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Early recognition of MALA and timely starting treatment may reduce its morbidity and mortality. <jats:italic>Objective<\/jats:italic> The aim of this study was to explore clinical parameters to identify patients with MALA in patients with suspected sepsis induced lactic acidosis in the emergency department ED. <jats:italic>Setting<\/jats:italic> A retrospective single centre study was conducted at the Deventer Teaching Hospital in the Netherlands. <jats:italic>Method<\/jats:italic> Patients with lactate concentration\u2009&gt;\u20094.0\u00a0mmol\/l admitted at the ED between 2010 and 2017 with suspected sepsis or confirmed MALA and referred to the Intensive Care Unit were included. Baseline characteristics (pH, lactate, creatinine and CRP) of MALA patients were compared with patients with suspected sepsis induced lactic acidosis. Creatinine and lactate concentration were selected as potential relevant parameters. <jats:italic>Main outcome measure<\/jats:italic> Sensitivity and specificity of the highest tertiles of the creatinine and the lactate concentrations separately, in combination, and both combined with metformin use, were calculated. <jats:italic>Results<\/jats:italic> Thirteen MALA and 90 suspected sepsis induced lactic acidosis patients were included. Lactate (14.7 vs 5.9\u00a0mmol\/l, p\u2009&lt;\u20090.01) and creatinine concentration (642 vs 174\u00a0\u03bcmol\/l, p\u2009&lt;\u20090.01) were significantly higher in the MALA group and arterial pH (7.04 vs 7.38, p\u2009&lt;\u20090.01) and CRP (90 vs 185\u00a0mg\/l, p\u2009&lt;\u20090.01) were significantly lower. The combined parameters lactate\u2009\u2265\u20098.4\u00a0mmol\/l, creatinine\u2009\u2265\u2009256\u00a0\u03bcmol\/l had a sensitivity of 85% and a specificity of 95% for identifying MALA in suspected sepsis induced lactic acidosis patients in the ED. When combined with metformin use the specificity increased to 99%. <jats:italic>Conclusion<\/jats:italic> When managing lactic acidosis in the ED the diagnosis MALA should be considered in patients with a creatinine concentration\u2009\u2265\u2009256\u00a0\u03bcmol\/l and lactate concentration\u2009\u2265\u20098.4\u00a0mmol\/l.<\/jats:p>","DOI":"10.1007\/s11096-020-01069-2","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T08:02:39Z","timestamp":1600761759000},"page":"1286-1292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identifying patients with metformin associated lactic acidosis in the emergency department"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-6706","authenticated-orcid":false,"given":"I. R. 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