{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:22:46Z","timestamp":1789435366979,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s11095-023-03599-6","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T20:32:01Z","timestamp":1694550721000},"page":"2215-2228","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hollow Mesoporous Silica\u00a0Nanoparticles for Dual Chemo-starvation Therapy of Hepatocellular Carcinoma"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-8313","authenticated-orcid":false,"given":"Aftab","family":"Ullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yibang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hasnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"issue":"4","key":"3599_CR1","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1001\/jamaoncol.2016.5688","volume":"3","author":"C Fitzmaurice","year":"2017","unstructured":"Fitzmaurice C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol. 2017;3(4):524\u201348.","journal-title":"JAMA Oncol"},{"issue":"9","key":"3599_CR2","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1111\/liv.12818","volume":"35","author":"JW Park","year":"2015","unstructured":"Park JW, et al. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int. 2015;35(9):2155\u201366.","journal-title":"Liver Int"},{"issue":"5","key":"3599_CR3","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359\u201386.","journal-title":"Int J Cancer"},{"key":"3599_CR4","doi-asserted-by":"crossref","unstructured":"Llovet JM, et al. Hepatocellular carcinoma, (in eng). Nat Rev Dis Primers. 2016;2:16018.","DOI":"10.1038\/nrdp.2016.18"},{"key":"3599_CR5","doi-asserted-by":"crossref","unstructured":"Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589\u2013604.","DOI":"10.1038\/s41575-019-0186-y"},{"issue":"1","key":"3599_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/1097-0142(197501)35:1<98::AID-CNCR2820350115>3.0.CO;2-B","volume":"35","author":"VT Devita Jr","year":"1975","unstructured":"Devita VT Jr, Young RC, Canellos GP. Combination versus single agent chemotherapy: a review of the basis for selection of drug treatment of cancer. Cancer. 1975;35(1):98\u2013110.","journal-title":"Cancer"},{"issue":"1","key":"3599_CR7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","volume":"53","author":"MM Gottesman","year":"2002","unstructured":"Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med. 2002;53(1):615\u201327.","journal-title":"Annu Rev Med"},{"issue":"28","key":"3599_CR8","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1002\/adma.201301890","volume":"25","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, Wang J, Chen C. Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv Mater. 2013;25(28):3869\u201380.","journal-title":"Adv Mater"},{"issue":"4","key":"3599_CR9","doi-asserted-by":"publisher","first-page":"853","DOI":"10.4103\/0973-1482.139267","volume":"10","author":"S Rivankar","year":"2014","unstructured":"Rivankar S. An overview of doxorubicin formulations in cancer therapy. J Cancer Res Ther. 2014;10(4):853.","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"3599_CR10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.bbrc.2017.10.156","volume":"495","author":"B-L Ye","year":"2018","unstructured":"Ye B-L, Zheng R, Ruan X-J, Zheng Z-H, Cai H-J. Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53\/PRC1 pathway. Biochem Biophys Res Commun. 2018;495(1):414\u201320.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3599_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","volume":"65","author":"O Tacar","year":"2013","unstructured":"Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013;65(2):157\u201370.","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"3599_CR12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1039\/C8PY01504J","volume":"10","author":"Y Tan","year":"2019","unstructured":"Tan Y, et al. In vivo programming of tumor mitochondria-specific doxorubicin delivery by a cationic glycolipid polymer for enhanced antitumor activity. Polym Chem. 2019;10(4):512\u201325.","journal-title":"Polym Chem"},{"issue":"7","key":"3599_CR13","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0006-2952(98)00307-4","volume":"57","author":"D Gewirtz","year":"1999","unstructured":"Gewirtz D. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999;57(7):727\u201341.","journal-title":"Biochem Pharmacol"},{"issue":"17","key":"3599_CR14","doi-asserted-by":"publisher","first-page":"6454","DOI":"10.1039\/C7CS00891K","volume":"47","author":"L-H Fu","year":"2018","unstructured":"Fu L-H, Qi C, Lin J, Huang P. Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment. Chem Soc Rev. 2018;47(17):6454\u201372.","journal-title":"Chem Soc Rev"},{"issue":"28","key":"3599_CR15","doi-asserted-by":"publisher","first-page":"23528","DOI":"10.1021\/acsami.7b06814","volume":"9","author":"W Zhao","year":"2017","unstructured":"Zhao W, Hu J, Gao W. Glucose oxidase\u2013polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl Mater Interfaces. 2017;9(28):23528\u201335.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"3","key":"3599_CR16","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1021\/acsnano.8b00309","volume":"12","author":"J Zhou","year":"2018","unstructured":"Zhou J, et al. Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy. ACS Nano. 2018;12(3):2858\u201372.","journal-title":"ACS Nano"},{"issue":"5","key":"3599_CR17","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1002\/anie.201610682","volume":"56","author":"W Fan","year":"2017","unstructured":"Fan W, et al. Glucose-responsive sequential generation of hydrogen peroxide and nitric oxide for synergistic cancer starving-like\/gas therapy. Angew Chem Int Ed. 2017;56(5):1229\u201333.","journal-title":"Angew Chem Int Ed"},{"issue":"35","key":"3599_CR18","doi-asserted-by":"publisher","first-page":"10471","DOI":"10.1002\/anie.201705615","volume":"56","author":"L Liu","year":"2017","unstructured":"Liu L, et al. An electrochemical biosensor with dual signal outputs: toward simultaneous quantification of pH and O2 in the brain upon ischemia and in a tumor during cancer starvation therapy. Angew Chem Int Ed. 2017;56(35):10471\u20135.","journal-title":"Angew Chem Int Ed"},{"issue":"7494","key":"3599_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature13110","volume":"508","author":"K Birsoy","year":"2014","unstructured":"Birsoy K, et al. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014;508(7494):108\u201312.","journal-title":"Nature"},{"issue":"7715","key":"3599_CR20","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41586-018-0350-5","volume":"559","author":"D Wu","year":"2018","unstructured":"Wu D, et al. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018;559(7715):637\u201341.","journal-title":"Nature"},{"issue":"40","key":"3599_CR21","doi-asserted-by":"publisher","first-page":"16677","DOI":"10.1039\/C5NR05139H","volume":"7","author":"Q Qu","year":"2015","unstructured":"Qu Q, Ma X, Zhao Y. Targeted delivery of doxorubicin to mitochondria using mesoporous silica nanoparticle nanocarriers. Nanoscale. 2015;7(40):16677\u201386.","journal-title":"Nanoscale"},{"issue":"48","key":"3599_CR22","doi-asserted-by":"publisher","first-page":"17525","DOI":"10.1021\/jacs.7b09323","volume":"139","author":"L Sun","year":"2017","unstructured":"Sun L, et al. Real-time imaging of single-molecule enzyme cascade using a DNA origami raft. J Am Chem Soc. 2017;139(48):17525\u201332.","journal-title":"J Am Chem Soc"},{"issue":"45","key":"3599_CR23","doi-asserted-by":"publisher","first-page":"16076","DOI":"10.1021\/jacs.7b09442","volume":"139","author":"AJ Gross","year":"2017","unstructured":"Gross AJ, Chen X, Giroud F, Travelet C, Borsali R, Cosnier S. Redox-active glyconanoparticles as electron shuttles for mediated electron transfer with bilirubin oxidase in solution. J Am Chem Soc. 2017;139(45):16076\u20139.","journal-title":"J Am Chem Soc"},{"issue":"5","key":"3599_CR24","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1002\/hep.28468","volume":"63","author":"MY Koh","year":"2016","unstructured":"Koh MY, et al. A new HIF-1\u03b1\/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART 1\/HAF in mice. Hepatology. 2016;63(5):1576\u201391.","journal-title":"Hepatology"},{"issue":"1","key":"3599_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13046-016-0412-1","volume":"35","author":"L Kong","year":"2016","unstructured":"Kong L, Zhou Y, Bu H, Lv T, Shi Y, Yang J. Deletion of interleukin-6 in monocytes\/macrophages suppresses the initiation of hepatocellular carcinoma in mice. J Exp Clin Cancer Res. 2016;35(1):131.","journal-title":"J Exp Clin Cancer Res"},{"issue":"8","key":"3599_CR26","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1021\/am507443p","volume":"7","author":"X Jia","year":"2015","unstructured":"Jia X, et al. Perfluoropentane-encapsulated hollow mesoporous prussian blue nanocubes for activated ultrasound imaging and photothermal therapy of cancer. ACS Appl Mater Interfaces. 2015;7(8):4579\u201388.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"52","key":"3599_CR27","doi-asserted-by":"publisher","first-page":"12505","DOI":"10.1002\/anie.201106180","volume":"50","author":"Y Chen","year":"2011","unstructured":"Chen Y, et al. Multifunctional mesoporous composite nanocapsules for highly efficient MRI-guided high-intensity focused ultrasound cancer surgery. Angew Chem Int Ed. 2011;50(52):12505\u20139.","journal-title":"Angew Chem Int Ed"},{"issue":"22","key":"3599_CR28","doi-asserted-by":"publisher","first-page":"18560","DOI":"10.1021\/acsami.8b04394","volume":"10","author":"WJ Yang","year":"2018","unstructured":"Yang WJ, et al. Nanogel-incorporated injectable hydrogel for synergistic therapy based on sequential local delivery of combretastatin-A4 phosphate (CA4P) and doxorubicin (DOX). ACS Appl Mater Interfaces. 2018;10(22):18560\u201373.","journal-title":"ACS Appl Mater Interfaces"},{"key":"3599_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.actbio.2018.11.050","volume":"84","author":"K Chen","year":"2019","unstructured":"Chen K, et al. Stimuli-responsive polymer-doxorubicin conjugate: Antitumor mechanism and potential as nano-prodrug. Acta Biomater. 2019;84:339\u201355.","journal-title":"Acta Biomater"},{"issue":"42","key":"3599_CR30","doi-asserted-by":"publisher","first-page":"35770","DOI":"10.1021\/acsami.8b12232","volume":"10","author":"Z Duan","year":"2018","unstructured":"Duan Z, et al. PEGylated multistimuli-responsive dendritic prodrug-based nanoscale system for enhanced anticancer activity. ACS Appl Mater Interfaces. 2018;10(42):35770\u201383.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"68","key":"3599_CR31","doi-asserted-by":"publisher","first-page":"9462","DOI":"10.1039\/C8CC05180A","volume":"54","author":"W Shao","year":"2018","unstructured":"Shao W, Liu X, Sun G, Hu X-Y, Zhu J-J, Wang L. Construction of drug\u2013drug conjugate supramolecular nanocarriers based on water-soluble pillar [6] arene for combination chemotherapy. Chem Commun. 2018;54(68):9462\u20135.","journal-title":"Chem Commun"},{"issue":"25","key":"3599_CR32","doi-asserted-by":"publisher","first-page":"8005","DOI":"10.1021\/jacs.8b04400","volume":"140","author":"G Yu","year":"2018","unstructured":"Yu G, et al. Supramolecular polymer-based nanomedicine: high therapeutic performance and negligible long-term immunotoxicity. J Am Chem Soc. 2018;140(25):8005\u201319.","journal-title":"J Am Chem Soc"},{"issue":"24","key":"3599_CR33","doi-asserted-by":"publisher","first-page":"8045","DOI":"10.1021\/acs.langmuir.9b01153","volume":"35","author":"H Yao","year":"2019","unstructured":"Yao H, et al. Ultrasound and redox-triggered morphology transitions of supramolecular self-assemblies with pH responsiveness for triple-controlled release. Langmuir. 2019;35(24):8045\u201351.","journal-title":"Langmuir"},{"issue":"14","key":"3599_CR34","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1039\/C8SC00098K","volume":"9","author":"Z Yu","year":"2018","unstructured":"Yu Z, et al. A pre-protective strategy for precise tumor targeting and efficient photodynamic therapy with a switchable DNA\/upconversion nanocomposite. Chem Sci. 2018;9(14):3563\u20139.","journal-title":"Chem Sci"},{"issue":"10","key":"3599_CR35","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1021\/bm201020h","volume":"12","author":"M Bottini","year":"2011","unstructured":"Bottini M, Rosato N, Bottini N. PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromol. 2011;12(10):3381\u201393.","journal-title":"Biomacromol"},{"issue":"2","key":"3599_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1021\/bc060261j","volume":"18","author":"B Ballou","year":"2007","unstructured":"Ballou B, et al. Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem. 2007;18(2):389\u201396.","journal-title":"Bioconjug Chem"},{"issue":"12","key":"3599_CR37","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nnano.2007.387","volume":"2","author":"D Peer","year":"2007","unstructured":"Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2007;2(12):751.","journal-title":"Nat Nanotechnol"},{"key":"3599_CR38","doi-asserted-by":"crossref","unstructured":"Hossen S, Hossain MK, Basher MK, Mia MNH, Rahman MT, Uddin MJ. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: a review. J Adv Res. 2019;15:1\u201318.","DOI":"10.1016\/j.jare.2018.06.005"},{"issue":"17","key":"3599_CR39","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1039\/c3tb00021d","volume":"1","author":"J-B Fan","year":"2013","unstructured":"Fan J-B, Huang C, Jiang L, Wang S. Nanoporous microspheres: from controllable synthesis to healthcare applications. J Mater Chem B. 2013;1(17):2222\u201335.","journal-title":"J Mater Chem B"},{"issue":"20","key":"3599_CR40","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1002\/adfm.200800521","volume":"18","author":"CH Lee","year":"2008","unstructured":"Lee CH, Lo LW, Mou CY, Yang CS. Synthesis and characterization of positive-charge functionalized mesoporous silica nanoparticles for oral drug delivery of an anti-inflammatory drug. Adv Func Mater. 2008;18(20):3283\u201392.","journal-title":"Adv Func Mater"},{"issue":"5","key":"3599_CR41","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1021\/nn103130q","volume":"5","author":"MH Kim","year":"2011","unstructured":"Kim MH, et al. Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery, (in eng). ACS Nano. 2011;5(5):3568\u201376.","journal-title":"ACS Nano"},{"key":"3599_CR42","doi-asserted-by":"crossref","unstructured":"Wu M, Meng Q, Chen Y, Du Y, Zhang L, Li Y, Zhang L, Shi J. Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle\/precursor co-templating assembly and nuclear-targeted gene delivery. Adv Mater. 2015;27(2):215\u201322.","DOI":"10.1002\/adma.201404256"},{"issue":"34","key":"3599_CR43","doi-asserted-by":"publisher","first-page":"9035","DOI":"10.1002\/anie.201403817","volume":"53","author":"Y Li","year":"2014","unstructured":"Li Y, et al. Highly ordered mesoporous tungsten oxides with a large pore size and crystalline framework for H2S sensing, (in eng). Angew Chem Int Ed Engl. 2014;53(34):9035\u201340.","journal-title":"Angew Chem Int Ed Engl"},{"key":"3599_CR44","doi-asserted-by":"crossref","unstructured":"Kobler J, M\u00f6ller K, Bein T. Colloidal suspensions of functionalized mesoporous silica nanoparticles. ACS Nano. 2008;2(4):791\u20139.","DOI":"10.1021\/nn700008s"},{"key":"3599_CR45","doi-asserted-by":"crossref","unstructured":"Kobler J, Bein T. Porous Thin Films of Functionalized Mesoporous Silica Nanoparticles. ACS Nano. 2008;2(11):2324\u20132330.","DOI":"10.1021\/nn800505g"},{"issue":"6878","key":"3599_CR46","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/416304a","volume":"416","author":"S Inagaki","year":"2002","unstructured":"Inagaki S, Guan S, Ohsuna T, Terasaki O. An ordered mesoporous organosilica hybrid material with a crystal-like wall structure, (in eng). Nature. 2002;416(6878):304\u20137.","journal-title":"Nature"},{"key":"3599_CR47","doi-asserted-by":"crossref","unstructured":"Liu R, Zhao X, Wu T, Feng P. Tunable redox-responsive hybrid nanogated ensembles. J Am Chem Soc. 2008;130(44):14418\u201314419.","DOI":"10.1021\/ja8060886"},{"issue":"3","key":"3599_CR48","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/anie.201005061","volume":"50","author":"Z Luo","year":"2011","unstructured":"Luo Z, et al. Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery, (in eng). Angew Chem Int Ed Engl. 2011;50(3):640\u20133.","journal-title":"Angew Chem Int Ed Engl"},{"key":"3599_CR49","doi-asserted-by":"crossref","unstructured":"Lu N, et al. Biodegradable hollow mesoporous organosilica nanotheranostics for mild hyperthermia-induced bubble-enhanced oxygen-sensitized radiotherapy. ACS Nano. 2018;12(2):1580\u20131591.","DOI":"10.1021\/acsnano.7b08103"},{"key":"3599_CR50","doi-asserted-by":"crossref","unstructured":"Pan L, et al. Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles. J Am Chem Soc. 2012;134(13):5722\u20135725.","DOI":"10.1021\/ja211035w"},{"issue":"6","key":"3599_CR51","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/adma.201104033","volume":"24","author":"X Wang","year":"2012","unstructured":"Wang X, et al. Perfluorohexane-encapsulated mesoporous silica nanocapsules as enhancement agents for highly efficient high intensity focused ultrasound (HIFU), (in eng). Adv Mater. 2012;24(6):785\u201391.","journal-title":"Adv Mater"},{"key":"3599_CR52","doi-asserted-by":"crossref","unstructured":"Cai X, Jia X, Gao W, Zhang K, Ma M, Wang S, Zheng Y, Shi J, Chen H. A versatile nanotheranostic agent for efficient dual-mode imaging guided synergistic chemo-thermal tumor therapy. Adv Funct Mater 2015;25:2520\u20132529.","DOI":"10.1002\/adfm.201403991"},{"issue":"7","key":"3599_CR53","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.1021\/acsnano.7b02533","volume":"11","author":"SY Li","year":"2017","unstructured":"Li SY, et al. Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy, (in eng). ACS Nano. 2017;11(7):7006\u201318.","journal-title":"ACS Nano"},{"key":"3599_CR54","doi-asserted-by":"crossref","unstructured":"Chen K-J, et al. Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy, (in eng). ACS Nano 2014;8(5):5105\u20135115.","DOI":"10.1021\/nn501162x"},{"issue":"2","key":"3599_CR55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1021\/acs.bioconjchem.8b00778","volume":"30","author":"D Pei","year":"2019","unstructured":"Pei D, Buyanova M. Overcoming endosomal entrapment in drug delivery, (in eng). Bioconjug Chem. 2019;30(2):273\u201383.","journal-title":"Bioconjug Chem"},{"key":"3599_CR56","doi-asserted-by":"crossref","unstructured":"Argyo C, Weiss V, Br\u00e4uchle C, Bein T. Multifunctional mesoporous silica nanoparticles as a universal platform for drug delivery. Chem Mater. 2014;26(1):435\u2013451.","DOI":"10.1021\/cm402592t"},{"key":"3599_CR57","doi-asserted-by":"publisher","unstructured":"Chen Y-C, et al. Chemo-photothermal effects of doxorubicin\/silica\u2013carbon hollow spheres on liver cancer. RSC Adv. 2018;8(64):36775\u201336784. https:\/\/doi.org\/10.1039\/C8RA08538B.","DOI":"10.1039\/C8RA08538B"},{"key":"3599_CR58","doi-asserted-by":"crossref","unstructured":"Yu Z, Zhou P, Pan W, Li N, Tang B. A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis. Nat Commun. 2018;9(1):5044.","DOI":"10.1038\/s41467-018-07197-8"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-023-03599-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-023-03599-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-023-03599-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:06:30Z","timestamp":1696352790000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-023-03599-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["3599"],"URL":"https:\/\/doi.org\/10.1007\/s11095-023-03599-6","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"27 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interest. The authors declare no competing\/financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}