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To regulate this release, the diffusion barrier provided by the matrix material \u2013 typically hydrolytically degradable polyesters \u2013 must be controlled through precise levels of matrix porosity. This mini-review presents processing methods that are alternatives to the most common batch emulsification techniques for the manufacturing of porous polymer particles. A focus is placed on mechanistically describing the particle and pore formation in droplet-based microfluidics, electrospraying, and by supercritical fluids, critically discussing their opportunities and challenges. Ultimately, this review assesses the potential of these techniques in advancing the engineering of porous polymeric carrier systems in the light of scale-up and continuous production.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s11095-025-03923-2","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:23:35Z","timestamp":1757607815000},"page":"1461-1480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Alternative Techniques for Porous Microparticle Production: Electrospraying, Microfluidics, and Supercritical CO2"],"prefix":"10.1007","volume":"42","author":[{"given":"Simon","family":"P\u00f6ttgen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-9033","authenticated-orcid":false,"given":"Christian","family":"Wischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"3923_CR1","doi-asserted-by":"publisher","unstructured":"Marquina S, Ozgul M, Robertson-Brown K, Kenney MC. 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