{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:50:44Z","timestamp":1762998644292},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1007\/s11102-007-0054-6","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T19:39:20Z","timestamp":1182368360000},"page":"267-274","source":"Crossref","is-referenced-by-count":15,"title":["Glucocorticoid inhibition of growth in rats: partial reversal with the full-length ghrelin analog BIM-28125"],"prefix":"10.1007","volume":"10","author":[{"given":"Giovanni","family":"Tulipano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A.","family":"Halem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse Z.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Culler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Giustina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"54_CR1","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1210\/endo-127-6-2705","volume":"127","author":"P Wehrenberg","year":"1990","unstructured":"Wehrenberg P, Bergman PJ, Stagg L, Ndon J, Giustina A (1990) Glucocorticoid inhibition of growth in rats: partial reversal with somatostatin antibodies. Endocrinology 127:2705\u20132708","journal-title":"Endocrinology"},{"key":"54_CR2","first-page":"669","volume-title":"Growth and growth disorders","author":"DB Allen","year":"1996","unstructured":"Allen DB (1996) Growth suppression by glucocorticoid therapy. In: Rosenfeld RL (ed) Growth and growth disorders. Saunders, Philadephia, pp 669\u2013718"},{"key":"54_CR3","first-page":"717","volume":"19","author":"A Giustina","year":"1998","unstructured":"Giustina A, Veldhuis JD (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the humans. Endocr Rev 19:717\u2013797","journal-title":"Endocr Rev"},{"key":"54_CR4","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1152\/physrev.1999.79.2.511","volume":"79","author":"EE Muller","year":"1999","unstructured":"Muller EE, Locatelli V, Cocchi D (1999) Neuroendocrine control of growth hormone secretion. Physiol Rev 79:3200\u20133203","journal-title":"Physiol Rev"},{"key":"54_CR5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1210\/endo.143.4.8716","volume":"143","author":"G Tulipano","year":"2002","unstructured":"Tulipano G, Soldi D, Bagnasco M et\u00a0al (2002) Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology 143:1218\u20131224","journal-title":"Endocrinology"},{"key":"54_CR6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.regpep.2004.07.027","volume":"125","author":"G Tulipano","year":"2005","unstructured":"Tulipano G, Rossi E, Culler MD et\u00a0al (2005) The somatostatin subtype-2 receptor antagonist, BIM-23627, improves the catabolic effects induced by long-term glucocorticoid treatment in the rat. Regul Peptides 125:85\u201392","journal-title":"Regul Peptides"},{"key":"54_CR7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y et\u00a0al (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656\u2013660","journal-title":"Nature"},{"key":"54_CR8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0024-3205(94)00478-B","volume":"56","author":"DM Voltz","year":"1995","unstructured":"Voltz DM, Piering AW, Magestro M et\u00a0al (1995) Effect of GHRP-6 and GHRH on GH secretion in rats following chronic glucocorticoid treatment. Life Sci 56:491\u2013497","journal-title":"Life Sci"},{"key":"54_CR9","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1210\/en.2005-0212","volume":"146","author":"P Zizzari","year":"2005","unstructured":"Zizzari P, Halem H, Taylor JE et\u00a0al (2005) Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH Pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor. Endocrinology 146:3836\u20133842","journal-title":"Endocrinology"},{"key":"54_CR10","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","volume":"407","author":"M Tschop","year":"2000","unstructured":"Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908\u2013913","journal-title":"Nature"},{"key":"54_CR11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","volume":"409","author":"M Nakazato","year":"2001","unstructured":"Nakazato M, Murakami N, Date Y et\u00a0al (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194\u2013198","journal-title":"Nature"},{"key":"54_CR12","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1210\/en.2002-220783","volume":"144","author":"K Choi","year":"2003","unstructured":"Choi K, Roh SG, Hong YH et\u00a0al (2003) The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Endocrinology 144:754\u2013759","journal-title":"Endocrinology"},{"key":"54_CR13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/en.2003-0899","volume":"145","author":"NM Thompson","year":"2004","unstructured":"Thompson NM, Gill DA, Davies R et\u00a0al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145:234\u2013242","journal-title":"Endocrinology"},{"key":"54_CR14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1530\/eje.0.1510573","volume":"151","author":"A Katsuki","year":"2004","unstructured":"Katsuki A, Urakawa H, Gabazza EC et\u00a0al (2004) Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. Eur J Endocrinol 151:573\u2013577","journal-title":"Eur J Endocrinol"},{"key":"54_CR15","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1530\/eje.0.151S071","volume":"151","author":"HA Halem","year":"2004","unstructured":"Halem HA, Taylor JE, Dong JZ et\u00a0al (2004) Novel analogs of ghrelin: physiological and clinical implications. Eur J Endocrinol 151:S71\u2013S75","journal-title":"Eur J Endocrinol"},{"key":"54_CR16","doi-asserted-by":"crossref","first-page":"10434","DOI":"10.1073\/pnas.0403465101","volume":"101","author":"B Yildiz","year":"2004","unstructured":"Yildiz B, Suchard MA, Wong ML (2004) Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. PNAS USA 101:10434\u201310439","journal-title":"PNAS USA"},{"key":"54_CR17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/eje.0.1510787","volume":"151","author":"H Rubinfeld","year":"2004","unstructured":"Rubinfeld H, Hadani M, Taylor JE et\u00a0al (2004) Novel ghrelin analogs with improved affinity for the GH secretagogue receptor stimulate GH and prolactin release from human pituitary cells. Eur J Endocrinol 151:787\u2013795","journal-title":"Eur J Endocrinol"},{"key":"54_CR18","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/j.1471-4159.1986.tb00742.x","volume":"47","author":"RM Snider","year":"1986","unstructured":"Snider RM, Forray C, Pfenning M, Richelson E (1986) Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115. J Neurochem 47:1214\u20131218","journal-title":"J Neurochem"},{"key":"54_CR19","first-page":"306","volume":"3","author":"WB Wehrenberg","year":"1992","unstructured":"Wehrenberg WB, Giustina A (1992) The role of glucocorticoids in the regulation of growth hormone secretion. TEM 3:306\u2013311","journal-title":"TEM"},{"key":"54_CR20","first-page":"1301","volume":"74","author":"A Giustina","year":"1992","unstructured":"Giustina A, Bossoni S, Bodini C et\u00a0al (1992) Arginine normalizes the growth hormone (GH) response to GH-releasing hormone in adult patients receiving chronic daily immunosuppression glucocorticoid therapy. J Clin Endocrinol Metab 74:1301\u20131305","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR21","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1210\/endo.136.11.7588209","volume":"136","author":"AP King","year":"1995","unstructured":"King AP, Carter-Su C (1995) Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts. Endocrinology 136:4796\u20134803","journal-title":"Endocrinology"},{"key":"54_CR22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1210\/jcem-61-4-618","volume":"61","author":"TG Unterman","year":"1985","unstructured":"Unterman TG, Philips LS (1985) Glucocorticoids effects on somatomedins and somatomedin inhibitors. J Clin Endocrinol Metab 61:618\u2013626","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR23","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1210\/jcem.83.8.5036","volume":"83","author":"DB Allen","year":"1998","unstructured":"Allen DB, Julius JR, Breen TJ, Attie KM (1998) Treatment of glucocorticoid-induced growth suppression with growth hormone. National cooperative growth study. J Clin Endocrinol Metab 83:2824\u20132829","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR24","first-page":"122","volume":"80","author":"A Giustina","year":"1995","unstructured":"Giustina A, Bussi AR, Jacobello C, Wehrenberg WB (1995) Effects of recombinant human growth hormone (GH) on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone. J Clin Endocrinol Metab 80:122\u2013129","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR25","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","volume":"85","author":"M Kojima","year":"2005","unstructured":"Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85:495\u2013522","journal-title":"Physiol Rev"},{"key":"54_CR26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2826.2005.01379.x","volume":"18","author":"JP Camina","year":"2006","unstructured":"Camina JP (2006) Cell biology of the ghrelin receptor. J Neuroendocrinol 18:65\u201376","journal-title":"J Neuroendocrinol"},{"key":"54_CR27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1152\/ajpendo.00115.2004","volume":"288","author":"R Barazzoni","year":"2004","unstructured":"Barazzoni R, Bosutti A, Stebel M et\u00a0al (2004) Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. AJP Endocrinol Metab 288:228\u2013235","journal-title":"AJP Endocrinol Metab"},{"key":"54_CR28","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/jc.2004-1069","volume":"90","author":"C Gauna","year":"2006","unstructured":"Gauna C, Delhanty PJD, Hofland LJ (2006) Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab 90:1055\u20131060","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR29","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/me.2003-0459","volume":"18","author":"MS Kim","year":"2004","unstructured":"Kim MS, Yoon CY, Jang PG (2004) The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 18:2291\u20132301","journal-title":"Mol Endocrinol"},{"key":"54_CR30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.regpep.2005.11.001","volume":"134","author":"AD Patel","year":"2006","unstructured":"Patel AD, Stanley SA, Murphy KG et\u00a0al (2006) Ghrelin stimulates insulin-induced glucose uptake in adipocytes. Regul Peptides 134:17\u201322","journal-title":"Regul Peptides"},{"key":"54_CR31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1677\/joe.1.05837","volume":"184","author":"G Maccarinelli","year":"2005","unstructured":"Maccarinelli G, Sibilia V, Torsello A et\u00a0al (2005) Ghrelin regulates proliferation and differentiation of osteoblastic cells. J Endocrinol 184:249\u2013256","journal-title":"J Endocrinol"},{"key":"54_CR32","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1359\/JBMR.041237","volume":"20","author":"N Fukushima","year":"2005","unstructured":"Fukushima N, Hanada R, Teranishi H (2005) Ghrelin directly regulates bone formation. J Bone Miner Res 20:790\u2013798","journal-title":"J Bone Miner Res"},{"key":"54_CR33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/joe.1.06404","volume":"188","author":"PJ Delhanty","year":"2006","unstructured":"Delhanty PJ, Van der Eerden BC, Van der Velde M et\u00a0al (2006) Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)\/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. J Endocrinol 188:37\u201347","journal-title":"J Endocrinol"},{"key":"54_CR34","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/en.2004-1379","volume":"146","author":"JE Caminos","year":"2006","unstructured":"Caminos JE, Gualillo O, Lago F (2006) The endogenous growth hormone secretagogue (ghrelin) is synthetized and secreted by chondrocytes. Endocrinology 146:1285\u20131292","journal-title":"Endocrinology"},{"key":"54_CR35","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1210\/en.2003-0529","volume":"144","author":"JE Caminos","year":"2003","unstructured":"Caminos JE, Nogueiras R, Blanco M et\u00a0al (2003) Cellular distribution and regulation of ghrelin messenger ribonucleic acid in the rat pituitary gland. Endocrinology 144:5089\u20135097","journal-title":"Endocrinology"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-007-0054-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-007-0054-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-007-0054-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T06:08:04Z","timestamp":1559369284000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-007-0054-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,21]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["54"],"URL":"https:\/\/doi.org\/10.1007\/s11102-007-0054-6","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,21]]}}}