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AbbVie participated in the interpretation of data, review, writing and approval of the publication. All authors declare no competing financial interest in this work. Patricia Muschong, Liang Jin, Jan Schejbal, Mario Mezler and Manuel Weinheimer are employees of AbbVie and may own AbbVie stock. Patricia Muschong and Manuel Weinheimer created the study conception and design, and drafted the manuscript. Material preparation, data collection and analysis were performed by Patricia Muschong. Proteomic data collection, analysis and interpretation were done by Liang Jin and Jan Schejbal. All authors commented on the draft, actively contributed to the final text, read and approved the final manuscript. All individuals who are listed in the Acknowledgements are employees of AbbVie or have been employees of AbbVie during the time of their contribution to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}