{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:58:02Z","timestamp":1772773082618,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003093","name":"the Ministry of Higher Education Malaysia","doi-asserted-by":"crossref","award":["LRGS\/1\/2019\/UM\/01\/1\/3"],"award-info":[{"award-number":["LRGS\/1\/2019\/UM\/01\/1\/3"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Clin Pharm"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11096-024-01791-1","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T08:02:19Z","timestamp":1726128139000},"page":"1453-1463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The usage of anticholinergic medications in a low- and middle-income country: a longitudinal comparison of 2013\u201315 and 2020\u201322 datasets"],"prefix":"10.1007","volume":"46","author":[{"given":"Xiang Jiang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyo Kyaw","family":"Myint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun Wen Huey","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalavathy","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siong Meng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Bakar Abdul","family":"Majeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuet Yen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaiyah","family":"Mat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor Izzati","family":"Saedon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazlina","family":"Mahadzir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejal","family":"Hasmukharay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-8540","authenticated-orcid":false,"given":"Maw Pin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"1791_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/bcp.15045","volume":"88","author":"J Mur","year":"2022","unstructured":"Mur J, Cox SR, Marioni RE, et al. Increase in anticholinergic burden from 1990 to 2015: age-period-cohort analysis in UK biobank. Br J Clin Pharmacol. 2022;88:983\u201393.","journal-title":"Br J Clin Pharmacol"},{"key":"1791_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40520-015-0359-7","volume":"28","author":"A Collamati","year":"2016","unstructured":"Collamati A, Martone AM, Poscia A, et al. Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res. 2016;28:25\u201335.","journal-title":"Aging Clin Exp Res"},{"key":"1791_CR3","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s11096-024-01725-x","volume":"46","author":"A Matsumoto","year":"2024","unstructured":"Matsumoto A, Yoshimura Y, Nagano F, et al. Exploring the impact of anticholinergic burden on urinary independence: insights from a post-stroke cohort of older adults. Int J Clin Pharm. 2024;46:910\u20137. https:\/\/doi.org\/10.1007\/s11096-024-01725-x.","journal-title":"Int J Clin Pharm"},{"key":"1791_CR4","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/fcp.12450","volume":"33","author":"S de Germay","year":"2019","unstructured":"de Germay S, Rueter M, Montastruc F, et al. Trends of atropinic (anticholinergic) exposure in the elderly: a 10-year analysis in the French EGB database. Fundam Clin Pharmacol. 2019;33:471\u20138.","journal-title":"Fundam Clin Pharmacol"},{"key":"1791_CR5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/CLEP.S153458","volume":"10","author":"L Morin","year":"2018","unstructured":"Morin L, Johnell K, Laroche ML, et al. The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Clin Epidemiol. 2018;10:289.","journal-title":"Clin Epidemiol"},{"key":"1791_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101860","author":"SR Chowdhury","year":"2023","unstructured":"Chowdhury SR, Das DC, Sunna TC, et al. Global and regional prevalence of multimorbidity in the adult population in community settings: a systematic review and meta-analysis. eClinical Med. 2023. https:\/\/doi.org\/10.1016\/j.eclinm.2023.101860.","journal-title":"eClinical Med."},{"key":"1791_CR7","doi-asserted-by":"publisher","first-page":"e13942","DOI":"10.1111\/ijcp.13942","volume":"75","author":"L Hellemans","year":"2021","unstructured":"Hellemans L, Nuyts S, Hias J, et al. Polypharmacy and excessive polypharmacy in community-dwelling middle aged and aged adults between 2011 and 2015. Int J Clin Pract. 2021;75:e13942.","journal-title":"Int J Clin Pract"},{"key":"1791_CR8","doi-asserted-by":"publisher","first-page":"k1315","DOI":"10.1136\/bmj.k1315","volume":"361","author":"K Richardson","year":"2018","unstructured":"Richardson K, Fox C, Maidment I, et al. Anticholinergic drugs and risk of dementia: case-control study. BMJ. 2018;361:k1315.","journal-title":"BMJ"},{"key":"1791_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00228-019-02795-x","volume":"76","author":"S Ali","year":"2020","unstructured":"Ali S, Peterson GM, Bereznicki LR, et al. Association between anticholinergic drug burden and mortality in older people: a systematic review. Eur J Clin Pharmacol. 2020;76:319\u201335.","journal-title":"Eur J Clin Pharmacol"},{"key":"1791_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.maturitas.2015.10.009","volume":"84","author":"A Zia","year":"2016","unstructured":"Zia A, Kamaruzzaman S, Myint PK, et al. Anticholinergic burden is associated with recurrent and injurious falls in older individuals. Maturitas. 2016;84:32\u20137.","journal-title":"Maturitas"},{"key":"1791_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2217\/1745509X.4.3.311","volume":"4","author":"M Boustani","year":"2008","unstructured":"Boustani M, Campbell N, Munger S, et al. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health. 2008;4:311\u201320.","journal-title":"Aging Health"},{"key":"1791_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/archinternmed.2007.106","volume":"168","author":"JL Rudolph","year":"2008","unstructured":"Rudolph JL, Salow MJ, Angelini MC, et al. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med. 2008;168:508\u201313. https:\/\/doi.org\/10.1001\/archinternmed.2007.106.","journal-title":"Arch Intern Med"},{"key":"1791_CR13","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1177\/0091270006292126","volume":"46","author":"RM Carnahan","year":"2006","unstructured":"Carnahan RM, Lund BC, Perry PJ, et al. The anticholinergic drug scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol. 2006;46:1481\u20136.","journal-title":"J Clin Pharmacol"},{"key":"1791_CR14","doi-asserted-by":"publisher","first-page":"103885","DOI":"10.1016\/j.archger.2019.05.010","volume":"87","author":"G Lozano-Ortega","year":"2020","unstructured":"Lozano-Ortega G, Johnston KM, Cheung A, et al. A review of published anticholinergic scales and measures and their applicability in database analyses. Arch Gerontol Geriatr. 2020;87:103885.","journal-title":"Arch Gerontol Geriatr"},{"key":"1791_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-020-01657-x","volume":"20","author":"CM Grossi","year":"2020","unstructured":"Grossi CM, Richardson K, Savva GM, et al. Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II. BMC Geriatr. 2020;20:1\u20138.","journal-title":"BMC Geriatr"},{"key":"1791_CR16","doi-asserted-by":"publisher","first-page":"e0173466","DOI":"10.1371\/journal.pone.0173466","volume":"12","author":"LM Lim","year":"2017","unstructured":"Lim LM, McStea M, Chung WW, et al. Prevalence, risk factors and health outcomes associated with polypharmacy among urban community-dwelling older adults in multi-ethnic Malaysia. PLoS ONE. 2017;12:e0173466.","journal-title":"PLoS ONE"},{"key":"1791_CR17","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s40520-015-0511-4","volume":"28","author":"S Shahar","year":"2016","unstructured":"Shahar S, Omar A, Vanoh D, et al. Approaches in methodology for population-based longitudinal study on neuroprotective model for healthy longevity (TUA) among Malaysian older adults. Aging Clin Exp Res. 2016;28:1089\u2013104.","journal-title":"Aging Clin Exp Res"},{"key":"1791_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.sapharm.2023.11.001","volume":"20","author":"NA Ibrahim","year":"2024","unstructured":"Ibrahim NA, Wong YY, Lean QY, et al. Medication self-management among older adults with cognitive frailty. Res Soc Adm Pharm. 2024;20:172\u201381.","journal-title":"Res Soc Adm Pharm"},{"issue":"3","key":"1791_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0005-7967(94)00075-U","volume":"33","author":"PF Lovibond","year":"1995","unstructured":"Lovibond PF, Lovibond SH. The structure of negative emotional states: comparison of the depression anxiety stress scales (DASS) with the beck depression and anxiety inventories. Behav Res Ther. 1995;33(3):335\u201343.","journal-title":"Behav Res Ther"},{"key":"1791_CR20","first-page":"165","volume":"5","author":"JI Sheikh","year":"2014","unstructured":"Sheikh JI, Yesavage JA. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 2014;5:165\u201373.","journal-title":"Clin gerontol"},{"issue":"S1","key":"1791_CR21","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1111\/jgs.2013.61.issue-s1","volume":"61","author":"NL Campbell","year":"2013","unstructured":"Campbell NL, Maidment I, Fox C, et al. The 2012 update to the anticholinergic cognitive burden scale. J Am Geriatr Soc. 2013;61(S1):S142\u20133. https:\/\/doi.org\/10.1111\/jgs.2013.61.issue-s1.","journal-title":"J Am Geriatr Soc"},{"key":"1791_CR22","doi-asserted-by":"publisher","first-page":"104535","DOI":"10.1016\/j.archger.2021.104535","volume":"98","author":"XJ Xu","year":"2022","unstructured":"Xu XJ, Myint PK, Kioh SH, et al. A five-year prospective evaluation of anticholinergic cognitive burden and falls in the Malaysian elders longitudinal research (MELoR) study. Arch Gerontol Geriatr. 2022;98:104535.","journal-title":"Arch Gerontol Geriatr"},{"key":"1791_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377\u201381.","journal-title":"J Biomed Inform"},{"key":"1791_CR24","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","volume":"95","author":"PA Harris","year":"2019","unstructured":"Harris PA, Taylor R, Minor BL, et al. The REDCap consortium: building an international community of software platform partners. J Biomed Inform. 2019;95:103208.","journal-title":"J Biomed Inform"},{"key":"1791_CR25","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00228-015-1815-1","volume":"71","author":"F Moriarty","year":"2015","unstructured":"Moriarty F, Bennett K, Fahey T, et al. Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people. Eur J Clin Pharmacol. 2015;71:473\u201382.","journal-title":"Eur J Clin Pharmacol"},{"key":"1791_CR26","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/ageing\/afu185","volume":"44","author":"PK Myint","year":"2015","unstructured":"Myint PK, Fox C, Kwok CS, et al. Total anticholinergic burden and risk of mortality and cardiovascular disease over 10 years in 21,636 middle-aged and older men and women of EPIC-Norfolk prospective population study. Age Ageing. 2015;44:219\u201325.","journal-title":"Age Ageing"},{"key":"1791_CR27","doi-asserted-by":"publisher","first-page":"l5832","DOI":"10.1136\/bmj.l5832","volume":"367","author":"E Mahase","year":"2019","unstructured":"Mahase E. FDA recalls ranitidine medicines over potential cancer causing impurity. BMJ. 2019;367:l5832.","journal-title":"BMJ"},{"key":"1791_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4103\/apjtm.apjtm_614_23","volume":"17","author":"A Sundus","year":"2024","unstructured":"Sundus A, Sellappans R, Tan MP. Informing policy makers in developing countries: practices and limitations of geriatric home medication review in Malaysia-a qualitative inquiry. Asian Pac J Trop Med. 2024;17:21\u20139.","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"1791_CR29","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1016\/j.japh.2020.08.029","volume":"61","author":"S Kuo","year":"2021","unstructured":"Kuo S, Ou HT, Wang CJ. Managing medication supply chains: lessons learned from Taiwan during the COVID-19 pandemic and preparedness planning for the future. J Am Pharm Assoc. 2021;61(1):e12\u20135.","journal-title":"J Am Pharm Assoc"},{"key":"1791_CR30","doi-asserted-by":"publisher","first-page":"iii","DOI":"10.52494\/TIOG4999","volume":"8","author":"CM Long","year":"2022","unstructured":"Long CM, Chan SY. The paradigm shift of pharmacy profession at post-COVID-19 era in Malaysia. Malays J Pharm. 2022;8:iii\u2013v.","journal-title":"Malays J Pharm"},{"key":"1791_CR31","doi-asserted-by":"publisher","first-page":"e002315","DOI":"10.1161\/JAHA.115.002315","volume":"4","author":"LC Kovell","year":"2015","unstructured":"Kovell LC, Ahmed HM, Misra S, et al. US hypertension management guidelines: a review of the recent past and recommendations for the future. J Am Heart Assoc. 2015;4:e002315.","journal-title":"J Am Heart Assoc"},{"key":"1791_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2840-8-18","volume":"8","author":"P Bramlage","year":"2009","unstructured":"Bramlage P, Hasford J. Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment\u2013a review. Cardiovasc Diabetol. 2009;8:1\u201313.","journal-title":"Cardiovasc diabetol"},{"key":"1791_CR33","unstructured":"Ministry of Health Malaysia. Specialty & subspecialty framework of ministry of health hospitals under 11th Malaysia plan (2016\u20132020). 2016. ISBN: 978-967-0509-17-4."},{"key":"1791_CR34","doi-asserted-by":"publisher","first-page":"e007218","DOI":"10.1161\/CIRCHEARTFAILURE.120.007218","volume":"13","author":"P Martinez-Amezcua","year":"2020","unstructured":"Martinez-Amezcua P, Haque W, Khera R, et al. The upcoming epidemic of heart failure in South Asia. Circ Heart Fail. 2020;13:e007218.","journal-title":"Circ Heart Fail"},{"key":"1791_CR35","doi-asserted-by":"publisher","first-page":"S622","DOI":"10.1067\/mai.2000.106153","volume":"105","author":"GG Kay","year":"2000","unstructured":"Kay GG. The effects of antihistamines on cognition and performance. J Allergy Clin Immunol. 2000;105:S622\u20137.","journal-title":"J Allergy Clin Immunol"},{"key":"1791_CR36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/S40037-016-0319-8","volume":"6","author":"RSY Wong","year":"2017","unstructured":"Wong RSY, Abdul Kadir SY. Medical education in Malaysia: quality versus quantity. Perspect Med Educ. 2017;6:10\u20131.","journal-title":"Perspect Med Educ"},{"key":"1791_CR37","doi-asserted-by":"publisher","first-page":"e12475","DOI":"10.1111\/appy.12475","volume":"14","author":"K Munawar","year":"2022","unstructured":"Munawar K, Mukhtar F, Choudhry FR, et al. Mental health literacy: a systematic review of knowledge and beliefs about mental disorders in Malaysia. Asia Pac Psychiatry. 2022;14:e12475.","journal-title":"Asia Pac Psychiatry"},{"key":"1791_CR38","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12877-019-1126-y","volume":"19","author":"MT Lornstad","year":"2019","unstructured":"Lornstad MT, Aar\u00f8en M, Bergh S, et al. Prevalence and persistent use of psychotropic drugs in older adults receiving domiciliary care at baseline. BMC Geriatr. 2019;19:119.","journal-title":"BMC Geriatr"},{"key":"1791_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/1529100614531398","volume":"15","author":"PW Corrigan","year":"2014","unstructured":"Corrigan PW, Druss BG, Perlick DA. The impact of mental illness stigma on seeking and participating in mental health care. Psychol Sci Public Interest. 2014;15:37\u201370.","journal-title":"Psychol Sci Public Interest"},{"key":"1791_CR40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.33879\/AMH.131.2020.10041","volume":"13","author":"NTH Ng","year":"2022","unstructured":"Ng NTH, Tan MP. Training needs among healthcare professionals managing patients with dementia. Aging Med Healthc. 2022;13:25\u201331.","journal-title":"Aging Med Healthc"},{"key":"1791_CR41","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1176\/appi.ajp.2011.11030347","volume":"169","author":"HC Kales","year":"2012","unstructured":"Kales HC, Kim HM, Zivin K, et al. Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry. 2012;169:71\u20139.","journal-title":"Am J Psychiatry"},{"key":"1791_CR42","doi-asserted-by":"publisher","first-page":"e814","DOI":"10.1111\/hsc.12804","volume":"27","author":"L Kerpershoek","year":"2019","unstructured":"Kerpershoek L, Wolfs C, Verhey F, et al. Optimizing access to and use of formal dementia care: qualitative findings from the European Actifcare study. Health Soc Care Community. 2019;27:e814\u201323.","journal-title":"Health Soc Care Community"}],"container-title":["International Journal of Clinical Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-024-01791-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11096-024-01791-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11096-024-01791-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T21:09:56Z","timestamp":1732050596000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11096-024-01791-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1791"],"URL":"https:\/\/doi.org\/10.1007\/s11096-024-01791-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4226774\/v1","asserted-by":"object"}]},"ISSN":["2210-7703","2210-7711"],"issn-type":[{"value":"2210-7703","type":"print"},{"value":"2210-7711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"6 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}