{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:33:32Z","timestamp":1740123212654,"version":"3.37.3"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s11095-022-03332-9","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:02:46Z","timestamp":1657756966000},"page":"2135-2145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preclinical Pharmacokinetic and Pharmacodynamic Investigation of 5\u2019-Methoxynobiletin from Ageratum conyzoides: In vivo and In silico Approaches"],"prefix":"10.1007","volume":"39","author":[{"given":"Larissa Gabriela","family":"Faqueti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layzon Antonio Lemos","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Salim Gomes","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scheila","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo dos Santos Catarina","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Aparecida","family":"Honorato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana Verlindo","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adair Roberto Soares","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Dalla","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maique Weber","family":"Biavatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"issue":"6","key":"3332_CR1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","volume":"140","author":"R Medzhitov","year":"2010","unstructured":"Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140(6):771\u20136.","journal-title":"Cell"},{"issue":"7","key":"3332_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.autrev.2010.12.006","volume":"10","author":"R Scrivo","year":"2011","unstructured":"Scrivo R, Vasile M, Bartosiewicz I, Valesini G. Inflammation as \u201ccommon soil\u201d of the multifactorial diseases. Autoimmun Rev. 2011;10(7):369\u201374.","journal-title":"Autoimmun Rev"},{"issue":"2","key":"3332_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267\u201384.","journal-title":"Cell"},{"issue":"3","key":"3332_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.jep.2008.08.024","volume":"120","author":"A Nelly","year":"2008","unstructured":"Nelly A, Annick D-D, Frederic D. Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon. J Ethnopharmacol. 2008;120(3):315\u201334.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"3332_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3164\/jcbn.2007002","volume":"41","author":"B Rathore","year":"2007","unstructured":"Rathore B, Mahdi AA, Paul BN, Saxena PN, Das SK. Indian herbal medicines: possible potent therapeutic agents for rheumatoid arthritis. J Clin Biochem Nutr. 2007;41(1):12\u20137.","journal-title":"J Clin Biochem Nutr"},{"issue":"3","key":"3332_CR6","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.jep.2013.06.007","volume":"149","author":"S Vogl","year":"2013","unstructured":"Vogl S, Picker P, Mihaly-Bison J, Fakhrudin N, Atanasov AG, Heiss EH, et al. Ethnopharmacological in vitro studies on Austria\u2019s folk medicine - An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs. J Ethnopharmacol. 2013;149(3):750\u201371.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"3332_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3390\/ani3010158","volume":"3","author":"TD Stark","year":"2013","unstructured":"Stark TD, Mtui DJ, Balemba OB. Ethnopharmacological survey of plants used in the traditional treatment of gastrointestinal pain, inflammation and diarrhea in Africa: future perspectives for integration into modern medicine. Animals. 2013;3(1):158\u2013227.","journal-title":"Animals"},{"key":"3332_CR8","unstructured":"Lorenzi H. Plantas daninhas do Brasil: terrestres, aqu\u00e1ticas, parasitas, t\u00f3xicas e medicinais. 2 ed. ed. Nova Odessa, SP: Editora Plantarum; 1991."},{"key":"3332_CR9","doi-asserted-by":"crossref","unstructured":"Moura ACA, Silva ELF, Fraga MCA, Wanderley AG, Afiatpour P, Maia MBS. Antiinflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats. Phytomedicine. 2005;12(1):138\u201342.","DOI":"10.1016\/j.phymed.2003.12.003"},{"issue":"20","key":"3332_CR10","first-page":"1469","volume":"6","author":"A Rahman","year":"2012","unstructured":"Rahman A, Akter N, Rashid H, Ahmed NU, Uddin N, Islam S. Analgesic and anti-inflammatory effect of whole Ageratum conyzoides and Emilia sonchifolia alcoholic extracts in animal models. Afr J Pharmacy Pharmacol. 2012;6(20):1469\u201376.","journal-title":"Afr J Pharmacy Pharmacol"},{"key":"3332_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jep.2016.09.003","volume":"194","author":"SVGV De Mello","year":"2016","unstructured":"De Mello SVGV, Da Rosa JS, Facchin BM, Luz ABG, Vicente G, Faqueti LG, et al. Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity. J Ethnopharmacol. 2016;194:337\u201347.","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"3332_CR12","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/S0031-9422(00)95215-4","volume":"30","author":"AG Gonz\u00e1lez","year":"1991","unstructured":"Gonz\u00e1lez AG, Aguiar ZE, Grillo TA, Luis JG, Rivera A, Calle J. Methoxyflavones from Ageratum conyzoides. Phytochemistry. 1991;30(4):1269\u201371.","journal-title":"Phytochemistry"},{"issue":"11","key":"3332_CR13","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1016\/S0031-9422(00)84523-9","volume":"25","author":"AV Vyas","year":"1986","unstructured":"Vyas AV, Mulchandani NB. Polyoxygenated flavones from Ageratum conyzoides. Phytochemistry. 1986;25(11):2625\u20137.","journal-title":"Phytochemistry"},{"key":"3332_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.jep.2016.09.025","volume":"194","author":"LG Faqueti","year":"2016","unstructured":"Faqueti LG, Brieudes V, Halabalaki M, Skaltsounis AL, Nascimento LF, Barros WM, et al. Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides. J Ethnopharmacol. 2016;194:369\u201377.","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"3332_CR15","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1007\/s10753-014-9994-y","volume":"38","author":"SF Ahmad","year":"2015","unstructured":"Ahmad SF, Attia SM, Bakheet SA, Zoheir KM, Ansari MA, Korashy HM, et al. Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-\u03bab, STAT3 and pro-inflammatory mediators and enhancement of I\u03baB\u03b1 and anti-inflammatory cytokines. Inflammation. 2015;38(2):846\u201357.","journal-title":"Inflammation"},{"issue":"4","key":"3332_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jtcme.2014.11.041","volume":"5","author":"P Mehta","year":"2015","unstructured":"Mehta P, Shah R, Lohidasan S, Mahadik K. Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants - a comprehensive review. J Tradit Complement Med. 2015;5(4):207\u201327.","journal-title":"J Tradit Complement Med"},{"issue":"2","key":"3332_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1208\/s12248-014-9716-2","volume":"17","author":"E Schuck","year":"2015","unstructured":"Schuck E, Bohnert T, Chakravarty A, Damian-Iordache V, Gibson C, Hsu C-P, et al. Preclinical pharmacokinetic\/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape. AAPS J. 2015;17(2):462\u201373.","journal-title":"AAPS J"},{"key":"3332_CR18","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s40262-020-00892-0","volume":"59","author":"A Jorda","year":"2020","unstructured":"Jorda A, Zeitlinger M. Preclinical pharmacokinetic\/pharmacodynamic studies and clinical trials in the drug development process of ema-approved antibacterial agents: A review. Clin Pharmacokinet. 2020;59:1071\u201384.","journal-title":"Clin Pharmacokinet"},{"key":"3332_CR19","first-page":"1","volume-title":"Principles and Practice of Clinical Trials","author":"SN Kalaria","year":"2020","unstructured":"Kalaria SN, Wang H, Gobburu JV. Pharmacokinetic and Pharmacodynamic Modeling. In: Piantadosi S, Meinert CL, editors. Principles and Practice of Clinical Trials. Cham: Springer; 2020. p. 1\u201324."},{"issue":"5","key":"3332_CR20","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.drudis.2019.03.015","volume":"24","author":"LL Ferreira","year":"2019","unstructured":"Ferreira LL, Andricopulo AD. ADMET modeling approaches in drug discovery. Drug Discov Today. 2019;24(5):1157\u201365.","journal-title":"Drug Discov Today"},{"issue":"726","key":"3332_CR21","first-page":"1","volume":"8","author":"F Wu","year":"2020","unstructured":"Wu F, Zhou Y, Li L, Shen X, Chen G, Wang X, et al. Computational approaches in preclinical studies on drug discovery and development. Front Chem. 2020;8(726):1\u201332.","journal-title":"Front Chem"},{"issue":"933","key":"3332_CR22","first-page":"1","volume":"11","author":"J Yuan","year":"2020","unstructured":"Yuan J, Wei F, Luo X, Zhang M, Qiao R, Zhong M, et al. Multi-component comparative pharmacokinetics in rats after oral administration of fructus aurantii extract, naringin, neohesperidin, and naringin-neohesperidin. Front Pharmacol. 2020;11(933):1\u201312.","journal-title":"Front Pharmacol"},{"issue":"2","key":"3332_CR23","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.jfda.2017.08.003","volume":"26","author":"W-L Hung","year":"2018","unstructured":"Hung W-L, Chang W-S, Lu W-C, Wei G-J, Wang Y, Ho C-T, et al. Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat. J Food Drug Anal. 2018;26(2):849\u201357.","journal-title":"J Food Drug Anal"},{"key":"3332_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113210","volume":"184","author":"C Niu","year":"2020","unstructured":"Niu C, Sun J, Zheng Y, Wang L, Zhang J, Chen R, et al. Determination of isosinensetin in rat plasma by UHPLC-MS\/MS: application to oral and intravenous pharmacokinetic study in healthy rats. J Pharm Biomed Anal. 2020;184: 113210.","journal-title":"J Pharm Biomed Anal"},{"key":"3332_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122387","volume":"1158","author":"LG Faqueti","year":"2020","unstructured":"Faqueti LG, da Silva LAL, Moreira GSG, Honorato LA, Dos Santos ARS, Dalla Costa T, et al. Simple and fast UPLC-MS method for quantifying the anti-inflammatory candidate 5\u2019-methoxynobiletin in rat plasma: validation and application in a preliminary pharmacokinetic study. J Chromatogr B. 2020;1158: 122387.","journal-title":"J Chromatogr B"},{"key":"3332_CR26","unstructured":"FDA. Food and Drugs Administration. Guidence for Industry: Bioanalytical Method Validation. 2018."},{"key":"3332_CR27","unstructured":"Shargel L, Andrew B, Wu-Pong S. Applied biopharmaceutics & pharmacokinetics. 6th ed. New York, NY: McGraw-Hill Book Co; 2012."},{"issue":"1","key":"3332_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","volume":"14","author":"S Hunskaar","year":"1985","unstructured":"Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods. 1985;14(1):69\u201376.","journal-title":"J Neurosci Methods"},{"issue":"1","key":"3332_CR29","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jep.2012.06.020","volume":"143","author":"C Nucci","year":"2012","unstructured":"Nucci C, Mazzardo-Martins L, Stramosk J, Brethanha LC, Pizzolatti MG, Santos AR, et al. Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain. J Ethnopharmacol. 2012;143(1):170\u20138.","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"3332_CR30","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1002\/jps.22525","volume":"100","author":"R Nagilla","year":"2011","unstructured":"Nagilla R, Nord M, Mcatee JJ, Jolivette LJ. Cassette dosing for pharmacokinetic screening in drug discovery: comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats. J Pharm Sci. 2011;100(9):3862\u201374.","journal-title":"J Pharm Sci"},{"key":"3332_CR31","doi-asserted-by":"crossref","unstructured":"Ward KW, Smith BR. A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. volume of distribution and mean residence time. Drug Metab Dispos. 2004;32(6):612\u20139.","DOI":"10.1124\/dmd.32.6.612"},{"issue":"7","key":"3332_CR32","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1023\/A:1018943613122","volume":"10","author":"B Davies","year":"1993","unstructured":"Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res. 1993;10(7):1093\u20135.","journal-title":"Pharm Res"},{"issue":"12","key":"3332_CR33","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1007\/s11095-015-1749-4","volume":"32","author":"MV Varma","year":"2015","unstructured":"Varma MV, Steyn SJ, Allerton C, El-Kattan AF. Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS). Pharm Res. 2015;32(12):3785\u2013802.","journal-title":"Pharm Res"},{"issue":"6","key":"3332_CR34","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1080\/00498250802001834","volume":"38","author":"T Mcintyre","year":"2008","unstructured":"Mcintyre T, Han C, Xiang H, Bambal R, Davis C. Differences in the total body clearance of lead compounds in the rat and mouse: Impact on pharmacokinetic screening strategy. Xenobiotica. 2008;38(6):605\u201319.","journal-title":"Xenobiotica"},{"issue":"9","key":"3332_CR35","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1002\/jps.22525","volume":"100","author":"R Nagilla","year":"2011","unstructured":"Nagilla R, Nord M, Mcatee JJ, Jolivette LJ. Cassette dosing for pharmacokinetic screening in drug discovery: comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats. J Pharm Sci. 2011;100(9):3862\u201374.","journal-title":"J Pharm Sci"},{"key":"3332_CR36","doi-asserted-by":"crossref","unstructured":"Yadav KS, Mishra DK, Deshpande A, Pethe AM. Levels of Drug Targeting. In: Tekade RK, editor. Basic Fundamentals of Drug Delivery: Academic Press; 2019. p. 269\u2013305.","DOI":"10.1016\/B978-0-12-817909-3.00007-8"},{"issue":"8","key":"3332_CR37","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/bmc.2904","volume":"27","author":"T Li","year":"2013","unstructured":"Li T, Yan Z, Zhou C, Sun J, Jiang C, Yang X. Simultaneous quantification of paeoniflorin, nobiletin, tangeretin, liquiritigenin, isoliquiritigenin, liquiritin and formononetin from Si-Ni-San extract in rat plasma and tissues by liquid chromatography\u2013tandem mass spectrometry. Biomed Chromatogr. 2013;27(8):1041\u201353.","journal-title":"Biomed Chromatogr"},{"issue":"3\u20134","key":"3332_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/biof.5520160303","volume":"16","author":"A Murakami","year":"2002","unstructured":"Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, et al. Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin. BioFactors. 2002;16(3\u20134):73\u201382.","journal-title":"BioFactors"},{"key":"3332_CR39","doi-asserted-by":"crossref","unstructured":"Keen P. Effect of binding to plasma proteins on the distribution, activity and elimination of drugs. In: Brodie BB, Gillette JR, Ackerman HS, editors. Concepts in Biochemical Pharmacology: Springer; 1971. p. 213\u201333.","DOI":"10.1007\/978-3-642-65052-9_10"},{"issue":"9","key":"3332_CR40","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1002\/jps.23614","volume":"102","author":"T Bohnert","year":"2013","unstructured":"Bohnert T, Gan L-S. Plasma protein binding: from discovery to development. J Pharm Sci. 2013;102(9):2953\u201394.","journal-title":"J Pharm Sci"},{"key":"3332_CR41","doi-asserted-by":"crossref","unstructured":"Poulin P, Theil FP. Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism\u2010based prediction of volume of distribution. J Pharm Sci. 2002;91(1):129\u201356.","DOI":"10.1002\/jps.10005"},{"issue":"15","key":"3332_CR42","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1021\/acs.jmedchem.5b00201","volume":"58","author":"DA Smith","year":"2015","unstructured":"Smith DA, Beaumont K, Maurer TS, Di L. Volume of distribution in drug design: miniperspective. J Med Chem. 2015;58(15):5691\u20138.","journal-title":"J Med Chem"},{"issue":"3","key":"3332_CR43","doi-asserted-by":"publisher","first-page":"515","DOI":"10.18433\/J3XC7S","volume":"18","author":"ZD Zhivkova","year":"2015","unstructured":"Zhivkova ZD, Mandova T, Doytchinova I. Quantitative structure\u2013pharmacokinetics relationships analysis of basic drugs: volume of distribution. J Pharm Pharm Sci. 2015;18(3):515\u201327.","journal-title":"J Pharm Pharm Sci"},{"key":"3332_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-12-369521-5.00007-5","volume-title":"Pharmacology: principles and practice","author":"PJ McNamara","year":"2009","unstructured":"McNamara PJ, Leggas M. Drug distribution. In: Hacker M, Messer W, Bachmann K, editors. Pharmacology: principles and practice. London, UK: Elsevier; 2009. p. 113\u201329."},{"issue":"1","key":"3332_CR45","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1034\/j.1600-0773.2003.930102.x","volume":"93","author":"VM Breinholt","year":"2003","unstructured":"Breinholt VM, Rasmussen SE, Br\u00f8sen K, Friedberg TH. In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. Pharmacol Toxicol. 2003;93(1):14\u201322.","journal-title":"Pharmacol Toxicol"},{"issue":"11","key":"3332_CR46","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3109\/00498254.2011.593208","volume":"41","author":"N Koga","year":"2011","unstructured":"Koga N, Ohta C, Kato Y, Haraguchi K, Endo T, Ogawa K, et al. In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. Xenobiotica. 2011;41(11):927\u201333.","journal-title":"Xenobiotica"},{"issue":"12","key":"3332_CR47","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1124\/dmd.112.047142","volume":"40","author":"C Mekjaruskul","year":"2012","unstructured":"Mekjaruskul C, Jay M, Sripanidkulchai B. Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. Drug Metab Dispos. 2012;40(12):2342\u201353.","journal-title":"Drug Metab Dispos"},{"issue":"39","key":"3332_CR48","doi-asserted-by":"publisher","first-page":"10709","DOI":"10.1021\/acs.jafc.0c04425","volume":"68","author":"M Zhang","year":"2020","unstructured":"Zhang M, Xin Y, Feng K, Yin B, Kan Q, Xiao J, et al. Comparative analyses of bioavailability, biotransformation, and excretion of nobiletin in lean and obese rats. J Agric Food Chem. 2020;68(39):10709\u201318.","journal-title":"J Agric Food Chem"},{"issue":"47","key":"3332_CR49","doi-asserted-by":"publisher","first-page":"14143","DOI":"10.1021\/acs.jafc.1c05024","volume":"69","author":"X Wang","year":"2021","unstructured":"Wang X, Li D, Cao Y, Ho C-T, Huang Q. Biotransformation and quantification of sinensetin and its metabolites in plasma, urine, and feces of rats. J Agric Food Chem. 2021;69(47):14143\u201350.","journal-title":"J Agric Food Chem"},{"issue":"12","key":"3332_CR50","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/bmc.2717","volume":"26","author":"A Kumar","year":"2012","unstructured":"Kumar A, Devaraj V, Giri KC, Giri S, Rajagopal S, Mullangi R. Development and validation of a highly sensitive LC-MS\/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2012;26(12):1464\u201371.","journal-title":"Biomed Chromatogr"},{"issue":"1","key":"3332_CR51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/pharmaceutics10010003","volume":"10","author":"MG Elhennawy","year":"2018","unstructured":"Elhennawy MG, Lin H-S. Determination of Tangeretin in Rat Plasma: Assessment of Its Clearance and Absolute Oral Bioavailability. Pharmaceutics. 2018;10(1):3.","journal-title":"Pharmaceutics"},{"key":"3332_CR52","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jff.2013.10.006","volume":"7","author":"G-J Wei","year":"2014","unstructured":"Wei G-J, Hwang LS, Tsai C-L. Absolute bioavailability, pharmacokinetics and excretion of 5, 7, 3\u2032, 4\u2032-tetramethoxyflavone in rats. J Funct Foods. 2014;7:136\u201341.","journal-title":"J Funct Foods"},{"issue":"1","key":"3332_CR53","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jff.2008.09.003","volume":"1","author":"S Li","year":"2009","unstructured":"Li S, Pan M-H, Lo C-Y, Tan D, Wang Y, Shahidi F, et al. Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones. J Funct Foods. 2009;1(1):2\u201312.","journal-title":"J Funct Foods"},{"issue":"2","key":"3332_CR54","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1590\/1983-084X\/15_140","volume":"18","author":"EKF Batista","year":"2016","unstructured":"Batista EKF, Trindade HI, Lira SRS, Muller JBBS, Silva LLB, Batista MCS. Atividades antinociceptiva e antiinflamat\u00f3ria do extrato etan\u00f3lico de Luehea divaricata. Rev Bras Pl Med. 2016;18(2):433\u201341.","journal-title":"Rev Bras Pl Med"},{"issue":"1","key":"3332_CR55","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","volume":"51","author":"A Tj\u00f8lsen","year":"1992","unstructured":"Tj\u00f8lsen A, Berge O-G, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain. 1992;51(1):5\u201317.","journal-title":"Pain"},{"key":"3332_CR56","first-page":"18","volume":"94","author":"JC Silva","year":"2013","unstructured":"Silva JC, Lima-Saraiva S, Oliveira-Junior R, Almeida J. Modelos experimentais para avalia\u00e7\u00e3o da atividade antinociceptiva de produtos naturais: uma revis\u00e3o. Rev Bras Farm. 2013;94:18\u201323.","journal-title":"Rev Bras Farm"},{"issue":"36","key":"3332_CR57","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.15585\/mmwr.mm6736a2","volume":"67","author":"J Dahlhamer","year":"2018","unstructured":"Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, et al. Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. Centers for Disease Control and Prevention - Morbidity and Mortality Weekly Report. 2018;67(36):1001.","journal-title":"Centers for Disease Control and Prevention - Morbidity and Mortality Weekly Report"},{"issue":"1","key":"3332_CR58","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/13543784.2017.1260544","volume":"26","author":"S Groesch","year":"2017","unstructured":"Groesch S, Niederberger E, Geisslinger G. Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. Expert Opin Investig Drugs. 2017;26(1):51\u201361.","journal-title":"Expert Opin Investig Drugs"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-022-03332-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-022-03332-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-022-03332-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T14:57:20Z","timestamp":1700837840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-022-03332-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["3332"],"URL":"https:\/\/doi.org\/10.1007\/s11095-022-03332-9","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"type":"print","value":"0724-8741"},{"type":"electronic","value":"1573-904X"}],"subject":[],"published":{"date-parts":[[2022,7,13]]},"assertion":[{"value":"13 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}