{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:19:11Z","timestamp":1773242351876,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm World Sci"],"published-print":{"date-parts":[[2007,10,15]]},"DOI":"10.1007\/s11096-007-9122-2","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T08:25:53Z","timestamp":1178526353000},"page":"577-583","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of diphenhydramine against cough in humans: a review"],"prefix":"10.1007","volume":"29","author":[{"given":"Ingunn","family":"Bj\u00f6rnsd\u00f3ttir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Ray","family":"Einarson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1rus Stein\u00fe\u00f3r","family":"Gu\u00f0mundsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rannveig Alma","family":"Einarsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"9122_CR1","unstructured":"Anonymous. Parke Davis & Co. - Benylin Expectorant; Opportunity for Hearing on Proposal to Deny Approval of Supplemental New Drug Application. Docket No. 76\u20130483. Federal Register 1976;41(231):52537\u20139. U.S. FDA, Center for Drug Evaluation and Research. Available from: http:\/\/www.fda.gov\/cder\/otcmonographs\/Cold&Cough\/antitussive_benylin_expectorant_deny_approval_suppl_NDhttp:\/\/194.192.187.171\/mdxcgi\/prodindx.exe?CTL=\/mdx\/mdxcgi\/MEGAT.SYS&SYS\u00a0=\u00a02&SET\u00a0=\u00a080A045834422809E38F00&POS\u00a0=\u00a07601795&T\u00a0=\u00a01614A_19761130.pdf Cited 19 May 2006."},{"issue":"2","key":"9122_CR2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0095-9561(16)38634-0","volume":"NS26&107","author":"WR. Garnett","year":"1986","unstructured":"Garnett WR. Diphenhydramine\u2014A monograph. Am Pharm 1986;NS26&107(2):35\u201340.","journal-title":"Am Pharm"},{"key":"9122_CR3","unstructured":"MARTINDALE PRODUCT INDEX {diphenhydramine}. Available from Scandinavian Medical Information. http:\/\/www.smi.dk\/index_mpas.html Cited 23 March 2006."},{"key":"9122_CR4","unstructured":"S\u00e9rlyfjaskr\u00e1 (Medicinal Product Information). Icelandic Medicines Control Agency. Available from http:\/\/www.vefpostur.lyfjastofnun.is\/focal\/gnh52.nsf\/TOC\/24D67F0E6CD52B7F00256ECA003FF6A5\/$FILE\/Pekt\u00f3l\u00edn.doc Cited 19 May 2006."},{"key":"9122_CR5","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1001\/jama.1993.03500170088039","volume":"269","author":"MBH Smith","year":"1993","unstructured":"Smith MBH, Feldman W. Over-the-counter cold medications: a critical review of clinical trials between 1950 and 1991. JAMA 1993;269:2258\u201363.","journal-title":"JAMA"},{"key":"9122_CR6","unstructured":"Lovell S. Cough medicines. On Continuing Practice 1982;9(4):21\u20134."},{"issue":"1","key":"9122_CR7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1542\/pir.17-1-12","volume":"17","author":"ML. Katcher","year":"1996","unstructured":"Katcher ML. Cold, cough, and allergy medications: uses and abuses. Pediatr Rev 1996;17(1):12\u20137.","journal-title":"Pediatr Rev"},{"issue":"7","key":"9122_CR8","first-page":"14","volume":"12","author":"WM. Corrao","year":"1986","unstructured":"Corrao WM. Chronic cough: an approach to management. Compr Ther 1986;12(7):14\u20139.","journal-title":"Compr Ther"},{"key":"9122_CR9","first-page":"77","volume":"27\/4","author":"PD Phelan","year":"1986","unstructured":"Phelan PD. Symptomatic treatment of cough in children. Curr Ther 1986;27\/4:77\u201382.","journal-title":"Curr Ther"},{"issue":"Suppl.153","key":"9122_CR10","first-page":"173","volume":"71","author":"RS Irwin","year":"1987","unstructured":"Irwin RS, Curley FJ, Pratter MR. The effects of drugs on cough. Eur J Respir Dis 1987;71(Suppl.153):173\u201381.","journal-title":"Eur J Respir Dis"},{"key":"9122_CR11","unstructured":"Micromedex. Drug consults. Antitussive agents\u2014comparative efficacy. Diphenhydramine. Available from Scandinavian Medical Information. http:\/\/www.smi.dk\/index_mpas.html Cited 23 March 2006."},{"key":"9122_CR12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02713631","volume":"164","author":"AS. Banner","year":"1986","unstructured":"Banner AS. Cough: physiology, evaluation and treatment. Lung 1986;164:79\u201392.","journal-title":"Lung"},{"issue":"3","key":"9122_CR13","first-page":"425","volume":"40","author":"NB Eddy","year":"1969","unstructured":"Eddy NB, Friebel H, Hahn KJ, Halbach H. Codeine and its alternates for pain and cough relief. 3. The antitussive action of codeine\u2013mechanism, methodology and evaluation. Bull World Health Organ 1969;40(3):425\u2013454.","journal-title":"Bull World Health Organ"},{"key":"9122_CR14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech.52.6.377","volume":"52","author":"SH Downs","year":"1998","unstructured":"Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998;52:377\u2013384.","journal-title":"J Epidemiol Community Health"},{"issue":"6","key":"9122_CR15","first-page":"470","volume":"5","author":"SG. Matts","year":"1977","unstructured":"Matts SG. A trial of Lotussin and linctus diphenhydramine in patients with an irritant cough. J Int Med Res 1977;5(6):470\u20132.","journal-title":"J Int Med Res"},{"key":"9122_CR16","first-page":"218","volume":"29","author":"EW Packman","year":"1991","unstructured":"Packman EW, Ciccone PE, Wilson J, Masurat T. Antitussive effects of diphenhydramine on the citric acid aerosol-induced cough response in humans. Int J Clin Pharmacol Ther Toxicol 1991;29:218\u201322.","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"9122_CR17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cpt1976194421","volume":"19","author":"LS Lilienfield","year":"1976","unstructured":"Lilienfield LS, Rose JC, Princiotto JV. Antitussive activity of diphenhydramine in chronic cough. Clin Pharmacol Ther 1976;19:421\u20135.","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"9122_CR18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1651-2227.1988.tb10716.x","volume":"77","author":"A Danzon","year":"1988","unstructured":"Danzon A, Lacroix J, Infante-Rivard C, Chicoine L. A double-blind clinical trial on Diphenhydramine in Pertussis. Acta Paediatr Scand 1988;77(4):614\u20135.","journal-title":"Acta Paediatr Scand"},{"key":"9122_CR19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1542\/peds.114.1.e85","volume":"114","author":"IM Paul","year":"2004","unstructured":"Paul IM, Yoder KE, et al. Effect of dextrometorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004;114:85\u201390.","journal-title":"Pediatrics"},{"key":"9122_CR20","first-page":"475","volume":"6","author":"G. Weippl","year":"1984","unstructured":"Weippl G. Therapeutic approaches to the common cold in children. Clin Ther 1984;6:475\u201382.","journal-title":"Clin Ther"},{"key":"9122_CR21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1742-1241.1981.tb08294.x","volume":"35","author":"RSW. Middleton","year":"1981","unstructured":"Middleton RSW. Double blind trial in general practice comparing the efficacy of \u201cBenylin Day and Night\u201d and paracetamol in the treatment of the common cold. Br J Clin Pract 1981;35:297\u2013300.","journal-title":"Br J Clin Pract"},{"key":"9122_CR22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1742-1241.1985.tb07826.x","volume":"39","author":"GV Jaffe","year":"1985","unstructured":"Jaffe GV, Grimshaw JJ. Benylin Expectorant versus Actifed Expectorant in the treatment of acute cough. Br J Clin Pract 1985;39:238\u201342.","journal-title":"Br J Clin Pract"},{"key":"9122_CR23","first-page":"68","volume":"98","author":"S Jayaram","year":"2000","unstructured":"Jayaram S, Desai A. Efficacy and safety of Ascoril Expectorant and other cough formula in the treatment of cough management in paediatric and adult patients\u2014a randomised double-blind comparative trial. J Indian Med Assoc 2000;98:68\u201370.","journal-title":"J Indian Med Assoc"},{"key":"9122_CR24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1164\/ajrccm\/138.2.305","volume":"138","author":"FC Curley","year":"1988","unstructured":"Curley FC, Irvin RS, Pratter MR, et al. Cough and the common cold. Am Rev Respir Dis 1988;138:305\u201311.","journal-title":"Am Rev Respir Dis"},{"key":"9122_CR25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-3476(05)81865-7","volume":"118","author":"N Hutton","year":"1991","unstructured":"Hutton N, Wilson MH, Mellits D, et al. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. J Pediatr 1991;118:125\u201330.","journal-title":"J Pediatr"},{"issue":"9","key":"9122_CR26","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","volume":"58","author":"JJ Deeks","year":"2005","unstructured":"Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 2005;58(9):882\u201393.","journal-title":"J Clin Epidemiol"},{"key":"9122_CR27","unstructured":"Kleinschmidt H. [Attempt to test a new antitussive agent] [In German] Z Allgemeinmed. 1974;50(4):185\u20137."},{"key":"9122_CR28","unstructured":"Elberg M. [The treatment of dry cough in orhinolaryngology] [In German] ZFA (Stuttgart). 1976;52(10):542\u20133."},{"key":"9122_CR29","unstructured":"Weilacher JS [Cough and its treatment with a new cough-blocking drug] [In German]. Z Allgemeinmed. 1972;48(4):185\u20137."},{"key":"9122_CR30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0197-2456(94)00031-W","volume":"16","author":"D Moher","year":"1995","unstructured":"Moher D, Jadad AR, Nichol G, et al. Assessing the quality of randomized controlled trials: an annotated bibliography of scales and checklists. Control Clin Trials 1995;16:62\u201373.","journal-title":"Control Clin Trials"},{"issue":"1","key":"9122_CR31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7326\/0003-4819-121-1-199407010-00003","volume":"121","author":"SN Goodman","year":"1994","unstructured":"Goodman SN, Berlin J, Fletcher SW, Fletcher RH Manuscript quality before and after peer review and editing at Annals of Internal Medicine. Ann Intern Med 1994;121(1):11\u201321.","journal-title":"Ann Intern Med"},{"key":"9122_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding Necessary? Control Clin Trials 1996;17:1\u201312.","journal-title":"Control Clin Trials"},{"key":"9122_CR33","unstructured":"Directive 2004\/24\/Ec of The European Parliament and of The Council. Official Journal of the European Union 2004(30.4) L 136\/85\u201390. Available from the homepage of European Commission, Enterprise and Industry, Pharmaceuticals at http:\/\/www.ec.europa.eu\/enterprise\/pharmaceuticals\/review\/doc\/final_publ\/dir_2004_24_20040430_en.pdf Cited 22 August 2006."}],"container-title":["Pharmacy World & Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-007-9122-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11096-007-9122-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-007-9122-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T18:44:41Z","timestamp":1683830681000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11096-007-9122-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,8]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,10,15]]}},"alternative-id":["9122"],"URL":"https:\/\/doi.org\/10.1007\/s11096-007-9122-2","relation":{},"ISSN":["0928-1231","1573-739X"],"issn-type":[{"value":"0928-1231","type":"print"},{"value":"1573-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,8]]}}}