{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:35:05Z","timestamp":1785386105925,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006389","name":"Universit\u00e9 de Gen\u00e8ve","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a well-known complication of transsphenoidal pituitary surgery, related to inappropriate secretion of arginine vasopressin (AVP). Its diagnosis is based on hyponatremia, with a peak of occurrence around day 7 after surgery and, to date, no early marker has been reported. In particular, copeptin levels are not predictive of hyponatremia in this case. Oxytocin (OXT) is secreted into the peripheral blood by axon terminals adjacent to those of AVP neurons in the posterior pituitary. Besides its role in childbirth and lactation, recent evidences suggested a role for OXT in sodium balance. The contribution of this hormone in the dysnatremias observed after pituitary surgery has however never been investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We analyzed the urinary output of OXT in patients subjected to transsphenoidal pituitary surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>While OXT excretion remained stable in patients who presented a normonatremic postoperative course, patients who were later diagnosed with SIADH-related hyponatremia presented with a significantly increased urinary secretion of OXT 4\u00a0days after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Taken together, these results show for the first time that urinary OXT output remains normally stable after transsphenoidal pituitary surgery. OXT excretion however becomes abnormally high on or around 4\u00a0days after surgery in patients later developing hyponatremia, suggesting that this abnormal dynamics of OXT secretion might serve as an early marker for transsphenoidal surgery-related hyponatremia attributed to SIADH.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-020-01121-4","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T08:25:56Z","timestamp":1611822356000},"page":"420-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased oxytocin release precedes hyponatremia after pituitary surgery"],"prefix":"10.1007","volume":"24","author":[{"given":"Paul Eug\u00e8ne","family":"Constanthin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Isidor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"de Seigneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahan","family":"Momjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"1121_CR1","doi-asserted-by":"publisher","first-page":"943","DOI":"10.4158\/EP-2019-0160","volume":"25","author":"Y Eisenberg","year":"2019","unstructured":"Eisenberg Y, Charles S, Dugas L, Agrawal N (2019) Clinical practice patterns for postoperative water balance after pituitary surgery. Endocr Pract 25:943\u2013950","journal-title":"Endocr Pract"},{"key":"1121_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1507\/endocrj.K10E-352","volume":"58","author":"Y Kinoshita","year":"2011","unstructured":"Kinoshita Y, Tominaga A, Arita K, Sugiyama K, Hanaya R, Hama S et al (2011) Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol. Endocr J 58:373\u2013379","journal-title":"Endocr J"},{"key":"1121_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3171\/2008.9.JNS08191","volume":"111","author":"RA Kristof","year":"2009","unstructured":"Kristof RA, Rother M, Neuloh G, Klingm\u00fcller D (2009) Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study. J Neurosurg 111:555\u2013562","journal-title":"J Neurosurg"},{"key":"1121_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.clineuro.2019.05.007","volume":"182","author":"KS Patel","year":"2019","unstructured":"Patel KS, Shu Chen J, Yuan F, Attiah M, Wilson B, Wang MB et al (2019) Prediction of post-operative delayed hyponatremia after endoscopic transsphenoidal surgery. Clin Neurol Neurosurg 182:87\u201391","journal-title":"Clin Neurol Neurosurg"},{"key":"1121_CR5","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1227\/00006123-199510000-00007","volume":"37","author":"SL Taylor","year":"1995","unstructured":"Taylor SL, Tyrrell JB, Wilson CB (1995) Delayed onset of hyponatremia after transsphenoidal surgery for pituitary adenomas. Neurosurgery 37:649\u2013653","journal-title":"Neurosurgery"},{"key":"1121_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00701-019-03818-3","volume":"161","author":"Y Tomita","year":"2019","unstructured":"Tomita Y, Kurozumi K, Inagaki K, Kameda M, Ishida J, Yasuhara T et al (2019) Delayed postoperative hyponatremia after endoscopic transsphenoidal surgery for pituitary adenoma. Acta Neurochir (Wien) 161:707\u2013715","journal-title":"Acta Neurochir (Wien)"},{"key":"1121_CR7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3171\/jns.1995.83.2.0363","volume":"83","author":"DF Kelly","year":"2009","unstructured":"Kelly DF, Laws ER, Fossett D (2009) Delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. J Neurosurg 83:363\u2013367","journal-title":"J Neurosurg"},{"key":"1121_CR8","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/cne.902870304","volume":"287","author":"AR Caff\u00e9","year":"1989","unstructured":"Caff\u00e9 AR, Van Ryen PC, Van Der Woude TP, Van Leeuwen FW (1989) Vasopressin and oxytocin systems in the brain and upper spinal cord of Macaca fascicularis. J Comp Neurol 287:302\u2013325","journal-title":"J Comp Neurol"},{"key":"1121_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.yhbeh.2011.04.008","volume":"60","author":"JA Barraza","year":"2011","unstructured":"Barraza JA, McCullough ME, Ahmadi S, Zak PJ (2011) Oxytocin infusion increases charitable donations regardless of monetary resources. Horm Behav 60:148\u2013151","journal-title":"Horm Behav"},{"key":"1121_CR10","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1073\/pnas.1015316108","volume":"108","author":"CKW De Dreu","year":"2011","unstructured":"De Dreu CKW, Greer LL, Van Kleef GA, Shalvi S, Handgraaf MJJ (2011) Oxytocin promotes human ethnocentrism. Proc Natl Acad Sci 108:1262\u20131266","journal-title":"Proc Natl Acad Sci"},{"key":"1121_CR11","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1126\/science.1189047","volume":"328","author":"CKW De Dreu","year":"2010","unstructured":"De Dreu CKW, Greer LL, Handgraaf MJJ, Shalvi S, Van Kleef GA, Baas M et al (2010) The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science 328:1408\u20131411","journal-title":"Science"},{"key":"1121_CR12","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nature03701","volume":"435","author":"M Kosfeld","year":"2005","unstructured":"Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435:673\u2013676","journal-title":"Nature"},{"key":"1121_CR13","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.yhbeh.2005.07.009","volume":"48","author":"PJ Zak","year":"2005","unstructured":"Zak PJ, Kurzban R, Matzner WT (2005) Oxytocin is associated with human trustworthiness. Horm Behav 48:522\u2013527","journal-title":"Horm Behav"},{"key":"1121_CR14","doi-asserted-by":"publisher","first-page":"16074","DOI":"10.1523\/JNEUROSCI.2755-12.2012","volume":"32","author":"D Scheele","year":"2012","unstructured":"Scheele D, Striepens N, Gunturkun O, Deutschlander S, Maier W, Kendrick KM et al (2012) Oxytocin modulates social distance between males and females. J Neurosci 32:16074\u201316079","journal-title":"J Neurosci"},{"key":"1121_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.yhbeh.2009.03.019","volume":"56","author":"A Theodoridou","year":"2009","unstructured":"Theodoridou A, Rowe AC, Penton-Voak IS, Rogers PJ (2009) Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Horm Behav 56:128\u2013132","journal-title":"Horm Behav"},{"key":"1121_CR16","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/oby.2009.12","volume":"17","author":"C Camerino","year":"2009","unstructured":"Camerino C (2009) Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity 17:980\u2013984","journal-title":"Obesity"},{"key":"1121_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025565","volume":"6","author":"N Deblon","year":"2011","unstructured":"Deblon N, Veyrat-Durebex C, Bourgoin L, Caillon A, Bussier AL, Petrosino S et al (2011) Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One 6:e25565","journal-title":"PLoS One"},{"key":"1121_CR18","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.18632\/aging.100408","volume":"3","author":"Y Maejima","year":"2011","unstructured":"Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T (2011) Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany, NY) 3:1169\u20131177","journal-title":"Aging (Albany, NY)"},{"key":"1121_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061477","volume":"8","author":"H Zhang","year":"2013","unstructured":"Zhang H, Wu C, Chen Q, Chen X, Xu Z, Wu J et al (2013) Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One 8:e61477","journal-title":"PLoS One"},{"key":"1121_CR20","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3181\/00379727-110-27621","volume":"110","author":"WY Chan","year":"1962","unstructured":"Chan WY, Sawyer WH (1962) Natriuresis in conscious dogs during arginine vasopressin infusion and after oxytocin injection. Proc Soc Exp Biol Med 110:697\u2013699","journal-title":"Proc Soc Exp Biol Med"},{"key":"1121_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1677\/joe.0.1440441","volume":"144","author":"RJ Windle","year":"1995","unstructured":"Windle RJ, Judah JM, Forsling ML (1995) Do vasopressin and oxytocin have synergistic renal effects in the conscious rat? J Endocrinol 144:441\u2013448","journal-title":"J Endocrinol"},{"key":"1121_CR22","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/jne.12038","volume":"25","author":"SM Kagerbauer","year":"2013","unstructured":"Kagerbauer SM, Martin J, Schuster T, Blobner M, Kochs EF, Landgraf R (2013) Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid. J Neuroendocrinol 25:668\u2013673","journal-title":"J Neuroendocrinol"},{"key":"1121_CR23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.psyneuen.2016.08.011","volume":"74","author":"SM Francis","year":"2016","unstructured":"Francis SM, Kirkpatrick MG, de Wit H, Jacob S (2016) Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration. Psychoneuroendocrinology 74:92\u2013100","journal-title":"Psychoneuroendocrinology"},{"key":"1121_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1126\/science.1261022","volume":"348","author":"M Nagasawa","year":"2015","unstructured":"Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y et al (2015) Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science 348:333\u2013336","journal-title":"Science"},{"key":"1121_CR25","first-page":"11","volume":"140","author":"M Katan","year":"2010","unstructured":"Katan M, Christ-Crain M (2010) The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly 140:11\u201315","journal-title":"Swiss Med Wkly"},{"key":"1121_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1055\/s-0035-1569341","volume":"124","author":"KC Lewandowski","year":"2016","unstructured":"Lewandowski KC, Brabant G (2016) Potential clinical utility of copeptin (C-terminal provasopressin) measurements in clinical medicine. Exp Clin Endocrinol Diabetes 124:173\u2013177","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1121_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","volume":"52","author":"NG Morgenthaler","year":"2006","unstructured":"Morgenthaler NG, Struck J, Alonso C, Bergmann A (2006) Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 52:112\u2013119","journal-title":"Clin Chem"},{"key":"1121_CR28","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/cen.13991","volume":"91","author":"J Refardt","year":"2019","unstructured":"Refardt J, Winzeler B, Christ-Crain M (2019) Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis. Clin Endocrinol (Oxf) 91:22\u201332","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1121_CR29","doi-asserted-by":"publisher","unstructured":"de Vries F, Lobatto DJ, Verstegen MJT, van Furth WR, Pereira AM, Biermasz NR (2020) Postoperative diabetes insipidus: how to define and grade this complication? Pituitary. https:\/\/doi.org\/10.1007\/s11102-020-01083-7","DOI":"10.1007\/s11102-020-01083-7"},{"key":"1121_CR30","doi-asserted-by":"publisher","first-page":"11704","DOI":"10.1073\/pnas.94.21.11704","volume":"94","author":"J Gutkowska","year":"2002","unstructured":"Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM (2002) Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart. Proc Natl Acad Sci 94:11704\u201311709","journal-title":"Proc Natl Acad Sci"},{"key":"1121_CR31","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1073\/pnas.96.1.278","volume":"96","author":"TJ Soares","year":"2002","unstructured":"Soares TJ, Coimbra TM, Martins AR, Pereira AGF, Carnio EC, Branco LGS et al (2002) Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP. Proc Natl Acad Sci 96:278\u2013283","journal-title":"Proc Natl Acad Sci"},{"key":"1121_CR32","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1210\/endo-128-3-1317","volume":"128","author":"JG Verbalis","year":"1991","unstructured":"Verbalis JG, Mangione MP, Stricker EM (1991) Oxytocin produces natriuresis in rats at physiological plasma concentrations. Endocrinology 128:1317\u20131322","journal-title":"Endocrinology"},{"key":"1121_CR33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/ki.2010.276","volume":"78","author":"JD Stockand","year":"2010","unstructured":"Stockand JD (2010) Vasopressin regulation of renal sodium excretion. Kidney Int 78:849\u2013856","journal-title":"Kidney Int"},{"key":"1121_CR34","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0079-6123(02)39027-7","volume":"139","author":"SM McCann","year":"2002","unstructured":"McCann SM, Antunes-Rodrigues J, Jankowski M, Gutkowska J (2002) Oxytocin, vasopressin and atrial natriuretic peptide control body fluid homeostasis by action on their receptors in brain, cardiovascular system and kidney. Prog Brain Res 139:309\u2013328","journal-title":"Prog Brain Res"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-020-01121-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-020-01121-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-020-01121-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T09:12:44Z","timestamp":1620897164000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-020-01121-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1121"],"URL":"https:\/\/doi.org\/10.1007\/s11102-020-01121-4","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"assertion":[{"value":"26 December 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflict of interest concerning the materials or methods used in this study or the findings presented in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data were collected in a prospective way. An informed consent was obtained from all patients included in the study. The ethical approval regarding blood and urinary samples and their analyzes and patients\u2019 data management was given by the local ethics committee (Ethics Committee Number: 14-153).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patients were not involved in any part of the research except for obtaining informed consent and biological samples.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}