{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:36:05Z","timestamp":1791041765917,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11102-022-01215-1","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T21:02:52Z","timestamp":1651698172000},"page":"540-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of recurrent and persistent Cushing\u2019s disease after first transsphenoidal surgery: lessons learned from an international meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"given":"Carlos","family":"Perez-Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Ramos-Fresnedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashwat","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Ravindran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Trifiletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisorn L.","family":"Chaichana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Quinones-Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-7093","authenticated-orcid":false,"given":"Susan L.","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"issue":"12","key":"1215_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S2213-8587(21)00235-7","volume":"9","author":"M Fleseriu","year":"2021","unstructured":"Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR et al (2021) Consensus on diagnosis and management of Cushing\u2019s disease: a guideline update. Lancet Diabetes Endocrinol 9(12):847\u2013875","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"1215_CR2","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.4158\/EP161512.DSCR","volume":"22","author":"M Fleseriu","year":"2016","unstructured":"Fleseriu M, Hamrahian AH, Hoffman AR, Kelly DF, Katznelson L (2016) American Association of clinical endocrinologists and American College of Endocrinology disease state clinical review: diagnosis of recurrence in cushing disease. Endocr Pract 22(12):1436\u20131448","journal-title":"Endocr Pract"},{"issue":"1","key":"1215_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3171\/JNS\/2008\/108\/01\/0009","volume":"108","author":"BM Hofmann","year":"2008","unstructured":"Hofmann BM, Hlavac M, Martinez R, Buchfelder M, M\u00fcller OA, Fahlbusch R (2008) Long-term results after microsurgery for Cushing disease: experience with 426 primary operations over 35 years. J Neurosurg 108(1):9\u201318","journal-title":"J Neurosurg"},{"issue":"2","key":"1215_CR4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1210\/jc.2009-1672","volume":"95","author":"E Valassi","year":"2010","unstructured":"Valassi E, Biller BM, Swearingen B, Pecori Giraldi F, Losa M, Mortini P et al (2010) Delayed remission after transsphenoidal surgery in patients with Cushing\u2019s disease. J Clin Endocrinol Metab 95(2):601\u2013610","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1215_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nrendo.2011.12","volume":"7","author":"NA Tritos","year":"2011","unstructured":"Tritos NA, Biller BM, Swearingen B (2011) Management of Cushing disease. Nat Rev Endocrinol 7(5):279\u2013289","journal-title":"Nat Rev Endocrinol"},{"key":"1215_CR6","doi-asserted-by":"crossref","unstructured":"Patil CG, Veeravagu A, Prevedello DM, Katznelson L, Vance ML, Laws ER, Jr (2008) Outcomes after repeat transsphenoidal surgery for recurrent Cushing's disease. Neurosurgery 63(2):266\u2013270; discussion 70\u201371.","DOI":"10.1227\/01.NEU.0000334682.38235.a9"},{"issue":"5","key":"1215_CR7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1046\/j.1365-2265.2001.01261.x","volume":"54","author":"GH Chee","year":"2001","unstructured":"Chee GH, Mathias DB, James RA, Kendall-Taylor P (2001) Transsphenoidal pituitary surgery in Cushing\u2019s disease: can we predict outcome? Clin Endocrinol (Oxf) 54(5):617\u2013626","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1215_CR8","doi-asserted-by":"crossref","unstructured":"Hofmann BM, Hlavac M, Kreutzer J, Grabenbauer G, Fahlbusch R (2006) Surgical treatment of recurrent Cushing's disease. Neurosurgery 58(6):1108\u20131118; discussion -18.","DOI":"10.1227\/01.NEU.0000215945.26764.92"},{"issue":"4","key":"1215_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/neuros\/nyz159","volume":"86","author":"JD Hughes","year":"2020","unstructured":"Hughes JD, Young WF, Chang AY, Link MJ, Garces YI, Laack NN et al (2020) Radiosurgical management of patients with persistent or recurrent cushing disease after prior transsphenoidal surgery: a management algorithm based on a 25-year experience. Neurosurgery 86(4):557\u2013564","journal-title":"Neurosurgery"},{"issue":"9","key":"1215_CR10","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.eprac.2021.06.012","volume":"27","author":"KCJ Yuen","year":"2021","unstructured":"Yuen KCJ (2021) Osilodrostat: a review of recent clinical studies and practical recommendations for its use in the treatment of Cushing disease. Endocr Pract 27(9):956\u2013965","journal-title":"Endocr Pract"},{"issue":"4","key":"1215_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3111\/13696998.2013.877470","volume":"17","author":"HL Truong","year":"2014","unstructured":"Truong HL, Nellesen D, Ludlam WH, Neary MP (2014) Budget impact of pasireotide for the treatment of Cushing\u2019s disease, a rare endocrine disorder associated with considerable comorbidities. J Med Econ 17(4):288\u2013295","journal-title":"J Med Econ"},{"issue":"5","key":"1215_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","volume":"8","author":"D Moher","year":"2010","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336\u2013341","journal-title":"Int J Surg"},{"issue":"2","key":"1215_CR13","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2265.2008.03334.x","volume":"70","author":"MA Wagenmakers","year":"2009","unstructured":"Wagenmakers MA, Netea-Maier RT, van Lindert EJ, Timmers HJ, Grotenhuis JA, Hermus AR (2009) Repeated transsphenoidal pituitary surgery (TS) via the endoscopic technique: a good therapeutic option for recurrent or persistent Cushing\u2019s disease (CD). Clin Endocrinol (Oxf) 70(2):274\u2013280","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"1215_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1530\/eje.1.02133","volume":"154","author":"RT Netea-Maier","year":"2006","unstructured":"Netea-Maier RT, van Lindert EJ, den Heijer M, van der Eerden A, Pieters GF, Sweep CG et al (2006) Transsphenoidal pituitary surgery via the endoscopic technique: results in 35 consecutive patients with Cushing\u2019s disease. Eur J Endocrinol 154(5):675\u2013684","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"1215_CR15","doi-asserted-by":"publisher","first-page":"5478","DOI":"10.1210\/jc.2004-2436","volume":"90","author":"M Locatelli","year":"2005","unstructured":"Locatelli M, Vance ML, Laws ER (2005) Clinical review: the strategy of immediate reoperation for transsphenoidal surgery for Cushing\u2019s disease. J Clin Endocrinol Metab 90(9):5478\u20135482","journal-title":"J Clin Endocrinol Metab"},{"key":"1215_CR16","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/j.wneu.2017.09.105","volume":"109","author":"M Feng","year":"2018","unstructured":"Feng M, Liu Z, Liu X, Bao X, Yao Y, Deng K et al (2018) Diagnosis and outcomes of 341 patients with Cushing\u2019s disease following transsphenoid surgery: a single-center experience. World Neurosurg 109:e75\u2013e80","journal-title":"World Neurosurg"},{"issue":"5","key":"1215_CR17","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s40618-019-01151-1","volume":"43","author":"AL Serban","year":"2020","unstructured":"Serban AL, Del Sindaco G, Sala E, Carosi G, Indirli R, Rodari G et al (2020) Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series. J Endocrinol Invest 43(5):631\u2013639","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"1215_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1055\/s-0033-1345688","volume":"75","author":"M Bodaghabadi","year":"2014","unstructured":"Bodaghabadi M, Riazi H, Aran S, Bitaraf MA, Alikhani M, Alahverdi M et al (2014) Repeated transsphenoidal surgery or gamma knife radiosurgery in recurrent cushing disease after transsphenoidal surgery. J Neurol Surg A Cent Eur Neurosurg 75(2):91\u201397","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"1215_CR19","doi-asserted-by":"publisher","first-page":"106151","DOI":"10.1016\/j.clineuro.2020.106151","volume":"197","author":"M Kara","year":"2020","unstructured":"Kara M, G\u00fcd\u00fck M, Samanci Y, Yilmaz M, \u015eeng\u00f6z M, Peker S (2020) Gamma knife radiosurgery in patients with Cushing\u2019s disease: comparison of aggressive pituitary corticotroph tumor versus corticotroph adenoma. Clin Neurol Neurosurg 197:106151","journal-title":"Clin Neurol Neurosurg"},{"issue":"6","key":"1215_CR20","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1227\/01.NEU.0000315281.83969.41","volume":"62","author":"BE Pollock","year":"2008","unstructured":"Pollock BE, Brown PD, Nippoldt TB, Young WF Jr (2008) Pituitary tumor type affects the chance of biochemical remission after radiosurgery of hormone-secreting pituitary adenomas. Neurosurgery 62(6):1271\u20131276","journal-title":"Neurosurgery"},{"issue":"6","key":"1215_CR21","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3171\/2013.7.JNS13217","volume":"119","author":"JP Sheehan","year":"2013","unstructured":"Sheehan JP, Xu Z, Salvetti DJ, Schmitt PJ, Vance ML (2013) Results of gamma knife surgery for Cushing\u2019s disease: clinical article. J Neurosurg 119(6):1486\u20131492","journal-title":"J Neurosurg"},{"issue":"3","key":"1215_CR22","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.ijrobp.2018.02.023","volume":"101","author":"DM Trifiletti","year":"2018","unstructured":"Trifiletti DM, Xu Z, Dutta SW, Qui\u00f1ones-Hinojosa A, Peterson J, Vance ML et al (2018) Endocrine remission after pituitary stereotactic radiosurgery: differences in rates of response for matched cohorts of cushing disease and acromegaly patients. Int J Radiat Oncol Biol Phys 101(3):610\u2013617","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1215_CR23","doi-asserted-by":"publisher","first-page":"e425","DOI":"10.1016\/j.wneu.2018.01.057","volume":"112","author":"JM Moore","year":"2018","unstructured":"Moore JM, Sala E, Amorin A, Martinez H Jr, Bhowmik AC, Chang SD et al (2018) CyberKnife radiosurgery in the multimodal management of patients with cushing disease. World Neurosurg 112:e425\u2013e430","journal-title":"World Neurosurg"},{"issue":"2","key":"1215_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1210\/jc.2007-1220","volume":"93","author":"JH Petit","year":"2008","unstructured":"Petit JH, Biller BM, Yock TI, Swearingen B, Coen JJ, Chapman P et al (2008) Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas. J Clin Endocrinol Metab 93(2):393\u2013399","journal-title":"J Clin Endocrinol Metab"},{"key":"1215_CR25","doi-asserted-by":"crossref","unstructured":"Hofmann BM, Fahlbusch R (2006) Treatment of Cushing's disease: a retrospective clinical study of the latest 100 cases. In: Laws Jr ER, Sheehan JP, editors. Front Hormone Res 158\u2013184","DOI":"10.1159\/000091580"},{"issue":"2","key":"1215_CR26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1530\/EJE-13-0634","volume":"170","author":"C Dimopoulou","year":"2014","unstructured":"Dimopoulou C, Schopohl J, Rachinger W, Buchfelder M, Honegger J, Reincke M et al (2014) Long-term remission and recurrence rates after first and second transsphenoidal surgery for Cushing\u2019s disease: care reality in the Munich Metropolitan Region. Eur J Endocrinol 170(2):283\u2013292","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1215_CR27","doi-asserted-by":"publisher","first-page":"E1030","DOI":"10.1093\/neuros\/nyz193","volume":"85","author":"WT Burke","year":"2019","unstructured":"Burke WT, Penn DL, Repetti CS, Iuliano S, Laws ER (2019) Outcomes after repeat transsphenoidal surgery for recurrent Cushing disease: updated. Neurosurgery 85(6):E1030\u2013E1036","journal-title":"Neurosurgery"},{"key":"1215_CR28","doi-asserted-by":"crossref","unstructured":"Almeida JP, de Andrade E, Reghin-Neto M, Radovanovic I, Recinos PF, Kshettry VR. From above and below: the microsurgical anatomy of endoscopic endonasal and transcranial microsurgical approaches to the parasellar region. World Neurosurg 2021.","DOI":"10.1016\/j.wneu.2021.12.023"},{"issue":"5","key":"1215_CR29","doi-asserted-by":"publisher","first-page":"738","DOI":"10.3171\/jns.2000.93.5.0738","volume":"93","author":"JM Sheehan","year":"2000","unstructured":"Sheehan JM, Vance ML, Sheehan JP, Ellegala DB, Laws ER Jr (2000) Radiosurgery for Cushing\u2019s disease after failed transsphenoidal surgery. J Neurosurg 93(5):738\u2013742","journal-title":"J Neurosurg"},{"issue":"7","key":"1215_CR30","doi-asserted-by":"publisher","first-page":"759","DOI":"10.4158\/EP171756.OR","volume":"23","author":"AL Espinosa-de-Los-Monteros","year":"2017","unstructured":"Espinosa-de-Los-Monteros AL, Sosa-Eroza E, Espinosa E, Mendoza V, Arreola R, Mercado M (2017) Long-term outcome of the different treatment alternatives for recurrent and persistent Cushing disease. Endocr Pract 23(7):759\u2013767","journal-title":"Endocr Pract"},{"issue":"3","key":"1215_CR31","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1017\/S031716710001427X","volume":"40","author":"H Alahmadi","year":"2013","unstructured":"Alahmadi H, Cusimano MD, Woo K et al (2013) Impact of technique on cushing disease outcome using strict remission criteria. Can J Neurol Sci 40(3):334\u2013341","journal-title":"Can J Neurol Sci"},{"issue":"6","key":"1215_CR32","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3171\/jns.2005.102.6.1004","volume":"102","author":"RJ Benveniste","year":"2005","unstructured":"Benveniste RJ, King WA, Walsh J, Lee JS, Delman BN, Post KD (2005) Repeated transsphenoidal surgery to treat recurrent or residual pituitary adenoma. J Neurosurg 102(6):1004\u20131012","journal-title":"J Neurosurg"},{"key":"1215_CR33","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/j.wneu.2018.07.055","volume":"119","author":"C Brichard","year":"2018","unstructured":"Brichard C, Costa E, Fomekong E, Maiter D, Raftopoulos C (2018) Outcome of transsphenoidal surgery for Cushing disease: a single-center experience over 20 years. World Neurosurg 119:e106\u2013e117","journal-title":"World Neurosurg"},{"issue":"1","key":"1215_CR34","first-page":"63","volume":"83","author":"LS Blevins Jr","year":"1998","unstructured":"Blevins LS Jr, Christy JH, Khajavi M, Tindall GT (1998) Outcomes of therapy for Cushing\u2019s disease due to adrenocorticotropin-secreting pituitary macroadenomas. J Clin Endocrinol Metab 83(1):63\u201367","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"1215_CR35","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.4158\/EP161380.OR","volume":"22","author":"TB Carroll","year":"2016","unstructured":"Carroll TB, Javorsky BR, Findling JW (2016) Postsurgical recurrent cushing disease: clinical benefit of early intervention in patients with normal urinary free cortisol. Endocr Pract 22(10):1216\u20131223","journal-title":"Endocr Pract"},{"issue":"11","key":"1215_CR36","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.4158\/EP-2020-0177","volume":"26","author":"C Dai","year":"2020","unstructured":"Dai C, Liang S, Liu X et al (2020) Outcomes of transsphenoidal surgery in cushing disease patients with negative pituitary magnetic resonance imaging findings: a single-center experience. Endocr Pract 26(11):1320\u20131330","journal-title":"Endocr Pract"},{"issue":"5","key":"1215_CR37","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.clineuro.2008.12.011","volume":"111","author":"E Fomekong","year":"2009","unstructured":"Fomekong E, Maiter D, Grandin C, Raftopoulos C (2009) Outcome of transsphenoidal surgery for Cushing\u2019s disease: a high remission rate in ACTH-secreting macroadenomas. Clin Neurol Neurosurg 111(5):442\u2013449","journal-title":"Clin Neurol Neurosurg"},{"issue":"4","key":"1215_CR38","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3171\/jns.1989.71.4.0520","volume":"71","author":"RB Friedman","year":"1989","unstructured":"Friedman RB, Oldfield EH, Nieman LK et al (1989) Repeat transsphenoidal surgery for Cushing\u2019s disease. J Neurosurg 71(4):520\u2013527","journal-title":"J Neurosurg"},{"issue":"4","key":"1215_CR39","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s11102-012-0455-z","volume":"16","author":"N Hameed","year":"2013","unstructured":"Hameed N, Yedinak CG, Brzana J et al (2013) Remission rate after transsphenoidal surgery in patients with pathologically confirmed Cushing\u2019s disease, the role of cortisol, ACTH assessment and immediate reoperation: a large single center experience. Pituitary 16(4):452\u2013458","journal-title":"Pituitary"},{"issue":"4","key":"1215_CR40","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1365-2265.2011.04268.x","volume":"76","author":"J Honegger","year":"2012","unstructured":"Honegger J, Schmalisch K, Beuschlein F et al (2012) Contemporary microsurgical concept for the treatment of Cushing\u2019s disease: endocrine outcome in 83 consecutive patients. Clin Endocrinol (Oxf) 76(4):560\u2013567","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"1215_CR41","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.21037\/apm-20-2230","volume":"10","author":"X Liu","year":"2021","unstructured":"Liu X, Dai C, Bao X et al (2021) Treatment and outcomes of recurrent\/persistent Cushing\u2019s disease: a single-center experience. Ann Palliat Med 10(3):2494\u20132504","journal-title":"Ann Palliat Med"},{"key":"1215_CR42","doi-asserted-by":"publisher","first-page":"e436","DOI":"10.1016\/j.wneu.2018.10.067","volume":"122","author":"AJ Martinez Ortega","year":"2019","unstructured":"Martinez Ortega AJ, Venegas-Moreno E, Dios E et al (2019) Surgical outcomes and comorbidities in Cushing disease: 30 years of experience in a referral center. World Neurosurgery 122:e436\u2013e442","journal-title":"World Neurosurgery"},{"issue":"5","key":"1215_CR43","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.3171\/2017.6.JNS17635","volume":"129","author":"M Mayberg","year":"2018","unstructured":"Mayberg M, Reintjes S, Patel A et al (2018) Dynamics of postoperative serum cortisol after transsphenoidal surgery for Cushing\u2019s disease: implications for immediate reoperation and remission. J Neurosurg 129(5):1268\u20131277","journal-title":"J Neurosurg"},{"issue":"1","key":"1215_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3171\/jns.1994.80.1.0037","volume":"80","author":"Z Ram","year":"1994","unstructured":"Ram Z, Nieman LK, Cutler GB Jr, Chrousos GP, Doppman JL, Oldfield EH (1994) Early repeat surgery for persistent Cushing\u2019s disease. J Neurosurg 80(1):37\u201345","journal-title":"J Neurosurg"},{"issue":"8","key":"1215_CR45","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1590\/S0004-27302007000800022","volume":"51","author":"G Rollin","year":"2007","unstructured":"Rollin G, Ferreira NP, Czepielewski MA (2007) Prospective evaluation of transsphenoidal pituitary surgery in 108 patients with Cushing\u2019s disease. Arq Bras Endocrinol Metabol 51(8):1355\u20131361","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"1215_CR46","doi-asserted-by":"crossref","unstructured":"Shimon I, Ram Z, Cohen ZR, Hadani M (2002) Transsphenoidal surgery for Cushing's disease: endocrinological follow-up monitoring of 82 patients. Neurosurgery 51(1):57\u201361; discussion 61\u201352.","DOI":"10.1097\/00006123-200207000-00008"},{"key":"1215_CR47","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.wneu.2015.11.046","volume":"87","author":"M Shirvani","year":"2016","unstructured":"Shirvani M, Motiei-Langroudi R, Sadeghian H (2016) Outcome of microscopic transsphenoidal surgery in Cushing disease: a case series of 96 patients. World Neurosurg 87:170\u2013175","journal-title":"World Neurosurg"},{"issue":"4","key":"1215_CR48","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.endonu.2013.10.008","volume":"61","author":"P Valderr\u00e1bano","year":"2014","unstructured":"Valderr\u00e1bano P, Aller J, Garc\u00eda-Valdecasas L et al (2014) Results of repeated transsphenoidal surgery in Cushing\u2019s disease Long-term follow-up. Endocrinol Nutr 61(4):176\u2013183","journal-title":"Endocrinol Nutr"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01215-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-022-01215-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01215-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T11:14:05Z","timestamp":1654514045000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-022-01215-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1215"],"URL":"https:\/\/doi.org\/10.1007\/s11102-022-01215-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,4]]},"assertion":[{"value":"9 March 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Susan L. Samson has been a site principal investigator for clinical trials involving patients with Cushing\u2019s disease for Novartis and Corcept. The remaining authors have no relevant financial or non-financial interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This is a meta-analysis; no ethical approval or informed consent was required by the institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}