{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:19:47Z","timestamp":1790860787908,"version":"4.1.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s11102-006-6042-4","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T03:30:46Z","timestamp":1141183846000},"page":"203-211","source":"Crossref","is-referenced-by-count":87,"title":["Hypopituitarism As a Consequence of Brain Tumours and Radiotherapy"],"prefix":"10.1007","volume":"8","author":[{"given":"Ken H.","family":"Darzy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Shalet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,2,27]]},"reference":[{"key":"6042_CR1","first-page":"89","volume-title":"Biological effects of radiation","author":"JE Coggle","year":"1983","unstructured":"Coggle JE. The effect of radiation at the tissue level. In: Biological effects of radiation. London: Taylor and Francis, 1983:89\u2013109."},{"key":"6042_CR2","first-page":"53","volume-title":"Fractionation in Radiotherapy","author":"HD Thames","year":"1987","unstructured":"Thames HD, Hendry JH. Response of tissues to fractionated irradiation: effect of repair. In: Fractionation in Radiotherapy. London: Taylor & Francis, 1987:53\u201399."},{"key":"6042_CR3","first-page":"5","volume-title":"Current radiation oncology","author":"HR Withers","year":"1994","unstructured":"Withers HR. Biology of radiation oncology. In: Tobias JS, Thomas PRM (Eds.) Current radiation oncology. London: Edward Arnold, 1994:5\u201323."},{"key":"6042_CR4","doi-asserted-by":"crossref","unstructured":"Hopewell JW. Radiation injury to the central nervous system. Med Pediatr Oncol 1998;(Suppl 1):1\u20139.","DOI":"10.1002\/(SICI)1096-911X(1998)30:1+<1::AID-MPO1>3.0.CO;2-Y"},{"key":"6042_CR5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2265.1976.tb01955.x","volume":"5","author":"SM Shalet","year":"1976","unstructured":"Shalet SM, Beardwell CG, Pearson D, Jones PH. The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol Oxf 1976;5:287\u2013290.","journal-title":"Clin Endocrinol Oxf"},{"key":"6042_CR6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1056\/NEJM199301143280203","volume":"328","author":"LS Constine","year":"1993","unstructured":"Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF, Rubin P. Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 1993;328:87\u201394.","journal-title":"N Engl J Med"},{"key":"6042_CR7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3476(05)80487-1","volume":"118","author":"PE Clayton","year":"1991","unstructured":"Clayton PE, Shalet SM. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr 1991;118:226\u2013228.","journal-title":"J Pediatr"},{"key":"6042_CR8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2265.1989.tb01260.x","volume":"31","author":"MD Littley","year":"1989","unstructured":"Littley MD, Shalet SM, Beardwell CG, Robinson EL, Sutton ML. Radiation-induced hypopituitarism is dose-dependent. Clin Endocrinol Oxf 1989;31:363\u2013373.","journal-title":"Clin Endocrinol Oxf"},{"key":"6042_CR9","first-page":"165","volume":"78","author":"KS Lam","year":"1991","unstructured":"Lam KS, Tse VK, Wang C, Yeung RT, Ho JH. Effects of cranial irradiation on hypothalamic-pituitary function\u2013a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med 1991;78:165\u2013176.","journal-title":"Q J Med"},{"key":"6042_CR10","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/1097-0142(19851101)56:9<2189::AID-CNCR2820560909>3.0.CO;2-I","volume":"56","author":"PK Duffner","year":"1985","unstructured":"Duffner PK, Cohen ME, Voorhess ML, MacGillivray MH, Brecher ML, Panahon A, Gilani BB. Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer 1985;56:2189\u20132193.","journal-title":"Cancer"},{"key":"6042_CR11","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/0360-3016(82)90442-4","volume":"8","author":"NA Samaan","year":"1982","unstructured":"Samaan NA, Vieto R, Schultz PN, Maor M, Meoz RT, Sampiere VA, Cangir A, Ried HL, Jesse RH Jr. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. Int J Radiat Oncol Biol Phys 1982;8:1857\u20131867.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6042_CR12","first-page":"265","volume":"19","author":"MS Chen","year":"1989","unstructured":"Chen MS, Lin FJ, Huang MJ, Wang PW, Tang S, Leung WM, Leung W. Prospective hormone study of hypothalamic-pituitary function in patients with nasopharyngeal carcinoma after high dose irradiation. Jpn J Clin Oncol 1989;19:265\u2013270.","journal-title":"Jpn J Clin Oncol"},{"key":"6042_CR13","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0360-3016(00)01387-0","volume":"49","author":"HH Pai","year":"2001","unstructured":"Pai HH, Thornton A, Katznelson L, Finkelstein DM, Adams JA, Fullerton BC, Loeffler JS, Leibsch NJ, Klibanski A, Munzenrider JE. Hypothalamic\/pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. J Radiat Oncol Biol Phys 2001;49:1079\u20131092.","journal-title":"J Radiat Oncol Biol Phys"},{"key":"6042_CR14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF03178355","volume":"24","author":"L Jones","year":"2001","unstructured":"Jones L, Hoban P, Metcalfe P. The use of the linear quadratic model in radiotherapy: a review. Australas Phys Eng Sci Med 2001;24:132\u2013146.","journal-title":"Australas Phys Eng Sci Med"},{"key":"6042_CR15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2265.2000.01079.x","volume":"53","author":"M Schmiegelow","year":"2000","unstructured":"Schmiegelow M, Lassen S, Poulsen HS, Feldt-Rasmussen U, Schmiegelow K, Hertz H, Muller J. Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study. Clin Endocrinol 2000;53:191\u2013197.","journal-title":"Clin Endocrinol"},{"key":"6042_CR16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1210\/jc.2002-021094","volume":"88","author":"KH Darzy","year":"2003","unstructured":"Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM. The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab 2003;88:95\u2013102.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR17","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/jc.2003-031224","volume":"89","author":"HK Gleeson","year":"2004","unstructured":"Gleeson HK, Gattamaneni HR, Smethurst L, Brennan BM, Shalet SM. Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy. J Clin Endocrinol Metab 2004;89:662\u2013666.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0022-3476(86)81027-7","volume":"108","author":"R Brauner","year":"1986","unstructured":"Brauner R, Czernichow P, Rappaport R. Greater susceptibility to hypothalamopituitary irradiation in younger children with acute lymphoblastic leukemia. J Pediatr 1986;108:332.","journal-title":"J Pediatr"},{"key":"6042_CR19","first-page":"364","volume":"109","author":"NA Samaan","year":"1987","unstructured":"Samaan NA, Schultz PN, Yang KP, Vassilopoulou-Sellin R, Maor MH, Cangir A, Goepfert H. Endocrine complications after radiotherapy for tumors of the head and neck. J Lab Clin Med 1987;109:364\u2013372.","journal-title":"J Lab Clin Med"},{"key":"6042_CR20","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/adc.67.9.1107","volume":"67","author":"AL Ogilvy-Stuart","year":"1992","unstructured":"Ogilvy-Stuart AL, Clark DJ, Wallace WH, Gibson BE, Stevens RF, Shalet SM, Donaldson MD. Endocrine deficit after fractionated total body irradiation. Arch Dis Child 1992;67:1107\u20131110.","journal-title":"Arch Dis Child"},{"key":"6042_CR21","first-page":"265","volume":"78","author":"MD Littley","year":"1991","unstructured":"Littley MD, Shalet SM, Morgenstern GR, Deakin DP. Endocrine and reproductive dysfunction following fractionated total body irradiation in adults. Q J Med 1991;78:265\u2013274.","journal-title":"Q J Med"},{"key":"6042_CR22","first-page":"145","volume":"70","author":"MD Littley","year":"1989","unstructured":"Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G, Sutton ML. Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med 1989;70:145\u2013160.","journal-title":"Q J Med"},{"key":"6042_CR23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0140-6736(75)90006-9","volume":"2","author":"SM Shalet","year":"1975","unstructured":"Shalet SM, Beardwell CG, Morris-Jones PH, Pearson D. Pituitary function after treatment of intracranial tumours in children. Lancet 1975;2:104\u2013107.","journal-title":"Lancet"},{"key":"6042_CR24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1651-2227.1986.tb10195.x","volume":"75","author":"SR Ahmed","year":"1986","unstructured":"Ahmed SR, Shalet SM, Beardwell CG. The effects of cranial irradiation on growth hormone secretion. Acta Paediatr Scand 1986;75:255\u2013260.","journal-title":"Acta Paediatr Scand"},{"key":"6042_CR25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1210\/jcem-54-6-1135","volume":"54","author":"GP Chrousos","year":"1982","unstructured":"Chrousos GP, Poplack D, Brown T, D ON, Schwade J, Bercu BB. Effects of cranial radiation on hypothalamic-adenohypophyseal function: abnormal growth hormone secretory dynamics. J Clin Endocrinol Metab 1982;54:1135\u20131139.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000180772","volume":"27","author":"B Lannering","year":"1987","unstructured":"Lannering B, Albertsson-Wikland K. Growth hormone release in children after cranial irradiation. Horm Res 1987;27:13\u201322.","journal-title":"Horm Res"},{"key":"6042_CR27","first-page":"847","volume":"142","author":"G Costin","year":"1988","unstructured":"Costin G. Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function. Am J Dis Child 1988;142:847\u2013852.","journal-title":"Am J Dis Child"},{"key":"6042_CR28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.0.1360331","volume":"136","author":"M Ryalls","year":"1993","unstructured":"Ryalls M, Spoudeas HA, Hindmarsh PC, Matthews DR, Tait DM, Meller ST, Brook CG. Short-term endocrine consequences of total body irradiation and bone marrow transplantation in children treated for leukemia. J Endocrinol 1993;136:331\u2013338.","journal-title":"J Endocrinol"},{"key":"6042_CR29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-83-6-771","volume":"83","author":"NA Samaan","year":"1975","unstructured":"Samaan NA, Bakdash MM, Caderao JB, Cangir A, Jesse RH Jr, Ballantyne AJ. Hypopituitarism after external irradiation. Evidence for both hypothalamic and pituitary origin. Ann Intern Med 1975;83:771\u2013777.","journal-title":"Ann Intern Med"},{"key":"6042_CR30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1677\/joe.0.1080025","volume":"108","author":"A Blacklay","year":"1986","unstructured":"Blacklay A, Grossman A, Ross RJ, Savage MO, Davies PS, Plowman PN, Coy DH, Besser GM. Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release. J Endocrinol 1986;108:25\u201329.","journal-title":"J Endocrinol"},{"key":"6042_CR31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2265.1986.tb01660.x","volume":"24","author":"KS Lam","year":"1986","unstructured":"Lam KS, Wang C, Yeung RT, Ma JT, Ho JH, Tse VK, Ling N. Hypothalamic hypopituitarism following cranial irradiation for nasopharyngeal carcinoma. Clin Endocrinol (Oxf) 1986;24:643\u2013651.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6042_CR32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/acta.0.1150301","volume":"115","author":"A Jadresic","year":"1987","unstructured":"Jadresic A, Jimenez LE, Joplin GF. Long-term effect of 90Y pituitary implantation in acromegaly. Acta Endocrinol (Copenh) 1987;115:301\u2013306.","journal-title":"Acta Endocrinol (Copenh)"},{"key":"6042_CR33","first-page":"53","volume":"54","author":"M Schmiegelow","year":"2000","unstructured":"Schmiegelow M, Lassen S, Poulsen HS, Feldt-Rasmussen U, Schmiegelow K, Hertz H, Muller J. Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumors. Horm Res 2000;54:53\u201359.","journal-title":"Horm Res"},{"key":"6042_CR34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1677\/joe.0.1500329","volume":"150","author":"HA Spoudeas","year":"1996","unstructured":"Spoudeas HA, Hindmarsh PC, Matthews DR, Brook CG. Evolution of growth hormone neurosecretory disturbance after cranial irradiation for childhood brain tumours: a prospective study. J Endocrinol 1996;150:329\u2013342.","journal-title":"J Endocrinol"},{"key":"6042_CR35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1530\/eje.0.1420359","volume":"142","author":"JC Achermann","year":"2000","unstructured":"Achermann JC, Brook CG, Hindmarsh PC. The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients with longstanding post-irradiation GH insufficiency. Eur J Endocrinol 2000;142:359\u2013364.","journal-title":"Eur J Endocrinol"},{"key":"6042_CR36","first-page":"661","volume":"12","author":"PU Chieng","year":"1991","unstructured":"Chieng PU, Huang TS, Chang CC, Chong PN, Tien RD, Su CT. Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients. Am J Neuroradiol 1991;12:661\u2013665.","journal-title":"Am J Neuroradiol"},{"key":"6042_CR37","first-page":"131","volume":"6","author":"EV Jorgensen","year":"1993","unstructured":"Jorgensen EV, Schwartz ID, Hvizdala E, Barbosa J, Phuphanich S, Shulman DI, Root AW, Estrada J, Hu CS, Bercu BB. Neurotransmitter control of growth hormone secretion in children after cranial radiation therapy. J Pediatr Endocrinol 1993;6:131\u2013142.","journal-title":"J Pediatr Endocrinol"},{"key":"6042_CR38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1677\/joe.0.1690519","volume":"169","author":"IC Robinson","year":"2001","unstructured":"Robinson IC, Fairhall KM, Hendry JH, Shalet SM. Differential radiosensitivity of hypothalamo-pituitary function in the young adult rat. J Endocrinol 2001;169:519\u2013526.","journal-title":"J Endocrinol"},{"key":"6042_CR39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2307\/3575908","volume":"94","author":"Z Hochberg","year":"1983","unstructured":"Hochberg Z, Kuten A, Hertz P, Tatcher M, Kedar A, Benderly A. The effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells. Radiat Res 1983;94:508\u2013512.","journal-title":"Radiat Res"},{"key":"6042_CR40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/adc.51.7.489","volume":"51","author":"SM Shalet","year":"1976","unstructured":"Shalet SM, Beardwell CG, Jones PH, Pearson D. Growth hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child 1976;51:489\u2013493.","journal-title":"Arch Dis Child"},{"key":"6042_CR41","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-3476(79)80137-7","volume":"94","author":"SM Shalet","year":"1979","unstructured":"Shalet SM, Price DA, Beardwell CG, Jones PH, Pearson D. Normal growth despite abnormalities of growth hormone secretion in children treated for acute leukemia. J Pediatr 1979;94:719\u2013722.","journal-title":"J Pediatr"},{"key":"6042_CR42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(87)90004-3","volume":"1","author":"JA Kirk","year":"1987","unstructured":"Kirk JA, Raghupathy P, Stevens MM, Cowell CT, Menser MA, Bergin M, Tink A, Vines RH, Silink M. Growth failure and growth-hormone deficiency after treatment for acute lymphoblastic leukaemia. Lancet 1987;1:190\u2013193.","journal-title":"Lancet"},{"key":"6042_CR43","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-2265.1998.00438.x","volume":"48","author":"BM Brennan","year":"1998","unstructured":"Brennan BM, Rahim A, Mackie EM, Eden OB, Shalet SM. Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clin Endocrinol (Oxf) 1998;48:777\u2013783.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6042_CR44","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1182\/blood.V86.2.825.bloodjournal862825","volume":"86","author":"G Giorgiani","year":"1995","unstructured":"Giorgiani G, Bozzola M, Locatelli F, Picco P, Zecca M, Cisternino M, Dallorso S, Bonetti F, Dini G, Borrone C, Regazzi MB, P DS, F S. Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Blood 1995;86:825\u2013831.","journal-title":"Blood"},{"key":"6042_CR45","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0022-3476(97)80022-4","volume":"130","author":"R Brauner","year":"1997","unstructured":"Brauner R, Adan L, Souberbielle JC, Esperou H, Michon J, Devergie A, Gluckman E, Zucker JM. Contribution of growth hormone deficiency to the growth failure that follows bone marrow transplantation. J Pediatr 1997;130:785\u2013792.","journal-title":"J Pediatr"},{"key":"6042_CR46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000181036","volume":"30","author":"JE Sanders","year":"1988","unstructured":"Sanders JE, Buckner CD, Sullivan KM, Doney K, Appelbaum F, Witherspoon R, Storb R, Thomas ED. Growth and development in children after bone marrow transplantation. Horm Res 1988;30:92\u201397.","journal-title":"Horm Res"},{"key":"6042_CR47","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/adc.66.6.689","volume":"66","author":"A Papadimitriou","year":"1991","unstructured":"Papadimitriou A, Urena M, Hamill G, Stanhope R, Leiper AD. Growth hormone treatment of growth failure secondary to total body irradiation and bone marrow transplantation. Arch Dis Child 1991;66:689\u2013692.","journal-title":"Arch Dis Child"},{"key":"6042_CR48","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000181037","volume":"30","author":"B Borgstrom","year":"1988","unstructured":"Borgstrom B, Bolme P. Growth and growth hormone in children after bone marrow transplantation. Horm Res 1988;30:98\u2013100.","journal-title":"Horm Res"},{"key":"6042_CR49","first-page":"381","volume":"12","author":"JS Olshan","year":"1993","unstructured":"Olshan JS, Willi SM, Gruccio D, Moshang T Jr. Growth hormone function and treatment following bone marrow transplant for neuroblastoma. Bone Marrow Transplant 1993;12:381\u2013385.","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl 1","key":"6042_CR50","first-page":"10","volume":"8","author":"L Hovi","year":"1991","unstructured":"Hovi L, Saarinen UM, Siimes MA. Growth failure in children after total body irradiation preparative for bone marrow transplantation. Bone Marrow Transplant 1991;8(Suppl 1):10\u201313.","journal-title":"Bone Marrow Transplant"},{"key":"6042_CR51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0300-595X(86)80010-X","volume":"15","author":"BB Bercu","year":"1986","unstructured":"Bercu BB, Diamond FBJ. Growth hormone neurosecretory dysfunction. J Clin Endocrinol Metab 1986;15:537\u2013590.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR52","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0022-3476(84)80989-0","volume":"104","author":"J Blatt","year":"1984","unstructured":"Blatt J, Bercu BB, Gillin JC, Mendelson WB, Poplack DG. Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia. J Pediatr 1984;104:182\u2013186.","journal-title":"J Pediatr"},{"key":"6042_CR53","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1651-2227.1987.tb17273.x","volume":"76","author":"K Albertsson-Wikland","year":"1987","unstructured":"Albertsson-Wikland K, Lannering B, Marky I, Mellander L, Wannholt U. A longitudinal study on growth and spontaneous growth hormone (GH) secretion in children with irradiated brain tumors. Acta Paediatr Scand 1987;76:966\u2013973.","journal-title":"Acta Paediatr Scand"},{"key":"6042_CR54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2265.1992.tb02903.x","volume":"36","author":"EC Crowne","year":"1992","unstructured":"Crowne EC, Moore C, Wallace WH, Ogilvy-Stuart AL, Addison GM, Morris-Jones PH, Shalet SM. A novel variant of growth hormone (GH) insufficiency following low dose cranial irradiation. Clin Endocrinol (Oxf) 1992;36:59\u201368.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6042_CR55","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/adc.64.2.252","volume":"64","author":"C Moell","year":"1989","unstructured":"Moell C, Garwicz S, Westgren U, Wiebe T, Albertsson-Wikland K. Suppressed spontaneous secretion of growth hormone in girls after treatment for acute lymphoblastic leukaemia. Arch Dis Child 1989;64:252\u2013258.","journal-title":"Arch Dis Child"},{"key":"6042_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08880018709141243","volume":"4","author":"C Moell","year":"1987","unstructured":"Moell C, Garwicz S, Westgren U, Wiebe T. Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia. Pediatr Hematol Oncol 1987;4:1\u20135.","journal-title":"Pediatr Hematol Oncol"},{"key":"6042_CR57","first-page":"2215","volume":"82","author":"AA Toogood","year":"1997","unstructured":"Toogood AA, Nass RM, Pezzoli SS, PA ON, Thorner MO, Shalet SM. Preservation of growth hormone pulsatility despite pituitary pathology, surgery, and irradiation. J Clin Endocrinol Metab 1997;82:2215\u20132221.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR58","first-page":"1591","volume":"81","author":"AT Reutens","year":"1996","unstructured":"Reutens AT, Veldhuis JD, Hoffman DM, Leung KC, Ho KK. A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency. J Clin Endocrinol Metab 1996;81:1591\u20131597.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR59","first-page":"84","volume":"81","author":"HB Baum","year":"1996","unstructured":"Baum HB, Biller BM, Katznelson L, Oppenheim DS, Clemmons DR, Cannistraro KB, Schoenfeld DA, Best SA, Klibanski A. Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency compared with that in normal men\u2013a clinical research center study. J Clin Endocrinol Metab 1996;81:84\u201392.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR60","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.0300-0664.2001.01433.x","volume":"56","author":"F Roelfsema","year":"2002","unstructured":"Roelfsema F, Biermasz NR, Veldhuis JD. Pulsatile, nyctohemeral and entropic characteristics of GH secretion in adult GH-deficient patients: selectively decreased pulsatile release and increased secretory disorderliness with preservation of diurnal timing and gender distinctions. Clin Endocrinol (Oxf) 2002;56:79\u201387.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6042_CR61","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1210\/jc.2004-2002","volume":"90","author":"K Darzy","year":"2005","unstructured":"Darzy K, Pezzoli S, Thorner M, Shalet S. The dynamics of GH secretion in adult cancer survivors with severe GH deficiency acquired following brain irradiation in childhood for non-pituitary brain tumors: evidence for preserved pulsatility and diurnal variation with increased secretory disorderliness. J Clin Endocrinol Metab 2005;90:2794\u20132803.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR62","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2265.1994.tb02525.x","volume":"41","author":"AL Ogilvy-Stuart","year":"1994","unstructured":"Ogilvy-Stuart AL, Wallace WH, Shalet SM. Radiation and neuroregulatory control of growth hormone secretion. Clin Endocrinol (Oxf) 1994;41:163\u2013168.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6042_CR63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00043426-198721000-00004","volume":"9","author":"T Pasqualini","year":"1987","unstructured":"Pasqualini T, Escobar ME, Domene H, Muriel FS, Pavlovsky S, Rivarola MA. Evaluation of gonadal function following long-term treatment for acute lymphoblastic leukemia in girls. Am J Pediatr Hematol Oncol 1987;9:15\u201322.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"6042_CR64","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00007890-198309000-00005","volume":"36","author":"JE Sanders","year":"1983","unstructured":"Sanders JE, Buckner CD, Leonard JM, Sullivan KM, Witherspoon RP, Deeg HJ, Storb R, Thomas ED. Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation 1983;36:252\u2013255.","journal-title":"Transplantation"},{"key":"6042_CR65","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1210\/jcem-54-6-1164","volume":"54","author":"R Rappaport","year":"1982","unstructured":"Rappaport R, Brauner R, Czernichow P, Thibaud E, Renier D, Zucker JM, Lemerle J. Effect of hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors. J Clin Endocrinol Metab 1982;54:1164\u20131168.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM197501302920505","volume":"292","author":"Y Yoshimoto","year":"1975","unstructured":"Yoshimoto Y, Moridera K, Imura H. Restoration of normal pituitary gonadotropin reserve by administration of luteinizing-hormone-releasing hormone in patients with hypogonadotropic hypogonadism. N Engl J Med 1975;292:242\u2013245.","journal-title":"N Engl J Med"},{"key":"6042_CR67","first-page":"1166","volume":"79","author":"JE Hall","year":"1994","unstructured":"Hall JE, Martin KA, Whitney HA, Landy H, Crowley WF Jr. Potential for fertility with replacement of hypothalamic gonadotropin-releasing hormone in long term female survivors of cranial tumors. J Clin Endocrinol Metab 1994;79:1166\u20131172.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR68","first-page":"920","volume":"311","author":"R Brauner","year":"1984","unstructured":"Brauner R, Czernichow P, Rappaport R. Precocious puberty after hypothalamic and pituitary irradiation in young children. N Engl J Med 1984;311:920.","journal-title":"N Engl J Med"},{"key":"6042_CR69","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000180076","volume":"22","author":"R Brauner","year":"1985","unstructured":"Brauner R, Rappaport R. Precocious puberty secondary to cranial irradiation for tumors distant from the hypothalamo-pituitary area. Horm Res 1985;22:78\u201382.","journal-title":"Horm Res"},{"key":"6042_CR70","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/adc.62.11.1107","volume":"62","author":"AD Leiper","year":"1987","unstructured":"Leiper AD, Stanhope R, Kitching P, Chessells JM. Precocious and premature puberty associated with treatment of acute lymphoblastic leukaemia. Arch Dis Child 1987;62:1107\u20131112.","journal-title":"Arch Dis Child"},{"key":"6042_CR71","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1056\/NEJM198907203210303","volume":"321","author":"C Quigley","year":"1989","unstructured":"Quigley C, Cowell C, Jimenez M, Burger H, Kirk J, Bergin M, Stevens M, Simpson J, Silink M. Normal or early development of puberty despite gonadal damage in children treated for acute lymphoblastic leukemia. N Engl J Med 1989;321:143\u2013151.","journal-title":"N Engl J Med"},{"key":"6042_CR72","first-page":"1282","volume":"78","author":"AL Ogilvy-Stuart","year":"1994","unstructured":"Ogilvy-Stuart AL, Clayton PE, Shalet SM. Cranial irradiation and early puberty. J Clin Endocrinol Metab 1994;78:1282\u20131286.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR73","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<280::AID-MPO8>3.0.CO;2-I","volume":"29","author":"B Lannering","year":"1997","unstructured":"Lannering B, Jansson C, Rosberg S, Albertsson-Wikland K. Increased LH and FSH secretion after cranial irradiation in boys. Med Pediatr Oncol 1997;29:280\u2013287.","journal-title":"Med Pediatr Oncol"},{"key":"6042_CR74","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1203\/00006450-200005000-00005","volume":"47","author":"C Roth","year":"2000","unstructured":"Roth C, Schmidberger H, Schaper O, Leonhardt S, Lakomek M, Wuttke W, Jarry H. Cranial irradiation of female rats causes dose-dependent and age-dependent activation or inhibition of pubertal development. Pediatr Res 2000;47:586\u2013591.","journal-title":"Pediatr Res"},{"key":"6042_CR75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(00)01663-3","volume":"297","author":"C Roth","year":"2001","unstructured":"Roth C, Schmidberger H, Lakomek M, Witt O, Wuttke W, Jarry H. Reduction of gamma-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats. Neurosci Lett 2001;297:45\u201348.","journal-title":"Neurosci Lett"},{"key":"6042_CR76","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/(SICI)1096-911X(200001)34:1<14::AID-MPO3>3.0.CO;2-W","volume":"34","author":"L Adan","year":"2000","unstructured":"Adan L, Sainte-Rose C, Souberbielle JC, Zucker JM, Kalifa C, Brauner R. Adult height after growth hormone (GH) treatment for GH deficiency due to cranial irradiation. Med Pediatr Oncol 2000;34:14\u201319.","journal-title":"Med Pediatr Oncol"},{"key":"6042_CR77","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1210\/jc.2003-030366","volume":"88","author":"HK Gleeson","year":"2003","unstructured":"Gleeson HK, Stoeter R, Ogilvy-Stuart AL, Gattamaneni HR, Brennan BM, Shalet SM. Improvements in final height over 25 years in growth hormone (GH)-deficient childhood survivors of brain tumors receiving GH replacement. J Clin Endocrinol Metab 2003;88:3682\u20133689.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR78","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/bjc.1990.138","volume":"61","author":"EA Livesey","year":"1990","unstructured":"Livesey EA, Hindmarsh PC, Brook CG, Whitton AC, Bloom HJ, Tobias JS, Godlee JN, Britton J. Endocrine disorders following treatment of childhood brain tumours. Br J Cancer 1990;61:622\u2013625.","journal-title":"Br J Cancer"},{"key":"6042_CR79","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF03346906","volume":"20","author":"A Mohn","year":"1997","unstructured":"Mohn A, Chiarelli F, Di Marzio A, Impicciatore P, Marsico S, Angrilli F. Thyroid function in children treated for acute lymphoblastic leukemia. J Endocrinol Invest 1997;20:215\u2013219.","journal-title":"J Endocrinol Invest"},{"key":"6042_CR80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2265.2001.01292.x","volume":"55","author":"A Lando","year":"2001","unstructured":"Lando A, Holm K, Nysom K, Rasmussen AK, Feldt-Rasmussen U, Petersen JH, Muller J. Thyroid function in survivors of childhood acute lymphoblastic leukaemia: the significance of prophylactic cranial irradiation. Clin Endocrinol 2001;55:21\u201325.","journal-title":"Clin Endocrinol"},{"key":"6042_CR81","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/1097-0142(19860401)57:7<1287::AID-CNCR2820570706>3.0.CO;2-O","volume":"57","author":"ML Voorhess","year":"1986","unstructured":"Voorhess ML, Brecher ML, Glicksman AS, Jones B, Harris M, Krischer J, Boyett J, Forman E, Freeman AI. Hypothalamic-pituitary function of children with acute lymphocytic leukemia after three forms of central nervous system prophylaxis. A retrospective study. Cancer 1986;57:1287\u20131291.","journal-title":"Cancer"},{"key":"6042_CR82","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0022-3476(77)80559-3","volume":"90","author":"SM Shalet","year":"1977","unstructured":"Shalet SM, Beardwell CG, Twomey JA, Jones PH, Pearson D. Endocrine function following the treatment of acute leukemia in childhood. J Pediatr 1977;90:920\u2013923.","journal-title":"J Pediatr"},{"key":"6042_CR83","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/adc.64.4.631","volume":"64","author":"EP Carter","year":"1989","unstructured":"Carter EP, Leiper AD, Chessells JM, Hurst A. Thyroid function in children after treatment for acute lymphoblastic leukaemia. Arch Dis Child 1989;64:631.","journal-title":"Arch Dis Child"},{"key":"6042_CR84","doi-asserted-by":"crossref","first-page":"266A","DOI":"10.1203\/00006450-198504000-00965","volume":"19","author":"LL Robison","year":"1985","unstructured":"Robison LL, Nesbit ME, Sather HN, Meadows AT, Ortega JA, Hammond GD. Thyroid abnormalities in long-term survivors of childhood acute lymphoblastic leukemia. Pediatr Res 1985;19:266A.","journal-title":"Pediatr Res"},{"key":"6042_CR85","volume-title":"Late effects of treatment for childhood cancer","author":"SE Oberfield","year":"1992","unstructured":"Oberfield SE, Sklar C, Allen J, Walker R, Mcelwain M, Papadakis V, Maenza J. Thyroid and gonadal function and growth of long-term survivors of medulloblastoma\/PNET. In: Green DM, D'Angio GJ (Eds.), Late effects of treatment for childhood cancer. New York: Wiley-Liss Inc., 1992."},{"key":"6042_CR86","first-page":"4472","volume":"84","author":"SR Rose","year":"1999","unstructured":"Rose SR, Lustig RH, Pitukcheewanont P, Broome DC, Burghen GA, Li H, Hudson MM, Kun LE, Heideman RL. Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J Clin Endocrinol Metab 1999;84:4472\u20134479.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR87","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1210\/jc.2002-020380","volume":"88","author":"M Schmiegelow","year":"2003","unstructured":"Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Poulsen HS, Muller J. A population-based study of thyroid function after radiotherapy and chemotherapy for a childhood brain tumor. J Clin Endocrinol Metab 2003;88:136\u2013140.","journal-title":"J Clin Endocrinol Metab"},{"key":"6042_CR88","doi-asserted-by":"crossref","unstructured":"Darzy KH, Shalet SM. Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. J Clin Endocrinol Metab 2005;90:6490\u20137.","DOI":"10.1210\/jc.2005-1593"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-006-6042-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-006-6042-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-006-6042-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T23:31:08Z","timestamp":1586734268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-006-6042-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":88,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["6042"],"URL":"https:\/\/doi.org\/10.1007\/s11102-006-6042-4","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}