{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:14:54Z","timestamp":1791519294881,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11095-026-04019-1","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:10:54Z","timestamp":1768507854000},"page":"927-939","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Cocrystal of Quercetagetin: In vitro and in vivo Insights into Biopharmaceutical Performance"],"prefix":"10.1007","volume":"43","author":[{"given":"Smita","family":"Suryawanshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Shaligram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh G.","family":"Gonnade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-5200","authenticated-orcid":false,"given":"Sharvil","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"4019_CR1","first-page":"1071","volume":"26","author":"A Phrutivorapongkul","year":"2013","unstructured":"Phrutivorapongkul A, Kiattisin K, Jantrawut P, Chansakaow S, Vejabhikul S, Leelapornpisid P. Appraisal of biological activities and identification of phenolic compound of African marigold (Tagetes erecta) flower extract. Pak J Pharm Sci. 2013;26:1071\u20136.","journal-title":"Pak J Pharm Sci"},{"key":"4019_CR2","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1007\/s13197-016-2228-6","volume":"53","author":"W Wang","year":"2016","unstructured":"Wang W, Xu H, Chen H, Tai K, Liu F, Gao Y. In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues. J Food Sci Technol. 2016;53:2614\u201324.","journal-title":"J Food Sci Technol"},{"key":"4019_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10534-023-00539-0","volume":"37","author":"A Alvi","year":"2024","unstructured":"Alvi A, Alqassim S, Khan NA, Khatoon B, Akbar N, Kawish M, et al. Antibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticles. BioMetals. 2024;37:171\u201384. https:\/\/doi.org\/10.1007\/s10534-023-00539-0.","journal-title":"BioMetals"},{"key":"4019_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4062\/biomolther.2013.001","volume":"21","author":"GJ Kang","year":"2013","unstructured":"Kang GJ, Han SC, Ock JW, Kang HK, Yoo ES. Anti-inflammatory effect of quercetagetin, an active component of immature Citrus unshiu, in HaCaT human keratinocytes. Biomol Ther Seoul. 2013;21:138\u201345.","journal-title":"Biomol Ther Seoul"},{"key":"4019_CR5","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.intimp.2010.05.012","volume":"10","author":"G Guti\u00e9rrez-Venegas","year":"2010","unstructured":"Guti\u00e9rrez-Venegas G, Bando-Campos CG. The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes. Int Immunopharmacol. 2010;10:1003\u20139. https:\/\/doi.org\/10.1016\/j.intimp.2010.05.012.","journal-title":"Int Immunopharmacol"},{"key":"4019_CR6","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s11010-022-04628-5","volume":"478","author":"T Mustafa","year":"2023","unstructured":"Mustafa T, Khan I, Iqbal H, Usman S, Naeem N, Faizi S, et al. Rutin and quercetagetin enhance the regeneration potential of young and aging bone marrow-derived mesenchymal stem cells in the rat infarcted myocardium. Mol Cell Biochem. 2023;478:1759\u201370. https:\/\/doi.org\/10.1007\/s11010-022-04628-5.","journal-title":"Mol Cell Biochem"},{"key":"4019_CR7","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.fitote.2011.12.013","volume":"83","author":"Y Gong","year":"2012","unstructured":"Gong Y, Liu X, He WH, Xu HG, Yuan F, Gao YX. Investigation into the antioxidant activity and chemical composition of alcoholic extracts from defatted marigold (Tagetes erecta L.) residue. Fitoterapia. 2012;83:481\u20139. https:\/\/doi.org\/10.1016\/j.fitote.2011.12.013.","journal-title":"Fitoterapia"},{"key":"4019_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102579","author":"JJ Alvarado-Sansininea","year":"2018","unstructured":"Alvarado-Sansininea JJ, S\u00e1nchez-S\u00e1nchez L, L\u00f3pez-Mu\u00f1oz H, Escobar ML, Flores-Guzm\u00e1n F, Tavera-Hern\u00e1ndez R, et al. Quercetagetin and patuletin: antiproliferative, necrotic and apoptotic activity in tumor cell lines. Molecules. 2018. https:\/\/doi.org\/10.3390\/molecules23102579.","journal-title":"Molecules"},{"key":"4019_CR9","doi-asserted-by":"publisher","first-page":"9399","DOI":"10.1093\/nar\/gku632","volume":"42","author":"A Ahmed-Belkacem","year":"2014","unstructured":"Ahmed-Belkacem A, Guichou JF, Brillet R, Ahnou N, Hernandez E, Pallier C, et al. Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res. 2014;42:9399\u2013409.","journal-title":"Nucleic Acids Res"},{"key":"4019_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.antiviral.2016.07.009","volume":"133","author":"R Lani","year":"2016","unstructured":"Lani R, Hassandarvish P, Shu MH, Phoon WH, Chu JJH, Higgs S, et al. Antiviral activity of selected flavonoids against Chikungunya virus. Antiviral Res. 2016;133:50\u201361. https:\/\/doi.org\/10.1016\/j.antiviral.2016.07.009.","journal-title":"Antiviral Res"},{"key":"4019_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113869","volume":"270","author":"Z Wang","year":"2021","unstructured":"Wang Z, Yang L. Chinese herbal medicine: fighting SARS-CoV-2 infection on all fronts. J Ethnopharmacol. 2021;270:113869. https:\/\/doi.org\/10.1016\/j.jep.2021.113869.","journal-title":"J Ethnopharmacol"},{"key":"4019_CR12","doi-asserted-by":"publisher","first-page":"7441","DOI":"10.1021\/acs.jafc.8b01046","volume":"66","author":"S Chen","year":"2018","unstructured":"Chen S, Sun C, Wang Y, Han Y, Dai L, Abliz A, et al. Quercetagetin-loaded composite nanoparticles based on zein and hyaluronic acid: formation, characterization, and physicochemical stability. J Agric Food Chem. 2018;66:7441\u201350.","journal-title":"J Agric Food Chem"},{"key":"4019_CR13","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1021\/acs.cgd.9b00294","volume":"19","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Li D, Luo C, Huang C, Qiu R, Deng Z, et al. Cocrystals of Natural Products: Improving the Dissolution Performance of Flavonoids Using Betaine. Cryst Growth Des. 2019;19:3851\u20139.","journal-title":"Cryst Growth Des"},{"key":"4019_CR14","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1021\/acs.cgd.6b00142","volume":"16","author":"H He","year":"2016","unstructured":"He H, Huang Y, Zhang Q, Wang JR, Mei X. Zwitterionic cocrystals of flavonoids and proline: solid-state characterization, pharmaceutical properties, and pharmacokinetic performance. Cryst Growth Des. 2016;16:2348\u201356.","journal-title":"Cryst Growth Des"},{"key":"4019_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.126034","volume":"683","author":"C Pan","year":"2025","unstructured":"Pan C. Multimodal characterization and density functional theory insights into the molecular structure and intermolecular interactions of the Aspirin\u2013Ligustrazine cocrystal. Int J Pharm. 2025;683:126034. https:\/\/doi.org\/10.1016\/j.ijpharm.2025.126034.","journal-title":"Int J Pharm"},{"key":"4019_CR16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.molstruc.2016.10.034","volume":"1130","author":"YN Zhang","year":"2017","unstructured":"Zhang YN, Yin HM, Zhang Y, Zhang DJ, Su X, Kuang HX. Cocrystals of kaempferol, quercetin and myricetin with 4,4\u2032-bipyridine: crystal structures, analyses of intermolecular interactions and antibacterial properties. J Mol Struct [Internet]. 2017;1130:199\u2013207. https:\/\/doi.org\/10.1016\/j.molstruc.2016.10.034.","journal-title":"J Mol Struct [Internet]"},{"key":"4019_CR17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.5c00662","author":"JG de Oliveira Neto","year":"2025","unstructured":"de Oliveira Neto JG, Ramos MC, Lima ADSG, Nogueira CES, Ayala AP, Souto EB, et al. A synergistic approach to a novel nicotinamide\u2013tridecanoic acid cocrystal: crystallization, properties, computational insights, and antibacterial activity. Cryst Growth Des. 2025. https:\/\/doi.org\/10.1021\/acs.cgd.5c00662.","journal-title":"Cryst Growth Des"},{"key":"4019_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ijpharm.2014.07.008","volume":"473","author":"Y Maeno","year":"2014","unstructured":"Maeno Y, Fukami T, Kawahata M, Yamaguchi K, Tagami T, Ozeki T, et al. Novel pharmaceutical cocrystal consisting of paracetamol and trimethylglycine, a new promising cocrystal former. Int J Pharm. 2014;473:179\u201386. https:\/\/doi.org\/10.1016\/j.ijpharm.2014.07.008.","journal-title":"Int J Pharm"},{"key":"4019_CR19","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s12192-019-01022-x","volume":"24","author":"F Kar","year":"2019","unstructured":"Kar F, Hacioglu C, Kacar S, Sahinturk V, Kanbak G. Betaine suppresses cell proliferation by increasing oxidative stress\u2013mediated apoptosis and inflammation in DU-145 human prostate cancer cell line. Cell Stress Chaperones. 2019;24:871\u201381.","journal-title":"Cell Stress Chaperones"},{"key":"4019_CR20","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1021\/mp200209j","volume":"8","author":"AJ Smith","year":"2011","unstructured":"Smith AJ, Kavuru P, Wojtas L, Zaworotko MJ, Shytle RD. Cocrystals of quercetin with improved solubility and oral bioavailability. Mol Pharm. 2011;8:1867\u201376.","journal-title":"Mol Pharm"},{"key":"4019_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110611","volume":"185","author":"GV Bonde","year":"2020","unstructured":"Bonde GV, Ajmal G, Yadav SK, Mittal P, Singh J, Bakde BV, et al. Assessing the viability of Soluplus\u00ae self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): optimisation and in-vitro characterisation. Colloids Surf B Biointerfaces. 2020;185:110611. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.110611.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"4019_CR22","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1007\/s11095-023-03533-w","volume":"40","author":"H Guo","year":"2023","unstructured":"Guo H, Liu S, Sun CC. Modulating pharmaceutical properties of berberine chloride through cocrystallization with benzendiol isomers. Pharm Res. 2023;40:2791\u2013800. https:\/\/doi.org\/10.1007\/s11095-023-03533-w.","journal-title":"Pharm Res"},{"key":"4019_CR23","unstructured":"Bruker. SAINT: Data Reduction Software. Madison (WI): Bruker AXS Inc.; 2012."},{"key":"4019_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S1600576714022985","volume":"48","author":"L Krause","year":"2015","unstructured":"Krause L, Herbst-Irmer R, Sheldrick GM, Stalke D. Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination. J Appl Crystallogr. 2015;48:3\u201310.","journal-title":"J Appl Crystallogr"},{"key":"4019_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053273314026370","volume":"71","author":"GM Sheldrick","year":"2015","unstructured":"Sheldrick GM. SHELXT - Integrated space-group and crystal-structure determination. Acta Crystallogr Sect A Found Crystallogr. 2015;71:3\u20138.","journal-title":"Acta Crystallogr Sect A Found Crystallogr"},{"key":"4019_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"GM Sheldrick","year":"2015","unstructured":"Sheldrick GM. Crystal structure refinement with SHELXL. Acta Crystallogr Sect C Struct Chem. 2015;71:3\u20138.","journal-title":"Acta Crystallogr Sect C Struct Chem"},{"key":"4019_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ejps.2016.04.030","volume":"89","author":"R Serrano","year":"2016","unstructured":"Serrano R, Persoons T, D\u2019Arcy M, Galiana C, Dea-Ayuela A, Healy M. Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine\/4-aminosalicylic acid cocrystals. Eur J Pharm Sci. 2016;89:125\u201336. https:\/\/doi.org\/10.1016\/j.ejps.2016.04.030.","journal-title":"Eur J Pharm Sci"},{"key":"4019_CR28","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1007\/s11095-023-03532-x","volume":"40","author":"K Shi","year":"2023","unstructured":"Shi K, Li M. Optimisation of pharmaceutical cocrystal dissolution performance through a synergistic precipitation inhibition. Pharm Res. 2023;40:2051\u201369. https:\/\/doi.org\/10.1007\/s11095-023-03532-x.","journal-title":"Pharm Res"},{"key":"4019_CR29","doi-asserted-by":"publisher","unstructured":"Guner G, Amjad A, Berrios M, Kannan M, Bilgili E. Nanoseeded desupersaturation and dissolution tests for elucidating supersaturation maintenance in amorphous solid dispersions. Pharmaceutics. 2023;15(2):450. https:\/\/doi.org\/10.3390\/pharmaceutics15020450.","DOI":"10.3390\/pharmaceutics15020450"},{"key":"4019_CR30","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.31788\/RJC.2021.1446373","volume":"14","author":"D Kishore","year":"2021","unstructured":"Kishore D, Prasad S, Darapureddy C, Phani H. Development and validation of a new HPLC bioanalytical internal standard method for the analysis of remdesivirin human plasma. Rasayan J Chem. 2021;14:2639\u201344.","journal-title":"Rasayan J Chem"},{"key":"4019_CR31","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3109\/03639045.2015.1096281","volume":"42","author":"M Ullah","year":"2016","unstructured":"Ullah M, Hussain I, Sun C. The development of carbamazepine-succinic acid cocrystal tablet formulations with improved in vitro and in vivo performance. Drug Dev Ind Pharm. 2016;42:969\u201376.","journal-title":"Drug Dev Ind Pharm"},{"key":"4019_CR32","doi-asserted-by":"crossref","unstructured":"Athiyah U, Kusuma PA, Tutik, Lestari MLAD, Isadiartuti D, Paramita DP, et al. Crystal engineering of quercetin by liquid assisted grinding method. J Teknol. 2019;81:39\u201345.","DOI":"10.11113\/jt.v81.12639"},{"key":"4019_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103491","volume":"74","author":"VD Vemuri","year":"2022","unstructured":"Vemuri VD, Lankalapalli S, Chandra Reddy Guntaka P. Posaconazole-amino acid cocrystals for improving solubility and oral bioavailability while maintaining antifungal activity and low in vivo toxicity. J Drug Deliv Sci Technol. 2022;74:103491. https:\/\/doi.org\/10.1016\/j.jddst.2022.103491.","journal-title":"J Drug Deliv Sci Technol"},{"key":"4019_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105671","volume":"96","author":"V. Oliveira","year":"2024","unstructured":"Oliveira V., Aguiar S, Siebel M, M\u00fcller G, Lerin A, Botti G, et al. Synthesis of naringenin-betaine cocrystal by gas antisolvent technique and cell models for in vitro permeation studies. J Drug Deliv Sci Technol. 2024;96:105671. https:\/\/doi.org\/10.1016\/j.jddst.2024.105671.","journal-title":"J Drug Deliv Sci Technol"},{"key":"4019_CR35","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jpba.2016.10.020","volume":"134","author":"R Chadha","year":"2017","unstructured":"Chadha R, Bhalla Y, Nandan A, Chadha K, Karan M. Chrysin cocrystals: characterization and evaluation. J Pharm Biomed Anal. 2017;134:361\u201371. https:\/\/doi.org\/10.1016\/j.jpba.2016.10.020.","journal-title":"J Pharm Biomed Anal"},{"key":"4019_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106093","volume":"100","author":"A Elshahat","year":"2024","unstructured":"Elshahat A, Hasan AA, Elghamry HA, Balata GF. Formulation and optimization of olanzapine-carboxylic acid cocrystals orodispersible tablets: in-vitro\/ in-vivo study. J Drug Deliv Sci Technol. 2024;100:106093. https:\/\/doi.org\/10.1016\/j.jddst.2024.106093.","journal-title":"J Drug Deliv Sci Technol"},{"key":"4019_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/cryst9070367","author":"P Yang","year":"2019","unstructured":"Yang P, Qin C, Du S, Jia L, Qin Y, Gong J, et al. Crystal structure, stability and desolvation of the solvates of sorafenib tosylate. Crystals. 2019. https:\/\/doi.org\/10.3390\/cryst9070367.","journal-title":"Crystals"},{"key":"4019_CR38","doi-asserted-by":"crossref","unstructured":"Kogawa AC, Gutierrez Antonio S. Characterization of Darunavir:  \u03b2-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate. J Pharm Sci Emerg Drugs. 2016;4:1\u20136.","DOI":"10.4172\/2380-9477.1000110"},{"key":"4019_CR39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/jps.10508","volume":"93","author":"C Nunes","year":"2004","unstructured":"Nunes C, Han J, Monkhouse DC, Suryanarayanan R. Preformulation studies to meet the challenges in the manufacture of betaine solid dosage form. J Pharm Sci. 2004;93:38\u201347.","journal-title":"J Pharm Sci"},{"key":"4019_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0040-6031(02)00087-4","volume":"392\u2013393","author":"EM Da Costa","year":"2002","unstructured":"Da Costa EM, Barbosa Filho JM, Do Nascimento TG, Mac\u00eado RO. Thermal characterization of the quercetin and rutin flavonoids. Thermochim Acta. 2002;392\u2013393:79\u201384.","journal-title":"Thermochim Acta"},{"key":"4019_CR41","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jpba.2015.03.008","volume":"111","author":"H Furuta","year":"2015","unstructured":"Furuta H, Mori S, Yoshihashi Y, Yonemochi E, Uekusa H, Sugano K, et al. Physicochemical and crystal structure analysis of pranlukast pseudo-polymorphs II: solvate and cocrystal. J Pharm Biomed Anal. 2015;111:44\u201350. https:\/\/doi.org\/10.1016\/j.jpba.2015.03.008.","journal-title":"J Pharm Biomed Anal"},{"key":"4019_CR42","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1039\/D0CE00014K","volume":"22","author":"OEY Kilinkissa","year":"2020","unstructured":"Kilinkissa OEY, Govender KK, B\u00e1thori NB. Melting point-solubility-structure correlations in chiral and racemic model cocrystals. CrystEngComm. 2020;22:2766\u201371.","journal-title":"CrystEngComm"},{"key":"4019_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131848","author":"L Liu","year":"2022","unstructured":"Liu L, Liu M, Zhang Y, Feng Y, Wu L, Zhang L, et al. The role of hydroxyl group of ethanol in the self-assembly of pharmaceutical cocrystal of myricetin with 4,4\u2032-bipyridine. J Mol Struct. 2022. https:\/\/doi.org\/10.1016\/j.molstruc.2021.131848.","journal-title":"J Mol Struct"},{"key":"4019_CR44","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1021\/acs.cgd.6b01863","volume":"17","author":"B Zhu","year":"2017","unstructured":"Zhu B, Zhang Q, Wang JR, Mei X. Cocrystals of Baicalein with higher solubility and enhanced bioavailability. Cryst Growth Des. 2017;17:1893\u2013901.","journal-title":"Cryst Growth Des"},{"key":"4019_CR45","doi-asserted-by":"crossref","unstructured":"Gupta R, Badhe Y, Rai B, Mitragotri S. Molecular mechanism of the skin permeation enhancing e ff ect of ethanol\u202f: a molecular dynamics. 2020;12234\u201348.","DOI":"10.1039\/D0RA01692F"},{"key":"4019_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123893","volume":"653","author":"N Fine-shamir","year":"2024","unstructured":"Fine-shamir N, Dahan A. Ethanol-based solubility-enabling oral drug formulation development\u202f: accounting for the solubility-permeability interplay. Int J Pharm. 2024;653:123893. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.123893.","journal-title":"Int J Pharm"},{"key":"4019_CR47","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1324-0","author":"W Cui","year":"2019","unstructured":"Cui W, He Z, Zhang Y, Fan Q, Feng N. Naringenin cocrystals prepared by solution crystallization method for improving bioavailability and anti-hyperlipidemia effects. AAPS PharmSciTech. 2019. https:\/\/doi.org\/10.1208\/s12249-019-1324-0.","journal-title":"AAPS PharmSciTech"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04019-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-026-04019-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04019-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:53:49Z","timestamp":1776088429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-026-04019-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4019"],"URL":"https:\/\/doi.org\/10.1007\/s11095-026-04019-1","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"9 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experimental protocol received approval from the Institutional Animal Ethics Committee (IAEC) of Poona College of Pharmacy, Pune, India, under the reference number PCP\/IAEC\/2023\/3\u201305.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing financial interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}