{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:42:17Z","timestamp":1793407337758,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009797","name":"Barrow Neurological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s11102-019-00981-9","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T17:02:33Z","timestamp":1565456553000},"page":"514-519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical, pathologic, and imaging characteristics of pituitary null cell adenomas as defined according to the 2017 World Health Organization criteria: a case series from two pituitary centers"],"prefix":"10.1007","volume":"22","author":[{"given":"Joao Paulo","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corbin C.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Eschbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Felicella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C. J.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Laure","family":"Bernat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Zadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Gentili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,10]]},"reference":[{"issue":"4","key":"981_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1590\/2359-3997000000179","volume":"60","author":"LN Vieira","year":"2016","unstructured":"Vieira LN, Boguszewski CL, Araujo LA, Bronstein MD, Miranda PA, Musolino NR, Naves LA, Vilar L, Ribeiro-Oliveira AJ, Gadelha MR (2016) A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism. Arch Endocrinol Metab 60(4):374\u2013390. \n                    https:\/\/doi.org\/10.1590\/2359-3997000000179","journal-title":"Arch Endocrinol Metab"},{"issue":"2","key":"981_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/BF00430697","volume":"387","author":"K Kovacs","year":"1980","unstructured":"Kovacs K, Horvath E, Ryan N, Ezrin C (1980) Null cell adenoma of the human pituitary. Virchows Arch A Pathol Anat Histol 387(2):165\u2013174","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"981_CR3","unstructured":"International Agency for Research on Cancer (2017) WHO Classification of Tumours of Endocrine Organs, 4th ed. Medicine"},{"issue":"6","key":"981_CR4","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41379-018-0016-8","volume":"31","author":"O Mete","year":"2018","unstructured":"Mete O, Cintosun A, Pressman I, Asa SL (2018) Epidemiology and biomarker profile of pituitary adenohypophysial tumors. Mod Pathol 31(6):900\u2013909. \n                    https:\/\/doi.org\/10.1038\/s41379-018-0016-8","journal-title":"Mod Pathol"},{"issue":"4","key":"981_CR5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s12022-015-9398-z","volume":"26","author":"H Nishioka","year":"2015","unstructured":"Nishioka H, Inoshita N, Mete O, Asa SL, Hayashi K, Takeshita A, Fukuhara N, Yamaguchi-Okada M, Takeuchi Y, Yamada S (2015) The complementary role of transcription factors in the accurate diagnosis of clinically nonfunctioning pituitary adenomas. Endocr Pathol 26(4):349\u2013355. \n                    https:\/\/doi.org\/10.1007\/s12022-015-9398-z","journal-title":"Endocr Pathol"},{"issue":"1","key":"981_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12022-014-9347-2","volume":"26","author":"JA Balogun","year":"2015","unstructured":"Balogun JA, Monsalves E, Juraschka K, Parvez K, Kucharczyk W, Mete O, Gentili F, Zadeh G (2015) Null cell adenomas of the pituitary gland: an institutional review of their clinical imaging and behavioral characteristics. Endocr Pathol 26(1):63\u201370. \n                    https:\/\/doi.org\/10.1007\/s12022-014-9347-2","journal-title":"Endocr Pathol"},{"key":"981_CR7","unstructured":"Lloyd RV, Osamura, RY, Kl\u00f6ppel G, Rosai J (2017) WHO classification of tumours of the endocrine organs, vol. 10, 4th ed. Medicine, vol. 10. International Agency For Research on Cancer, Lyon"},{"key":"981_CR8","first-page":"37","volume-title":"WHO classification of tumours of the endocrine organs","author":"K Nishioka","year":"2017","unstructured":"Nishioka K, Kontogeorgas G, Lloyd RV, Lopes MB, Mete O, Nose V (2017) Null cell adenoma. In: Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J (eds) WHO classification of tumours of the endocrine organs, vol 10. International Agency For Research on Cancer, Lyon Cedex, pp 37\u201338"},{"issue":"4","key":"981_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00401-017-1769-8","volume":"134","author":"MBS Lopes","year":"2017","unstructured":"Lopes MBS (2017) The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol 134(4):521\u2013535. \n                    https:\/\/doi.org\/10.1007\/s00401-017-1769-8","journal-title":"Acta Neuropathol"},{"issue":"1","key":"981_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.5858\/arpa.2016-0082-OA","volume":"141","author":"WC McDonald","year":"2017","unstructured":"McDonald WC, Banerji N, McDonald KN, Ho B, Macias V, Kajdacsy-Balla A (2017) Steroidogenic factor 1, Pit-1, and adrenocorticotropic hormone: a rational starting place for the immunohistochemical characterization of pituitary adenoma. Arch Pathol Lab Med 141(1):104\u2013112. \n                    https:\/\/doi.org\/10.5858\/arpa.2016-0082-OA","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"981_CR11","first-page":"610","volume":"33","author":"E Knosp","year":"1993","unstructured":"Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33(4):610\u2013617 discussion 617-618","journal-title":"Neurosurgery"},{"key":"981_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000094259","volume":"35","author":"I Donangelo","year":"2006","unstructured":"Donangelo I, Melmed S (2006) Implication of pituitary tropic status on tumor development. Front Horm Res 35:1\u20138. \n                    https:\/\/doi.org\/10.1159\/000094259","journal-title":"Front Horm Res"},{"key":"981_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mce.2016.09.016","volume":"445","author":"LY Cheung","year":"2017","unstructured":"Cheung LY, Davis SW, Brinkmeier ML, Camper SA, Perez-Millan MI (2017) Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways. Mol Cell Endocrinol 445:14\u201326. \n                    https:\/\/doi.org\/10.1016\/j.mce.2016.09.016","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"981_CR14","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.ygcen.2009.11.007","volume":"166","author":"H Vankelecom","year":"2010","unstructured":"Vankelecom H, Gremeaux L (2010) Stem cells in the pituitary gland: a burgeoning field. Gen Comp Endocrinol 166(3):478\u2013488. \n                    https:\/\/doi.org\/10.1016\/j.ygcen.2009.11.007","journal-title":"Gen Comp Endocrinol"},{"issue":"2","key":"981_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10014-017-0307-7","volume":"35","author":"H Nishioka","year":"2018","unstructured":"Nishioka H, Inoshita N (2018) New WHO classification of pituitary adenomas (4th edition): assessment of pituitary transcription factors and the prognostic histological factors. Brain Tumor Pathol 35(2):57\u201361. \n                    https:\/\/doi.org\/10.1007\/s10014-017-0307-7","journal-title":"Brain Tumor Pathol"},{"key":"981_CR16","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1016\/j.wneu.2018.08.043","volume":"120","author":"RL Batista","year":"2018","unstructured":"Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR (2018) Nonfunctioning pituitary adenoma recurrence and its relationship with sex, size, and hormonal immunohistochemical profile. World Neurosurg 120:e241\u2013e246. \n                    https:\/\/doi.org\/10.1016\/j.wneu.2018.08.043","journal-title":"World Neurosurg"},{"issue":"5","key":"981_CR17","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.beem.2009.05.005","volume":"23","author":"Y Greenman","year":"2009","unstructured":"Greenman Y, Stern N (2009) Non-functioning pituitary adenomas. Best Pract Res Clin Endocrinol Metab 23(5):625\u2013638. \n                    https:\/\/doi.org\/10.1016\/j.beem.2009.05.005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"981_CR18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1750-3639.2012.00599.x","volume":"22","author":"O Mete","year":"2012","unstructured":"Mete O, Asa SL (2012) Clinicopathological correlations in pituitary adenomas. Brain Pathol 22(4):443\u2013453. \n                    https:\/\/doi.org\/10.1111\/j.1750-3639.2012.00599.x","journal-title":"Brain Pathol"},{"issue":"8","key":"981_CR19","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1043\/1543-2165(2008)132[1231:pppwdt]2.0.co;2","volume":"132","author":"SL Asa","year":"2008","unstructured":"Asa SL (2008) Practical pituitary pathology: what does the pathologist need to know? Arch Pathol Lab Med 132(8):1231\u20131240. \n                    https:\/\/doi.org\/10.1043\/1543-2165(2008)132%5b1231:pppwdt%5d2.0.co;2","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"981_CR20","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0025-6196(11)63002-4","volume":"71","author":"WF Young Jr","year":"1996","unstructured":"Young WF Jr, Scheithauer BW, Kovacs KT, Horvath E, Davis DH, Randall RV (1996) Gonadotroph adenoma of the pituitary gland: a clinicopathologic analysis of 100 cases. Mayo Clin Proc 71(7):649\u2013656. \n                    https:\/\/doi.org\/10.1016\/S0025-6196(11)63002-4","journal-title":"Mayo Clin Proc"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-019-00981-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11102-019-00981-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-019-00981-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T23:31:31Z","timestamp":1596929491000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11102-019-00981-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["981"],"URL":"https:\/\/doi.org\/10.1007\/s11102-019-00981-9","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,10]]},"assertion":[{"value":"10 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Little is a stockholder in Kogent Surgical, LLC, and has stock options in SPIWay, LLC. Dr. Yuen is a consultant for Pfizer, Novo Nordisk, Sandoz, Aeterna Zentaris, Novartis, Corcept Therapeutics, and Strongbridge. Drs. White, Mooney, Felicella, Zadeh, Almeida, Gentili, Mete, Bernat, Eschbacher, and Mr. Stephens have no disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}