{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:50:54Z","timestamp":1791305454097,"version":"4.3.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-13-00031-P"],"award-info":[{"award-number":["22-13-00031-P"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s11095-026-04177-2","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:14Z","timestamp":1786120454000},"page":"3333-3347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Solution to Sublimation: Thermodynamic Evaluation of Iproniazid Multicomponent Crystals for Robust Pharmaceutical Solid Form Development"],"prefix":"10.1007","volume":"43","author":[{"given":"Ksenia V.","family":"Drozd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna G.","family":"Ramazanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila E.","family":"Shmukler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-5244","authenticated-orcid":false,"given":"German L.","family":"Perlovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"4177_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijpharm.2008.08.029","volume":"365","author":"RR Schartman","year":"2009","unstructured":"Schartman RR. On the thermodynamics of cocrystal formation. Int J Pharm. 2009;365:77\u201380. https:\/\/doi.org\/10.1016\/j.ijpharm.2008.08.029.","journal-title":"Int J Pharm"},{"key":"4177_CR2","doi-asserted-by":"publisher","first-page":"7019","DOI":"10.1039\/C5CE00992H","volume":"17","author":"GL Perlovich","year":"2015","unstructured":"Perlovich GL. Thermodynamic characteristics of cocrystal formation and melting points for rational design of pharmaceutical two-component systems. Cryst Eng Comm. 2015;17:7019\u201328. https:\/\/doi.org\/10.1039\/C5CE00992H.","journal-title":"Cryst Eng Comm."},{"key":"4177_CR3","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1039\/C7CE00554G","volume":"19","author":"GL Perlovich","year":"2017","unstructured":"Perlovich GL. Two-component molecular crystals: evaluation of the formation thermodynamics based on melting points and sublimation data. Cryst Eng Comm. 2017;19:2870\u201383. https:\/\/doi.org\/10.1039\/C7CE00554G.","journal-title":"Cryst Eng Comm"},{"key":"4177_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125793","volume":"411","author":"NA Vasilev","year":"2024","unstructured":"Vasilev NA, Perlovich GL. Thermodynamic characteristics of multi-component crystals: experimental evaluation, prediction and relationship with crystal parameters. J Mol Liq. 2024;411:125793. https:\/\/doi.org\/10.1016\/j.molliq.2024.125793.","journal-title":"J Mol Liq."},{"key":"4177_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202500831","volume":"10","author":"SBN Agostini","year":"2025","unstructured":"Agostini SBN, Borges BA, de Ara\u00fajo MB, Bonfilio R. Growing interest in pharmaceutical cocrystals: a comprehensive review of applications and trends. Chemistry Select. 2025;10:e00831. https:\/\/doi.org\/10.1002\/slct.202500831.","journal-title":"Chemistry Select."},{"key":"4177_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/9781394302505","volume":"5","author":"H Singh","year":"2025","unstructured":"Singh H, Singh BK, Kumar A, Kumar A, Mishra AK, Rathi R, Singh I. Design and structural characteristics of pharmaceutical cocrystals. Cocrystals in Pharmaceutical Sciences. 2025;5:29\u201353. https:\/\/doi.org\/10.1002\/9781394302505.","journal-title":"Cocrystals in Pharmaceutical Sciences"},{"key":"4177_CR7","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1021\/acs.cgd.9b01253","volume":"20","author":"M Sv\u00e4rd","year":"2020","unstructured":"Sv\u00e4rd M, Ahuja D, Rasmuson \u00c5C. Calorimetric determination of co-crystal thermodynamic stability \u2013sulfamethazine-salicylic acid case study. Cryst Growth Des. 2020;20:4243. https:\/\/doi.org\/10.1021\/acs.cgd.9b01253.","journal-title":"Cryst Growth Des."},{"key":"4177_CR8","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1021\/cg0503346","volume":"6","author":"SJ Nehm","year":"2006","unstructured":"Nehm SJ, Rodr\u00edguez-Spong B, Rodr\u00edguez-Hornedo N. Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation. Cryst Growth Des. 2006;6:592\u2013600. https:\/\/doi.org\/10.1021\/cg0503346.","journal-title":"Cryst Growth Des."},{"key":"4177_CR9","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1524\/zpch.2009.5454","volume":"223","author":"T Rager","year":"2009","unstructured":"Rager T, Hilfi ker R. Stability domains of multi-component crystals in ternary phase diagrams. Z Phys Chem. 2009;223:793\u2013813. https:\/\/doi.org\/10.1524\/zpch.2009.5454.","journal-title":"Z Phys Chem"},{"key":"4177_CR10","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1021\/acs.molpharmaceut.5b00629","volume":"12","author":"AO Surov","year":"2015","unstructured":"Surov AO, Manin AN, Churakov AV, Perlovich GL. New solid forms of the antiviral drug Arbidol: crystal structures, thermodynamic stability, and solubility. Mol Pharm. 2015;12:4154\u201365. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.5b00629.","journal-title":"Mol Pharm."},{"key":"4177_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2019.111644","volume":"295","author":"KV Drozd","year":"2019","unstructured":"Drozd KV, Manin AN, Perlovich GL. Comparative analysis of experimental methods for determining thermodynamic parameters of formation of multi-component molecular crystals: benefits and limitations. J Mol Liq. 2019;295:111644. https:\/\/doi.org\/10.1016\/j.molliq.2019.111644.","journal-title":"J Mol Liq."},{"key":"4177_CR12","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cherd.2025.04.048","volume":"218","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Liu J, Yin L, Yan C, Jiang B, Deng Y. Three indomethacin cocrystals: peparation, characterization and formation thermodynamics. Chem Eng Res Des. 2025;218:539\u201347. https:\/\/doi.org\/10.1016\/j.cherd.2025.04.048.","journal-title":"Chem Eng Res Des."},{"key":"4177_CR13","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1021\/acs.cgd.4c00529","volume":"24","author":"DE Boycov","year":"2024","unstructured":"Boycov DE, Drozd KV, Manin AN, Churakov AV, Perlovich GL. Rational design of the carbamazepine ternary cocrystals. Cryst Growth Des. 2024;24:4862\u201373. https:\/\/doi.org\/10.1021\/acs.cgd.4c00529.","journal-title":"Cryst Growth Des."},{"key":"4177_CR14","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1021\/acs.cgd.2c00044","volume":"22","author":"AO Surov","year":"2022","unstructured":"Surov AO, Voronin AP, Drozd KV, Volkova TV, Vasilev N, Batov D, Churakov AV, Perlovich GL. Extending the range of nitrofurantoin solid forms: effect of molecular and crystal structure on formation thermodynamics and physicochemical properties. Cryst Growth Des. 2022;22:2569\u201386. https:\/\/doi.org\/10.1021\/acs.cgd.2c00044.","journal-title":"Cryst Growth Des."},{"key":"4177_CR15","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1021\/acs.cgd.3c00949","volume":"24","author":"AN Manin","year":"2024","unstructured":"Manin AN, Boycov DE, Simonova OR, Drozd KV, Volkova TV, Perlovich GL. How molecular packing affects the thermodynamic parameters of cocrystal formation: the case of carbamazepine cocrystals. Cryst Growth Des. 2024;24:252\u201361. https:\/\/doi.org\/10.1021\/acs.cgd.3c00949.","journal-title":"Cryst Growth Des."},{"key":"4177_CR16","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1021\/acs.cgd.3c00891","volume":"24","author":"M Hong","year":"2024","unstructured":"Hong M, Wu N, Wang Q, Zhou R, Zhu B, Qi M-H, Ren G-B. Insight into the relationship of aqueous solubility and single-crystal structure of Harmine\u2019s new organic salt forms. Cryst Growth Des. 2024;24:3114\u201332. https:\/\/doi.org\/10.1021\/acs.cgd.3c00891.","journal-title":"Cryst Growth Des."},{"key":"4177_CR17","doi-asserted-by":"publisher","first-page":"10466","DOI":"10.1021\/acs.jpcb.5b05082","volume":"119","author":"AN Manin","year":"2015","unstructured":"Manin AN, Voronin AP, Shishkina AV, Vener MV, Churakov AV, Perlovich GL. Influence of secondary interactions on the structure, sublimation thermodynamics, and solubility of salicylate:4-hydroxybenzamide cocrystals. Combined experimental and theoretical study. J Phys Chem B. 2015;119:10466\u201377. https:\/\/doi.org\/10.1021\/acs.jpcb.5b05082.","journal-title":"J Phys Chem B."},{"key":"4177_CR18","doi-asserted-by":"publisher","first-page":"6803","DOI":"10.1021\/jp5032898","volume":"118","author":"AN Manin","year":"2014","unstructured":"Manin AN, Voronin AP, Manin NG, Vener MV, Shishkina AV, Lermontov AS, Perlovich GL. Salicylamide cocrystals:screening, crystal structure, sublimation thermodynamics, dissolution, and solid-state DFT calculations. J Phys Chem B. 2014;118:6803\u201314. https:\/\/doi.org\/10.1021\/jp5032898.","journal-title":"J Phys Chem B."},{"key":"4177_CR19","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1021\/acs.cgd.1c01241","volume":"22","author":"S Sanvordenker","year":"2022","unstructured":"Sanvordenker S, Borsadia S, Morris S, Rodr\u00edguez-Hornedo N, Shtein M. Gas-assisted cocrystal desublimation. Cryst Growth Des. 2022;22:1528. https:\/\/doi.org\/10.1021\/acs.cgd.1c01241.","journal-title":"Cryst Growth Des."},{"key":"4177_CR20","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41467-019-08712-1","volume":"10","author":"X Ye","year":"2019","unstructured":"Ye X, Liu Y, Guo Q, Han Q, Ge C, Cui S, Leilei Zhang L, Tao X. 1D versus 2D cocrystals growth via microspacing in-air sublimation. Nat Commun. 2019;10:761. https:\/\/doi.org\/10.1038\/s41467-019-08712-1.","journal-title":"Nat Commun."},{"key":"4177_CR21","doi-asserted-by":"publisher","first-page":"7840","DOI":"10.1021\/acs.cgd.0c01148","volume":"20","author":"J Lombard","year":"2020","unstructured":"Lombard J, Haynes DA, le Roex T. Assessment of Co-sublimation for the formation of multicomponent crystals. Cryst Growth Des. 2020;20:7840\u20139. https:\/\/doi.org\/10.1021\/acs.cgd.0c01148.","journal-title":"Cryst Growth Des."},{"key":"4177_CR22","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1021\/acs.cgd.4c00202","volume":"24","author":"P Harsha","year":"2024","unstructured":"Harsha P, Khan M, Thakuria R, Das D. Synthesis of a cocrystal hydrate by sublimation and reversible polymorphic transformation through single-crystal to single-crystal fashion. Cryst Growth Des. 2024;24:3109\u201313. https:\/\/doi.org\/10.1021\/acs.cgd.4c00202.","journal-title":"Cryst Growth Des."},{"key":"4177_CR23","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.1021\/acs.cgd.3c00931","volume":"23","author":"AL Volkwyn","year":"2023","unstructured":"Volkwyn AL, Haynes DA. Crystallization of organic salts and co-crystals by sublimation: the effect of experimental conditions. Cryst Growth Des. 2023;23:8212\u201320. https:\/\/doi.org\/10.1021\/acs.cgd.3c00931.","journal-title":"Cryst Growth Des."},{"key":"4177_CR24","doi-asserted-by":"publisher","first-page":"7826","DOI":"10.1039\/D0CE01470B","volume":"22","author":"J Lombard","year":"2020","unstructured":"Lombard J, Smith VJ, le Roex T, Haynes DA. Crystallization of organic salts by sublimation: salt formation from the gasphase. Cryst Eng Comm. 2020;22:7826\u201331. https:\/\/doi.org\/10.1039\/D0CE01470B.","journal-title":"Cryst Eng Comm."},{"key":"4177_CR25","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1039\/D1CE01717A","volume":"24","author":"DE Boycov","year":"2022","unstructured":"Boycov DE, Manin AN, Drozd KV, Churakov AV, Perlovich GL. Thermal method usage features for multicomponent crystal screening. Cryst Eng Comm. 2022;24:2280\u201390. https:\/\/doi.org\/10.1039\/D1CE01717A.","journal-title":"Cryst Eng Comm."},{"key":"4177_CR26","doi-asserted-by":"publisher","first-page":"9137","DOI":"10.1021\/acs.cgd.5c01007","volume":"25","author":"FJ Acebedo-Mart\u00ednez","year":"2025","unstructured":"Acebedo-Mart\u00ednez FJ, Alarc\u00f3n-Payer C, Dom\u00ednguez-Mart\u00edn A, Frontera A, Prohens R, Barbas R, Choquesillo-Lazarte D. Exploring sublimation as a tool for polymorphic screening in niflumic acid\u2013caffeine pharmaceutical cocrystals. Cryst Growth Des. 2025;25:9137\u201349. https:\/\/doi.org\/10.1021\/acs.cgd.5c01007.","journal-title":"Cryst Growth Des."},{"key":"4177_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.gce.2025.02.001","volume":"7","author":"S Wang","year":"2026","unstructured":"Wang S, Xiao Y, Su Y, Liu Y, Feng S, Cao H, Xhou L, Yin Q. Sublimation crystallization: from mechanism to applications. Green Chem Eng. 2026;7:147\u201367. https:\/\/doi.org\/10.1016\/j.gce.2025.02.001.","journal-title":"Green Chem Eng."},{"key":"4177_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jct.2020.106369","volume":"155","author":"KV Drozd","year":"2021","unstructured":"Drozd KV, Manin AN, Voronin AP, Perlovich GL. Sublimation thermodynamics of pyrazinoic, dipicolinic and quinolinicacids: Experiment and theoretical prediction. J Chem Thermodyn. 2021;155:106369. https:\/\/doi.org\/10.1016\/j.jct.2020.106369.","journal-title":"J Chem Thermodyn."},{"key":"4177_CR29","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1021\/acs.chemrev.4c00855","volume":"125","author":"DJ Fowles","year":"2025","unstructured":"Fowles DJ, Connaughton BJ, Carter JW, Mitchell JBO, Palmer DS. Physics-based solubility prediction for organic molecules. Chem Rev. 2025;125:7057\u201398. https:\/\/doi.org\/10.1021\/acs.chemrev.4c00855.","journal-title":"Chem Rev."},{"key":"4177_CR30","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.tca.2015.09.022","volume":"622","author":"BN Solomonov","year":"2015","unstructured":"Solomonov BN, Varfolomeev MA, Nagrimanov RN, Novikov VB, Buzyurov AV, Fedorova YV, Mukhametzyanov TA. New method for determination of vaporization and sublimation enthalpy of aromatic compounds at 298.15 K using solution calorimetry technique and group-additivity scheme. Thermochim Acta. 2015;622:88\u201396. https:\/\/doi.org\/10.1016\/j.tca.2015.09.022.","journal-title":"Thermochim Acta."},{"key":"4177_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tca.2016.03.031","volume":"633","author":"BN Solomonov","year":"2016","unstructured":"Solomonov BN, Nagrimanov RN, Mukhametzyanov TA. Additive scheme for calculation of solvation enthalpies ofheterocyclic aromatic compounds. Sublimation\/vaporization enthalpy at 298.15 K. Thermochim Acta. 2016;633:37\u201347. https:\/\/doi.org\/10.1016\/j.tca.2016.03.031.","journal-title":"Thermochim Acta."},{"key":"4177_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctta.2022.100087","volume":"8","author":"RS Abdullah","year":"2022","unstructured":"Abdullah RS, Solomonov BN. Sublimation\/vaporization and solvation enthalpies of monosubstituted pyridine derivatives. Chem Thermodyn Therm Anal. 2022;8:100087. https:\/\/doi.org\/10.1016\/j.ctta.2022.100087.","journal-title":"Chem Thermodyn Therm Anal."},{"key":"4177_CR33","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1021\/acs.cgd.6c00274","volume":"26","author":"KV Drozd","year":"2026","unstructured":"Drozd KV, Ramazanova AG, Shmukler LE, Churakov AV, Perlovich GL. Structural diversity of iproniazid multicomponent crystals with isomeric dihydroxybenzoic acids: implications for solid-state properties. Cryst Growth Des. 2026;26:4184\u201397. https:\/\/doi.org\/10.1021\/acs.cgd.6c00274.","journal-title":"Cryst Growth Des."},{"key":"4177_CR34","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/cite.202400085","volume":"96","author":"P Rapeenun","year":"2024","unstructured":"Rapeenun P, Songsermsawad S, Flood AE. Shortcut method for solubility prediction and preferred stability of diastereomeric cocrystals. Chem Ing Tec. 2024;96:1613\u20139. https:\/\/doi.org\/10.1002\/cite.202400085.","journal-title":"Chem Ing Tec."},{"key":"4177_CR35","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1021\/acs.cgd.1c00247","volume":"21","author":"P Rapeenun","year":"2021","unstructured":"Rapeenun P, Rarey J, Flood AE. Shortcut method for the prediction of the cocrystal solubility line. Cryst Growth Des. 2021;21:5534\u201343. https:\/\/doi.org\/10.1021\/acs.cgd.1c00247.","journal-title":"Cryst Growth Des."},{"key":"4177_CR36","unstructured":"Prausnitz JM, Lichtenthaler RN, De Azevedo EG. Molecular thermodynamics of fluid-phase equilibria. Pearson Education. 1998."},{"key":"4177_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.128968","volume":"440","author":"KV Drozd","year":"2025","unstructured":"Drozd KV, Manin AN, Perlovich GL. Phase behavior and relative stability of iproniazid polymorphs. J Mol Liq. 2025;440:128968. https:\/\/doi.org\/10.1016\/j.molliq.2025.128968.","journal-title":"J Mol Liq."},{"key":"4177_CR38","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molliq.2015.06.041","volume":"209","author":"F Chen","year":"2015","unstructured":"Chen F, Yang Z, Chen Z, Hu J, Chen C, Cai J. Density, viscosity, speed of sound, excess property and bulk modulus ofbinary mixtures of \u03b3-butyrolactone with acetonitrile, dimethyl carbonate, and tetrahydrofuran at temperatures (293.15 to 333.15) K. J Mol Liq. 2015;209:683\u201392. https:\/\/doi.org\/10.1016\/j.molliq.2015.06.041.","journal-title":"J Mol Liq."},{"key":"4177_CR39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1021\/cg101162a","volume":"11","author":"DE Braun","year":"2011","unstructured":"Braun DE, Karamertzanis PG, Arlin J-B, Florence AJ, Kahlenberg V, Tocher DA, Griesser UJ, Price SL. solid-state formsof \u03b2-resorcylic acid: how exhaustive should a polymorph screen be? Cryst Growth Des. 2011;11:210\u201320. https:\/\/doi.org\/10.1021\/cg101162a.","journal-title":"Cryst Growth Des."},{"key":"4177_CR40","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1021\/je900777q","volume":"55","author":"MJS Monte","year":"2010","unstructured":"Monte MJS, Gon\u00e7alves MV, Ribeiro da Silva MDMC. Vapor pressures and enthalpies of combustion of the dihydroxybenzoic acid isomers. J Chem Eng Data. 2010;55:2246\u201351. https:\/\/doi.org\/10.1021\/je900777q.","journal-title":"J Chem Eng Data."},{"key":"4177_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11095-018-2343-3","volume":"35","author":"A Avdeef","year":"2018","unstructured":"Avdeef A. Cocrystal solubility product prediction using an in combo model and simulations to improve design of experiments. Pharm Res. 2018;35:40. https:\/\/doi.org\/10.1007\/s11095-018-2343-3.","journal-title":"Pharm Res."},{"key":"4177_CR42","doi-asserted-by":"publisher","first-page":"6566","DOI":"10.1021\/acs.cgd.9b01006","volume":"19","author":"JS Chickos","year":"2019","unstructured":"Chickos JS, Gavezzotti A. Sublimation enthalpies of organic compounds: a very large database with a match to crystal structure determinations and a comparison with lattice energies. Cryst Growth Des. 2019;19:6566\u201376. https:\/\/doi.org\/10.1021\/acs.cgd.9b01006.","journal-title":"Cryst Growth Des."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04177-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11095-026-04177-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-026-04177-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:54:17Z","timestamp":1791302057000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11095-026-04177-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["4177"],"URL":"https:\/\/doi.org\/10.1007\/s11095-026-04177-2","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"18 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Competing Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}