{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:41:11Z","timestamp":1793407271288,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Woolcock Institute of Medical Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11095-020-02913-w","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T16:03:41Z","timestamp":1599235421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nasal Powder Formulation of Tranexamic Acid and Hyaluronic Acid for the Treatment of Epistaxis"],"prefix":"10.1007","volume":"37","author":[{"given":"Larissa","family":"Gomes dos Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh","family":"Ghadiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-017X","authenticated-orcid":false,"given":"Daniela","family":"Traini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"issue":"3","key":"2913_CR1","first-page":"164","volume":"152","author":"J Smith","year":"2019","unstructured":"Smith J, Hanson J, Chowdhury R, Bungard TJ. Community-based management of epistaxis: Who bloody knows? Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada. RPC. 2019;152(3):164\u201376.","journal-title":"RPC"},{"issue":"6","key":"2913_CR2","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/coa.12645","volume":"41","author":"Y Kamhieh","year":"2016","unstructured":"Kamhieh Y, Fox H. Tranexamic acid in epistaxis: a systematic review. Clin Otolaryngol: Off J ENT-UK; Off J Netherlands Soc Oto-Rhino-Laryngology Cervico-Facial Surg. 2016;41(6):771\u20136.","journal-title":"Clin Otolaryngol: Off J ENT-UK; Off J Netherlands Soc Oto-Rhino-Laryngology Cervico-Facial Surg"},{"issue":"6","key":"2913_CR3","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1177\/194589240501900607","volume":"19","author":"SP Rajapaksa","year":"2005","unstructured":"Rajapaksa SP, Cowin A, Adams D, Wormald PJ. The effect of a hyaluronic acid-based nasal pack on mucosal healing in a sheep model of sinusitis. Am J Rhinol. 2005;19(6):572\u20136.","journal-title":"Am J Rhinol"},{"issue":"11","key":"2913_CR4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1136\/emermed-2016-206351.1","volume":"33","author":"N Penrose","year":"2016","unstructured":"Penrose N, May G. Tranexamic acid in epistaxis: who bloody nose? Emerg Med J. 2016;33(11):823\u20135.","journal-title":"Emerg Med J"},{"key":"2913_CR5","unstructured":"Organization WH. Updated WHO recommendation on tranexamic acid for the treatment of postpartum haemorrhage: highlights and key messages from the World Health Organization's 2017 global recommendation. 2017. Contract No.: WHO\/RHR\/17.21."},{"issue":"2","key":"2913_CR6","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.chest.2015.10.016","volume":"149","author":"G Segrelles Calvo","year":"2016","unstructured":"Segrelles Calvo G, De Granda-Orive I, L\u00f3pez PD. Inhaled Tranexamic acid as an alternative for hemoptysis treatment. Chest. 2016;149(2):604.","journal-title":"Chest"},{"issue":"1","key":"2913_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1089\/jamp.2019.1534","volume":"33","author":"JA Dhanani","year":"2020","unstructured":"Dhanani JA, Roberts J, Reade MC. Nebulized Tranexamic acid therapy for hemoptysis associated with submassive pulmonary embolism. J Aerosol Med Pulm Drug Deliv. 2020;33(1):12\u20134.","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"2913_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ejpb.2015.04.015","volume":"93","author":"M Haghi","year":"2015","unstructured":"Haghi M, van den Oetelaar W, Moir LM, Zhu B, Phillips G, Crapper J, et al. Inhalable tranexamic acid for haemoptysis treatment. Eur J Pharm Biopharm. 2015;93:311\u20139.","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"2913_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1208\/s12249-019-1517-6","volume":"20","author":"H Gholizadeh","year":"2019","unstructured":"Gholizadeh H, Messerotti E, Pozzoli M, Cheng S, Traini D, Young P, et al. Application of a Thermosensitive in situ gel of chitosan-based nasal spray loaded with Tranexamic acid for localised treatment of nasal wounds. AAPS PharmSciTech. 2019;20(7):299.","journal-title":"AAPS PharmSciTech"},{"issue":"9","key":"2913_CR10","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.ajem.2013.06.043","volume":"31","author":"R Zahed","year":"2013","unstructured":"Zahed R, Moharamzadeh P, Alizadeharasi S, Ghasemi A, Saeedi M. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med. 2013;31(9):1389\u201392.","journal-title":"Am J Emerg Med"},{"issue":"9","key":"2913_CR11","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jama.2016.11724","volume":"316","author":"KJ Whitehead","year":"2016","unstructured":"Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, et al. Effect of topical intranasal therapy on epistaxis frequency in patients with hereditary hemorrhagic telangiectasia: a randomized clinical trial. Jama. 2016;316(9):943\u201351.","journal-title":"Jama"},{"key":"2913_CR12","first-page":"Cd004328","volume":"12","author":"J Joseph","year":"2018","unstructured":"Joseph J, Martinez-Devesa P, Bellorini J, Burton MJ. Tranexamic acid for patients with nasal haemorrhage (epistaxis). Cochrane Database Syst Rev. 2018;12:Cd004328.","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"2913_CR13","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1002\/lary.24150","volume":"123","author":"OA Henriquez","year":"2013","unstructured":"Henriquez OA, Schlosser RJ, Mace JC, Smith TL, Soler ZM. Impact of synechiae after endoscopic sinus surgery on long-term outcomes in chronic rhinosinusitis. Laryngoscope. 2013;123(11):2615\u20139.","journal-title":"Laryngoscope"},{"issue":"10","key":"2913_CR14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/alr.21193","volume":"3","author":"M Gelardi","year":"2013","unstructured":"Gelardi M, Iannuzzi L, Quaranta N. Intranasal sodium hyaluronate on the nasal cytology of patients with allergic and nonallergic rhinitis. Int Forum Allergy Rhinol. 2013;3(10):807\u201313.","journal-title":"Int Forum Allergy Rhinol"},{"key":"2913_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ijporl.2016.03.015","volume":"85","author":"M Casale","year":"2016","unstructured":"Casale M, Vella P, Moffa A, Oliveto G, Sabatino L, Grimaldi V, et al. Hyaluronic acid and upper airway inflammation in pediatric population: a systematic review. Int J Pediatr Otorhinolaryngol. 2016;85:22\u20136.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2913_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ijpharm.2019.01.012","volume":"558","author":"A Fallacara","year":"2019","unstructured":"Fallacara A, Busato L, Pozzoli M, Ghadiri M, Ong HX, Young PM, et al. In vitro characterization of physico-chemical properties, cytotoxicity, bioactivity of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate nasal powder formulation. Int J Pharm. 2019;558:341\u201350.","journal-title":"Int J Pharm"},{"issue":"4","key":"2913_CR17","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","volume":"10","author":"KT Dicker","year":"2014","unstructured":"Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X. Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater. 2014;10(4):1558\u201370.","journal-title":"Acta Biomater"},{"issue":"4","key":"2913_CR18","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","volume":"10","author":"KT Dicker","year":"2014","unstructured":"Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X. Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater. 2014;10(4):1558\u201370.","journal-title":"Acta Biomater"},{"key":"2913_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ejps.2017.09.027","volume":"113","author":"L Tiozzo Fasiolo","year":"2018","unstructured":"Tiozzo Fasiolo L, Manniello MD, Tratta E, Buttini F, Rossi A, Sonvico F, et al. Opportunity and challenges of nasal powders: drug formulation and delivery. Eur J Pharm Sci. 2018;113:2\u201317.","journal-title":"Eur J Pharm Sci"},{"key":"2913_CR20","unstructured":"FDA. Guidance for Industry- Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products \u2014 Chemistry, Manufacturing, and Controls Documentation. 2002."},{"key":"2913_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ejpb.2016.07.010","volume":"107","author":"M Pozzoli","year":"2016","unstructured":"Pozzoli M, Ong HX, Morgan L, Sukkar M, Traini D, Young PM, et al. Application of RPMI 2650 nasal cell model to a 3D printed apparatus for the testing of drug deposition and permeation of nasal products. Eur J Pharm Biopharm. 2016;107:223\u201333.","journal-title":"Eur J Pharm Biopharm"},{"key":"2913_CR22","doi-asserted-by":"publisher","unstructured":"Muller L, Brighton LE, Carson JL, Fischer WA, Jaspers I. Culturing of human nasal epithelial cells at the air liquid interface. J Vis Exp. 2013;80. https:\/\/doi.org\/10.3791\/50646.","DOI":"10.3791\/50646"},{"issue":"1","key":"2913_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s40199-016-0160-y","volume":"24","author":"N Shabani Ravari","year":"2016","unstructured":"Shabani Ravari N, Goodarzi N, Alvandifar F, Amini M, Souri E, Khoshayand MR, et al. Fabrication and biological evaluation of chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles in CD44(+) cancer cells. Daru. 2016;24(1):21.","journal-title":"Daru"},{"key":"2913_CR24","unstructured":"TGA. Inhalation and nasal spray registered medicines (version 2.1). 2019:1\u201318."},{"issue":"10","key":"2913_CR25","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3109\/03639045.2016.1160110","volume":"42","author":"M Pozzoli","year":"2016","unstructured":"Pozzoli M, Rogueda P, Zhu B, Smith T, Young PM, Traini D, et al. Dry powder nasal drug delivery: challenges, opportunities and a study of the commercial Teijin Puvlizer Rhinocort device and formulation. Drug Dev Ind Pharm. 2016;42(10):1660\u20138.","journal-title":"Drug Dev Ind Pharm"},{"issue":"9","key":"2913_CR26","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1080\/03639045.2017.1321659","volume":"43","author":"M Pozzoli","year":"2017","unstructured":"Pozzoli M, Traini D, Young PM, Sukkar MB, Sonvico F. Development of a Soluplus budesonide freeze-dried powder for nasal drug delivery. Drug Dev Ind Pharm. 2017;43(9):1510\u20138.","journal-title":"Drug Dev Ind Pharm"},{"key":"2913_CR27","unstructured":"FDA. Bioavailability and Bioequivalence Studies for Nasal Aersols and Nasal Sprays for Local Action. 2003:1\u201337."},{"issue":"1","key":"2913_CR28","first-page":"7","volume":"31","author":"L Thorsson","year":"1993","unstructured":"Thorsson L, Newman SP, Weisz A, Trofast E, Moren F. Nasal distribution of budesonide inhaled via a powder inhaler. Rhinology. 1993;31(1):7\u201310.","journal-title":"Rhinology."},{"issue":"1","key":"2913_CR29","doi-asserted-by":"publisher","first-page":"e0147618","DOI":"10.1371\/journal.pone.0147618","volume":"11","author":"S Azizi","year":"2016","unstructured":"Azizi S, Nematollahi MA, Mojazi Amiri B, V\u00e9lez EJ, Lutfi E, Navarro I, et al. Lysine and Leucine deficiencies affect Myocytes development and IGF signaling in Gilthead Sea bream (Sparus aurata). PLoS One. 2016;11(1):e0147618.","journal-title":"PLoS One"},{"key":"2913_CR30","doi-asserted-by":"crossref","unstructured":"Hasan MS, Crenshaw MA, Liao SF. Dietary lysine affects amino acid metabolism and growth performance, which may not involve the GH\/IGF-1 axis, in young growing pigs1. J Animal Sci. 2020;98(1).","DOI":"10.1093\/jas\/skaa004"},{"issue":"6","key":"2913_CR31","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S1671-2927(09)60168-1","volume":"9","author":"J W-q","year":"2010","unstructured":"W-q J, F-c L. Effects of dietary lysine on growth performance, serum concentrations of insulin-like growth factor-I (IGF-I) and IGF-I mRNA expression in growing rabbits. Agric Sci China. 2010;9(6):887\u201395.","journal-title":"Agric Sci China"},{"issue":"6","key":"2913_CR32","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s12223-008-0089-8","volume":"53","author":"P Fundov\u00e1","year":"2008","unstructured":"Fundov\u00e1 P, Filipovsk\u00fd T, Funda DP, Hovorka O, Hol\u00fd R, Navara M, et al. Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis. Folia Microbiol. 2008;53(6):558\u201362.","journal-title":"Folia Microbiol"},{"issue":"8","key":"2913_CR33","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/ijd.12099","volume":"53","author":"C Yuan","year":"2014","unstructured":"Yuan C, Wang XM, Yang LJ, Wu PL. Tranexamic acid accelerates skin barrier recovery and upregulates occludin in damaged skin. Int J Dermatol. 2014;53(8):959\u201365.","journal-title":"Int J Dermatol"},{"issue":"6","key":"2913_CR34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1097\/TA.0000000000000703","volume":"79","author":"ME Diebel","year":"2015","unstructured":"Diebel ME, Diebel LN, Manke CW, Liberati DM, Whittaker JR. Early tranexamic acid administration: a protective effect on gut barrier function following ischemia\/reperfusion injury. J Trauma Acute Care Surg. 2015;79(6):1015\u201322.","journal-title":"J Trauma Acute Care Surg"},{"key":"2913_CR35","unstructured":"(TGA) TGA. Australian Public Assessment Report for Tranexamic Acid. 2010. Report No.: PM-2009-00587."},{"issue":"3","key":"2913_CR36","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","volume":"89","author":"S Guo","year":"2010","unstructured":"Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219\u201329.","journal-title":"J Dent Res"},{"issue":"3","key":"2913_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/cc11374","volume":"16","author":"A Godier","year":"2012","unstructured":"Godier A, Roberts I, Hunt BJ. Tranexamic acid: less bleeding and less thrombosis? Crit Care. 2012;16(3):135.","journal-title":"Crit Care"},{"issue":"6","key":"2913_CR38","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s10787-019-00616-2","volume":"27","author":"K Hiramoto","year":"2019","unstructured":"Hiramoto K, Yamate Y, Sugiyama D, Matsuda K, Iizuka Y, Yamaguchi T. Effect of tranexamic acid in improving the lifespan of naturally aging mice. Inflammopharmacology. 2019;27(6):1319\u201323.","journal-title":"Inflammopharmacology"},{"key":"2913_CR39","doi-asserted-by":"crossref","unstructured":"Hiramoto K, Oikawa H, Yamate Y, Sato EF. Tranexamic acid protects ovary and testis functions and ameliorates osteoporosis in mice. Pharmacology. 2020:1\u201310.","DOI":"10.1159\/000506233"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-020-02913-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-020-02913-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-020-02913-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T01:59:18Z","timestamp":1630720758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-020-02913-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["2913"],"URL":"https:\/\/doi.org\/10.1007\/s11095-020-02913-w","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"assertion":[{"value":"18 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"186"}}