{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:11:09Z","timestamp":1741237869535,"version":"3.38.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["No.2020YFE0201700"],"award-info":[{"award-number":["No.2020YFE0201700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenyang Leading the Charge with Open Competition Program","award":["No.22101012"],"award-info":[{"award-number":["No.22101012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11095-025-03821-7","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:42:12Z","timestamp":1738100532000},"page":"401-412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Tylvalosin Tartrate Enteric Amorphous Pellets Prepared by Liquid Layering"],"prefix":"10.1007","volume":"42","author":[{"given":"Haoran","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Gou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-9901","authenticated-orcid":false,"given":"Xing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"3821_CR1","doi-asserted-by":"crossref","unstructured":"Gaynor M, Mankin AS. Macrolide antibiotics: binding site, mechanism of action, resistance. Curr Top Med Chem. 2003 2003\u201301\u201320;3(9):949\u201361.","DOI":"10.2174\/1568026033452159"},{"issue":"3","key":"3821_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ijantimicag.2017.05.020","volume":"51","author":"B Arsic","year":"2018","unstructured":"Arsic B, Barber J, \u010ciko\u0161 A, Mladenovic M, Stankovic N, Novak P. 16-membered macrolide antibiotics: a review. Int J Antimicrob Ag. 2018;51(3):283\u201398.","journal-title":"Int J Antimicrob Ag"},{"issue":"11","key":"3821_CR3","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.7164\/antibiotics.33.1300","volume":"33","author":"R Okamoto","year":"1980","unstructured":"Okamoto R, Fukumoto T, Nomura H, Kiyoshima K, Nakamura K, Takamatsu A, et al. Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation. J Antibiot. 1980;33(11):1300\u20138.","journal-title":"J Antibiot"},{"issue":"No1","key":"3821_CR4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1637\/0005-2086(2002)046[0215:IVASOF]2.0.CO;2","volume":"46","author":"RO Cerd\u00e1","year":"2002","unstructured":"Cerd\u00e1 RO, Giacoboni GI, Xavier JA, Sansalone PL, Landoni MF. In vitro antibiotic susceptibility of field isolates of Mycoplasma synoviae in Argentina. Avian Dis. 2002;46(No1):215\u20138.","journal-title":"Avian Dis."},{"issue":"1","key":"3821_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rvsc.2005.02.004","volume":"80","author":"M Pringle","year":"2006","unstructured":"Pringle M, Land\u00e9n A, Franklin A. Tiamulin resistance in porcine Brachyspira pilosicoli isolates. Res Vet Sci. 2006;80(1):1\u20134.","journal-title":"Res Vet Sci"},{"key":"3821_CR6","doi-asserted-by":"crossref","unstructured":"Inamoto T, Kikuchi K, Iijima H, Kawashima Y, Nakai Y, Ogimoto K. Antibacterial activity of tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumoniae isolated from pneumonic lesions in swine. J Vet Med Sci. 1994 1994\u201310\u201301;56(5):917\u201321.","DOI":"10.1292\/jvms.56.917"},{"key":"3821_CR7","doi-asserted-by":"crossref","unstructured":"Lopez Rodriguez A, Berge AC, Ramage C, Saltzman R, Domangue RJ, Gnozzio MJ, et al. Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigs. Porcine Health Manag. 2020;6(1).","DOI":"10.1186\/s40813-020-00177-9"},{"key":"3821_CR8","doi-asserted-by":"crossref","unstructured":"Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C, Asano K. Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics. Mediat Inflamm. 2012 2012\u201301\u201301;2012:584217\u201362.","DOI":"10.1155\/2012\/584262"},{"key":"3821_CR9","doi-asserted-by":"crossref","unstructured":"Dhindwal P, Myziuk I, Ruzzini A. Macrolide esterases: current threats and opportunities. Trends Microbiol (Regular ed.). 2023 2023\u201301\u201301;31(12):1199\u2013201.","DOI":"10.1016\/j.tim.2023.08.008"},{"issue":"2","key":"3821_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0928-0987(93)90019-7","volume":"1","author":"M Skinner","year":"1993","unstructured":"Skinner M, Taylor RB, Kanfer I. The pH-stability and acid degradation of the macrolide antibiotic, josamycin. Eur J Pharm Sci. 1993;1(2):61\u201372.","journal-title":"Eur J Pharm Sci"},{"key":"3821_CR11","volume-title":"Preliminary study on influence factors of Acetylisovaleryltylosin Tarate oral bioavailability","author":"L Liu","year":"2015","unstructured":"Liu L. Preliminary study on influence factors of Acetylisovaleryltylosin Tarate oral bioavailability. Nanjing: Nanjing Agricultural University; 2015."},{"key":"3821_CR12","unstructured":"Dalvadi H, Patel JK. Chronpharmaceutics, pulsatile drug delivery system as current trend. Asian J Pharm Sci. 2010(No.5):207\u201330."},{"key":"3821_CR13","doi-asserted-by":"crossref","unstructured":"Patel H, Gohel M. A Review on enteric coated pellets composed of core pellets prepared by extrusion-spheronization. Recent Patents Drug Deliv Formulation. 2019 2019\u201301\u201301;13(2):83.","DOI":"10.2174\/1872211313666190212115139"},{"key":"3821_CR14","doi-asserted-by":"crossref","unstructured":"Bikiaris DN. Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 2011 2011\u201311\u201301;8(11):1501\u201319.","DOI":"10.1517\/17425247.2011.618181"},{"key":"3821_CR15","doi-asserted-by":"crossref","unstructured":"Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007 2007\u201301\u201301;12(23):1068\u201375.","DOI":"10.1016\/j.drudis.2007.09.005"},{"key":"3821_CR16","doi-asserted-by":"crossref","unstructured":"H\u00f6rter D, Dressman JB. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv Drug Deliver Rev. 1997 1997\u201301\u201301;25(1):3\u201314.","DOI":"10.1016\/S0169-409X(96)00487-5"},{"key":"3821_CR17","doi-asserted-by":"crossref","unstructured":"Moseson DE, Taylor LS. Crystallinity: a complex critical quality attribute of amorphous solid dispersions. Mol Pharmaceut. 2023 2023\u201301\u201301;20(10):4802\u201325.","DOI":"10.1021\/acs.molpharmaceut.3c00526"},{"key":"3821_CR18","doi-asserted-by":"crossref","unstructured":"Pisay M, Padya S, Mutalik S, Koteshwara KB. Stability challenges of amorphous solid dispersions of drugs: a critical review on mechanistic aspects. Crit Rev Ther Drug Carrier Syst. 2024 2024\u201301\u201320;41(3):45\u201394.","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2023039877"},{"key":"3821_CR19","doi-asserted-by":"crossref","unstructured":"Zhang HJ, Chiang CW, Maschmeyer-Tombs T, Conklin B, Napolitano JG, Lubach JW, et al. Generality of enhancing the dissolution rates of free acid amorphous solid dispersions by the incorporation of sodium hydroxide. Mol Pharmaceut. 2024 2024\u201301\u201301;21(7):3395\u2013406.","DOI":"10.1021\/acs.molpharmaceut.4c00118"},{"key":"3821_CR20","doi-asserted-by":"crossref","unstructured":"Pandi P, Bulusu R, Kommineni N, Khan W, Singh M. Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products. Int J Pharmaceut. 2020 2020\u201301\u201301;586:119560.","DOI":"10.1016\/j.ijpharm.2020.119560"},{"issue":"6","key":"3821_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.102676","volume":"102","author":"J Cao","year":"2023","unstructured":"Cao J, Zhang S, Hao Y, Fan K, Wang L, Zhao X, et al.. Amorphous solid dispersion preparation via coprecipitation improves the dissolution, oral bioavailability, and intestinal health enhancement properties of magnolol. Poultry sci. 2023;102(6): 102676.","journal-title":"Poultry sci"},{"issue":"2","key":"3821_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ejpb.2007.02.008","volume":"67","author":"K Sigfridsson","year":"2007","unstructured":"Sigfridsson K, Forss\u00e9n S, Holl\u00e4nder P, Skantze U, de Verdier J. A formulation comparison, using a solution and different nanosuspensions of a poorly soluble compound. Eur J Pharm Biopharm. 2007;67(2):540\u20137.","journal-title":"Eur J Pharm Biopharm"},{"key":"3821_CR23","doi-asserted-by":"crossref","unstructured":"Liu C, Liu Z, Chen Y, Chen Z, Chen H, Pui Y, et al. Oral bioavailability enhancement of beta-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion. Eur J Pharm Biopharm. 2018 2018\u201303\u201301;124:73\u201381.","DOI":"10.1016\/j.ejpb.2017.12.016"},{"key":"3821_CR24","doi-asserted-by":"crossref","unstructured":"Tomar D, Singh PK, Hoque S, Modani S, Sriram A, Kumar R, et al. Amorphous systems for delivery of nutraceuticals: challenges opportunities. Crit Rev Food Sci Nutr. 2022 2022\u201301\u201320;62(5):1204\u201321.","DOI":"10.1080\/10408398.2020.1836607"},{"key":"3821_CR25","doi-asserted-by":"crossref","unstructured":"Nunes PD, Ferreira AF, Pinto JF, Bauer-Brandl A, Brandl M, Henriques J, et al. In vitro dissolution\/permeation tools for amorphous solid dispersions bioavailability forecasting II: Comparison and mechanistic insights. Eur J Pharm Sci. 2023 2023\u201301\u201301;188:106513.","DOI":"10.1016\/j.ejps.2023.106513"},{"key":"3821_CR26","doi-asserted-by":"crossref","unstructured":"Puccetti M, Giovagnoli S, Zelante T, Romani L, Ricci M. Development of Novel Indole-3-Aldehyde-Loaded Gastro-Resistant Spray-Dried Microparticles for Postbiotic Small Intestine Local Delivery. J Pharm Sci. 2018 2018\u201309\u201301;107(9):2341\u201353.","DOI":"10.1016\/j.xphs.2018.04.023"},{"key":"3821_CR27","doi-asserted-by":"crossref","unstructured":"Kim YI, Pradhan R, Paudel BK, Choi JY, Im HT, Kim JO. Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater. Arch Pharm Res. 2015 2015\u201312\u201301;38(12):2163\u201371.","DOI":"10.1007\/s12272-015-0590-y"},{"key":"3821_CR28","doi-asserted-by":"crossref","unstructured":"Ahn S, Lee Y, Kwak H. Physicochemical and sensory properties of milk supplemented with lactase microcapsules coated with enteric coating materials. J Dairy Sci. 2019 2019\u201301\u201301;102(8):6959\u201370.","DOI":"10.3168\/jds.2018-15865"},{"key":"3821_CR29","doi-asserted-by":"crossref","unstructured":"Ding Q, Chen K, Liu X, Ding C, Zhao Y, Sun S, et al. Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway. Biomed Pharmacother. 2022 2022\u201301\u201301;152:113242.","DOI":"10.1016\/j.biopha.2022.113242"},{"key":"3821_CR30","doi-asserted-by":"crossref","unstructured":"Thoma K, Bechtold K. Influence of aqueous coatings on the stability of enteric coated pellets and tablets. Eur J Pharm Biopharm. 1999 1999\u201301\u201301;47(1):39\u201350.","DOI":"10.1016\/S0939-6411(98)00086-1"},{"key":"3821_CR31","first-page":"P491","volume":"2","author":"W Yan","year":"2015","unstructured":"Yan W, Yulong MA, Lin MA, Xuan C, Sun R, Min W, et al. Study on microbial degradation pathway and products of tylosin residue in pharmaceutical waste. Acta Scientiae Circumstantiae. 2015;2:P491-8.","journal-title":"Acta Scientiae Circumstantiae."},{"issue":"12","key":"3821_CR32","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1007\/s11095-023-03547-4","volume":"40","author":"M Bookwala","year":"2023","unstructured":"Bookwala M, Wildfong PLD. The Implications of Drug-Polymer Interactions on the Physical Stability of Amorphous Solid Dispersions. PHARM RES-DORDR. 2023;40(12):2963\u201381.","journal-title":"PHARM RES-DORDR"},{"key":"3821_CR33","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ijpharm.2018.11.063","volume":"555","author":"S Zhang","year":"2019","unstructured":"Zhang S, Lee TWY, Chow AHL. Thermodynamic and kinetic evaluation of the impact of polymer excipients on storage stability of amorphous itraconazole. Int J Pharmaceut. 2019;555:394\u2013403.","journal-title":"Int J Pharmaceut"},{"key":"3821_CR34","unstructured":"Bodmeier R, Paeratakul O. Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms. Pharm Res-Dordr. 1994 1994\u201301\u201301;11(6):882\u20138."},{"key":"3821_CR35","doi-asserted-by":"crossref","unstructured":"Yan L. Entropy favors heterogeneous structures of networks near the rigidity threshold. Nat Commun. 2018 2018\u201304\u201310;9(1):1359.","DOI":"10.1038\/s41467-018-03859-9"},{"key":"3821_CR36","doi-asserted-by":"crossref","unstructured":"Yang R, Wang D, Li H, He Y, Zheng X, Yuan M, et al. Preparation and characterization of bletilla striata polysaccharide\/polylactic acid composite. Molecules (Basel, Switzerland). 2019 2019\u201301\u201301;24(11):2104.","DOI":"10.3390\/molecules24112104"},{"key":"3821_CR37","doi-asserted-by":"crossref","unstructured":"Sharma P, Denny WA, Garg S. Effect of wet milling process on the solid state of indomethacin and simvastatin. Int J Pharm. 2009 2009\u201310\u201301;380(1\u20132):40\u20138.","DOI":"10.1016\/j.ijpharm.2009.06.029"},{"key":"3821_CR38","doi-asserted-by":"crossref","unstructured":"Liu P, Rong X, Laru J, van Veen B, Kiesvaara J, Hirvonen J, et al. Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling. Int J Pharmaceut. 2011 2011\u201301\u201301;411(1):215\u201322.","DOI":"10.1016\/j.ijpharm.2011.03.050"},{"key":"3821_CR39","doi-asserted-by":"crossref","unstructured":"Mirank\u00f3 M, Trif L, T\u00f3th J, Feczk\u00f3 T. Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in amorphous polymer matrix prepared by nano spray drying. Adv Powder Technol. 2021 2021\u201301\u201301;32(7):2621\u201333.","DOI":"10.1016\/j.apt.2021.05.037"},{"key":"3821_CR40","unstructured":"Saeedi M, Akbari J, Morteza-Semnani K, Khanalipoor N. Preparation and characterization of piroxicam solid dispersion using PEG4000 and tween 40. J Mazandaran Univ Med Sci. 2015;24(No.122):1\u201311."},{"key":"3821_CR41","doi-asserted-by":"crossref","unstructured":"Raina SA, Alonzo DE, Zhang GG, Gao Y, Taylor LS. Impact of polymers on the crystallization and phase transition kinetics of amorphous nifedipine during dissolution in aqueous media. Mol Pharm. 2014 2014\u201310\u201306;11(10):3565\u201376.","DOI":"10.1021\/mp500333v"},{"key":"3821_CR42","doi-asserted-by":"crossref","unstructured":"Tambe S, Jain D, Meruva SK, Rongala G, Juluri A, Nihalani G, et al. Recent advances in amorphous solid dispersions: Preformulation, formulation strategies, technological advancements and characterization. Pharmaceutics. 2022 2022\u201310\u201316;14(10).","DOI":"10.3390\/pharmaceutics14102203"},{"issue":"1","key":"3821_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0169-409X(01)00098-9","volume":"48","author":"L Yu","year":"2001","unstructured":"Yu L. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Adv Drug Deliver Rev. 2001;48(1):27\u201342.","journal-title":"Adv Drug Deliver Rev"},{"key":"3821_CR44","doi-asserted-by":"crossref","unstructured":"Craig D. The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems. Int J Pharmaceut. 1999 1999\u201303\u201315;179(2):179\u2013207.","DOI":"10.1016\/S0378-5173(98)00338-X"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-025-03821-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-025-03821-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-025-03821-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T08:54:38Z","timestamp":1741164878000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-025-03821-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3821"],"URL":"https:\/\/doi.org\/10.1007\/s11095-025-03821-7","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"type":"print","value":"0724-8741"},{"type":"electronic","value":"1573-904X"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"9 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}]}}