{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:53:25Z","timestamp":1773258805745,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Pain is a common symptom of acromegaly, impairing health-related quality of life (HR-QoL) significantly despite long-term disease\u00a0remission. Neuropathic-like pain (NP-like) symptoms are invalidating, with great impact on HR-QoL. Studies characterizing or investigating the etiology of pain in acromegaly are scarce. Therefore, we aimed to assess NP-like symptoms in a cohort of controlled acromegaly patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty-four long-term controlled acromegaly patients (aged 62.6\u2009\u00b1\u200912.6\u00a0years; 56.8% female) were included in this cross-sectional study. NP-like symptoms were assessed using the validated painDETECT questionnaire. Patients were divided in three probability-based NP-like symptoms categories based on the total score (range 0\u201335): unlikely (\u2264\u200912), indeterminate (13\u201318) and likely (\u2265\u200919). HR-QoL (physical component score (PCS), and mental component score (MCS)), and self-reported pain were assessed using Short Form-36 (SF-36). Potential risk factors were determined using linear regression analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Self-reported pain was reported by 35 patients (79.5%). Likely NP-like symptoms were present in 4\/44 patients (9.1%), and indeterminate NP-like symptoms in 6\/44 patients (13.6%). All patients with likely NP-like symptoms were female. Higher painDETECT scores were negatively associated with HR-QoL (PCS: r\u2009=\u2009\u2212\u00a00.46, P\u2009=\u20090.003; MCS: r\u2009=\u2009\u2212\u00a00.37, P\u2009=\u20090.018), and SF-36 pain scores (r\u2009=\u2009\u2212\u00a00.63, P\u2009&lt;\u20090.0001). Female sex was a risk factor for NP-like symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pain was prevalent in controlled acromegaly patients, whereas NP-like symptoms were relatively infrequent, and only observed in females. NP-like symptoms were associated with lower HR-QoL in acromegaly. Since specific analgesic therapy is available, awareness for characterization, increased understanding, and clinical trials regarding neuropathic pain identification and treatment in acromegaly patients are warranted.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-021-01190-z","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T09:02:43Z","timestamp":1634979763000},"page":"229-237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low prevalence of neuropathic-like pain symptoms in long-term controlled acromegaly"],"prefix":"10.1007","volume":"25","author":[{"given":"Victoria R.","family":"van Trigt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-4037","authenticated-orcid":false,"given":"Iris C. 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