{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:21:38Z","timestamp":1783488098411,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_182753"],"award-info":[{"award-number":["320030_182753"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Schweizerische Gesellschaft f\u00fcr Endokrinologie und Diabetologie","award":["Young Investigator Award 2019"],"award-info":[{"award-number":["Young Investigator Award 2019"]}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The test with the highest diagnostic accuracy for diabetes insipidus is copeptin measurement after hypertonic saline infusion. However, the procedure is cumbersome and unpleasant due to rapid sodium increase. An oral stimulation test would be highly desirable. Macimorelin, an oral ghrelin agonist, is a newly approved diagnostic test for growth hormone (GH) deficiency, but its effects on copeptin\/vasopressin are unknown and the effects on other pituitary hormones only scarcely investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective, interventional, proof-of-concept study Copeptin and anterior pituitary hormones were measured in 28 healthy volunteers on two test days at baseline, 30, 45, 60, 90 and 120\u00a0min after a single dose of macimorelin (first visit: 0.5\u00a0mg\/kg, second visit: 0.75\u00a0mg\/kg).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Baseline copeptin levels were 5.26\u00a0pmol\/L [1.57, 6.81] and did not change after macimorelin intake (0.5\u00a0mg\/kg: maximal median change 0.40 [\u2212 0.49, 0.65] pmol\/L, p\u2009=\u20090.442; 0.75\u00a0mg\/kg: \u2212 0.13 [\u2212 0.45, 0.17] pmol\/L, p\u2009=\u20090.442. Median GH levels increased from 3.67\u00a0mU\/L with a maximal median change of 94.66 [IQR 56.5; 110.96] mU\/L, p\u2009&lt;\u20090.001. No effect was seen on cortisol, ACTH, LH and FSH levels. Prolactin (max. median change 100 [2.5; 146.5] mU\/L, p\u2009=\u20090.004) and free thyroxine (fT4) (0.5 [0.2; 0.8] pmol\/L, p\u2009&lt;\u20090.001) increased, whereas TSH decreased (\u2212 0.18 [\u2212 0.22, \u2212 0.09] mU\/L, p\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We confirm an increase of GH upon macimorelin in healthy volunteers. However, macimorelin did not stimulate copeptin and therefore does not provide an oral test alternative for the diagnosis of diabetes insipidus. Additionally, a stimulatory effect was seen for prolactin and fT4, but not for ACTH and gonadotropic hormones.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Registration<\/jats:title>\n                <jats:p>The trial was registered on ClinicalTrials.gov (NCT03844217) on February 18, 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-021-01132-9","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T02:02:56Z","timestamp":1613959376000},"page":"555-563","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers"],"prefix":"10.1007","volume":"24","clinical-trial-number":[{"clinical-trial-number":"nct03844217","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-2262","authenticated-orcid":false,"given":"Sandrine A.","family":"Urwyler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Lustenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana R.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Santana","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C. J.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ribeiro-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"issue":"9\u201310","key":"1132_CR1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1159\/000505548","volume":"110","author":"M Christ-Crain","year":"2020","unstructured":"Christ-Crain M (2020) Diabetes insipidus\u2014new concepts for diagnosis. 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All other authors have nothing to disclose in relation to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in compliance with the ethical principles based on the Declaration of Helsinki and the applicable International Conference on Harmonization (ICH) guidelines on good clinical practice. Local ethic committees and Swissmedic approved the study protocol. Written informed consent was obtained from all study participants before inclusion. The study was preregistered on ClinicalTrials.gov (NCT03844217).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}