{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:44:33Z","timestamp":1780397073768,"version":"3.54.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11095-026-04059-7","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:50:14Z","timestamp":1772574614000},"page":"1241-1257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Solid-State Stability of Pentobarbital in Fast-Dissolving Suppositories: Implications for Dissolution Behavior and Pediatric Formulation Performance"],"prefix":"10.1007","volume":"43","author":[{"given":"Aur\u00e9lien","family":"Freisz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Dhifallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Chennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouloud","family":"Yessaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Wasiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Jouffret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Jouannet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Sautou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-1796","authenticated-orcid":false,"given":"Yassine","family":"Bouattour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"4059_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1046\/j.1460-9592.2000.00510.x","volume":"10","author":"T Voepel-Lewis","year":"2000","unstructured":"Voepel-Lewis T, Malviya S, Prochaska G, Tait AR. Sedation failures in children undergoing MRI and CT: is temperament a factor? Pediatr Anesth. 2000;10:319\u201323. https:\/\/doi.org\/10.1046\/j.1460-9592.2000.00510.x.","journal-title":"Pediatr Anesth"},{"key":"4059_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(06)68230-5","volume":"367","author":"B Krauss","year":"2006","unstructured":"Krauss B, Green SM. Procedural sedation and analgesia in children. Lancet. 2006;367:766\u201380. https:\/\/doi.org\/10.1016\/S0140-6736(06)68230-5.","journal-title":"Lancet"},{"key":"4059_CR3","volume-title":"Procedural sedation for infants, children, and adolescents","year":"2016","unstructured":"Tobias JD, Cravero JP, editors. Procedural sedation for infants, children, and adolescents. Elk Grove Village: American Academy of Pediatrics; 2016."},{"key":"4059_CR4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1000","volume":"143","author":"CJ Cot\u00e9","year":"2019","unstructured":"Cot\u00e9 CJ, Wilson S. Guidelines for monitoring and management of pediatric patients before, during, and after sedation for diagnostic and therapeutic procedures. Pediatrics. 2019;143:e20191000. https:\/\/doi.org\/10.1542\/peds.2019-1000.","journal-title":"Pediatrics"},{"key":"4059_CR5","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1542\/peds.110.4.836","volume":"110","author":"Committee on Drugs","year":"2002","unstructured":"Committee on Drugs. American Academy of Pediatrics, Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: addendum. Pediatrics. 2002;110:836\u20138. https:\/\/doi.org\/10.1542\/peds.110.4.836.","journal-title":"Pediatrics"},{"key":"4059_CR6","first-page":"1","volume":"9","author":"R Fallah","year":"2015","unstructured":"Fallah R, Ferdosian F, Shajari A. Non-parenteral medications for procedural sedation in children- a narrative: review article. Iran J Child Neurol. 2015;9:1\u20138.","journal-title":"Iran J Child Neurol"},{"key":"4059_CR7","unstructured":"Actualit\u00e9 - Utilisation de l\u2019hydrate de chloral dans la s\u00e9dation de l\u2019enfant pour les examens \u00e0 vis\u00e9e diagnostique, ANSM. (n.d.) https:\/\/ansm.sante.fr\/actualites\/utilisation-de-lhydrate-de-chloral-dans-la-sedation-de-lenfant-pour-les-examens-a-visee-diagnostique. Accessed 12 Dec 2022"},{"key":"4059_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bja.2022.09.007","volume":"130","author":"I De Rover","year":"2023","unstructured":"De Rover I, Wylleman J, Dogger JJ, Bramer WM, Hoeks SE, de Graaff JC. Needle-free pharmacological sedation techniques in paediatric patients for imaging procedures: a systematic review and meta-analysis. Br J Anaesth. 2023;130:51\u201373. https:\/\/doi.org\/10.1016\/j.bja.2022.09.007.","journal-title":"Br J Anaesth"},{"key":"4059_CR9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/jphysiol.1996.sp021784","volume":"497","author":"JM Rho","year":"1996","unstructured":"Rho JM, Donevan SD, Rogawski MA. Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons. J Physiol. 1996;497:509. https:\/\/doi.org\/10.1113\/jphysiol.1996.sp021784.","journal-title":"J Physiol"},{"key":"4059_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2214\/ajr.177.2.1770427","volume":"177","author":"KP Mason","year":"2001","unstructured":"Mason KP, Zurakowski D, Karian VE, Connor L, Fontaine PJ, Burrows PE. Sedatives used in pediatric imaging: comparison of IV pentobarbital with IV pentobarbital with midazolam added. AJR Am J Roentgenol. 2001;177:427\u201330. https:\/\/doi.org\/10.2214\/ajr.177.2.1770427.","journal-title":"AJR Am J Roentgenol"},{"key":"4059_CR11","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.pharma.2018.03.002","volume":"76","author":"J Schlatter","year":"2018","unstructured":"Schlatter J, Kabiche S, Sellier N, Fontan J-E. Oral pentobarbital suspension for children sedation during MR imaging. Ann Pharm Fr. 2018;76:286\u201390. https:\/\/doi.org\/10.1016\/j.pharma.2018.03.002.","journal-title":"Ann Pharm Fr"},{"key":"4059_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071497","volume":"14","author":"\u0141J Walczak-Nowicka","year":"2022","unstructured":"Walczak-Nowicka \u0141J, Herbet M. Sodium benzoate-harmfulness and potential use in therapies for disorders related to the nervous system: a review. Nutrients. 2022;14:1497. https:\/\/doi.org\/10.3390\/nu14071497.","journal-title":"Nutrients"},{"key":"4059_CR13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1177\/0018578719901276","volume":"56","author":"S Belo","year":"2021","unstructured":"Belo S, Touchard J, Secretan P-H, Vidal F, Boudy V, Cisternino S, et al. Stability of pentobarbital hydrogel for rectal administration in pediatric procedural sedation. Hosp Pharm. 2021;56:332\u20137. https:\/\/doi.org\/10.1177\/0018578719901276.","journal-title":"Hosp Pharm"},{"key":"4059_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030755","volume":"15","author":"M Lebrat","year":"2023","unstructured":"Lebrat M, Bouattour Y, Gaudet C, Yessaad M, Jouannet M, Wasiak M, et al. Development and stability of a new formulation of pentobarbital suppositories for paediatric procedural sedation. Pharmaceutics. 2023;15:755. https:\/\/doi.org\/10.3390\/pharmaceutics15030755.","journal-title":"Pharmaceutics"},{"key":"4059_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2024.114532","volume":"204","author":"A Freisz","year":"2024","unstructured":"Freisz A, Dhifallah I, Basle YL, Jouannet M, Chennell P, Garrait G, et al. Development and characterization of novel fast-dissolving pentobarbital suppositories for pediatric procedural sedation and comparison with lipophilic formulations. Eur J Pharm Biopharm. 2024;204:114532. https:\/\/doi.org\/10.1016\/j.ejpb.2024.114532.","journal-title":"Eur J Pharm Biopharm"},{"key":"4059_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/pharmacy3040379","volume":"3","author":"C Anderson","year":"2015","unstructured":"Anderson C, MacKay M. Stability of fentanyl citrate, hydromorphone hydrochloride, ketamine hydrochloride, midazolam, morphine sulfate, and pentobarbital sodium in polypropylene syringes. Pharmacy. 2015;3:379\u201385. https:\/\/doi.org\/10.3390\/pharmacy3040379.","journal-title":"Pharmacy"},{"key":"4059_CR17","unstructured":"2.9.40. Uniformity of dosage units - European Pharmacopoeia 11.5. (n.d.)."},{"key":"4059_CR18","unstructured":"2.9.3. Dissolution test for solid dosage forms - European Pharmacopoeia 11.5. (n.d.)."},{"key":"4059_CR19","unstructured":"Bio-Rad Laboratories, SpectraBase. https:\/\/spectrabase.com\/ (n.d.) Accessed 17 Sept 2025."},{"key":"4059_CR20","unstructured":"2.9.22. Softening time determination of lipophilic suppositories - European Pharmacopoeia 11.5. (n.d.)."},{"key":"4059_CR21","unstructured":"2.9.24. Resitance to rupture - European Pharmacopoeia 6.0. (n.d.)."},{"key":"4059_CR22","unstructured":"European Pharmacopoeia Commission. European Pharmacopoeia, 11th ed. Chapter 5.1.4: Microbiological quality of non-sterile pharmaceutical preparations and substances for pharmaceutical use. Strasbourg: EDQM; 2023."},{"key":"4059_CR23","doi-asserted-by":"publisher","first-page":"5302","DOI":"10.1021\/acs.jpcc.6b12021","volume":"121","author":"L Bentea","year":"2017","unstructured":"Bentea L, Watzky MA, Finke RG. Sigmoidal nucleation and growth curves across nature fit by the Finke-Watzky model of slow continuous nucleation and autocatalytic growth: explicit formulas for the lag and growth times plus other key insights. J Phys Chem C. 2017;121:5302\u201312. https:\/\/doi.org\/10.1021\/acs.jpcc.6b12021.","journal-title":"J Phys Chem C"},{"key":"4059_CR24","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s12034-017-1441-x","volume":"40","author":"J Res\u00e9ndiz-Mu\u00f1oz","year":"2017","unstructured":"Res\u00e9ndiz-Mu\u00f1oz J, Corona-Rivera MA, Fern\u00e1ndez-Mu\u00f1oz JL, Zapata-Torres M, M\u00e1rquez-Herrera A, Ovando-Medina VM. Mathematical model of Boltzmann\u2019s sigmoidal equation applicable to the set-up of the RF-magnetron co-sputtering in thin films deposition of BaxSr1\u2212xTiO3. Bull Mater Sci. 2017;40:1043\u20137. https:\/\/doi.org\/10.1007\/s12034-017-1441-x.","journal-title":"Bull Mater Sci"},{"key":"4059_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/B978-0-323-88541-6.00034-X","volume-title":"Essentials of Medical Biochemistry","author":"CE Ha","year":"2023","unstructured":"Ha CE, Bhagavan NV. Chapter 2 - water, acid-base, buffers, and homeostatic control systems of body fluids. In: Ha CE, Bhagavan NV, editors. Essentials of Medical Biochemistry. 3rd ed. San Diego: Academic Press; 2023. p. 15\u201338. https:\/\/doi.org\/10.1016\/B978-0-323-88541-6.00034-X.","edition":"3"},{"key":"4059_CR26","doi-asserted-by":"publisher","DOI":"10.1021\/ed078p1499","volume":"78","author":"HN Po","year":"2001","unstructured":"Po HN, Senozan NM. The Henderson-Hasselbalch equation: its history and limitations. J Chem Educ. 2001;78:1499. https:\/\/doi.org\/10.1021\/ed078p1499.","journal-title":"J Chem Educ"},{"key":"4059_CR27","unstructured":"PubChem, Pentobarbital. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/4737 (n.d.) Accessed 28 July 2025."},{"key":"4059_CR28","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1021\/ac60315a032","volume":"44","author":"JN Willis","year":"1972","unstructured":"Willis JN, Cook RB, Jankow R. Raman spectrometry of some common barbiturates. Anal Chem. 1972;44:1228\u201334. https:\/\/doi.org\/10.1021\/ac60315a032.","journal-title":"Anal Chem"},{"key":"4059_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/pssb.2220940224","volume":"94","author":"S Nakashima","year":"1979","unstructured":"Nakashima S, Aziza A, le Postolc M, Balkanski M. Raman and infrared spectra in organic layer crystals of squaric acid. Phys Status Solidi B. 1979;94:529\u201339. https:\/\/doi.org\/10.1002\/pssb.2220940224.","journal-title":"Phys Status Solidi B"},{"key":"4059_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121341","volume":"611","author":"D Khanal","year":"2022","unstructured":"Khanal D, Ke W-R, Chan H-K. Raman spectroscopic evaluation of crystallinity, chemical composition and stability of pharmaceutical powder aerosols. Int J Pharm. 2022;611:121341. https:\/\/doi.org\/10.1016\/j.ijpharm.2021.121341.","journal-title":"Int J Pharm"},{"key":"4059_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081114","volume":"13","author":"J Boniatti","year":"2021","unstructured":"Boniatti J, Januskaite P, da Fonseca LB, Vi\u00e7osa AL, Amendoeira FC, Tuleu C, et al. Direct powder extrusion 3D printing of praziquantel to overcome neglected disease formulation challenges in paediatric populations. Pharmaceutics. 2021;13:1114. https:\/\/doi.org\/10.3390\/pharmaceutics13081114.","journal-title":"Pharmaceutics"},{"key":"4059_CR32","volume-title":"Handbook of pharmaceutical excipients","year":"2017","unstructured":"Sheskey PJ, Cook WG, Cable CG, editors. Handbook of pharmaceutical excipients. eighth edition. London: Pharmaceutical Press; APhA; 2017.","edition":"eighth edition"},{"key":"4059_CR33","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/jps.2600741213","volume":"74","author":"CM Ofner","year":"1985","unstructured":"Ofner CM, Schott H. Shifts in the apparent ionization constant of the carboxylic acid groups of gelatin. J Pharm Sci. 1985;74:1317\u201321. https:\/\/doi.org\/10.1002\/jps.2600741213.","journal-title":"J Pharm Sci"},{"key":"4059_CR34","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1002\/fsn3.1282","volume":"7","author":"J Lin","year":"2019","unstructured":"Lin J, Pan D, Sun Y, Ou C, Wang Y, Cao J. The modification of gelatin films: based on various cross-linking mechanism of glutaraldehyde at acidic and alkaline conditions. Food Sci Nutr. 2019;7:4140\u20136. https:\/\/doi.org\/10.1002\/fsn3.1282.","journal-title":"Food Sci Nutr"},{"key":"4059_CR35","doi-asserted-by":"publisher","DOI":"10.1063\/1.3632990","volume":"135","author":"SH Lee","year":"2011","unstructured":"Lee SH, Rasaiah JC. Proton transfer and the mobilities of the H+ and OH- ions from studies of a dissociating model for water. J Chem Phys. 2011;135:124505. https:\/\/doi.org\/10.1063\/1.3632990.","journal-title":"J Chem Phys"},{"key":"4059_CR36","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1021\/ja1099209","volume":"133","author":"H Forbert","year":"2011","unstructured":"Forbert H, Masia M, Kaczmarek-Kedziera A, Nair NN, Marx D. Aggregation-induced chemical reactions: acid dissociation in growing water clusters. J Am Chem Soc. 2011;133:4062\u201372. https:\/\/doi.org\/10.1021\/ja1099209.","journal-title":"J Am Chem Soc"},{"key":"4059_CR37","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1208\/s12248-015-9743-7","volume":"17","author":"MG Papich","year":"2015","unstructured":"Papich MG, Martinez MN. Applying biopharmaceutical classification system (BCS) criteria to predict oral absorption of drugs in dogs: challenges and pitfalls. AAPS J. 2015;17:948\u201364. https:\/\/doi.org\/10.1208\/s12248-015-9743-7.","journal-title":"AAPS J"},{"key":"4059_CR38","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4274\/tjps.galenos.2021.73554","volume":"19","author":"R Samineni","year":"2022","unstructured":"Samineni R, Chimakurthy J, Konidala S. Emerging role of biopharmaceutical classification and biopharmaceutical drug disposition system in dosage form development: a systematic review. Turk J Pharm Sci. 2022;19:706\u201313. https:\/\/doi.org\/10.4274\/tjps.galenos.2021.73554.","journal-title":"Turk J Pharm Sci"},{"key":"4059_CR39","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1002\/jps.2600671122","volume":"67","author":"JT Doluisio","year":"1978","unstructured":"Doluisio JT, Smith RB, Chun AHC, Dittert LW. Pentobarbital absorption from capsules and suppositories in humans. J Pharm Sci. 1978;67:1586\u20138. https:\/\/doi.org\/10.1002\/jps.2600671122.","journal-title":"J Pharm Sci"},{"key":"4059_CR40","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1002\/jps.21138","volume":"97","author":"C Bhugra","year":"2008","unstructured":"Bhugra C, Pikal MJ. Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous state. J Pharm Sci. 2008;97:1329\u201349. https:\/\/doi.org\/10.1002\/jps.21138.","journal-title":"J Pharm Sci"},{"key":"4059_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/gels9030244","volume":"9","author":"A Bassi","year":"2023","unstructured":"Bassi A, Sharma G, Deol PK, Madempudi RS, Kaur IP. Preclinical potential of probiotic-loaded novel gelatin\u2013oil vaginal suppositories: efficacy, stability, and safety studies. Gels. 2023;9:244. https:\/\/doi.org\/10.3390\/gels9030244.","journal-title":"Gels"},{"key":"4059_CR42","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-4615-6093-7_6","volume-title":"Principles of food processing","author":"DR Heldman","year":"1997","unstructured":"Heldman DR, Hartel RW. Freezing and frozen-food storage. In: Heldman DR, Hartel RW, editors. Principles of food processing. Boston: Springer, US; 1997. p. 113\u201337. https:\/\/doi.org\/10.1007\/978-1-4615-6093-7_6."},{"key":"4059_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1574-6941.1999.tb00639.x","volume":"30","author":"DB Nedwell","year":"1999","unstructured":"Nedwell DB. Effect of low temperature on microbial growth: lowered affinity for substrates limits growth at low temperature. FEMS Microbiol Ecol. 1999;30:101\u201311. https:\/\/doi.org\/10.1111\/j.1574-6941.1999.tb00639.x.","journal-title":"FEMS Microbiol Ecol"},{"key":"4059_CR44","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.vascn.2015.07.012","volume":"76","author":"SM Priest","year":"2015","unstructured":"Priest SM, Geisbuhler TP. Injectable sodium pentobarbital: stability at room temperature. J Pharmacol Toxicol Methods. 2015;76:38\u201342. https:\/\/doi.org\/10.1016\/j.vascn.2015.07.012.","journal-title":"J Pharmacol Toxicol Methods"},{"key":"4059_CR45","doi-asserted-by":"publisher","DOI":"10.1177\/0018578719901276","author":"S Belo","year":"2021","unstructured":"Belo S, Touchard J, Secretan P-H, Vidal F, Boudy V, Cisternino S, et al. Stability of pentobarbital hydrogel for rectal administration in pediatric procedural sedation. Hosp Pharm. 2021. https:\/\/doi.org\/10.1177\/0018578719901276.","journal-title":"Hosp Pharm"},{"key":"4059_CR46","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/BF03005418","volume":"36","author":"JP Jantzen","year":"1989","unstructured":"Jantzen JP, Tzanova I, Witton PK, Klein AM. Rectal pH in children. Can J Anaesth. 1989;36:665\u20137. https:\/\/doi.org\/10.1007\/BF03005418.","journal-title":"Can J Anaesth"},{"key":"4059_CR47","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1021\/acs.molpharmaceut.3c00442","volume":"20","author":"A Aljabbari","year":"2023","unstructured":"Aljabbari A, Kihara S, Rades T, Boyd BJ, Be\u0305rzi\u0146\u0161 K. The influence of gastrointestinal biomolecules on solid-state transformations in pharmaceutical particulates. Mol Pharm. 2023;20:4297\u2013306. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.3c00442.","journal-title":"Mol Pharm"},{"key":"4059_CR48","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/jps.2600820318","volume":"82","author":"ATM Serajuddin","year":"1993","unstructured":"Serajuddin ATM, Jarowski CI. Influence of pH on release of phenytoin sodium from slow-release dosage forms. J Pharm Sci. 1993;82:306\u201310. https:\/\/doi.org\/10.1002\/jps.2600820318.","journal-title":"J Pharm Sci"},{"key":"4059_CR49","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s11095-009-0021-1","volume":"27","author":"DE Alonzo","year":"2010","unstructured":"Alonzo DE, Zhang GGZ, Zhou D, Gao Y, Taylor LS. Understanding the behavior of amorphous pharmaceutical systems during dissolution. Pharm Res. 2010;27:608\u201318. https:\/\/doi.org\/10.1007\/s11095-009-0021-1.","journal-title":"Pharm Res"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04059-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-026-04059-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04059-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:54:10Z","timestamp":1778867650000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-026-04059-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4059"],"URL":"https:\/\/doi.org\/10.1007\/s11095-026-04059-7","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"6 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}