{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:30:55Z","timestamp":1772119855923,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s11102-014-0610-9","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T10:56:25Z","timestamp":1413284185000},"page":"561-567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Frequent development of combined pituitary hormone deficiency in patients initially diagnosed as isolated growth hormone deficiency: a long term follow-up of patients from a single center"],"prefix":"10.1007","volume":"18","author":[{"given":"Aline P.","family":"Otto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela M.","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda A.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everlayny F.","family":"Costalonga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia C.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice B.","family":"Mendonca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo J. P.","family":"Arnhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciani R. S.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A. L.","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"issue":"11","key":"610_CR1","first-page":"3990","volume":"85","author":"Growth Hormone Research Society","year":"2000","unstructured":"Growth Hormone Research Society (2000) Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab 85(11):3990\u20133993. doi: 10.1210\/jcem.85.11.6984","journal-title":"J Clin Endocrinol Metab"},{"issue":"9571","key":"610_CR2","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(07)60673-4","volume":"369","author":"HJ Schneider","year":"2007","unstructured":"Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E (2007) Hypopituitarism. Lancet 369(9571):1461\u20131470. doi: 10.1016\/S0140-6736(07)60673-4","journal-title":"Lancet"},{"issue":"2","key":"610_CR3","doi-asserted-by":"crossref","first-page":"e484","DOI":"10.1542\/peds.2006-1612","volume":"119","author":"DI Shulman","year":"2007","unstructured":"Shulman DI, Palmert MR, Kemp SF (2007) Adrenal insufficiency: still a cause of morbidity and death in childhood. Pediatrics 119(2):e484\u2013e494. doi: 10.1542\/peds.2006-1612","journal-title":"Pediatrics"},{"issue":"4","key":"610_CR4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/eje.0.1430493","volume":"143","author":"M Bozzola","year":"2000","unstructured":"Bozzola M, Mengarda F, Sartirana P, Tato L, Chaussain JL (2000) Long-term follow-up evaluation of magnetic resonance imaging in the prognosis of permanent GH deficiency. Eur J Endocrinol 143(4):493\u2013496. doi: 10.1530\/eje.0.1430493","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"610_CR5","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1210\/jc.2007-1081","volume":"92","author":"N Iorgi di","year":"2007","unstructured":"di Iorgi N, Secco A, Napoli F, Tinelli C, Calcagno A, Fratangeli N, Ambrosini L, Rossi A, Lorini R, Maghnie M (2007) Deterioration of growth hormone (GH) response and anterior pituitary function in young adults with childhood-onset GH deficiency and ectopic posterior pituitary: a two-year prospective follow-up study. J Clin Endocrinol Metab 92(10):3875\u20133884. doi: 10.1210\/jc.2007-1081","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"610_CR6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11102-011-0321-4","volume":"15","author":"VS Jagtap","year":"2012","unstructured":"Jagtap VS, Acharya SV, Sarathi V, Lila AR, Budyal SR, Kasaliwal R, Sankhe SS, Bandgar TR, Menon PS, Shah NS (2012) Ectopic posterior pituitary and stalk abnormality predicts severity and coexisting hormone deficiencies in patients with congenital growth hormone deficiency. Pituitary 15(2):243\u2013250. doi: 10.1007\/s11102-011-0321-4","journal-title":"Pituitary"},{"issue":"5","key":"610_CR7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000350829","volume":"79","author":"C Deal","year":"2013","unstructured":"Deal C, Hasselmann C, Pfaffle RW, Zimmermann AG, Quigley CA, Child CJ, Shavrikova EP, Cutler GB Jr, Blum WF (2013) Associations between pituitary imaging abnormalities and clinical and biochemical phenotypes in children with congenital growth hormone deficiency: data from an international observational study. Horm Res Paediatr 79(5):283\u2013292. doi: 10.1159\/000350829","journal-title":"Horm Res Paediatr"},{"issue":"1","key":"610_CR8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/EJE-13-0643","volume":"170","author":"WF Blum","year":"2014","unstructured":"Blum WF, Deal C, Zimmermann AG, Shavrikova EP, Child CJ, Quigley CA, Drop SL, Cutler GB Jr, Rosenfeld RG (2014) Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated GH deficiency. Eur J Endocrinol 170(1):13\u201321. doi: 10.1530\/EJE-13-0643","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"610_CR9","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1210\/jc.2003-030529","volume":"88","author":"M Lange","year":"2003","unstructured":"Lange M, Feldt-Rasmussen U, Svendsen OL, Kastrup KW, Juul A, Muller J (2003) High risk of adrenal insufficiency in adults previously treated for idiopathic childhood onset growth hormone deficiency. J Clin Endocrinol Metab 88(12):5784\u20135789. doi: 10.1210\/jc.2003-030529","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"610_CR10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/jc.2004-1274","volume":"90","author":"J Leger","year":"2005","unstructured":"Leger J, Danner S, Simon D, Garel C, Czernichow P (2005) Do all patients with childhood-onset growth hormone deficiency (GHD) and ectopic neurohypophysis have persistent GHD in adulthood? J Clin Endocrinol Metab 90(2):650\u2013656. doi: 10.1210\/jc.2004-1274","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"610_CR11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000089425","volume":"64","author":"M Tauber","year":"2005","unstructured":"Tauber M, Chevrel J, Diene G, Moulin P, Jouret B, Oliver I, Pienkowski C, Sevely A (2005) Long-term evolution of endocrine disorders and effect of GH therapy in 35 patients with pituitary stalk interruption syndrome. Horm Res 64(6):266\u2013273. doi: 10.1159\/000089425","journal-title":"Horm Res"},{"issue":"3","key":"610_CR12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000324087","volume":"93","author":"E Fernandez-Rodriguez","year":"2011","unstructured":"Fernandez-Rodriguez E, Quinteiro C, Barreiro J, Marazuela M, Pereiro I, Peino R, Cabezas-Agricola JM, Dominguez F, Casanueva FF, Bernabeu I (2011) Pituitary stalk dysgenesis-induced hypopituitarism in adult patients: prevalence, evolution of hormone dysfunction and genetic analysis. Neuroendocrinology 93(3):181\u2013188. doi: 10.1159\/000324087","journal-title":"Neuroendocrinology"},{"issue":"4","key":"610_CR13","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1210\/jc.2004-1280","volume":"90","author":"PE Mullis","year":"2005","unstructured":"Mullis PE, Robinson IC, Salemi S, Eble A, Besson A, Vuissoz JM, Deladoey J, Simon D, Czernichow P, Binder G (2005) Isolated autosomal dominant growth hormone deficiency: an evolving pituitary deficit? A multicenter follow-up study. J Clin Endocrinol Metab 90(4):2089\u20132096. doi: 10.1210\/jc.2004-1280","journal-title":"J Clin Endocrinol Metab"},{"key":"610_CR14","unstructured":"Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, Mei Z, Curtin LR, Roche AF, Johnson CL (2000) CDC growth charts: United States. Adv Data (314):1\u201327. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11183293"},{"issue":"5","key":"610_CR15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000070222","volume":"59","author":"EG Silva","year":"2003","unstructured":"Silva EG, Slhessarenko N, Arnhold IJ, Batista MC, Estefan V, Osorio MG, Marui S, Mendonca BB (2003) GH values after clonidine stimulation measured by immunofluorometric assay in normal prepubertal children and GH-deficient patients. Horm Res 59(5):229\u2013233. doi: 10.1159\/000070222","journal-title":"Horm Res"},{"issue":"11","key":"610_CR16","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1210\/jc.2001-011936","volume":"87","author":"MG Osorio","year":"2002","unstructured":"Osorio MG, Marui S, Jorge AA, Latronico AC, Lo LS, Leite CC, Estefan V, Mendonca BB, Arnhold IJ (2002) Pituitary magnetic resonance imaging and function in patients with growth hormone deficiency with and without mutations in GHRH-R, GH-1, or PROP-1 genes. J Clin Endocrinol Metab 87(11):5076\u20135084","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"610_CR17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1172\/JCI18589","volume":"112","author":"LR Carvalho","year":"2003","unstructured":"Carvalho LR, Woods KS, Mendonca BB, Marcal N, Zamparini AL, Stifani S, Brickman JM, Arnhold IJ, Dattani MT (2003) A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction. J Clin Invest 112(8):1192\u20131201. doi: 10.1172\/JCI18589","journal-title":"J Clin Invest"},{"issue":"7","key":"610_CR18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1515\/JPEM.2008.21.7.673","volume":"21","author":"MG Rocha","year":"2008","unstructured":"Rocha MG, Marchisotti FG, Osorio MG, Marui S, Carvalho LR, Jorge AA, Mendonca BB, Arnhold IJ (2008) High prevalence of pituitary magnetic resonance abnormalities and gene mutations in a cohort of Brazilian children with growth hormone deficiency and response to treatment. J Pediatr Endocrinol Metab 21(7):673\u2013680","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"11","key":"610_CR19","doi-asserted-by":"crossref","first-page":"E384","DOI":"10.1210\/jc.2010-1050","volume":"95","author":"MM Franca","year":"2010","unstructured":"Franca MM, Jorge AA, Carvalho LR, Costalonga EF, Vasques GA, Leite CC, Mendonca BB, Arnhold IJ (2010) Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly. J Clin Endocrinol Metab 95(11):E384\u2013E391. doi: 10.1210\/jc.2010-1050","journal-title":"J Clin Endocrinol Metab"},{"key":"610_CR20","doi-asserted-by":"crossref","unstructured":"Marui S, Trarbach EB, Boguszewski MC, Franca MM, Jorge AA, Inoue H, Nishi MY, de Lacerda Filho L, Aguiar-Oliveira MH, Mendonca BB, Arnhold IJ (2012) GH-releasing hormone receptor gene: a novel splice-disrupting mutation and study of founder effects. Horm Res Paediatr 78(3):165\u2013172. doi: 10.1159\/000342760","DOI":"10.1159\/000342760"},{"issue":"2","key":"610_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1507\/endocrj.49.231","volume":"49","author":"S Makino","year":"2002","unstructured":"Makino S, Kawasaki D, Irimoto H, Tanimoto M (2002) Late onset of adrenocortical failure in GH deficiency with invisible pituitary stalk: a case report of a 48-year-old Japanese man and review of the literature. Endocr J 49(2):231\u2013240","journal-title":"Endocr J"},{"issue":"4","key":"610_CR22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000097755","volume":"67","author":"C Garel","year":"2007","unstructured":"Garel C, Leger J (2007) Contribution of magnetic resonance imaging in non-tumoral hypopituitarism in children. Horm Res 67(4):194\u2013202. doi: 10.1159\/000097755","journal-title":"Horm Res"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-014-0610-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-014-0610-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-014-0610-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T02:08:22Z","timestamp":1559354902000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-014-0610-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["610"],"URL":"https:\/\/doi.org\/10.1007\/s11102-014-0610-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722007954.793528613","asserted-by":"object"}]},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]}}}