{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:07:35Z","timestamp":1772579255338,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s11102-011-0296-1","type":"journal-article","created":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T05:36:54Z","timestamp":1298266614000},"page":"318-322","source":"Crossref","is-referenced-by-count":10,"title":["Ghrelin immunoexpression in pituitary adenomas"],"prefix":"10.1007","volume":"14","author":[{"given":"Fabio","family":"Rotondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cusimano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Rotondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis V.","family":"Syro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"296_CR1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1074\/jbc.M205366200","volume":"278","author":"H Hosoda","year":"2003","unstructured":"Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K (2003) Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 278:64\u201370","journal-title":"J Biol Chem"},{"key":"296_CR2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1006\/bbrc.2001.5014","volume":"284","author":"M Matsumoto","year":"2001","unstructured":"Matsumoto M, Kitajima Y, Iwanami T, Hayashi Y, Tanaka S, Minamitake Y, Hosoda H, Kojima M, Matsuo H, Kangawa K (2001) Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues. Biochem Biophys Res Commun 284:655\u2013659","journal-title":"Biochem Biophys Res Commun"},{"key":"296_CR3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656\u2013660","journal-title":"Nature"},{"key":"296_CR4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1152\/physrev.00009.2005","volume":"86","author":"JE Silva","year":"2006","unstructured":"Silva JE (2006) Thermogenic mechanisms and their hormonal regulation. Physiol Rev 86:435\u2013464","journal-title":"Physiol Rev"},{"key":"296_CR5","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1210\/jc.2004-0613","volume":"89","author":"DH St-Pierre","year":"2004","unstructured":"St-Pierre DH, Karelis AD, Cianflone K, Conus F, Mignault D, Rabasa-Lhoret R, St-Onge M, Tremblay-Lebeau A, Poehlman ET (2004) Relationship between ghrelin and energy expenditure in healthy young women. J Clin Endocrinol Metab 89:5993\u20135997","journal-title":"J Clin Endocrinol Metab"},{"key":"296_CR6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/en.143.1.155","volume":"143","author":"CB Lawrence","year":"2002","unstructured":"Lawrence CB, Snape AC, Baudoin FM, Luckman SM (2002) Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143:155\u2013162","journal-title":"Endocrinology"},{"key":"296_CR7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","volume":"407","author":"M Tschop","year":"2000","unstructured":"Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908\u2013913","journal-title":"Nature"},{"key":"296_CR8","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/en.141.11.4255","volume":"141","author":"Y Date","year":"2000","unstructured":"Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255\u20134261","journal-title":"Endocrinology"},{"key":"296_CR9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1210\/en.142.2.788","volume":"142","author":"O Gualillo","year":"2001","unstructured":"Gualillo O, Caminos J, Blanco M, Garcia-Caballero T, Kojima M, Kangawa K, Dieguez C, Casanueva F (2001) Ghrelin, a novel placental-derived hormone. Endocrinology 142:788\u2013794","journal-title":"Endocrinology"},{"key":"296_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:14:1:101","volume":"14","author":"M Korbonits","year":"2001","unstructured":"Korbonits M, Kojima M, Kangawa K, Grossman AB (2001) Presence of ghrelin in normal and adenomatous human pituitary. Endocrine 14:101\u2013104","journal-title":"Endocrine"},{"key":"296_CR11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-5793(00)02308-5","volume":"486","author":"K Mori","year":"2000","unstructured":"Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K, Mukoyama M, Sugawara A, Hosoda H, Kojima M, Kangawa K, Nakao K (2000) Kidney produces a novel acylated peptide, ghrelin. FEBS Lett 486:213\u2013216","journal-title":"FEBS Lett"},{"key":"296_CR12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/en.143.2.717","volume":"143","author":"M Tena-Sempere","year":"2002","unstructured":"Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE, Pinilla L, Casanueva FF, Dieguez C, Aguilar E (2002) Novel expression and functional role of ghrelin in rat testis. Endocrinology 143:717\u2013725","journal-title":"Endocrinology"},{"key":"296_CR13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1055\/s-0029-1233462","volume":"41","author":"B Ueberberg","year":"2009","unstructured":"Ueberberg B, Unger N, Saeger W, Mann K, Petersenn S (2009) Expression of ghrelin and its receptor in human tissues. Horm Metab Res 41:814\u2013821","journal-title":"Horm Metab Res"},{"key":"296_CR14","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1210\/jc.86.10.5052","volume":"86","author":"M Papotti","year":"2001","unstructured":"Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E (2001) Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 86:5052\u20135059","journal-title":"J Clin Endocrinol Metab"},{"key":"296_CR15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1530\/EJE-09-0073","volume":"161","author":"T Walter","year":"2009","unstructured":"Walter T, Chardon L, Hervieu V, Cohen R, Chayvialle JA, Scoazec JY, Lombard-Bohas C (2009) Major hyperghrelinemia in advanced well-differentiated neuroendocrine carcinomas: report of three cases. Eur J Endocrinol 161:639\u2013645","journal-title":"Eur J Endocrinol"},{"key":"296_CR16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/(SICI)1097-0142(19960801)78:3<502::AID-CNCR18>3.0.CO;2-2","volume":"78","author":"K Kovacs","year":"1996","unstructured":"Kovacs K, Scheithauer BW, Horvath E, Lloyd RV (1996) The World Health Organization classification of adenohypophysial neoplasms. A proposed five-tier scheme. Cancer 78:502\u2013510","journal-title":"Cancer"},{"key":"296_CR17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/PAI.0b013e31818fa0ed","volume":"17","author":"F Rotondo","year":"2009","unstructured":"Rotondo F, Scheithauer BW, Kovacs K, Bell DC (2009) Rab3B immunoexpression in human pituitary adenomas. Appl Immunohistochem Mol Morphol 17:185\u2013188","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"296_CR18","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.2106\/JBJS.H.00717","volume":"92","author":"SA Nakagawa","year":"2010","unstructured":"Nakagawa SA, Lopes A, Lopes de Carvalho A, Rossi BM, Werneck da Cunha I, Soares FA, Chung WT, Alves LA (2010) Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis. J Bone Joint Surg Am 92:1738\u20131746","journal-title":"J Bone Joint Surg Am"},{"key":"296_CR19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2826.1999.00351.x","volume":"11","author":"A Barlier","year":"1999","unstructured":"Barlier A, Zamora AJ, Grino M, Gunz G, Pellegrini-Bouiller I, Morange-Ramos I, Figarella-Branger D, Dufour H, Jaquet P, Enjalbert A (1999) Expression of functional growth hormone secretagogue receptors in human pituitary adenomas: polymerase chain reaction, triple in situ hybridization and cell culture studies. J Neuroendocrinol 11:491\u2013502","journal-title":"J Neuroendocrinol"},{"key":"296_CR20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jc.86.2.881","volume":"86","author":"M Korbonits","year":"2001","unstructured":"Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB (2001) The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 86:881\u2013887","journal-title":"J Clin Endocrinol Metab"},{"key":"296_CR21","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1210\/jc.2006-0235","volume":"91","author":"AJ Martinez-Fuentes","year":"2006","unstructured":"Martinez-Fuentes AJ, Moreno-Fernandez J, Vazquez-Martinez R, Duran-Prado M, De la Riva A, Tena-Sempere M, Dieguez C, Jimenez-Reina L, Webb SM, Pumar A, Leal-Cerro A, Benito-Lopez P, Malagon MM, Castano JP (2006) Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas. J Clin Endocrinol Metab 91:2225\u20132231","journal-title":"J Clin Endocrinol Metab"},{"key":"296_CR22","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/153537020422901004","volume":"229","author":"G Rindi","year":"2004","unstructured":"Rindi G, Torsello A, Locatelli V, Solcia E (2004) Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system. Exp Biol Med (Maywood) 229:1007\u20131016","journal-title":"Exp Biol Med (Maywood)"},{"key":"296_CR23","first-page":"929","volume":"29","author":"R Wasko","year":"2008","unstructured":"Wasko R, Jaskula M, Kotwicka M, Andrusiewicz M, Jankowska A, Liebert W, Sowinski J (2008) The expression of ghrelin in somatotroph and other types of pituitary adenomas. Neuro Endocrinol Lett 29:929\u2013938","journal-title":"Neuro Endocrinol Lett"},{"key":"296_CR24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(03)00051-6","volume":"536","author":"PG Andreis","year":"2003","unstructured":"Andreis PG, Malendowicz LK, Trejter M, Neri G, Spinazzi R, Rossi GP, Nussdorfer GG (2003) Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells. FEBS Lett 536:173\u2013179","journal-title":"FEBS Lett"},{"key":"296_CR25","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.200207165","volume":"159","author":"G Baldanzi","year":"2002","unstructured":"Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1\/2 and PI 3-kinase\/AKT. J Cell Biol 159:1029\u20131037","journal-title":"J Cell Biol"},{"key":"296_CR26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000069065","volume":"59","author":"F Broglio","year":"2003","unstructured":"Broglio F, Gottero C, Arvat E, Ghigo E (2003) Endocrine and non-endocrine actions of ghrelin. Horm Res 59:109\u2013117","journal-title":"Horm Res"},{"key":"296_CR27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1359\/JBMR.041237","volume":"20","author":"N Fukushima","year":"2005","unstructured":"Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H, Takeda S, Takeuchi Y, Fukumoto S, Kangawa K, Nagata K, Kojima M (2005) Ghrelin directly regulates bone formation. J Bone Miner Res 20:790\u2013798","journal-title":"J Bone Miner Res"},{"key":"296_CR28","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1373\/clinchem.2004.040667","volume":"51","author":"M Groschl","year":"2005","unstructured":"Groschl M, Topf HG, Bohlender J, Zenk J, Klussmann S, Dotsch J, Rascher W, Rauh M (2005) Identification of ghrelin in human saliva: production by the salivary glands and potential role in proliferation of oral keratinocytes. Clin Chem 51:997\u20131006","journal-title":"Clin Chem"},{"key":"296_CR29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1359-6101(02)00089-8","volume":"14","author":"PL Jeffery","year":"2003","unstructured":"Jeffery PL, Herington AC, Chopin LK (2003) The potential autocrine\/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine Growth Factor Rev 14:113\u2013122","journal-title":"Cytokine Growth Factor Rev"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-011-0296-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-011-0296-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-011-0296-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T17:48:15Z","timestamp":1560016095000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-011-0296-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,22]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["296"],"URL":"https:\/\/doi.org\/10.1007\/s11102-011-0296-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,22]]}}}