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Trichomoniasis is a critical public health problem, and it is aggravated due to its association with a higher risk of HIV-1 acquisition and transmission and complications such as preterm delivery and pelvic inflammatory disease. This STI is treated mainly through the 5-nitroimidazole class, specifically metronidazole and tinidazole. However, drug resistance, which can represent between 5 and 20% of clinical cases, and hypersensitivity reactions are a general concern. In this context, drug development for trichomoniasis is an ever-growing research field. Therefore, considering how important drug targets and the mechanism of action of compounds can be to drug discovery, there is a growing interest in better understanding how some molecules can be used as targets. This article offers an overview of\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    drug targets, their significance in metabolism, pathogenesis, or survival, and their contribution to drug development for trichomoniasis.\n                  <\/jats:p>","DOI":"10.1007\/s11095-026-04098-0","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:35:37Z","timestamp":1778009737000},"page":"1357-1378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trichomonas vaginalis Drug Targets and Their Role in Drug Discovery and Development"],"prefix":"10.1007","volume":"43","author":[{"given":"Mirna Samara Di\u00e9","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela","family":"Sena-Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Domingues","family":"Moron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara da Rocha","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibele","family":"Borsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"4098_CR1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.2471\/BLT.18.228486","volume":"97","author":"J Rowley","year":"2019","unstructured":"Rowley J, vander Hoorn S, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, et al. 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