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The objective of this study was to investigate the feasibility of transdermal delivery of ADT-OH, a H\n                      <jats:sub>2<\/jats:sub>\n                      S donor, by investigating the transdermal flux of aqueous gels loaded with penetration enhancers or liposomes. Furthermore, we explored the ability of permeated ADT-OH to promote angiogenesis and mitochondrial bioenergetics in HUVEC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Aqueous hypromellose gels (5% w\/v) were prepared with up to 10% v\/v propylene glycol (PG) or deformable liposomes with 0.025% w\/w ADT-OH. ADT-OH permeation from formulations across excised murine skin into PBS was quantified over 24\u00a0h using HPLC-UV detection. Media was collected and applied to HUVEC cells to evidence ADT-OH functionality following permeation. Tube formation assays were performed as indicative of angiogenesis and mitochondrial oxygen consumption was evaluated using a Seahorse XF24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increasing the loading of PG caused an increase in ADT-OH permeation rate across skin and a decrease in dermal drug retention whereas liposomal gels produced a slow-release profile. Treatment of HUVEC\u2019s using conditioned media collected from the ADT-OH loaded permeation studies enhanced tube formation and the basal oxygen consumption rates after 30\u00a0min of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate that transdermal delivery of ADT-OH may provide a promising approach in the treatment of impaired vascular function. Gels prepared with 10% v\/v PG have the potential for use in conditions requiring rapid H\n                      <jats:sub>2<\/jats:sub>\n                      S release whereas liposomal loaded gels for treatment requiring sustained H\n                      <jats:sub>2<\/jats:sub>\n                      S release.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11095-021-03164-z","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T14:03:46Z","timestamp":1643292226000},"page":"341-352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function: an Ex Vivo Study"],"prefix":"10.1007","volume":"39","author":[{"given":"Mandeep Kaur","family":"Marwah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Shokr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissette","family":"Sanchez-Aranguren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kumar Singh","family":"Badhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-0475","authenticated-orcid":false,"given":"Shakil","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"3164_CR1","first-page":"4","volume":"59","author":"E \u0141owickaand","year":"2007","unstructured":"\u0141owickaand E, Be\u0142towski J. 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