{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T11:18:51Z","timestamp":1742642331051,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Pharm"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s11096-020-01135-9","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T18:51:56Z","timestamp":1599763916000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Discontinuation of antipsychotics treatment for elderly patients within a specialized behavioural unit: a retrospective review"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-1584","authenticated-orcid":false,"given":"Raymond LinBin","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate Sungeun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul Sunny","family":"Luthra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"1135_CR1","unstructured":"Public Health Agency of Canada. Dementia in Canada, including Alzheimer\u2019s disease highlights from the Canadian chronic disease surveillance system, Ottawa, Canada. Available from: https:\/\/www.canada.ca\/content\/dam\/phac-aspc\/documents\/services\/publications\/diseases-conditions\/dementia-highlights-canadian-chronic-disease-surveillance\/dementia-highlights-canadian-chronic-disease-surveillance.pdf. Accessed 11 Jul 2020."},{"key":"1135_CR2","unstructured":"Canadian Institute of Health Information. Use of antipsychotics among seniors living in long-term care facilities, Canada. Available from: https:\/\/secure.cihi.ca\/free_products\/LTC_AiB_v2_19_EN_web.pdf. Accessed 11 July 2020."},{"issue":"5","key":"1135_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1176\/appi.ajp.2015.173501","volume":"173","author":"VI Reus","year":"2016","unstructured":"Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, et al. The american psychiatric association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543\u20136.","journal-title":"Am J Psychiatry"},{"issue":"2","key":"1135_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/gps.1032","volume":"19","author":"PPD Deyn","year":"2004","unstructured":"Deyn PPD, Carrasco MM, Deberdt W, Jeandel C, Hay DP, Feldman PD, et al. Olanzapine versus placebo in the treatment of psychosis with or without associated behavioral disturbances in patients with Alzheimer\u2019s disease. Int J Geriatr Psychiatry. 2004;19(2):115\u201326.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"10","key":"1135_CR5","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1001\/archpsyc.57.10.968","volume":"57","author":"JS Street","year":"2000","unstructured":"Street JS, Clark SW, Gannon KS. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities. Arch Gen Psychiatry. 2000;57(10):968.","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"1135_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4088\/JCP.v60n0207","volume":"60","author":"IR Katz","year":"1999","unstructured":"Katz IR, Jeste DV, Mintzer JE, Clyde C, Napolitano J, Brecher M. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia. J Clin Psychiatry. 1999;60(2):107\u201315.","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"1135_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2174\/156720507779939805","volume":"4","author":"KX Zhong","year":"2007","unstructured":"Zhong KX, Tariot PN, Mintzer J, Minkwitz MC, Devine NA. Quetiapine to treat agitation in dementia: a randomized, double-blind, placebo-controlled study. Curr Alzheimer Res. 2007;4(1):81\u201393.","journal-title":"Curr Alzheimer Res"},{"issue":"2","key":"1135_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1474-4422(08)70295-3","volume":"8","author":"C Ballard","year":"2009","unstructured":"Ballard C, Hanney ML, Theodoulou M, Douglas S, Mcshane R, Kossakowski K, et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol. 2009;8(2):151\u20137.","journal-title":"Lancet Neurol"},{"key":"1135_CR9","doi-asserted-by":"crossref","unstructured":"Van Leeuwen E, Petrovic M, van Driel ML, De Sutter AI. Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia [Internet]. The Cochrane database of systematic reviews. U.S. National Library of Medicine; 2018 [cited 2020Sep7]. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29605970\/.","DOI":"10.1002\/14651858.CD007726.pub3"},{"key":"1135_CR10","unstructured":"Deprescribing Guidelines and Algorithms. Deprescribing.org. 2019. Available from: https:\/\/deprescribing.org\/resources\/deprescribing-guidelines-algorithms\/. Accessed 12 Jul 2020."},{"issue":"2","key":"1135_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1017\/S1041610202008396","volume":"14","author":"RV Reekum","year":"2002","unstructured":"Reekum RV, Clarke D, Conn D, Herrmann N, Eryavec G, Cohen T, et al. A randomized, placebo-controlled trial of the discontinuation of long-term antipsychotics in dementia. Int Psychogeriatr. 2002;14(2):197\u2013210.","journal-title":"Int Psychogeriatr"},{"issue":"4","key":"1135_CR12","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1176\/appi.ajp.2016.16020226","volume":"174","author":"AN Patel","year":"2017","unstructured":"Patel AN, Lee S, Andrews HF, Pelton GH, Schultz SK, Sultzer DL, et al. Prediction of relapse after discontinuation of antipsychotic treatment in Alzheimer\u2019s disease: the role of hallucinations. Am J Psychiatry. 2017;174(4):362\u20139.","journal-title":"Am J Psychiatry"},{"issue":"1","key":"1135_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4088\/JCP.v65n0120","volume":"65","author":"CG Ballard","year":"2004","unstructured":"Ballard CG, Thomas A, Fossey J, Lee L, Jacoby R, Lana MM, et al. A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome. J Clin Psychiatry. 2004;65(1):114\u20139.","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"1135_CR14","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/00019442-199503040-00003","volume":"3","author":"GJ Hortwitz","year":"1995","unstructured":"Hortwitz GJ, Tariot PN, Mead K, Cox C. Discontinuation of antipsychotics in nursing home patients with dementia. Am J Geriatr Psychiatry. 1995;3(4):290\u20139.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"260","key":"1135_CR15","first-page":"2","volume":"4","author":"AS Luthra","year":"2015","unstructured":"Luthra AS. A new behavioural assessment tool for patients with major neurocognitve disorders: results of a clinical study. J Gerontol Geriatr Res. 2015;4(260):2.","journal-title":"J Gerontol Geriatr Res"},{"issue":"12","key":"1135_CR16","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s00228-017-2333-0","volume":"73","author":"SW Narayan","year":"2017","unstructured":"Narayan SW, Nishtala PS. Development and validation of a Medicines Comorbidity Index for older people. Eur J Clin Pharmacol. 2017;73(12):1665\u201372.","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"1135_CR17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1176\/appi.ajp.2009.09060802","volume":"167","author":"DM Gardner","year":"2010","unstructured":"Gardner DM, Murphy AL, O\u2019donnell H, Centorrino F, Baldessarini RJ. International consensus study of antipsychotic dosing. Am J Psychiatry. 2010;167(6):686\u201393.","journal-title":"Am J Psychiatry"},{"issue":"2","key":"1135_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s40801-016-0073-6","volume":"3","author":"G Mast","year":"2016","unstructured":"Mast G, Fernandes K, Tadrous M, Martins D, Herrmann N, Gomes T. Persistence of antipsychotic treatment in elderly dementia patients: a retrospective, population-based cohort study. Drugs Real World Outcomes. 2016;3(2):175\u201382.","journal-title":"Drugs Real World Outcomes"},{"key":"1135_CR19","unstructured":"Tadrous M, Martins D, Herrmann N, Fernandes K, Yao Z, Singh S. Antipsychotics in the elderly (FINALReport: pharmacoepidemiology unit), Toronto, Canada 2015. Available from: https:\/\/odprn.ca\/wp-content\/uploads\/2015\/06\/Antipsychotic-Pepi-Report.pdf. Accessed 11 Jul 2020."},{"key":"1135_CR20","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2019","unstructured":"R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2019."},{"issue":"9","key":"1135_CR21","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/j.1468-1331.2012.03784.x","volume":"19","author":"S Sorbi","year":"2012","unstructured":"Sorbi S, Hort J, Erkinjuntti T, Fladby T, Gainotti G, Gurvit H, et al. EFNS-ENS guidelines on the diagnosis and management of disorders associated with dementia. Eur J Neurol. 2012;19(9):1159\u201379.","journal-title":"Eur J Neurol"},{"key":"1135_CR22","first-page":"5","volume":"65","author":"GS Alexopoulos","year":"2004","unstructured":"Alexopoulos GS, Streim J, Carpenter D, Docherty JP. Expert consensus panel for using antipsychotic drugs in older patients. Using antipsychotic agents in older patients. J Clin Psychiatry. 2004;65:5.","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"1135_CR23","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1177\/0269881117744996","volume":"32","author":"SJ Davies","year":"2018","unstructured":"Davies SJ, Burhan AM, Kim D, Gerretsen P, Graff-Guerrero A, Woo VL, et al. Sequential drug treatment algorithm for agitation and aggression in Alzheimer\u2019s and mixed dementia. J Psychopharmacol. 2018;32(5):509\u201323.","journal-title":"J Psychopharmacol"},{"issue":"15","key":"1135_CR24","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1056\/NEJMoa061240","volume":"355","author":"LS Schneider","year":"2006","unstructured":"Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer\u2019s disease. N Engl J Med. 2006;355(15):1525\u201338.","journal-title":"N Engl J Med"},{"issue":"1","key":"1135_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jgs.12061","volume":"61","author":"PA Rochon","year":"2013","unstructured":"Rochon PA, Gruneir A, Gill SS, Wu W, Fischer HD, Bronskill SE, et al. Older men with dementia are at greater risk than women of serious events after initiating antipsychotic therapy. J Am Geriatr Soc. 2013;61(1):55\u201361.","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"1135_CR26","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1001\/jamapsychiatry.2014.3018","volume":"72","author":"DT Maust","year":"2015","unstructured":"Maust DT, Kim HM, Seyfried LS, Chiang C, Kavanagh J, Schneider LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia. JAMA Psychiatry. 2015;72(5):438.","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"1135_CR27","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1177\/0091270011405665","volume":"52","author":"CS Sterke","year":"2012","unstructured":"Sterke CS, Beeck EFV, Velde NVD, Ziere G, Petrovic M, Looman CWN, et al. New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia. J Clin Pharmacol. 2012;52(6):947\u201355.","journal-title":"J Clin Pharmacol"}],"container-title":["International Journal of Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-020-01135-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11096-020-01135-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-020-01135-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T01:06:14Z","timestamp":1631235974000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11096-020-01135-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1135"],"URL":"https:\/\/doi.org\/10.1007\/s11096-020-01135-9","relation":{},"ISSN":["2210-7703","2210-7711"],"issn-type":[{"type":"print","value":"2210-7703"},{"type":"electronic","value":"2210-7711"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"7 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors declare no conflict of interest in the writing of this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}