{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:33:00Z","timestamp":1768710780633,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Pharm"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11096-022-01401-y","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T06:03:04Z","timestamp":1655272984000},"page":"922-929","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polypharmacy and medication regimen complexity in older patients with hemophilia or von willebrand disease: the M\u2019HEMORRH-AGE study"],"prefix":"10.1007","volume":"44","author":[{"given":"Teddy","family":"Novais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Prudent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Cransac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Gervais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Jouglen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Gigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Cahoreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Chamouard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"1401_CR1","unstructured":"Centre de R\u00e9f\u00e9rence H\u00e9mophilie et autres d\u00e9ficits constitutionnels en prot\u00e9ines de la coagulation. Protocole National de Diagnostic et de Soins (PNDS) H\u00e9mophilie. Version n\u00b03. [Internet]. 2019. Available on: https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2019-10\/pnds_hemophilie_argumentaire_10.10.19.pdf."},{"issue":"3","key":"1401_CR2","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1182\/blood-2006-10-050435","volume":"110","author":"SC Darby","year":"2007","unstructured":"Darby SC, Kan SW, Spooner RJ, et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood. 2007;110(3):815\u201325.","journal-title":"Blood"},{"issue":"3","key":"1401_CR3","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/jth.15182","volume":"19","author":"S Hassan","year":"2021","unstructured":"Hassan S, Monahan RC, Mauser-Bunschoten EP, et al. Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001\u20132018. J Thromb Haemost JTH. 2021;19(3):645\u201353.","journal-title":"J Thromb Haemost JTH"},{"issue":"4","key":"1401_CR4","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/j.1365-2141.2009.08005.x","volume":"148","author":"M Franchini","year":"2010","unstructured":"Franchini M, Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br J Haematol. 2010;148(4):522\u201333.","journal-title":"Br J Haematol"},{"issue":"2","key":"1401_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.critrevonc.2013.07.005","volume":"89","author":"C Hermans","year":"2014","unstructured":"Hermans C, de Moerloose P, Dolan G. Clinical management of older persons with haemophilia. Crit Rev Oncol Hematol. 2014;89(2):197\u2013206.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"12","key":"1401_CR6","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s40266-017-0500-8","volume":"34","author":"M Franchini","year":"2017","unstructured":"Franchini M, Mannucci PM. Management of Hemophilia in Older Patients. Drugs Aging. 2017;34(12):881\u20139.","journal-title":"Drugs Aging"},{"key":"1401_CR7","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.2147\/CIA.S136931","volume":"13","author":"J Chapin","year":"2018","unstructured":"Chapin J. Von Willebrand disease in the elderly: clinical perspectives. Clin Interv Aging. 2018;13:1531\u201341.","journal-title":"Clin Interv Aging"},{"issue":"1","key":"1401_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","volume":"10","author":"N Masnoon","year":"2017","unstructured":"Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;10(1):230. 17(.","journal-title":"BMC Geriatr"},{"issue":"1","key":"1401_CR9","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/hae.13262","volume":"24","author":"S Riva","year":"2018","unstructured":"Riva S, Mancuso ME, Cortesi L, et al. Polypharmacy in older adults with severe haemophilia. Haemoph Off J World Fed Hemoph. 2018;24(1):e1\u20133.","journal-title":"Haemoph Off J World Fed Hemoph"},{"issue":"5","key":"1401_CR10","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/hae.13595","volume":"24","author":"PM Mannucci","year":"2018","unstructured":"Mannucci PM, Nobili A, Marchesini E, et al. Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age-matched controls. Haemoph Off J World Fed Hemoph. 2018;24(5):726\u201332.","journal-title":"Haemoph Off J World Fed Hemoph"},{"issue":"4","key":"1401_CR11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1001\/jamainternmed.2015.8581","volume":"176","author":"DM Qato","year":"2016","unstructured":"Qato DM, Wilder J, Schumm LP, et al. Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011. JAMA Intern Med. 2016;176(4):473\u201382.","journal-title":"JAMA Intern Med"},{"key":"1401_CR12","unstructured":"McGarrigle C, Donoghue O, Scarlett S, et al. Health andWellbeing: Active Ageing for Older Adults in Ireland. Dublin: TheIrish Longitudinal Study on Ageing (TILDA). [Internet]. 2017. Available on: https:\/\/tilda.tcd.ie\/publications\/reports\/pdf\/w3-key-findings-report\/TILDA%20Wave%203%20Key%20Findings%20report.pdf."},{"issue":"2","key":"1401_CR13","first-page":"203","volume":"16","author":"D Stewart","year":"2017","unstructured":"Stewart D, Mair A, Wilson M, et al. Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments. Expert Opin Drug Saf f\u00e9vr. 2017;16(2):203\u201313.","journal-title":"Expert Opin Drug Saf f\u00e9vr"},{"issue":"12","key":"1401_CR14","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1111\/jgs.13153","volume":"62","author":"TR Fried","year":"2014","unstructured":"Fried TR, O\u2019Leary J, Towle V, et al. Health outcomes associated with polypharmacy in community-dwelling older adults: a systematic review. J Am Geriatr Soc. 2014;62(12):2261\u201372.","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"1401_CR15","first-page":"484","volume":"33","author":"EG Brysch","year":"2018","unstructured":"Brysch EG, Cauthon KAB, Kalich BA, et al. Medication Regimen Complexity Index in the Elderly in an Outpatient Setting: A Literature Review. Consult Pharm J Am Soc Consult Pharm. 2018;33(9):484\u201396.","journal-title":"Consult Pharm J Am Soc Consult Pharm"},{"issue":"9","key":"1401_CR16","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1345\/aph.1D479","volume":"38","author":"J George","year":"2004","unstructured":"George J, Phun Y-T, Bailey MJ, et al. Development and validation of the medication regimen complexity index. Ann Pharmacother. 2004;38(9):1369\u201376.","journal-title":"Ann Pharmacother"},{"key":"1401_CR17","unstructured":"WHOCC - Structure and principles [Internet]. Available on: https:\/\/www.whocc.no\/atc\/structure_and_principles\/. (Accessed 11.02.2021)."},{"issue":"4","key":"1401_CR18","first-page":"156","volume":"28","author":"DS Lee","year":"2012","unstructured":"Lee DS, de Rekeneire N, Hanlon JT, et al. Cognitive Impairment and Medication Complexity in Community-Living Older Adults: The Health, Aging and Body Composition Study. J Pharm Technol JPT Off Publ Assoc Pharm Tech. 2012;28(4):156\u201362.","journal-title":"J Pharm Technol JPT Off Publ Assoc Pharm Tech"},{"issue":"6","key":"1401_CR19","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/ggi.13261","volume":"18","author":"LL Pantuzza","year":"2018","unstructured":"Pantuzza LL, Ceccato M, das GB, et al. Validation and standardization of the Brazilian version of the Medication Regimen Complexity Index for older adults in primary care. Geriatr Gerontol Int. 2018;18(6):853\u20139.","journal-title":"Geriatr Gerontol Int"},{"key":"1401_CR20","doi-asserted-by":"crossref","unstructured":"Say\u0131n Z, Sancar M, \u00d6zen Y, et al. Polypharmacy, potentially inappropriate prescribing and medication complexity in Turkish older patients in the community pharmacy setting. Acta Clin Belg. 2022;77(2):273\u2013279.","DOI":"10.1080\/17843286.2020.1829251"},{"issue":"4","key":"1401_CR21","first-page":"659","volume":"13","author":"JM Ferreira","year":"2015","unstructured":"Ferreira JM, Galato D, Melo AC. Medication regimen complexity in adults and the elderly in a primary healthcare setting: determination of high and low complexities. Pharm Pract. 2015;13(4):659.","journal-title":"Pharm Pract"},{"issue":"2","key":"1401_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11096-012-9730-3","volume":"35","author":"RA Elliott","year":"2013","unstructured":"Elliott RA, O\u2019Callaghan C, Paul E, et al. Impact of an intervention to reduce medication regimen complexity for older hospital inpatients. Int J Clin Pharm. 2013;35(2):217\u201324.","journal-title":"Int J Clin Pharm"},{"issue":"5","key":"1401_CR23","first-page":"396","volume":"19","author":"D Stange","year":"2013","unstructured":"Stange D, Kriston L, von-Wolff A, et al. Reducing cardiovascular medication complexity in a German university hospital: effects of a structured pharmaceutical management intervention on adherence. J Manag Care Pharm JMCP. 2013;19(5):396\u2013407.","journal-title":"J Manag Care Pharm JMCP"},{"issue":"12","key":"1401_CR24","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nrgastro.2017.117","volume":"14","author":"P Malfertheiner","year":"2017","unstructured":"Malfertheiner P, Kandulski A, Venerito M. Proton-pump inhibitors: understanding the complications and risks. Nat Rev Gastroenterol Hepatol. 2017;14(12):697\u2013710.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"1401_CR25","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1182\/bloodadvances.2018018226","volume":"2","author":"SL Sood","year":"2018","unstructured":"Sood SL, Cheng D, Ragni M, et al. A cross-sectional analysis of cardiovascular disease in the hemophilia population. Blood Adv. 2018;2(11):1325\u201333.","journal-title":"Blood Adv"},{"issue":"1","key":"1401_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12877-018-0978-x","volume":"18","author":"A Todd","year":"2018","unstructured":"Todd A, Jansen J, Colvin J, et al. The deprescribing rainbow: a conceptual framework highlighting the importance of patient context when stopping medication in older people. BMC Geriatr. 2018;18(1):295.","journal-title":"BMC Geriatr"}],"container-title":["International Journal of Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-022-01401-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11096-022-01401-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-022-01401-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T20:00:31Z","timestamp":1670616031000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11096-022-01401-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1401"],"URL":"https:\/\/doi.org\/10.1007\/s11096-022-01401-y","relation":{},"ISSN":["2210-7703","2210-7711"],"issn-type":[{"value":"2210-7703","type":"print"},{"value":"2210-7711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"assertion":[{"value":"18 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}