaux VFJ, Ryffel B, et al. Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation. Sci Rep Nature Publishing Group. 2016;6:39499.","journal-title":"Sci Rep Nature Publishing Group"},{"key":"2528_CR62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2567.2003.01489.x","volume":"108","author":"W Zhang","year":"2003","unstructured":"Zhang W, Chen Z, Li F, Kamencic H, Juurlink B, Gordon JR, et al. Tumour necrosis factor-alpha (TNF-alpha) transgene-expressing dendritic cells (DCs) undergo augmented cellular maturation and induce more robust T-cell activation and anti-tumour immunity than DCs generated in recombinant TNF-alpha. Immunology. 2003;108:177\u201388.","journal-title":"Immunology"},{"key":"2528_CR63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molimm.2017.09.001","volume":"91","author":"S Ahmad","year":"2017","unstructured":"Ahmad S, Zamry AA, Tan H-TT, Wong KK, Lim J, Mohamud R. Targeting dendritic cells through gold nanoparticles: a review on the cellular uptake and subsequent immunological properties. Mol Immunol. 2017;91:123\u201333.","journal-title":"Mol Immunol"},{"key":"2528_CR64","doi-asserted-by":"crossref","first-page":"13894","DOI":"10.1038\/ncomms13894","volume":"7","author":"KL Griffiths","year":"2016","unstructured":"Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, et al. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016;7:13894.","journal-title":"Nat Commun"},{"key":"2528_CR65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJM198903023200901","volume":"320","author":"PA Selwyn","year":"1989","unstructured":"Selwyn PA, Hartel D, Lewis VA, Schoenbaum EE, Vermund SH, Klein RS, et al. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med. 1989;320:545\u201350.","journal-title":"N Engl J Med"},{"issue":"1","key":"2528_CR66","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cid\/cis798","volume":"56","author":"T Lahey","year":"2013","unstructured":"Lahey T, Mackenzie T, Arbeit RD, Bakari M, Mtei L, Matee M, et al. Recurrent tuberculosis risk among HIV-infected adults in Tanzania with prior active tuberculosis. Clin Infect Dis Oxford University Press. 2013;56(1):151\u20138.","journal-title":"Clin Infect Dis Oxford University Press"},{"key":"2528_CR67","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.192.3.347","volume":"192","author":"CA Scanga","year":"2000","unstructured":"Scanga CA, Mohan VP, Yu K, Joseph H, Tanaka K, Chan J, et al. Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. J Exp Med. 2000;192:347\u201358.","journal-title":"J Exp Med"},{"key":"2528_CR68","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","volume":"178","author":"AM Cooper","year":"1993","unstructured":"Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med. 1993;178:2243\u20137.","journal-title":"J Exp Med"},{"key":"2528_CR69","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","volume":"178","author":"JL Flynn","year":"1993","unstructured":"Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to mycobacterium tuberculosis infection. J Exp Med. 1993;178:2249\u201354.","journal-title":"J Exp Med"},{"key":"2528_CR70","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1172\/JCI119810","volume":"100","author":"E Jouanguy","year":"1997","unstructured":"Jouanguy E, Lamhamedi-Cherradi S, Altare F, Fondan\u00e8che MC, Tuerlinckx D, Blanche S, et al. Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Gu\u00e9rin infection and a sibling with clinical tuberculosis. J Clin Invest American Society for Clinical Investigation. 1997;100:2658\u201364.","journal-title":"J Clin Invest American Society for Clinical Investigation"},{"key":"2528_CR71","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.smim.2014.10.005","volume":"26","author":"J Chan","year":"2014","unstructured":"Chan J, Mehta S, Bharrhan S, Chen Y, Achkar JM, Casadevall A, et al. The role of B cells and humoral immunity in mycobacterium tuberculosis infection. Semin Immunol NIH Public Access. 2014;26:588\u2013600.","journal-title":"Semin Immunol NIH Public Access"},{"key":"2528_CR72","first-page":"180","volume":"8","author":"N-J Hsu","year":"2017","unstructured":"Hsu N-J, Francisco NM, Keeton R, Allie N, Quesniaux VFJ, Ryffel B, et al. Myeloid and T cell-derived tnf protects against central nervous system tuberculosis. Front Immunol. 2017;8:180.","journal-title":"Front Immunol"},{"key":"2528_CR73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/imr.12276","volume":"264","author":"JM Achkar","year":"2015","unstructured":"Achkar JM, Chan J, Casadevall A. B cells and antibodies in the defense against mycobacterium tuberculosis infection. Immunol Rev NIH Public Access. 2015;264:167\u201381.","journal-title":"Immunol Rev NIH Public Access"},{"key":"2528_CR74","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1128\/CVI.00355-08","volume":"16","author":"KR Steingart","year":"2009","unstructured":"Steingart KR, Dendukuri N, Henry M, Schiller I, Nahid P, Hopewell PC, et al. Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis. Clin Vaccine Immunol American Society for Microbiology. 2009;16:260\u201376.","journal-title":"Clin Vaccine Immunol American Society for Microbiology"},{"key":"2528_CR75","first-page":"513","volume":"187","author":"RM Brown","year":"2003","unstructured":"Brown RM, Cruz O, Brennan M, Gennaro ML, Schlesinger L, Skeiky YAW, et al. Lipoarabinomannan-reactive human secretory immunoglobulin a responses induced by mucosal Bacille Calmette-Gu\u00e9rin vaccination. J Infect Dis Oxford University Press. 2003;187:513\u20137.","journal-title":"J Infect Dis Oxford University Press"},{"key":"2528_CR76","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1128\/IAI.73.10.6711-6720.2005","volume":"73","author":"S de Valli\u00e8re","year":"2005","unstructured":"de Valli\u00e8re S, Abate G, Blazevic A, Heuertz RM, Hoft DF. Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies. Infect Immun American Society for Microbiology. 2005;73:6711\u201320.","journal-title":"Infect Immun American Society for Microbiology"},{"key":"2528_CR77","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/35084083","volume":"412","author":"K Pethe","year":"2001","unstructured":"Pethe K, Alonso S, Biet F, Delogu G, Brennan MJ, Locht C, et al. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature. 2001;412:190\u20134.","journal-title":"Nature"},{"key":"2528_CR78","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tube.2004.11.001","volume":"85","author":"A Williams","year":"2005","unstructured":"Williams A, James BW, Bacon J, Hatch KA, Hatch GJ, Hall GA, et al. An assay to compare the infectivity of mycobacterium tuberculosis isolates based on aerosol infection of Guinea pigs and assessment of bacteriology. Tuberculosis (Edinb) Elsevier. 2005;85:177\u201384.","journal-title":"Tuberculosis (Edinb) Elsevier"},{"key":"2528_CR79","doi-asserted-by":"crossref","first-page":"e1006250","DOI":"10.1371\/journal.ppat.1006250","volume":"13","author":"R Prados-Rosales","year":"2017","unstructured":"Prados-Rosales R, Carre\u00f1o L, Cheng T, Blanc C, Weinrick B, Malek A, et al. Enhanced control of mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine. Salgame P, editor. PLOS Pathog Public Library of Science. 2017;13:e1006250.","journal-title":"PLOS Pathog Public Library of Science"},{"key":"2528_CR80","doi-asserted-by":"crossref","first-page":"E1360","DOI":"10.1073\/pnas.1200484109","volume":"109","author":"E Greco","year":"2012","unstructured":"Greco E, Quintiliani G, Santucci MB, Serafino A, Ciccaglione AR, Marcantonio C, et al. Janus-faced liposomes enhance antimicrobial innate immune response in mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2012;109:E1360\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2528_CR81","doi-asserted-by":"crossref","first-page":"45120","DOI":"10.1038\/srep45120","volume":"7","author":"N Poerio","year":"2017","unstructured":"Poerio N, Bugli F, Taus F, Santucci MB, Rodolfo C, Cecconi F, et al. Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance. Sci Rep. 2017;7:45120.","journal-title":"Sci Rep"},{"key":"2528_CR82","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.nano.2013.11.012","volume":"10","author":"A Dube","year":"2014","unstructured":"Dube A, Reynolds JL, Law W-C, Maponga CC, Prasad PN, Morse GD. Multimodal nanoparticles that provide immunomodulation and intracellular drug delivery for infectious diseases. Nanomedicine Elsevier. 2014;10:831\u20138.","journal-title":"Nanomedicine Elsevier"},{"key":"2528_CR83","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-065X.2009.00793.x","volume":"230","author":"HS Goodridge","year":"2009","unstructured":"Goodridge HS, Wolf AJ, Underhill DM. Beta-glucan recognition by the innate immune system. Immunol Rev. 2009;230:38\u201350.","journal-title":"Immunol Rev"},{"key":"2528_CR84","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1756-8722-2-25","volume":"2","author":"G Chan","year":"2009","unstructured":"Chan G, Chan W, Sze D, et al. J Hematol Oncol. 2009;2:25.","journal-title":"J Hematol Oncol"},{"key":"2528_CR85","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1074\/jbc.M806650200","volume":"284","author":"S Xu","year":"2009","unstructured":"Xu S, Huo J, Lee K-G, Kurosaki T, Lam K-P. Phospholipase C\u03b32 is critical for Dectin-1-mediated ca 2+ flux and cytokine production in dendritic cells. J Biol Chem. 2009;284:7038\u201346.","journal-title":"J Biol Chem"},{"key":"2528_CR86","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s11095-015-1733-z","volume":"32","author":"M Tukulula","year":"2015","unstructured":"Tukulula M, Hayeshi R, Fonteh P, Meyer D, Ndamase A, Madziva MT, et al. Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities. Pharm Res. 2015;32:2713\u201326.","journal-title":"Pharm Res"},{"key":"2528_CR87","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jiec.2017.09.051","volume":"58","author":"J Hwang","year":"2018","unstructured":"Hwang J, Son J, Seo Y, Jo Y, Lee K, Lee D, et al. Functional silica nanoparticles conjugated with beta-glucan to deliver anti-tuberculosis drug molecules. J Ind Eng Chem. 2018;58:376\u201385.","journal-title":"J Ind Eng Chem"},{"key":"2528_CR88","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1016\/j.vaccine.2011.07.039","volume":"29","author":"M Ballester","year":"2011","unstructured":"Ballester M, Nembrini C, Dhar N, de Titta A, de Piano C, Pasquier M, et al. Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine Elsevier. 2011;29:6959\u201366.","journal-title":"Vaccine Elsevier"},{"key":"2528_CR89","first-page":"177","volume":"376","author":"Y Chen","year":"1995","unstructured":"Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature Nature Publishing Group. 1995;376:177\u201380.","journal-title":"Nature Nature Publishing Group"},{"key":"2528_CR90","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1574-695X.2006.00087.x","volume":"47","author":"PK Giri","year":"2006","unstructured":"Giri PK, Verma I, Khuller GK. Enhanced immunoprotective potential of mycobacterium tuberculosis Ag85 complex protein based vaccine against airway mycobacterium tuberculosis challenge following intranasal administration. FEMS Immunol Med Microbiol Oxford University Press. 2006;47:233\u201341.","journal-title":"FEMS Immunol Med Microbiol Oxford University Press"},{"key":"2528_CR91","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/eji.201343887","volume":"44","author":"E Stylianou","year":"2014","unstructured":"Stylianou E, Diogo GR, Pepponi I, van Dolleweerd C, Arias MA, Locht C, et al. Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice. Eur J Immunol. 2014;44:440\u20139.","journal-title":"Eur J Immunol"},{"key":"2528_CR92","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.4049\/jimmunol.0901466","volume":"189","author":"I Belyakov","year":"2009","unstructured":"Belyakov I, Ahlers J. What role does the route of immunization play in the generation of protective immunity against mucosal pathogens? J Immunol. 2009;189:6883\u201392.","journal-title":"J Immunol"},{"key":"2528_CR93","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm0896-893","volume":"2","author":"K Huygen","year":"1996","unstructured":"Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, Randall Deck R, et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat Med Nature Publishing Group. 1996;2:893\u20138.","journal-title":"Nat Med Nature Publishing Group"},{"key":"2528_CR94","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1016\/j.vaccine.2004.11.051","volume":"23","author":"JAM Langermans","year":"2005","unstructured":"Langermans JAM, Doherty TM, Vervenne RAW, van der Laan T, Lyashchenko K, Greenwald R, et al. Protection of macaques against mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine Elsevier. 2005;23:2740\u201350.","journal-title":"Vaccine Elsevier"},{"key":"2528_CR95","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/79631","volume":"6","author":"SHE Kaufmann","year":"2000","unstructured":"Kaufmann SHE. Is the development of a new tuberculosis vaccine possible? Nat Med. 2000;6:955\u201360.","journal-title":"Nat Med"},{"key":"2528_CR96","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.vaccine.2010.12.135","volume":"29","author":"JT van Dissel","year":"2011","unstructured":"van Dissel JT, Soonawala D, Joosten SA, Prins C, Arend SM, Bang P, et al. Ag85B\u2013ESAT-6 adjuvanted with IC31\u00ae promotes strong and long-lived mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection. Vaccine. 2011;29:2100\u2013009.","journal-title":"Vaccine"},{"key":"2528_CR97","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1016\/j.vaccine.2010.02.094","volume":"28","author":"JT van Dissel","year":"2010","unstructured":"van Dissel JT, Arend SM, Prins C, Bang P, Tingskov PN, Lingnau K, et al. Ag85B\u2013ESAT-6 adjuvanted with IC31\u00ae promotes strong and long-lived mycobacterium tuberculosis specific T cell responses in na\u00efve human volunteers. Vaccine. 2010;28:3571\u201381.","journal-title":"Vaccine"},{"key":"2528_CR98","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13063-017-2354-0","volume":"19","author":"J Hussein","year":"2018","unstructured":"Hussein J, Zewdie M, Yamuah L, Bedru A, Abebe M, Dagnew AF, et al. A phase I, open-label trial on the safety and immunogenicity of the adjuvanted tuberculosis subunit vaccine H1\/IC31\u00ae in people living in a TB-endemic area. Trials. 2018;19:24.","journal-title":"Trials"},{"key":"2528_CR99","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.nano.2012.02.015","volume":"8","author":"F Yu","year":"2012","unstructured":"Yu F, Wang J, Dou J, Yang H, He X, Xu W, et al. Nanoparticle-based adjuvant for enhanced protective efficacy of DNA vaccine Ag85A-ESAT-6-IL-21 against mycobacterium tuberculosis infection. Nanomed Nanotechnol, Biol MedElsevier. 2012;8:1337\u201344.","journal-title":"Nanomed Nanotechnol, Biol MedElsevier"},{"key":"2528_CR100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2015.05.004","volume":"210","author":"F Rose","year":"2015","unstructured":"Rose F, Wern JE, Ingvarsson PT, van de Weert M, Andersen P, Follmann F, et al. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: a quality-by-design approach. J Control ReleaseElsevier. 2015;210:48\u201357.","journal-title":"J Control ReleaseElsevier"},{"key":"2528_CR101","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1128\/CVI.00148-13","volume":"20","author":"D Carl\u00e9tti","year":"2013","unstructured":"Carl\u00e9tti D, Morais da Fonseca D, Gembre AF, Masson AP, Weijenborg Campos L, LCC L, et al. A single dose of a DNA vaccine encoding apa coencapsulated with 6,6\u2032-trehalose dimycolate in microspheres confers long-term protection against tuberculosis in mycobacterium bovis BCG-primed mice. Clin Vaccine Immunol. 2013;20:1162\u20139.","journal-title":"Clin Vaccine Immunol"},{"key":"2528_CR102","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/10611860801900462","volume":"16","author":"DJ Kirby","year":"2008","unstructured":"Kirby DJ, Rosenkrands I, Agger EM, Andersen P, Coombes AGA, Perrie Y. PLGA microspheres for the delivery of a novel subunit TB vaccine. J Drug Target. 2008;16:282\u201393.","journal-title":"J Drug Target"},{"key":"2528_CR103","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1016\/j.vaccine.2009.04.033","volume":"27","author":"M Bivas-Benita","year":"2009","unstructured":"Bivas-Benita M, Lin MY, Bal SM, van Meijgaarden KE, Franken KLMC, Friggen AH, et al. Pulmonary delivery of DNA encoding mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA\u2013PEI nanoparticles enhances T cell responses in a DNA prime\/protein boost vaccination regimen in mice. Vaccine Elsevier. 2009;27:4010\u20137.","journal-title":"Vaccine Elsevier"},{"key":"2528_CR104","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1586\/14760584.2.2.269","volume":"2","author":"DT O\u2019Hagan","year":"2003","unstructured":"O\u2019Hagan DT, Singh M. Microparticles as vaccine adjuvants and delivery systems. Expert Rev Vaccines. 2003;2:269\u201383.","journal-title":"Expert Rev Vaccines"},{"key":"2528_CR105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2172-9-38","volume":"9","author":"RS Rosada","year":"2008","unstructured":"Rosada RS, Torre L, Frantz FG, Trombone AP, Z\u00e1rate-Blad\u00e9s CR, Fonseca DM, et al. Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes. BMC Immunol. 2008;9:38.","journal-title":"BMC Immunol"},{"key":"2528_CR106","first-page":"2990","volume":"25","author":"M Okada","year":"2007","unstructured":"Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, et al. Evaluation of a novel vaccine (HVJ\u2013liposome\/HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB. VaccineElsevier. 2007;25:2990\u20133.","journal-title":"VaccineElsevier"},{"issue":"4","key":"2528_CR107","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S2213-2600(18)30077-8","volume":"6","author":"A Penn-Nicholson","year":"2018","unstructured":"Penn-Nicholson A, Tameris M, Smit E, Day TA, Musvosvi M, Jayashankar L, et al. Safety and immunogenicity of the novel tuberculosis vaccine ID93+ GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial. Lancet Respir Med. 2018;6(4):287\u201398.","journal-title":"Lancet Respir Med"},{"key":"2528_CR108","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijbiomac.2018.08.037","volume":"120","author":"S Khoshnood","year":"2018","unstructured":"Khoshnood S, Heidary M, Haeili M, Drancourt M, Darban-Sarokhalil D, Nasiri MJ, et al. Novel vaccine candidates against Mycobacterium tuberculosis. Int J Biol Macromol. 2018;120:180\u20138.","journal-title":"Int J Biol Macromol."},{"key":"2528_CR109","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/jama.2018.12852","volume":"320","author":"AS Fauci","year":"2018","unstructured":"Fauci AS. Addressing the tuberculosis epidemic. JAMA. 2018;320:1315\u201316.","journal-title":"JAMA"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-018-2528-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-018-2528-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-018-2528-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:14:30Z","timestamp":1744150470000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-018-2528-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["2528"],"URL":"https:\/\/doi.org\/10.1007\/s11095-018-2528-9","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"23 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"8"}}