{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:56:10Z","timestamp":1793321770115,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:00:00Z","timestamp":1302220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s11102-011-0306-3","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T19:47:23Z","timestamp":1302205643000},"page":"193-201","source":"Crossref","is-referenced-by-count":41,"title":["Spontaneous recovery of bone mass after cure of endogenous hypercortisolism"],"prefix":"10.1007","volume":"15","author":[{"given":"Maria Elena","family":"Randazzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Grossrubatscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Dalino Ciaramella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Vanzulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Loli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,8]]},"reference":[{"key":"306_CR1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11102-005-1051-2","volume":"7","author":"T Mancini","year":"2004","unstructured":"Mancini T, Doga M, Mazziotti G, Giustina A (2004) Cushing\u2019s syndrome and bone. Pituitary 7:249\u2013252","journal-title":"Pituitary"},{"key":"306_CR2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000061073","volume":"30","author":"G Kaltsas","year":"2002","unstructured":"Kaltsas G, Manetti L, Grossman AB (2002) Osteoporosis in Cushing\u2019s syndrome. Front Horm Res 30:60\u201372","journal-title":"Front Horm Res"},{"key":"306_CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1043-2760(00)00234-4","volume":"11","author":"F Manelli","year":"2000","unstructured":"Manelli F, Giustina A (2000) Glucocorticoid-induced osteoporosis. Trends Endocrinol Metab 11:79\u201385","journal-title":"Trends Endocrinol Metab"},{"key":"306_CR4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/jc.86.2.604","volume":"86","author":"G Osella","year":"2001","unstructured":"Osella G, Reimondo G, Peretti P, Ali A, Paccotti P, Angeli A, Terzolo M (2001) The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis. J Clin Endocrinol Metab 86:604\u2013607","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1530\/eje.0.1460051","volume":"146","author":"P Vestergaard","year":"2002","unstructured":"Vestergaard P, Lindholm J, Jorgensen JO, Hagen C, Hoeck HC, Laurberg P, Rejnmark L, Brixen K, Kristensen LO, Feldt-Rasmussen U, Mosekilde L (2002) Increased risk of osteoporotic fractures in patients with Cushing\u2019s syndrome. Eur J Endocrinol 146:51\u201356","journal-title":"Eur J Endocrinol"},{"key":"306_CR6","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jc.2003-030871","volume":"88","author":"G Arnaldi","year":"2003","unstructured":"Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M (2003) Diagnosis and complications of Cushing\u2019s syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593\u20135602","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR7","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1002\/art.11283","volume":"48","author":"TP Staa Van","year":"2003","unstructured":"Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48:3224\u20133229","journal-title":"Arthritis Rheum"},{"key":"306_CR8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1530\/eje.1.01841","volume":"152","author":"S Bonadonna","year":"2005","unstructured":"Bonadonna S, Burattin A, Nuzzo M, Bugari G, Rosei EA, Valle D, Iori N, Bilezikian JP, Veldhuis JD, Giustina A (2005) Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects. Eur J Endocrinol 152:199\u2013205","journal-title":"Eur J Endocrinol"},{"key":"306_CR9","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1210\/jc.81.10.3441","volume":"81","author":"E Canalis","year":"1996","unstructured":"Canalis E (1996) Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 81:3441\u20133447","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1053\/beem.2000.0074","volume":"14","author":"IR Reid","year":"2000","unstructured":"Reid IR (2000) Glucocorticoid-induced osteoporosis. Baillieres Best Pract Res Clin Endocrinol Metab 14:279\u2013298","journal-title":"Baillieres Best Pract Res Clin Endocrinol Metab"},{"key":"306_CR11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/1043-2760(92)90142-N","volume":"3","author":"A Giustina","year":"1992","unstructured":"Giustina A, Wehrenberg WB (1992) The role of glucocorticoids in the regulation of Growth Hormone secretion: mechanisms and clinical significance. Trends Endocrinol Metab 3:306\u2013311","journal-title":"Trends Endocrinol Metab"},{"key":"306_CR12","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1210\/me.15.10.1781","volume":"15","author":"AM Delany","year":"2001","unstructured":"Delany AM, Durant D, Canalis E (2001) Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol 15:1781\u20131789","journal-title":"Mol Endocrinol"},{"key":"306_CR13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00198-004-1616-3","volume":"15","author":"M Minetto","year":"2004","unstructured":"Minetto M, Reimondo G, Osella G, Ventura M, Angeli A, Terzolo M (2004) Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing\u2019s syndrome. Osteoporos Int 15:855\u2013861","journal-title":"Osteoporos Int"},{"key":"306_CR14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/eje.1.02067","volume":"154","author":"C Kristo","year":"2006","unstructured":"Kristo C, Jemtland R, Ueland T, Godang K, Bollerslev J (2006) Restoration of the coupling process and normalization of bone mass following successful treatment of endogenous Cushing\u2019s syndrome: a prospective, long-term study. Eur J Endocrinol 154:109\u2013118","journal-title":"Eur J Endocrinol"},{"key":"306_CR15","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1210\/jc.80.10.2859","volume":"80","author":"AR Hermus","year":"1995","unstructured":"Hermus AR, Smals AG, Swinkels LM, Huysmans DA, Pieters GF, Sweep CF, Corstens FH, Kloppenborg PW (1995) Bone mineral density and bone turnover before and after surgical cure of Cushing\u2019s syndrome. J Clin Endocrinol Metab 80:2859\u20132865","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR16","first-page":"203","volume":"57","author":"B Catargi","year":"1996","unstructured":"Catargi B, Tabarin A, Basse-Cathalinat B, Ducassou D, Roger P (1996) Development of bone mineral density after cure of Cushing\u2019s syndrome]. Ann Endocrinol (Paris) 57:203\u2013208","journal-title":"Ann Endocrinol (Paris)"},{"key":"306_CR17","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s00268-007-9394-7","volume":"32","author":"A Kawamata","year":"2008","unstructured":"Kawamata A, Iihara M, Okamoto T, Obara T (2008) Bone mineral density before and after surgical cure of Cushing\u2019s syndrome due to adrenocortical adenoma: prospective study. World J Surg 32:890\u2013896","journal-title":"World J Surg"},{"key":"306_CR18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2265.1992.tb01437.x","volume":"36","author":"PJ Manning","year":"1992","unstructured":"Manning PJ, Evans MC, Reid IR (1992) Normal bone mineral density following cure of Cushing\u2019s syndrome. Clin Endocrinol (Oxf) 36:229\u2013234","journal-title":"Clin Endocrinol (Oxf)"},{"key":"306_CR19","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s001980170025","volume":"12","author":"G Luisetto","year":"2001","unstructured":"Luisetto G, Zangari M, Camozzi V, Boscaro M, Sonino N, Fallo F (2001) Recovery of bone mineral density after surgical cure, but not by ketoconazole treatment, in Cushing\u2019s syndrome. Osteoporos Int 12:956\u2013960","journal-title":"Osteoporos Int"},{"key":"306_CR20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jbmr.5650110716","volume":"11","author":"HK Genant","year":"1996","unstructured":"Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D, Cummings SR (1996) Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 11:984\u2013996","journal-title":"J Bone Miner Res"},{"key":"306_CR21","unstructured":"Stazi AV, Manno V, Torre M (2009) Osteoporosi: cause, prevenzione, terapie e dati epidemiologici. Notiziario dell\u2019istituto superiore di sanit\u00e0 22(12): 3\u20138. http:\/\/www.iss.it\/binary\/cont\/NotiziarioDicembre_2009.pdf . Accessed 27 December 2010"},{"key":"306_CR22","unstructured":"World Health Organization Scientific Group on the Prevention and Management of Osteoporosis (2000) Prevention and management of osteoporosis: report of a WHO scientific group. WHO technical report series n. 921"},{"key":"306_CR23","first-page":"1027","volume":"20","author":"C Albala","year":"1996","unstructured":"Albala C, Yanez M, Devoto E, Sostin C, Zeballos L, Santos JL (1996) Obesity as a protective factor for postmenopausal osteoporosis. Int J Obes Relat Metab Disord 20:1027\u20131032","journal-title":"Int J Obes Relat Metab Disord"},{"key":"306_CR24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1742-1241.2009.02301.x","volume":"64","author":"EA Greco","year":"2010","unstructured":"Greco EA, Fornari R, Rossi F, Santiemma V, Prossomariti G, Annoscia C, Aversa A, Brama M, Marini M, Donini LM, Spera G, Lenzi A, Lubrano C, Migliaccio S (2010) Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract 64:817\u2013820","journal-title":"Int J Clin Pract"},{"key":"306_CR25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1007\/s00198-005-1863-y","volume":"16","author":"C Laet De","year":"2005","unstructured":"De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330\u20131338","journal-title":"Osteoporos Int"},{"key":"306_CR26","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/jn\/136.6.1453","volume":"136","author":"SA Shapses","year":"2006","unstructured":"Shapses SA, Riedt CS (2006) Bone, body weight, and weight reduction: what are the concerns? J Nutr 136:1453\u20131456","journal-title":"J Nutr"},{"key":"306_CR27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1530\/EJE-07-0137","volume":"157","author":"L Tauchmanova","year":"2007","unstructured":"Tauchmanova L, Pivonello R, De Martino MC, Rusciano A, De Leo M, Ruosi C, Mainolfi C, Lombardi G, Salvatore M, Colao A (2007) Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism. Eur J Endocrinol 157:359\u2013366","journal-title":"Eur J Endocrinol"},{"key":"306_CR28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2265.1994.tb01830.x","volume":"41","author":"JU Weaver","year":"1994","unstructured":"Weaver JU, Thaventhiran L, Noonan K, Burrin JM, Taylor NF, Norman MR, Monson JP (1994) The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults. Clin Endocrinol (Oxf) 41:639\u2013648","journal-title":"Clin Endocrinol (Oxf)"},{"key":"306_CR29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2007-0036","volume":"29","author":"A Giustina","year":"2008","unstructured":"Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29:535\u2013559","journal-title":"Endocr Rev"},{"key":"306_CR30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1015362822901","volume":"4","author":"A Faggiano","year":"2001","unstructured":"Faggiano A, Pivonello R, Filippella M, Di Somma C, Orio F Jr, Lombard G, Colao A (2001) Spine abnormalities and damage in patients cured from Cushing\u2019s disease. Pituitary 4:153\u2013161","journal-title":"Pituitary"},{"key":"306_CR31","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1210\/jc.83.6.1863","volume":"83","author":"I Chiodini","year":"1998","unstructured":"Chiodini I, Carnevale V, Torlontano M, Fusilli S, Guglielmi G, Pileri M, Modoni S, Di Giorgio A, Liuzzi A, Minisola S, Cammisa M, Trischitta V, Scillitani A (1998) Alterations of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: study in eumenorrheic patients with Cushing\u2019s syndrome. J Clin Endocrinol Metab 83:1863\u20131867","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR32","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1210\/jc.2005-0582","volume":"91","author":"L Tauchmanova","year":"2006","unstructured":"Tauchmanova L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A (2006) Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status. J Clin Endocrinol Metab 91:1779\u20131784","journal-title":"J Clin Endocrinol Metab"},{"key":"306_CR33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11926-004-0085-1","volume":"6","author":"J Compston","year":"2004","unstructured":"Compston J (2004) US and UK guidelines for glucocorticoid-induced osteoporosis: similarities and differences. Curr Rheumatol Rep 6:66\u201369","journal-title":"Curr Rheumatol Rep"},{"key":"306_CR34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1056\/NEJM199708073370603","volume":"337","author":"JD Adachi","year":"1997","unstructured":"Adachi JD, Bensen WG, Brown J, Hanley D, Hodsman A, Josse R, Kendler DL, Lentle B, Olszynski W, Ste-Marie LG, Tenenhouse A, Chines AA (1997) Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med 337:382\u2013387","journal-title":"N Engl J Med"},{"key":"306_CR35","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199807303390502","volume":"339","author":"KG Saag","year":"1998","unstructured":"Saag KG, Emkey R, Schnitzer TJ, Brown JP, Hawkins F, Goemaere S, Thamsborg G, Liberman UA, Delmas PD, Malice MP, Czachur M, Daifotis AG (1998) Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med 339:292\u2013299","journal-title":"N Engl J Med"},{"key":"306_CR36","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF03346473","volume":"32","author":"L Tauchmanova","year":"2009","unstructured":"Tauchmanova L, Guerra E, Pivonello R, De Martino MC, De Leo M, Caggiano F, Lombardi G, Colao A (2009) Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing\u2019s syndrome. J Endocrinol Invest 32:390\u2013394","journal-title":"J Endocrinol Invest"},{"key":"306_CR37","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1365-2265.1998.00486.x","volume":"48","author":"C Di Somma","year":"1998","unstructured":"Di Somma C, Colao A, Pivonello R, Klain M, Faggiano A, Tripodi FS, Merola B, Salvatore M, Lombardi G (1998) Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing\u2019s disease. Clin Endocrinol (Oxf) 48:655\u2013662","journal-title":"Clin Endocrinol (Oxf)"},{"key":"306_CR38","doi-asserted-by":"crossref","unstructured":"Plotkin LI, Bivi N, Bellido T (2010) A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice. Bone","DOI":"10.1016\/j.bone.2010.08.011"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-011-0306-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-011-0306-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-011-0306-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T16:38:54Z","timestamp":1560098334000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-011-0306-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["306"],"URL":"https:\/\/doi.org\/10.1007\/s11102-011-0306-3","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,8]]}}}