{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:45:34Z","timestamp":1790959534170,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11102-021-01186-9","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T14:02:57Z","timestamp":1631541777000},"page":"970-977","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Primary sellar melanocytoma"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-2845","authenticated-orcid":false,"given":"M.","family":"Claus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Van Der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Van Dorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lapauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"T\u2019Sjoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"1186_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/bpa.12241","volume":"25","author":"HVN K\u00fcsters-Vandevelde","year":"2015","unstructured":"K\u00fcsters-Vandevelde HVN, K\u00fcsters B, van Engen-Van Grunsven ACH et al (2015) Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects. Brain Pathol 25:209\u2013226","journal-title":"Brain Pathol"},{"key":"1186_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11060-015-2006-8","volume":"127","author":"C Yang","year":"2016","unstructured":"Yang C, Fang J, Li G et al (2016) Spinal meningeal melanocytomas: clinical manifestations, radiological and pathological characteristics, and surgical outcomes. J Neurooncol 127:279\u2013286. https:\/\/doi.org\/10.1007\/s11060-015-2006-8","journal-title":"J Neurooncol"},{"key":"1186_CR3","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3171\/jns.2004.100.5.0931","volume":"100","author":"J T\u00fcttenberg","year":"2004","unstructured":"T\u00fcttenberg J, Fink W, Back W et al (2004) A rare case of primary sellar melanoma. J Neurosurg 100:931\u2013934. https:\/\/doi.org\/10.3171\/jns.2004.100.5.0931","journal-title":"J Neurosurg"},{"key":"1186_CR4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3171\/jns.2003.99.5.0913","volume":"99","author":"GKK Leung","year":"2003","unstructured":"Leung GKK, Chow WS, Tan KCB et al (2003) Metastatic melanoma of the pituitary gland. J Neurosurg 99:913\u2013915. https:\/\/doi.org\/10.3171\/jns.2003.99.5.0913","journal-title":"J Neurosurg"},{"key":"1186_CR5","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1148\/rg.295095109","volume":"29","author":"AB Smith","year":"2009","unstructured":"Smith AB, Rushing EJ, Smirniotopoulos JG (2009) From the archives of the AFIP pigmented lesions of the central nervous system: radiologic-pathologic correlation. Radiographics 29:1503\u20131524. https:\/\/doi.org\/10.1148\/rg.295095109","journal-title":"Radiographics"},{"key":"1186_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s11102-015-0635-8","volume":"18","author":"K Sakata","year":"2015","unstructured":"Sakata K, Miyoshi J, Takeshige N et al (2015) Primary meningeal melanocytoma of the sellar region: review of the literature and differential diagnosis with special reference to angiographical features. Pituitary 18:685\u2013694","journal-title":"Pituitary"},{"key":"1186_CR7","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803\u2013820","journal-title":"Acta Neuropathol"},{"key":"1186_CR8","first-page":"13","volume":"7","author":"D Weinstein","year":"2014","unstructured":"Weinstein D, Leininger J, Hamby C, Safai B (2014) Diagnostic and prognostic biomarkers in melanoma. J Clin Aesthet Dermatol 7:13\u201324","journal-title":"J Clin Aesthet Dermatol"},{"key":"1186_CR9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/00000478-199907000-00001","volume":"23","author":"DJ Brat","year":"1999","unstructured":"Brat DJ, Giannini C, Scheithauer BW, Burger PC (1999) Primary melanocytic neoplasms of the central nervous system. Am J Surg Pathol 23:745\u2013754. https:\/\/doi.org\/10.1097\/00000478-199907000-00001","journal-title":"Am J Surg Pathol"},{"key":"1186_CR10","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1227\/01.NEU.0000372919.96651.34","volume":"67","author":"P Perrini","year":"2010","unstructured":"Perrini P, Caniglia M, Pieroni M et al (2010) Malignant transformation of intramedullary melanocytoma: case report. Neurosurgery 67:867\u2013869. https:\/\/doi.org\/10.1227\/01.NEU.0000372919.96651.34","journal-title":"Neurosurgery"},{"key":"1186_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11060-009-9907-3","volume":"95","author":"M Navas","year":"2009","unstructured":"Navas M, Pascual JM, Fraga J et al (2009) Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota. J Neurooncol 95:105\u2013115. https:\/\/doi.org\/10.1007\/s11060-009-9907-3","journal-title":"J Neurooncol"},{"key":"1186_CR12","doi-asserted-by":"publisher","first-page":"974","DOI":"10.5858\/arpa.2019-0010-OA","volume":"144","author":"M van der Linden","year":"2020","unstructured":"van der Linden M, Raman L, Vander Trappen A et al (2020) Detection of copy number alterations by shallow whole-genome sequencing of formalin-fixed, paraffin-embedded tumor tissue. Arch Pathol Lab Med 144:974\u2013981. https:\/\/doi.org\/10.5858\/arpa.2019-0010-OA","journal-title":"Arch Pathol Lab Med"},{"key":"1186_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/jcp.16.2.144","volume":"16","author":"JM Neilson","year":"1963","unstructured":"Neilson JM, Moffat AD (1963) Hypopituitarism caused by a melanoma of the pituitary gland. J Clin Pathol 16:144\u2013149. https:\/\/doi.org\/10.1136\/jcp.16.2.144","journal-title":"J Clin Pathol"},{"key":"1186_CR14","first-page":"1054","volume":"11","author":"PM Chappell","year":"1990","unstructured":"Chappell PM, Kelly WM, Ercius M (1990) Primary sellar melanoma simulating hemorrhagic pituitary adenoma: MR and pathologic findings. AJNR Am J Neuroradiol 11:1054\u20131056","journal-title":"AJNR Am J Neuroradiol"},{"key":"1186_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.wno.0000204665.79300.f8","volume":"26","author":"S Jacob","year":"2006","unstructured":"Jacob S, Pye E, Hbahbih M et al (2006) Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma. J Neuroophthalmol 26:49\u201350. https:\/\/doi.org\/10.1097\/01.wno.0000204665.79300.f8","journal-title":"J Neuroophthalmol"},{"key":"1186_CR16","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.neuchi.2016.08.002","volume":"62","author":"J Todeschi","year":"2016","unstructured":"Todeschi J, Chibbaro S, Clavier JB et al (2016) An unusual pituitary stalk lesion: What is the place of surgery? Neurochirurgie 62:339\u2013343. https:\/\/doi.org\/10.1016\/j.neuchi.2016.08.002","journal-title":"Neurochirurgie"},{"key":"1186_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3171\/jns.1976.45.1.0101","volume":"45","author":"CL Scholtz","year":"1976","unstructured":"Scholtz CL, Siu K (1976) Melanoma of the pituitary. J Neurosurg 45:101\u2013103. https:\/\/doi.org\/10.3171\/jns.1976.45.1.0101","journal-title":"J Neurosurg"},{"key":"1186_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1440-1789.2012.01331.x","volume":"33","author":"M Sidiropoulos","year":"2013","unstructured":"Sidiropoulos M, Syro LV, Rotondo F et al (2013) Melanoma of the sellar region mimicking pituitary adenoma. Neuropathology 33:175\u2013178. https:\/\/doi.org\/10.1111\/j.1440-1789.2012.01331.x","journal-title":"Neuropathology"},{"key":"1186_CR19","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1080\/02688699746771","volume":"11","author":"MJ Aubin","year":"1997","unstructured":"Aubin MJ, Hardy J, Comtois R (1997) Primary sellar haemorragic melanoma: case report and review of the literature. Br J Neurosurg 11:80\u201383. https:\/\/doi.org\/10.1080\/02688699746771","journal-title":"Br J Neurosurg"},{"key":"1186_CR20","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1227\/00006123-198005000-00008","volume":"6","author":"DD Copeland","year":"1980","unstructured":"Copeland DD, Sink JD, Seigler HF (1980) Primary intracranial melanoma presenting as a suprasellar tumor. Neurosurgery 6:542\u2013545. https:\/\/doi.org\/10.1227\/00006123-198005000-00008","journal-title":"Neurosurgery"},{"key":"1186_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1023\/a:1015872207398","volume":"58","author":"J Classen","year":"2002","unstructured":"Classen J, Hehr T, Paulus W et al (2002) Suprasellar melanocytoma: a case of primary radiotherapy and review of the literature. J Neuro-Oncol 58:39\u201346. https:\/\/doi.org\/10.1023\/a:1015872207398","journal-title":"J Neuro-Oncol"},{"key":"1186_CR22","doi-asserted-by":"publisher","first-page":"E369","DOI":"10.1227\/01.NEU.0000166686.19823.A9","volume":"57","author":"A Rousseau","year":"2005","unstructured":"Rousseau A, Bernier M, Kujas M et al (2005) Primary intracranial melanocytic tumor simulating pituitary macroadenoma: case report and review of the literature. Neurosurgery 57:E369","journal-title":"Neurosurgery"},{"key":"1186_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11102-007-0076-0","volume":"12","author":"D Vezzosi","year":"2009","unstructured":"Vezzosi D, Capuani C, Loubes-Lacroix F et al (2009) Primary sellar melanocytic tumor: report of new case and literature review. Pituitary 12:51\u201356. https:\/\/doi.org\/10.1007\/s11102-007-0076-0","journal-title":"Pituitary"},{"key":"1186_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.annpat.2010.09.007","volume":"31","author":"B Coulibaly","year":"2011","unstructured":"Coulibaly B, Bouvier C, de Paula AM et al (2011) Un m\u00e9lanocytome mimant un ad\u00e9nome hypophysaire. Ann Pathol 31:50\u201352. https:\/\/doi.org\/10.1016\/j.annpat.2010.09.007","journal-title":"Ann Pathol"},{"key":"1186_CR25","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.prp.2015.04.005","volume":"211","author":"AA Mohammed","year":"2015","unstructured":"Mohammed AA, Rotondo F, Munoz DG et al (2015) Diagnostic and prognostic biomarkers of a sellar melanocytic tumor mimicking pituitary adenoma: case report and literature review. Pathol Res Pract 211:682\u2013687. https:\/\/doi.org\/10.1016\/j.prp.2015.04.005","journal-title":"Pathol Res Pract"},{"key":"1186_CR26","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3109\/02688697.2014.967752","volume":"29","author":"HJ Zhou","year":"2015","unstructured":"Zhou HJ, Zhan RY, Ma YH et al (2015) Primary sellar melanocytic tumor mimicking hemorrhagic pituitary macroadenoma: case report and literature review. Br J Neurosurg 29:298\u2013302","journal-title":"Br J Neurosurg"},{"key":"1186_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5414\/NP300885","volume":"35","author":"AB Brito","year":"2016","unstructured":"Brito AB, Rogerio F, Reis F et al (2016) Primary meningeal melanocytoma mimicking a nonfunctioning pituitary adenoma. Clin Neuropathol 35:158\u2013161","journal-title":"Clin Neuropathol"},{"key":"1186_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/bpa.12577","volume":"28","author":"G Zielinski","year":"2018","unstructured":"Zielinski G, Podgorski A, Maksymowicz M et al (2018) A 39-year-old woman with progressive vision impairment. Brain Pathol 28:127\u2013128. https:\/\/doi.org\/10.1111\/bpa.12577","journal-title":"Brain Pathol"},{"key":"1186_CR29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5414\/NP301033","volume":"36","author":"B Lach","year":"2017","unstructured":"Lach B, Reddy K, Sommer DD et al (2017) Amelanotic melanocytoma of the sella mimicking pituitary adenoma. Clin Neuropathol 36:283\u2013287. https:\/\/doi.org\/10.5414\/NP301033","journal-title":"Clin Neuropathol"},{"key":"1186_CR30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.wneu.2018.01.145","volume":"112","author":"F Wang","year":"2018","unstructured":"Wang F, Ling S (2018) Primary meningeal melanocytoma in sellar Region, simulating a nonfunctioning pituitary adenoma: case report and literature review. World Neurosurg 112:209\u2013213. https:\/\/doi.org\/10.1016\/j.wneu.2018.01.145","journal-title":"World Neurosurg"},{"key":"1186_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/02688697.2019.1667485","volume":"20","author":"L Albano","year":"2019","unstructured":"Albano L, Losa M, Spatola G et al (2019) Primary sellar melanocytoma: report of two cases treated at the same institution and their long-term outcome. Br J Neurosurg 20:1\u20135. https:\/\/doi.org\/10.1080\/02688697.2019.1667485","journal-title":"Br J Neurosurg"},{"key":"1186_CR32","first-page":"133","volume":"27","author":"MK Tewari","year":"1990","unstructured":"Tewari MK, Radotra BD, Sharma BS et al (1990) Meningeal melanocytoma: report of two cases. Indian J Cancer 27:133\u2013137","journal-title":"Indian J Cancer"},{"key":"1186_CR33","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1158\/1078-0432.CCR-18-0763","volume":"24","author":"KG Griewank","year":"2018","unstructured":"Griewank KG, Koelsche C, van de Nes JAP et al (2018) Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling. Clin Cancer Res 24:4494\u20134504. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-0763","journal-title":"Clin Cancer Res"},{"key":"1186_CR34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3171\/spi.2001.95.2.0225","volume":"95","author":"D Rades","year":"2001","unstructured":"Rades D, Heidenreich F, Tatagiba M et al (2001) Therapeutic options for meningeal melanocytoma. J Neurosurg Spine 95:225\u2013231. https:\/\/doi.org\/10.3171\/spi.2001.95.2.0225","journal-title":"J Neurosurg Spine"},{"key":"1186_CR35","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s40618-019-01158-8","volume":"43","author":"L Albano","year":"2020","unstructured":"Albano L, Losa M, Barzaghi LR et al (2020) Primary sellar melanocytoma: pathological, clinical and treatment review. J Endocrinol Invest 43:575\u2013585","journal-title":"J Endocrinol Invest"},{"key":"1186_CR36","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1200\/JCO.20.00605","volume":"39","author":"MS Pelster","year":"2021","unstructured":"Pelster MS, Gruschkus SK, Bassett R et al (2021) Nivolumab and ipilimumab in metastatic uveal melanoma: results from a single-arm phase II study. J Clin Oncol 39:599\u2013607. https:\/\/doi.org\/10.1200\/JCO.20.00605","journal-title":"J Clin Oncol"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-021-01186-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-021-01186-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-021-01186-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T05:23:07Z","timestamp":1635225787000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-021-01186-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1186"],"URL":"https:\/\/doi.org\/10.1007\/s11102-021-01186-9","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"3 September 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the ethics committee of Ghent University Hospital, Belgium. Approval was announced in the commission for medical ethics\u2019 meeting report on 20\/4\/2021, with internal reference number EC\/043-2021\/sds.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the patient described in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Written informed consent was obtained from the patient described in this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}