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The molecular docking study targeting the sterol 14\u03b1-demethylase (CYP51) enzyme of the pathogenic yeast <jats:italic>Candida albicans<\/jats:italic> was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>DSC results indicated compatibility between co-crystal and six tested excipients: lactose monohydrate, polyvinylpyrrolidone K90, microcrystalline cellulose, corn starch, colloidal silicon dioxide, and talc. In the case of the co-crystal and magnesium stearate mixture, DSC revealed a change in the thermal behavior, suggesting the formation of a eutectic system. However, TGA demonstrated that the decomposition profile of the co-crystal remained unaffected in all binary mixtures. PXRD and FT-IR further confirmed the absence of chemical interactions between the co-crystal and all excipients under ambient conditions. Moreover, the KTZ-AA co-crystal maintained its chemical stability without degradation after three months storage under accelerated conditions (40\u00b0C\/75% RH). The molecular docking study demonstrated that co-crystallization of KTZ with AA enhances its binding affinity to CYP51 enzyme compared to KTZ alone.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The excipient compatibility study conducted on the Ketoconazole-Adipic Acid co-crystal confirmed its potential for development as a solid oral dosage form with improved antifungal activity, presenting a promising alternative to the parent drug.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11095-025-03910-7","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T16:44:39Z","timestamp":1757004279000},"page":"1603-1616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmaceutical Co-crystal of Ketoconazole-adipic Acid: Excipient Compatibility and In Silico Antifungal Potential Studies"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-9735","authenticated-orcid":false,"given":"Flavia","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-2417","authenticated-orcid":false,"given":"Maria","family":"Miclaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-2534","authenticated-orcid":false,"given":"Ana Maria Raluca","family":"Gherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-229X","authenticated-orcid":false,"given":"Monica","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-2790","authenticated-orcid":false,"given":"Ioana","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-3793","authenticated-orcid":false,"given":"Xenia","family":"Filip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-0543","authenticated-orcid":false,"given":"Irina","family":"Kacso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"5","key":"3910_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3390\/pharmaceutics12050393","volume":"12","author":"J van der Merwe","year":"2020","unstructured":"van der Merwe J, Steenekamp J, Steyn D, Hamman J. 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