{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:07:03Z","timestamp":1772579223269,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,10,13]],"date-time":"2013-10-13T00:00:00Z","timestamp":1381622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s11102-013-0526-9","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T04:38:29Z","timestamp":1381552709000},"page":"457-463","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of pituitary cells targeted by antipituitary antibodies in patients with isolated autoimmune diseases without pituitary insufficiency may help to foresee the kind of future hypopituitarism"],"prefix":"10.1007","volume":"17","author":[{"given":"A.","family":"De Bellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dello Iacovo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bellastella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Savoia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cozzolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Sinisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bizzarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bellastella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Giugliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,13]]},"reference":[{"key":"526_CR1","first-page":"2302","volume":"80","author":"E Thodou","year":"1995","unstructured":"Thodou E, Asa SL, Kontogeorgos G, Kovacs K, Horvath E, Ezzat S (1995) Lymphocytic hypophysitis: clinicopathological findings. J Clin Endocrinol Metab 80:2302\u20132311","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR2","first-page":"327","volume":"150","author":"N Beressi","year":"1999","unstructured":"Beressi N, Beressi JP, Cohen R, Modigliani E (1999) Lymphocytic hypophysitis. A review of 145 cases. Ann Int Med 150:327\u2013341","journal-title":"Ann Int Med"},{"key":"526_CR3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11102-006-6598-z","volume":"9","author":"JA Rivera","year":"2006","unstructured":"Rivera JA (2006) Lymphocytic hypophysitis: disease spectrum and approach to diagnosis and therapy. Pituitary 9:35\u201345","journal-title":"Pituitary"},{"key":"526_CR4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2004-0011","volume":"26","author":"P Caturegli","year":"2005","unstructured":"Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR (2005) Autoimmune hypophysitis. Endocr Rev 26:599\u2013614","journal-title":"Endocr Rev"},{"key":"526_CR5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/eje.0.1490363","volume":"149","author":"A Bellastella","year":"2003","unstructured":"Bellastella A, Bizzarro A, Coronella C, Bellastella G, Sinisi AA, De Bellis A (2003) Lymphocytic hypophysitis: a rare or underestimated disease? Eur J Endocrinol 149:363\u2013376","journal-title":"Eur J Endocrinol"},{"key":"526_CR6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/CS20070051","volume":"114","author":"A Bellis De","year":"2008","unstructured":"De Bellis A, Ruocco G, Battaglia M, Conte M, Coronella C, Tirelli G, Bellastella A, Pane E, Sinisi AA, Bizzarro A, Bellastella G (2008) Immunological and clinical aspects of lymphocytic hypophysitis. Clin Sci 114:413\u2013421","journal-title":"Clin Sci"},{"key":"526_CR7","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1210\/jc.2010-0551","volume":"95","author":"G Bellastella","year":"2010","unstructured":"Bellastella G, Rotondi M, Pane E, Dello Iacovo A, Pirali B, Dalla Mora L, Falorni A, Sinisi AA, Bizzarro A, Colao A, Chiovato L, De Bellis A, Italian Autoimmune Hypophysitis Network Study (2010) Predictive role of the immunostaining pattern of immunofluorescence and the titres of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a 5-year follow-up. J Clin Endocrinol Metab 95:3750\u20133757","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR8","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0140-6736(74)90140-8","volume":"2","author":"GF Bottazzo","year":"1974","unstructured":"Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:1279\u20131283","journal-title":"Lancet"},{"key":"526_CR9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000179516","volume":"16","author":"A Pouplard","year":"1982","unstructured":"Pouplard A (1982) Pituitary autoimmunity. Horm Res 16:289\u2013297","journal-title":"Horm Res"},{"key":"526_CR10","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/jc.2006-0040","volume":"91","author":"A Bellis De","year":"2006","unstructured":"De Bellis A, Salerno M, Conte M, Coronella C, Tirelli G, Battaglia M, Esposito V, Ruocco G, Bellastella G, Bizzarro A, Bellastella A (2006) Antipituitary antibodies recognizing growth hormone (GH)-producing cells in children with idiopathic GH deficiency and in children with idiopathic short stature. J Clin Endocrinol Metab 91:2484\u20132489","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.beem.2004.11.007","volume":"19","author":"A Bellis De","year":"2005","unstructured":"De Bellis A, Bizzarro A, Bellastella A (2005) Pituitary antibodies and lymphocytic hypophysitis. Best Pract Res Clin Endocrinol Metab 19:67\u201384","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"526_CR12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/jc.2006-1216","volume":"92","author":"A Bellis De","year":"2007","unstructured":"De Bellis A, Sinisi AA, Conte M, Coronella C, Bellastella G, Esposito D, Pasquali D, Ruocco G, Bizzarro A, Bellastella A (2007) Antipituitary antibodies against gonadotropin-secreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 92:604\u2013607","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2265.2011.04056.x","volume":"75","author":"A Bellis De","year":"2011","unstructured":"De Bellis A, Pane E, Bellastella G, Sinisi AA, Colella C, Giordano R, Giavoli C, Lania A, Ambrosio MR, Di Somma C, Zatelli MC, Arvat E, Colao A, Bizzarro A, Bellastella A, Italian Autoimmune Hypophysitis Network Study (2011) Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism. Clin Endocrinol 75:361\u2013366","journal-title":"Clin Endocrinol"},{"key":"526_CR14","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1210\/jc.2012-2269","volume":"97","author":"A Bellis De","year":"2012","unstructured":"De Bellis A, Sinisi AA, Pane E, Dello Iacovo A, Bellastella G, Di Scala G, Falorni A, Giavoli C, Gasco V, Giordano R, Ambrosio MR, Colao A, Bizzarro A, Bellastella A, Italian Autoimmune Hypophysitis Network Group (2012) Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells. J Clin Endocrinol Metab 97:3684\u20133690","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2265.2005.02296.x","volume":"63","author":"A Bellis De","year":"2005","unstructured":"De Bellis A, Bizzarro A, Perrino S, Coronella C, Conte M, Pasquali D, Sinisi AA, Betterle C, Bellastella A (2005) Characterization of antipituitary antibodies targeting pituitary hormone-secreting cells in idiopathic growth hormone deficiency and autoimmune endocrine diseases. Clin Endocrinol 63:45\u201349","journal-title":"Clin Endocrinol"},{"key":"526_CR16","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.autrev.2008.04.016","volume":"7","author":"P Caturegli","year":"2008","unstructured":"Caturegli P, Lupi I, Landek-Salgado M, Kimura H, Rose NR (2008) Pituitary autoimmunity: 30\u00a0years later. Autoimmunity 7:631\u2013637","journal-title":"Autoimmunity"},{"key":"526_CR17","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000050015","volume":"55","author":"T Takao","year":"2001","unstructured":"Takao T, Nanamiya W, Matsumoto R, Asaba K, Okabayashi T, Hashimoto K (2001) Antipituitary antibodies in patients with lymphocytic hypophysitis. Horm Res 55:288\u2013292","journal-title":"Horm Res"},{"key":"526_CR18","first-page":"609","volume":"83","author":"PA Crock","year":"1998","unstructured":"Crock PA (1998) Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metab 83:609\u2013618","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1210\/jc.87.2.752","volume":"87","author":"DT O\u2019 Dwyer","year":"2002","unstructured":"O\u2019 Dwyer DT, Smith AI, Matthew ML, Andronicos NM, Ranson M, Robinson PJ, Crock PA (2002) Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase. J Clin Endocrinol Metab 87:752\u2013757","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR20","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1530\/eje.0.1470767","volume":"147","author":"S Tanaka","year":"2002","unstructured":"Tanaka S, Tatsumi KI, Kimura M, Takano T, Murakami Y, Takao T, Hashimoto K, Kato Y, Amino N (2002) Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. Eur J Endocrinol 147:767\u2013775","journal-title":"Eur J Endocrinol"},{"key":"526_CR21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1073\/pnas.0610070104","volume":"104","author":"S Bensing","year":"2007","unstructured":"Bensing S, Fetissov SO, Mulder J, Perheentupa J, Gustafsson J, Husebye ES, Oscarson M, Ekwall O, Crock PA, Hokfelt T, Hulting AL, Kampe O (2007) Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. Proc Natl Acad Sci 104:949\u2013954","journal-title":"Proc Natl Acad Sci"},{"key":"526_CR22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2265.2008.03180.x","volume":"69","author":"I Lupi","year":"2008","unstructured":"Lupi I, Broman KW, Tzou SC, Gutenberg A, Martino E, Caturegli P (2008) Novel autoantigens in autoimmune hypophysitis. Clin Endocrinol 69:269\u2013278","journal-title":"Clin Endocrinol"},{"key":"526_CR23","first-page":"1002","volume":"76","author":"A Bellis De","year":"1993","unstructured":"De Bellis A, Bizzarro A, Rossi R, Paglionico VA, Criscuolo T, Lombardi G, Bellastella A (1993) Remission of subclinical adrenocortical failure in subjects with adrenal autoantibodies. J Clin Endocrinol Metab 76:1002\u20131007","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.beem.2011.11.008","volume":"26","author":"A Bellastella","year":"2012","unstructured":"Bellastella A, Bizzarro A, Colella C, Bellastella G, Sinisi AA, De Bellis A (2012) Subclinical diabetes insipidus. Best Pract Res Clin Endocrinol Metab 26:471\u2013483","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"526_CR25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/EJE-11-1015","volume":"166","author":"CJ Smith","year":"2012","unstructured":"Smith CJ, Bensing S, Burns C, Robinson PJ, Kasperlik-Zaluska AA, Scott RJ, K\u00e4mpe O, Crock PA (2012) Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. Eur J Endocrinol 166:391\u2013398","journal-title":"Eur J Endocrinol"},{"key":"526_CR26","first-page":"248","volume":"1","author":"DT O\u2019 Dwyer","year":"2007","unstructured":"O\u2019 Dwyer DT, McElduff P, Peterson P, Perheentupa J, Crock PA (2007) Pituitary autoantibodies in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Acta Biomed 1:248\u2013254","journal-title":"Acta Biomed"},{"key":"526_CR27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0140-6736(82)91809-8","volume":"1","author":"R Mirakian","year":"1982","unstructured":"Mirakian R, Cudworth AG, Bottazzo GF, Richardson CA, Doniach D (1982) Autoimmunity to anterior pituitary cells and the pathogenesis of insulin-dependent diabetes mellitus. Lancet 1:755\u2013759","journal-title":"Lancet"},{"key":"526_CR28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/jc.2002-021054","volume":"88","author":"A Bellis De","year":"2003","unstructured":"De Bellis A, Bizzarro A, Conte M, Perrino S, Coronella C, Solimeno S, Sinisi AM, Stile LA, Pisano G, Bellastella A (2003) Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases. J Clin Endocrinol Metab 88:650\u2013654","journal-title":"J Clin Endocrinol Metab"},{"key":"526_CR29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/thy.2011.0373","volume":"22","author":"F Guaraldi","year":"2012","unstructured":"Guaraldi F, Landek-Salgado MA, Hutfless S, Samoni F, Talor MV, Matos PG, Salvatori R, Rose NR, Caturegli P (2012) Pituitary antibodies in women with Hashimoto\u2019s thyroiditis: prevalence in diagnostic and prediagnostic sera. Thyroid 22:509\u2013515","journal-title":"Thyroid"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-013-0526-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-013-0526-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-013-0526-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T06:08:18Z","timestamp":1559369298000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-013-0526-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,13]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["526"],"URL":"https:\/\/doi.org\/10.1007\/s11102-013-0526-9","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,13]]}}}