{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:45:18Z","timestamp":1757450718226},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s11102-014-0594-5","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T16:48:28Z","timestamp":1408639708000},"page":"456-460","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of leukemia inhibitory receptor gene mutations on human hypothalamo\u2013pituitary\u2013adrenal function"],"prefix":"10.1007","volume":"18","author":[{"given":"Tulay","family":"Guran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Guran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Paketci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Kipoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Firat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Turan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Atay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belma","family":"Haliloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Bereket","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,22]]},"reference":[{"key":"594_CR1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1399-0004.2009.01314.x","volume":"77","author":"C Jung","year":"2010","unstructured":"Jung C, Dagoneau N, Baujat G, Le Merrer M, David A, Di Rocco M, Hamel B, M\u00e9garban\u00e9 A, Superti-Furga A, Unger S, Munnich A, Cormier-Daire V (2010) Stuve\u2013Wiedemann syndrome: long-term follow-up and genetic heterogeneity. Clin Genet 77:266\u2013272","journal-title":"Clin Genet"},{"key":"594_CR2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/archdischild-2011-301075","volume":"97","author":"D Rigante","year":"2012","unstructured":"Rigante D (2012) Are there febrile diseases with a risk of sudden death in children? Arch Dis Child 97:180","journal-title":"Arch Dis Child"},{"key":"594_CR3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1086\/381715","volume":"74","author":"N Dagoneau","year":"2004","unstructured":"Dagoneau N, Scheffer D, Huber C, Al-Gazali LI, Di Rocco M, Godard A, Martinovic J, Raas-Rothschild A, Sigaudy S, Unger S, Nicole S, Fontaine B, Taupin JL, Moreau JF, Superti-Furga A, Le Merrer M, Bonaventure J, Munnich A, Legeai-Mallet L, Cormier-Daire V (2004) Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve\u2013Wiedemann\/Schwartz\u2013Jampel type 2 syndrome. Am J Hum Genet 74:298\u2013305","journal-title":"Am J Hum Genet"},{"key":"594_CR4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1359-6101(98)80005-1","volume":"8","author":"T Hirano","year":"1997","unstructured":"Hirano T, Nakajima K, Hibi M (1997) Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev 8:241\u2013252","journal-title":"Cytokine Growth Factor Rev"},{"key":"594_CR5","doi-asserted-by":"crossref","first-page":"32976","DOI":"10.1074\/jbc.M111.218016","volume":"286","author":"AM Lefrancois-Martinez","year":"2011","unstructured":"Lefrancois-Martinez AM, Blondet-Trichard A, Binart N, Val P, Chambon C, Sahut-Barnola I, Pointud JC, Martinez A (2011) Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor. J Biol Chem 286:32976\u201332985","journal-title":"J Biol Chem"},{"key":"594_CR6","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1172\/JCI117779","volume":"95","author":"S Akita","year":"1995","unstructured":"Akita S, Webster J, Ren SG, Takino H, Said J, Zand O, Melmed S (1995) Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J Clin Invest 95:1288\u20131298","journal-title":"J Clin Invest"},{"key":"594_CR7","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1172\/JCI118615","volume":"97","author":"DW Ray","year":"1996","unstructured":"Ray DW, Ren SG, Melmed S (1996) Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway. J Clin Invest 97:1852\u20131859","journal-title":"J Clin Invest"},{"key":"594_CR8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.1998.tb09560.x","volume":"840","author":"DW Ray","year":"1998","unstructured":"Ray DW, Ren SG, Melmed S (1998) Leukemia inhibitory factor regulates proopiomelanocortin transcription. Ann NY Acad Sci 840:162\u2013173","journal-title":"Ann NY Acad Sci"},{"key":"594_CR9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.8272873","volume":"263","author":"N Stahl","year":"1994","unstructured":"Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S et al (1994) Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 263:92\u201395","journal-title":"Science"},{"key":"594_CR10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0303-7207(00)00200-8","volume":"162","author":"AM Bamberger","year":"2000","unstructured":"Bamberger AM, Schulte HM, Wullbrand A, Jung R, Beil FU, Bamberger CM (2000) Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis. Mol Cell Endocinol 162:145\u2013149","journal-title":"Mol Cell Endocinol"},{"key":"594_CR11","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1016\/j.febslet.2005.07.014","volume":"579","author":"CB Ware","year":"2005","unstructured":"Ware CB, Kariagina A, Zonis S, Alon D, Chesnokova V (2005) Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis. FEBS Lett 579:4465\u20134469","journal-title":"FEBS Lett"},{"key":"594_CR12","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1210\/endo.137.7.8770918","volume":"137","author":"Z Wang","year":"1996","unstructured":"Wang Z, Ren SG, Melmed S (1996) Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface. Endocrinology 137:2947\u20132953","journal-title":"Endocrinology"},{"key":"594_CR13","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1210\/endo.139.5.6016","volume":"139","author":"V Chesnokova","year":"1998","unstructured":"Chesnokova V, Auernhammer CJ, Melmed S (1998) Murine leukemia inhibitory factor gene disruption attenuates the hypothalamo\u2013pituitary\u2013adrenal axis stress response. Endocrinology 139:2209\u20132216","journal-title":"Endocrinology"},{"key":"594_CR14","first-page":"1708","volume":"12","author":"H Yano","year":"1998","unstructured":"Yano H, Readhead C, Nakashima M, Ren SG, Melmed S (1998) Pituitary-directed leukemia inhibitory factor transgene causes Cushing\u2019s syndrome: neuro-immune-endocrine modulation of pituitary development. Mol Cell Endocinol 12:1708\u20131720","journal-title":"Mol Cell Endocinol"},{"key":"594_CR15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1677\/JOE-08-0377","volume":"199","author":"IV Mikhaylova","year":"2008","unstructured":"Mikhaylova IV, J\u00e4\u00e4skel\u00e4inen T, J\u00e4\u00e4skel\u00e4inen J, Palvimo JJ, Voutilainen R (2008) Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells. J Endocrinol 199:435\u2013444","journal-title":"J Endocrinol"},{"key":"594_CR16","doi-asserted-by":"crossref","unstructured":"Ye\u015fil G, Lebre AS, Santos SD, G\u00fcran O, Ozahi II, Daire VC, G\u00fcran T (2014) Stuve\u2013Wiedemann syndrome: is it underrecognized? Am J Med Genet A. doi: 10.1002\/ajmg.a.36626 . (Epub ahead of print)","DOI":"10.1002\/ajmg.a.36626"},{"key":"594_CR17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1677\/joe.0.1300475","volume":"130","author":"S Crowley","year":"1991","unstructured":"Crowley S, Hindmarsh PC, Holownia P, Honour JW, Brook CG (1991) The use of low doses of ACTH in the investigation of adrenal function in man. J Endocrinol 130:475\u2013479","journal-title":"J Endocrinol"},{"key":"594_CR18","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1210\/jc.2009-2697","volume":"95","author":"N Iorgi di","year":"2010","unstructured":"di Iorgi N, Napoli F, Allegri A, Secco A, Calandra E, Calcagno A, Frassinetti C, Ghezzi M, Ambrosini L, Parodi S, Gastaldi R, Loche S, Maghnie M (2010) The accuracy of the glucagon test compared to the insulin tolerance test in the diagnosis of adrenal insufficiency in young children with growth hormone deficiency. J Clin Endocrinol Metab 95:2132\u20132139","journal-title":"J Clin Endocrinol Metab"},{"key":"594_CR19","first-page":"433","volume":"18","author":"A B\u00f6ttner","year":"2005","unstructured":"B\u00f6ttner A, Kratzsch J, Liebermann S, Keller A, Pfaffle RW, Kiess W, Keller E (2005) Comparison of adrenal function tests in children-the glucagon stimulation test allows the simultaneous assessment of adrenal function and growth hormone response in children. J Pediatr Endocr Met 18:433\u2013442","journal-title":"J Pediatr Endocr Met"},{"key":"594_CR20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000073232","volume":"60","author":"EN Gonc","year":"2003","unstructured":"Gonc EN, Kandemir N, Kinik ST (2003) Significance of low dose and standart-dose ACTH tests compared overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res 60:191\u2013197","journal-title":"Horm Res"},{"key":"594_CR21","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.272.16.10551","volume":"272","author":"C Bousquet","year":"1997","unstructured":"Bousquet C, Ray DW, Melmed S (1997) A common pro-opiomelanocortin-binding element mediates leukemia inhibitory factor and corticotropin-releasing hormone transcriptional synergy. J Biol Chem 272:10551\u201310557","journal-title":"J Biol Chem"},{"key":"594_CR22","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/endo.139.5.6017","volume":"139","author":"CJ Auernhammer","year":"1998","unstructured":"Auernhammer CJ, Chesnokova V, Melmed S (1998) Leukemia inhibitory factor modulates interleukin-1beta-induced activation of the hypothalamo\u2013pituitary\u2013adrenal axis. Endocrinology 139:2201\u20132208","journal-title":"Endocrinology"},{"key":"594_CR23","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/00007611-196106000-00021","volume":"54","author":"I Taliaferro","year":"1961","unstructured":"Taliaferro I (1961) Cushing\u2019s syndrome associated with acute leukemia. South Med J 54:686\u2013689","journal-title":"South Med J"},{"key":"594_CR24","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1056\/NEJM198112313052706","volume":"305","author":"KH Pfl\u00fcger","year":"1981","unstructured":"Pfl\u00fcger KH, Gramse M, Gropp C, Havemann K (1981) Ectopic ACTH production with autoantibody formation in a patient with acute myeloblastic leukemia. N Engl J Med 305:1632\u20131636","journal-title":"N Engl J Med"},{"key":"594_CR25","first-page":"967","volume":"26","author":"NM Sahin","year":"2013","unstructured":"Sahin NM, Avci Z, Malbora B, Abaci A, Kinik ST, Ozbek NY (2013) Cushing syndrome related to leukemic infiltration of the central nervous system: a case report and a possible role of LIF. J Pediatr Endocr Met 26:967\u2013997","journal-title":"J Pediatr Endocr Met"},{"issue":"1","key":"594_CR26","doi-asserted-by":"crossref","first-page":"E121","DOI":"10.1210\/jc.2011-0407","volume":"97","author":"MH Quentien","year":"2012","unstructured":"Quentien MH, Delemer B, Papadimitriou DT, Souchon PF, Jaussaud R, Pagnier A, Munzer M, Jullien N, Reynaud R, Galon-Faure N, Enjalbert A, Barlier A, Brue T (2012) Deficit in anterior pituitary function and variable immune deficiency (DAVID) in children presenting with adrenocorticotropin deficiency and severe infections. J Clin Endocrinol Metab 97(1):E121\u2013E128","journal-title":"J Clin Endocrinol Metab"},{"key":"594_CR27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000262532","volume":"17","author":"R Kazlauskaite","year":"2010","unstructured":"Kazlauskaite R, Maghnie M (2010) Pitfalls in the diagnosis of central adrenal insufficiency in children. Endocr Dev 17:96\u2013107","journal-title":"Endocr Dev"},{"key":"594_CR28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrendo.2010.152","volume":"6","author":"HL Claahsen-van der Grinten","year":"2010","unstructured":"Claahsen-van der Grinten HL, Otten BJ (2010) Adrenal function: a gold standard test for adrenal insufficiency in children? Nat Rev Endocrinol 6:605\u2013606","journal-title":"Nat Rev Endocrinol"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-014-0594-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-014-0594-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-014-0594-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:15:24Z","timestamp":1565759724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-014-0594-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,22]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["594"],"URL":"https:\/\/doi.org\/10.1007\/s11102-014-0594-5","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,22]]}}}