{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:10:05Z","timestamp":1793326205322,"version":"4.5.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Acromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-one acromegaly patients (56% female, mean age 64\u2009\u00b1\u200912\u00a0years) in long-term remission for 18.3\u00a0years (median, IQR 7.2\u201325.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA [defined as Kellgren &amp; Lawrence (KL)\u2009\u2265\u20092] was scored using (modified) KL methods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Radiographic signs of OA were present in 46 patients (90.2%) with\u2009\u2265\u20092 joints affected in virtually all of these patients (N\u2009=\u200944; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N\u2009=\u200926, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA [N\u2009=\u200921 (41.2%) <jats:italic>vs.<\/jats:italic> N\u2009=\u200924 (47.1%)]. Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels [OR 1.06 (1.01\u20131.12), <jats:italic>P<\/jats:italic>\u2009=\u20090.021], and current pharmacological treatment [OR 5.01 (1.03\u201324.54), <jats:italic>P<\/jats:italic>\u2009=\u20090.047], whereas no risk factors for MTP1 joint OA could be identified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Similar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-022-01233-z","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T17:02:56Z","timestamp":1655744576000},"page":"622-635","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical and radiographic assessment of peripheral joints in controlled acromegaly"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-4037","authenticated-orcid":false,"given":"Iris C. M.","family":"Pelsma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman M.","family":"Kroon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria R.","family":"van Trigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke R.","family":"Biermasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M. J. A.","family":"Claessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"issue":"1","key":"1233_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1210\/jc.2007-1191","volume":"93","author":"OM Dekkers","year":"2008","unstructured":"Dekkers OM, Biermasz NR, Pereira AM, Romijn JA, Vandenbroucke JP (2008) Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Metab 93(1):61\u201367. https:\/\/doi.org\/10.1210\/jc.2007-1191","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1233_CR2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ghir.2010.02.003","volume":"20","author":"MJ Wassenaar","year":"2010","unstructured":"Wassenaar MJ, Biermasz NR, Kloppenburg M, van der Klaauw AA, Tiemensma J, Smit JW, Pereira AM, Roelfsema F, Kroon HM, Romijn JA (2010) Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients. Growth Horm IGF Res 20(3):226\u2013233. https:\/\/doi.org\/10.1016\/j.ghir.2010.02.003","journal-title":"Growth Horm IGF Res"},{"issue":"3","key":"1233_CR3","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/eje-08-0845","volume":"160","author":"MJ Wassenaar","year":"2009","unstructured":"Wassenaar MJ, Biermasz NR, van Duinen N, van der Klaauw AA, Pereira AM, Roelfsema F, Smit JW, Kroon HM, Kloppenburg M, Romijn JA (2009) High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly: a case-control study. Eur J Endocrinol 160(3):357\u2013365. https:\/\/doi.org\/10.1530\/eje-08-0845","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1233_CR4","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1097\/00000658-190912000-00003","volume":"50","author":"H Cushing","year":"1909","unstructured":"Cushing H (1909) III. Partial hypophysectomy for acromegaly: with remarks on the function of the hypophysis. Ann Surg 50(6):1002\u20131017","journal-title":"Ann Surg"},{"issue":"1","key":"1233_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1210\/er.2002-0022","volume":"25","author":"A Colao","year":"2004","unstructured":"Colao A, Ferone D, Marzullo P, Lombardi G (2004) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 25(1):102\u2013152. https:\/\/doi.org\/10.1210\/er.2002-0022","journal-title":"Endocr Rev"},{"issue":"5","key":"1233_CR6","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1210\/jc.2004-2297","volume":"90","author":"NR Biermasz","year":"2005","unstructured":"Biermasz NR, Pereira AM, Smit JW, Romijn JA, Roelfsema F (2005) Morbidity after long-term remission for acromegaly: persisting joint-related complaints cause reduced quality of life. J Clin Endocrinol Metab 90(5):2731\u20132739. https:\/\/doi.org\/10.1210\/jc.2004-2297","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1233_CR7","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1136\/ard.2010.131698","volume":"70","author":"MJ Wassenaar","year":"2011","unstructured":"Wassenaar MJ, Biermasz NR, Bijsterbosch J, Pereira AM, Meulenbelt I, Smit JW, Roelfsema F, Kroon HM, Romijn JA, Kloppenburg M (2011) Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. Ann Rheum Dis 70(2):320\u2013325. https:\/\/doi.org\/10.1136\/ard.2010.131698","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"1233_CR8","doi-asserted-by":"publisher","first-page":"864","DOI":"10.2519\/jospt.2019.8302","volume":"49","author":"JT Cirolia","year":"2019","unstructured":"Cirolia JT (2019) Acromegalic arthropathy. J Orthop Sports Phys Ther 49(11):864. https:\/\/doi.org\/10.2519\/jospt.2019.8302","journal-title":"J Orthop Sports Phys Ther"},{"issue":"Suppl 1","key":"1233_CR9","first-page":"S41","volume":"155","author":"A Barkan","year":"1997","unstructured":"Barkan A (1997) Acromegalic arthropathy and sleep apnea. J Endocrinol 155(Suppl 1):S41\u2013S44","journal-title":"J Endocrinol"},{"issue":"4","key":"1233_CR10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1023\/A:1020754615863","volume":"4","author":"AL Barkan","year":"2001","unstructured":"Barkan AL (2001) Acromegalic arthropathy. Pituitary 4(4):263\u2013264","journal-title":"Pituitary"},{"issue":"1","key":"1233_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1530\/eje.0.1480031","volume":"148","author":"A Colao","year":"2003","unstructured":"Colao A, Cannavo S, Marzullo P, Pivonello R, Squadrito S, Vallone G, Almoto B, Bichisao E, Trimarchi F, Lombardi G (2003) Twelve months of treatment with octreotide-LAR reduces joint thickness in acromegaly. Eur J Endocrinol 148(1):31\u201338","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"1233_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1046\/j.1365-2265.1999.00851.x","volume":"51","author":"A Colao","year":"1999","unstructured":"Colao A, Marzullo P, Vallone G, Giaccio A, Ferone D, Rossi E, Scarpa R, Smaltino F, Lombardi G (1999) Ultrasonographic evidence of joint thickening reversibility in acromegalic patients treated with lanreotide for 12 months. Clin Endocrinol (Oxf) 51(5):611\u2013618","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"1233_CR13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1530\/eje-12-0147","volume":"167","author":"KM Claessen","year":"2012","unstructured":"Claessen KM, Ramautar SR, Pereira AM, Smit JW, Roelfsema F, Romijn JA, Kroon HM, Kloppenburg M, Biermasz NR (2012) Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study. Eur J Endocrinol 167(2):235\u2013244. https:\/\/doi.org\/10.1530\/eje-12-0147","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1233_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11102-013-0464-6","volume":"17","author":"KM Claessen","year":"2014","unstructured":"Claessen KM, Ramautar SR, Pereira AM, Romijn JA, Kroon HM, Kloppenburg M, Biermasz NR (2014) Increased clinical symptoms of acromegalic arthropathy in patients with long-term disease control: a prospective follow-up study. Pituitary 17(1):44\u201352. https:\/\/doi.org\/10.1007\/s11102-013-0464-6","journal-title":"Pituitary"},{"key":"1233_CR15","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa747","author":"ICM Pelsma","year":"2020","unstructured":"Pelsma ICM, Biermasz NR, van Furth WR, Pereira AM, Kroon HM, Kloppenburg M, Claessen K (2020) Progression of acromegalic arthropathy in long-term controlled acromegaly patients: 9 years of longitudinal follow-up. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgaa747","journal-title":"J Clin Endocrinol Metab"},{"key":"1233_CR16","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2021.1887376","author":"IN Ackerman","year":"2021","unstructured":"Ackerman IN, Fotis K, Pearson L, Schoch P, Broughton N, Brennan-Olsen SL, Bucknill A, Cross E, Bunting-Frame N, Page RS (2021) Impaired health-related quality of life, psychological distress, and productivity loss in younger people with persistent shoulder pain: a cross-sectional analysis. Disabil Rehabil. https:\/\/doi.org\/10.1080\/09638288.2021.1887376","journal-title":"Disabil Rehabil"},{"issue":"4","key":"1233_CR17","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1515\/sjpain-2020-0044","volume":"20","author":"KB Engebretsen","year":"2020","unstructured":"Engebretsen KB, Brox JI, Juel NG (2020) Patients with shoulder pain referred to specialist care; treatment, predictors of pain and disability, emotional distress, main symptoms and sick-leave: a cohort study with a six-months follow-up. Scand J Pain 20(4):775\u2013783. https:\/\/doi.org\/10.1515\/sjpain-2020-0044","journal-title":"Scand J Pain"},{"issue":"17","key":"1233_CR18","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.2106\/JBJS.19.00017","volume":"101","author":"SS Jain","year":"2019","unstructured":"Jain SS, DeFroda SF, Paxton ES, Green A (2019) Patient-reported outcome measures and health-related quality-of-life scores of patients undergoing anatomic total shoulder arthroplasty. J Bone Joint Surg Am 101(17):1593\u20131600. https:\/\/doi.org\/10.2106\/JBJS.19.00017","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"1233_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.csm.2008.03.001","volume":"27","author":"LA Michener","year":"2008","unstructured":"Michener LA, Snyder AR (2008) Evaluation of health-related quality of life in patients with shoulder pai. Clin Sports Med 27(3):491\u2013505. https:\/\/doi.org\/10.1016\/j.csm.2008.03.001","journal-title":"Clin Sports Med"},{"issue":"7","key":"1233_CR20","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s10067-013-2219-1","volume":"32","author":"LL Kropf","year":"2013","unstructured":"Kropf LL, Madeira M, Vieira Neto L, Gadelha MR, de Farias ML (2013) Functional evaluation of the joints in acromegalic patients and associated factors. Clin Rheumatol 32(7):991\u2013998. https:\/\/doi.org\/10.1007\/s10067-013-2219-1","journal-title":"Clin Rheumatol"},{"issue":"5","key":"1233_CR21","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s11102-019-00966-8","volume":"22","author":"LM Fatti","year":"2019","unstructured":"Fatti LM, Cangiano B, Vitale G, Persani L, Mantovani G, Sala E, Arosio M, Maffei P, Dassie F, Mormando M, Giampietro A, Tanda L, Masiello ER, Nazzari E, Ferone D, Corbetta S, Passeri E, Guaraldi F, Grottoli S, Cannavo S, Torre MLT, Soranna D, Zambon A, Cavagnini F, Scacchi M, Study Group on Motor Disability in Acromegaly of the Italian Society of E (2019) Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity. Pituitary 22(5):552\u2013560. https:\/\/doi.org\/10.1007\/s11102-019-00966-8","journal-title":"Pituitary"},{"issue":"1","key":"1233_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.11152\/mu.2013.2066.181.edo","volume":"18","author":"ED Onal","year":"2016","unstructured":"Onal ED, Ipek A, Evranos B, Idilman IS, Cakir B, Ersoy R (2016) Structural tendon changes in patients with acromegaly: assessment of Achilles tendon with sonoelastography. Med Ultrason 18(1):30\u201335. https:\/\/doi.org\/10.11152\/mu.2013.2066.181.edo","journal-title":"Med Ultrason"},{"issue":"2","key":"1233_CR23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1365-2265.2009.03626.x","volume":"72","author":"TJ Reid","year":"2010","unstructured":"Reid TJ, Post KD, Bruce JN, Nabi Kanibir M, Reyes-Vidal CM, Freda PU (2010) Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed. Clin Endocrinol (Oxf) 72(2):203\u2013208. https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03626.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"1233_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1136\/annrheumdis-2013-203804","volume":"74","author":"E Roddy","year":"2015","unstructured":"Roddy E, Thomas MJ, Marshall M, Rathod T, Myers H, Menz HB, Thomas E, Peat G (2015) The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the clinical assessment study of the foot. Ann Rheum Dis 74(1):156\u2013163. https:\/\/doi.org\/10.1136\/annrheumdis-2013-203804","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"1233_CR25","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1002\/acr.21729","volume":"64","author":"SM Bergin","year":"2012","unstructured":"Bergin SM, Munteanu SE, Zammit GV, Nikolopoulos N, Menz HB (2012) Impact of first metatarsophalangeal joint osteoarthritis on health-related quality of life. Arthritis Care Res (Hoboken) 64(11):1691\u20131698. https:\/\/doi.org\/10.1002\/acr.21729","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1233_CR26","first-page":"229","volume":"25","author":"ICM Pelsma","year":"2021","unstructured":"Pelsma ICM, van Trigt VR, Kroon HM, Pereira AM, van der Meulen C, Kloppenburg M, Biermasz NR, Claessen KMJA (2021) Low prevalence of neuropathic-like pain symptoms in long-term controlled acromegaly. Pituitary 25:229","journal-title":"Pituitary"},{"key":"1233_CR27","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0415","author":"ICM Pelsma","year":"2020","unstructured":"Pelsma ICM, Biermasz NR, Pereira AM, van Furth W, Appelman-Dijkstra NM, Kloppenburg M, Kroon H, Claessen K (2020) Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study. Eur J Endocrinol. https:\/\/doi.org\/10.1530\/EJE-20-0415","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"1233_CR28","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1210\/jc.2013-2695","volume":"98","author":"KM Claessen","year":"2013","unstructured":"Claessen KM, Kroon HM, Pereira AM, Appelman-Dijkstra NM, Verstegen MJ, Kloppenburg M, Hamdy NA, Biermasz NR (2013) Progression of vertebral fractures despite long-term biochemical control of acromegaly: a prospective follow-up study. J Clin Endocrinol Metab 98(12):4808\u20134815. https:\/\/doi.org\/10.1210\/jc.2013-2695","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1233_CR29","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12020-015-0810-8","volume":"52","author":"SE Franck","year":"2016","unstructured":"Franck SE, Muhammad A, van der Lely AJ, Neggers SJ (2016) Combined treatment of somatostatin analogues with pegvisomant in acromegaly. Endocrine 52(2):206\u2013213. https:\/\/doi.org\/10.1007\/s12020-015-0810-8","journal-title":"Endocrine"},{"issue":"16","key":"1233_CR30","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM200004203421604","volume":"342","author":"PJ Trainer","year":"2000","unstructured":"Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML, Besser GM, Scarlett JA, Thorner MO, Parkinson C, Klibanski A, Powell JS, Barkan AL, Sheppard MC, Malsonado M, Rose DR, Clemmons DR, Johannsson G, Bengtsson BA, Stavrou S, Kleinberg DL, Cook DM, Phillips LS, Bidlingmaier M, Strasburger CJ, Hackett S, Zib K, Bennett WF, Davis RJ (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med 342(16):1171\u20131177. https:\/\/doi.org\/10.1056\/NEJM200004203421604","journal-title":"N Engl J Med"},{"issue":"4","key":"1233_CR31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1530\/EJE-10-1005","volume":"164","author":"MJ Wassenaar","year":"2011","unstructured":"Wassenaar MJ, Biermasz NR, Hamdy NA, Zillikens MC, van Meurs JB, Rivadeneira F, Hofman A, Uitterlinden AG, Stokkel MP, Roelfsema F, Kloppenburg M, Kroon HM, Romijn JA, Pereira AM (2011) High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly. Eur J Endocrinol 164(4):475\u2013483. https:\/\/doi.org\/10.1530\/EJE-10-1005","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1233_CR32","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1210\/jc.2003-032041","volume":"89","author":"NR Biermasz","year":"2004","unstructured":"Biermasz NR, Dekker FW, Pereira AM, van Thiel SW, Schutte PJ, van Dulken H, Romijn JA, Roelfsema F (2004) Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements. J Clin Endocrinol Metab 89(6):2789\u20132796. https:\/\/doi.org\/10.1210\/jc.2003-032041","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"1233_CR33","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1210\/jcem.85.12.7042","volume":"85","author":"NR Biermasz","year":"2000","unstructured":"Biermasz NR, van Dulken H, Roelfsema F (2000) Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. J Clin Endocrinol Metab 85(12):4596\u20134602. https:\/\/doi.org\/10.1210\/jcem.85.12.7042","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1233_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.beem.2017.03.001","volume":"31","author":"V Gasco","year":"2017","unstructured":"Gasco V, Caputo M, Lanfranco F, Ghigo E, Grottoli S (2017) Management of GH treatment in adult GH deficiency. Best Pract Res Clin Endocrinol Metab 31(1):13\u201324. https:\/\/doi.org\/10.1016\/j.beem.2017.03.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"1233_CR35","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1530\/EJE-12-0563","volume":"168","author":"V Gasco","year":"2013","unstructured":"Gasco V, Prodam F, Grottoli S, Marzullo P, Longobardi S, Ghigo E, Aimaretti G (2013) GH therapy in adult GH deficiency: a review of treatment schedules and the evidence for low starting doses. Eur J Endocrinol 168(3):R55-66. https:\/\/doi.org\/10.1530\/EJE-12-0563","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1233_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ghir.2007.07.004","volume":"18","author":"E Ghigo","year":"2008","unstructured":"Ghigo E, Aimaretti G, Corneli G (2008) Diagnosis of adult GH deficiency. Growth Horm IGF Res 18(1):1\u201316. https:\/\/doi.org\/10.1016\/j.ghir.2007.07.004","journal-title":"Growth Horm IGF Res"},{"key":"1233_CR37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cca.2014.01.008","volume":"432","author":"HA Ross","year":"2014","unstructured":"Ross HA, Lentjes EW, Menheere PM, Sweep CG, Endocrinology S, Project group \"Calibration \" of the S (2014) Harmonization of growth hormone measurement results: the empirical approach. Clin Chim Acta 432:72\u201376. https:\/\/doi.org\/10.1016\/j.cca.2014.01.008","journal-title":"Clin Chim Acta"},{"issue":"1","key":"1233_CR38","first-page":"45","volume":"44","author":"TJ Cole","year":"1990","unstructured":"Cole TJ (1990) The LMS method for constructing normalized growth standards. Eur J Clin Nutr 44(1):45\u201360","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"1233_CR39","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000023268","volume":"50","author":"B Rikken","year":"1998","unstructured":"Rikken B, van Doorn J, Ringeling A, Van den Brande JL, Massa G, Wit JM (1998) Plasma levels of insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein-3 in the evaluation of childhood growth hormone deficiency. Horm Res 50(3):166\u2013176. https:\/\/doi.org\/10.1159\/000023268","journal-title":"Horm Res"},{"issue":"3","key":"1233_CR40","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s11552-008-9090-6","volume":"3","author":"WS Khan","year":"2008","unstructured":"Khan WS, Jain R, Dillon B, Clarke L, Fehily M, Ravenscroft M (2008) The \u2019M2 DASH\u2019-Manchester-modified disabilities of arm shoulder and hand score. Hand (N Y) 3(3):240\u2013244. https:\/\/doi.org\/10.1007\/s11552-008-9090-6","journal-title":"Hand (N Y)"},{"issue":"2","key":"1233_CR41","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0894-1130(01)80043-0","volume":"14","author":"DE Beaton","year":"2001","unstructured":"Beaton DE, Katz JN, Fossel AH, Wright JG, Tarasuk V, Bombardier C (2001) Measuring the whole or the parts? Validity, reliability, and responsiveness of the disabilities of the arm, shoulder and hand outcome measure in different regions of the upper extremity. J Hand Ther 14(2):128\u2013146","journal-title":"J Hand Ther"},{"key":"1233_CR42","volume-title":"The DASH outcome measure user\u2019s manual","author":"S Solway","year":"2002","unstructured":"Solway S, Beaton D, McConnell S, Bombardier C (2002) The DASH outcome measure user\u2019s manual, 2nd edn. Institute for Work & Health, Toronto","edition":"2"},{"issue":"4","key":"1233_CR43","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/s0894-1130(02)80006-0","volume":"15","author":"MM Veehof","year":"2002","unstructured":"Veehof MM, Sleegers EJ, van Veldhoven NH, Schuurman AH, van Meeteren NL (2002) Psychometric qualities of the Dutch language version of the disabilities of the arm, shoulder, and hand questionnaire (DASH-DLV). J Hand Ther 15(4):347\u2013354. https:\/\/doi.org\/10.1016\/s0894-1130(02)80006-0","journal-title":"J Hand Ther"},{"issue":"11","key":"1233_CR44","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1053\/joca.2002.0838","volume":"10","author":"N Bellamy","year":"2002","unstructured":"Bellamy N, Campbell J, Haraoui B, Gerecz-Simon E, Buchbinder R, Hobby K, MacDermid JC (2002) Clinimetric properties of the AUSCAN osteoarthritis hand index: an evaluation of reliability, validity and responsiveness. Osteoarthr Cartil 10(11):863\u2013869. https:\/\/doi.org\/10.1053\/joca.2002.0838","journal-title":"Osteoarthr Cartil"},{"issue":"12","key":"1233_CR45","first-page":"1833","volume":"15","author":"N Bellamy","year":"1988","unstructured":"Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833\u20131840","journal-title":"J Rheumatol"},{"issue":"11","key":"1233_CR46","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/s0895-4356(98)00097-3","volume":"51","author":"NK Aaronson","year":"1998","unstructured":"Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, Sprangers MA, te Velde A, Verrips E (1998) Translation, validation, and norming of the Dutch language version of the SF-36 health survey in community and chronic disease populations. J Clin Epidemiol 51(11):1055\u20131068. https:\/\/doi.org\/10.1016\/s0895-4356(98)00097-3","journal-title":"J Clin Epidemiol"},{"issue":"6846","key":"1233_CR47","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","volume":"305","author":"JE Brazier","year":"1992","unstructured":"Brazier JE, Harper R, Jones NM, O\u2019Cathain A, Thomas KJ, Usherwood T, Westlake L (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 305(6846):160\u2013164. https:\/\/doi.org\/10.1136\/bmj.305.6846.160","journal-title":"BMJ"},{"issue":"6890","key":"1233_CR48","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1136\/bmj.306.6890.1437","volume":"306","author":"C Jenkinson","year":"1993","unstructured":"Jenkinson C, Coulter A, Wright L (1993) Short form 36 (SF36) health survey questionnaire: normative data for adults of working age. BMJ 306(6890):1437\u20131440. https:\/\/doi.org\/10.1136\/bmj.306.6890.1437","journal-title":"BMJ"},{"issue":"4","key":"1233_CR49","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16(4):494\u2013502. https:\/\/doi.org\/10.1136\/ard.16.4.494","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1233_CR50","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1002\/jmri.26251","volume":"49","author":"PM Jungmann","year":"2019","unstructured":"Jungmann PM, Gersing AS, Woertler K, Dietrich TJ, Baum T, Baumann F, Bensler S (2019) Reliable semiquantitative whole-joint MRI score for the shoulder joint: the shoulder osteoarthritis severity (SOAS) score. J Magn Reson Imaging 49(7):e152\u2013e163. https:\/\/doi.org\/10.1002\/jmri.26251","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"1233_CR51","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00776-013-0369-2","volume":"18","author":"J Kukkonen","year":"2013","unstructured":"Kukkonen J, Joukainen A, Lehtinen J, Aarimaa V (2013) The effect of glenohumeral osteoarthritis on the outcome of isolated operatively treated supraspinatus tears. J Orthop Sci 18(3):405\u2013409. https:\/\/doi.org\/10.1007\/s00776-013-0369-2","journal-title":"J Orthop Sci"},{"issue":"7","key":"1233_CR52","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/MNM.0000000000000858","volume":"39","author":"BJ Nguyen","year":"2018","unstructured":"Nguyen BJ, Burt A, Baldassarre RL, Smitaman E, Morshedi M, Kao S, Chang EY, Obrzut S (2018) The prognostic and diagnostic value of 18F-FDG PET\/CT for assessment of symptomatic osteoarthritis. Nucl Med Commun 39(7):699\u2013706. https:\/\/doi.org\/10.1097\/MNM.0000000000000858","journal-title":"Nucl Med Commun"},{"issue":"2","key":"1233_CR53","first-page":"151","volume":"7","author":"A Schumaier","year":"2019","unstructured":"Schumaier A, Abboud J, Grawe B, Horneff JG, Getz C, Romeo A, Keener J, Friedman R, Yian E, Muh S, Nicholson G, Delaney R, Otto R, William W, Tokish JT, Williams G, Kazanjian J, Dines J, Ramsey M, Green A, Paxton S, Namdari S, Flanagin B, Hasan S, Kaar S, Miniaci A, Cuomo F (2019) Evaluating glenohumeral osteoarthritis: the relative impact of patient age, activity level, symptoms, and Kellgren-Lawrence grade on treatment. Arch Bone Jt Surg 7(2):151\u2013160","journal-title":"Arch Bone Jt Surg"},{"issue":"1","key":"1233_CR54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/JOM.0b013e3181c40e98","volume":"52","author":"TE Bernard","year":"2010","unstructured":"Bernard TE, Wilder FV, Aluoch M, Leaverton PE (2010) Job-related osteoarthritis of the knee, foot, hand, and cervical spine. J Occup Environ Med 52(1):33\u201338. https:\/\/doi.org\/10.1097\/JOM.0b013e3181c40e98","journal-title":"J Occup Environ Med"},{"issue":"3","key":"1233_CR55","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.joca.2004.10.021","volume":"13","author":"FV Wilder","year":"2005","unstructured":"Wilder FV, Barrett JP, Farina EJ (2005) The association of radiographic foot osteoarthritis and radiographic osteoarthritis at other sites. Osteoarthr Cartil 13(3):211\u2013215. https:\/\/doi.org\/10.1016\/j.joca.2004.10.021","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"1233_CR56","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/s1058-2746(99)90093-9","volume":"8","author":"Y Nakagawa","year":"1999","unstructured":"Nakagawa Y, Hyakuna K, Otani S, Hashitani M, Nakamura T (1999) Epidemiologic study of glenohumeral osteoarthritis with plain radiography. J Shoulder Elbow Surg 8(6):580\u2013584. https:\/\/doi.org\/10.1016\/s1058-2746(99)90093-9","journal-title":"J Shoulder Elbow Surg"},{"key":"1233_CR57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/ORR.S134732","volume":"10","author":"CB Ansok","year":"2018","unstructured":"Ansok CB, Muh SJ (2018) Optimal management of glenohumeral osteoarthritis. Orthop Res Rev 10:9\u201318. https:\/\/doi.org\/10.2147\/ORR.S134732","journal-title":"Orthop Res Rev"},{"key":"1233_CR58","doi-asserted-by":"publisher","DOI":"10.1177\/1457496920935018","author":"T Ibounig","year":"2020","unstructured":"Ibounig T, Simons T, Launonen A, Paavola M (2020) Glenohumeral osteoarthritis: an overview of etiology and diagnostics. Scand J Surg. https:\/\/doi.org\/10.1177\/1457496920935018","journal-title":"Scand J Surg"},{"issue":"5","key":"1233_CR59","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.jse.2011.01.021","volume":"20","author":"JH Oh","year":"2011","unstructured":"Oh JH, Chung SW, Oh CH, Kim SH, Park SJ, Kim KW, Park JH, Lee SB, Lee JJ (2011) The prevalence of shoulder osteoarthritis in the elderly Korean population: association with risk factors and function. J Shoulder Elbow Surg 20(5):756\u2013763. https:\/\/doi.org\/10.1016\/j.jse.2011.01.021","journal-title":"J Shoulder Elbow Surg"},{"issue":"4","key":"1233_CR60","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/1759720X17753337","volume":"10","author":"E Roddy","year":"2018","unstructured":"Roddy E, Menz HB (2018) Foot osteoarthritis: latest evidence and developments. Ther Adv Musculoskelet Dis 10(4):91\u2013103. https:\/\/doi.org\/10.1177\/1759720X17753337","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"6","key":"1233_CR61","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.semarthrit.2013.12.007","volume":"43","author":"AE Nelson","year":"2014","unstructured":"Nelson AE, Smith MW, Golightly YM, Jordan JM (2014) \u201cGeneralized osteoarthritis\u201d: a systematic review. Semin Arthritis Rheum 43(6):713\u2013720. https:\/\/doi.org\/10.1016\/j.semarthrit.2013.12.007","journal-title":"Semin Arthritis Rheum"},{"key":"1233_CR62","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fendo.2017.00040","volume":"8","author":"VJ Geraedts","year":"2017","unstructured":"Geraedts VJ, Andela CD, Stalla GK, Pereira AM, van Furth WR, Sievers C, Biermasz NR (2017) Predictors of quality of life in acromegaly: no consensus on biochemical parameters. Front Endocrinol (Lausanne) 8:40. https:\/\/doi.org\/10.3389\/fendo.2017.00040","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1233_CR63","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000375450","volume":"103","author":"KM Claessen","year":"2016","unstructured":"Claessen KM, Mazziotti G, Biermasz NR, Giustina A (2016) Bone and joint disorders in acromegaly. Neuroendocrinology 103(1):86\u201395. https:\/\/doi.org\/10.1159\/000375450","journal-title":"Neuroendocrinology"},{"issue":"2","key":"1233_CR64","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2106\/00004623-200202000-00007","volume":"84","author":"FG Hunsaker","year":"2002","unstructured":"Hunsaker FG, Cioffi DA, Amadio PC, Wright JG, Caughlin B (2002) The American academy of orthopaedic surgeons outcomes instruments: normative values from the general population. J Bone Joint Surg Am 84(2):208\u2013215. https:\/\/doi.org\/10.2106\/00004623-200202000-00007","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"1233_CR65","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jhsb.2006.10.001","volume":"32","author":"L De Smet","year":"2007","unstructured":"De Smet L, De Kesel R, Degreef I, Debeer P (2007) Responsiveness of the Dutch version of the DASH as an outcome measure for carpal tunnel syndrome. J Hand Surg Eur 32(1):74\u201376. https:\/\/doi.org\/10.1016\/j.jhsb.2006.10.001","journal-title":"J Hand Surg Eur"},{"issue":"12","key":"1233_CR66","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.3899\/jrheum.080067","volume":"35","author":"EE Raven","year":"2008","unstructured":"Raven EE, Haverkamp D, Sierevelt IN, van Montfoort DO, Poll RG, Blankevoort L, Tak PP (2008) Construct validity and reliability of the disability of arm, shoulder and hand questionnaire for upper extremity complaints in rheumatoid arthritis. J Rheumatol 35(12):2334\u20132338. https:\/\/doi.org\/10.3899\/jrheum.080067","journal-title":"J Rheumatol"},{"issue":"6","key":"1233_CR67","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1210\/jcem.83.6.4865","volume":"83","author":"A Colao","year":"1998","unstructured":"Colao A, Marzullo P, Vallone G, Marino V, Annecchino M, Ferone D, De BD, Scarpa R, Oriente P, Lombardi G (1998) Reversibility of joint thickening in acromegalic patients: an ultrasonography study. J Clin Endocrinol Metab 83(6):2121\u20132125. https:\/\/doi.org\/10.1210\/jcem.83.6.4865","journal-title":"J Clin Endocrinol Metab"},{"issue":"8548","key":"1233_CR68","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/s0140-6736(87)92209-4","volume":"1","author":"CW Hutton","year":"1987","unstructured":"Hutton CW (1987) Generalised osteoarthritis: an evolutionary problem? Lancet 1(8548):1463\u20131465. https:\/\/doi.org\/10.1016\/s0140-6736(87)92209-4","journal-title":"Lancet"},{"key":"1233_CR69","doi-asserted-by":"publisher","first-page":"370231","DOI":"10.1155\/2013\/370231","volume":"2013","author":"C Chillemi","year":"2013","unstructured":"Chillemi C, Franceschini V (2013) Shoulder osteoarthritis. Arthritis 2013:370231. https:\/\/doi.org\/10.1155\/2013\/370231","journal-title":"Arthritis"},{"issue":"4","key":"1233_CR70","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1136\/ard.48.4.271","volume":"48","author":"JL van Saase","year":"1989","unstructured":"van Saase JL, van Romunde LK, Cats A, Vandenbroucke JP, Valkenburg HA (1989) Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis 48(4):271\u2013280. https:\/\/doi.org\/10.1136\/ard.48.4.271","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1233_CR71","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1210\/jc.2008-2393","volume":"94","author":"NR Biermasz","year":"2009","unstructured":"Biermasz NR, Wassenaar MJ, van der Klaauw AA, Pereira AM, Smit JW, Roelfsema F, Wolterbeek R, Kroon HM, Kloppenburg M, Romijn JA (2009) Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease. J Clin Endocrinol Metab 94(7):2374\u20132379. https:\/\/doi.org\/10.1210\/jc.2008-2393","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1233_CR72","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ghir.2013.05.003","volume":"23","author":"KM Claessen","year":"2013","unstructured":"Claessen KM, Kloppenburg M, Kroon HM, Romijn JA, Pereira AM, Biermasz NR (2013) Two phenotypes of arthropathy in long-term controlled acromegaly? A comparison between patients with and without joint space narrowing (JSN). Growth Horm IGF Res 23(5):159\u2013164. https:\/\/doi.org\/10.1016\/j.ghir.2013.05.003","journal-title":"Growth Horm IGF Res"},{"issue":"4","key":"1233_CR73","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s11102-020-01037-z","volume":"23","author":"B Ozturk Gokce","year":"2020","unstructured":"Ozturk Gokce B, Gogus F, Bolayir B, Tecer D, Gokce O, Eroglu Altinova A, Balos Toruner F, Akturk M (2020) The evaluation of the tendon and muscle changes of lower extremity in patients with acromegaly. Pituitary 23(4):338\u2013346. https:\/\/doi.org\/10.1007\/s11102-020-01037-z","journal-title":"Pituitary"},{"issue":"7","key":"1233_CR74","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/rheumatology\/keq092","volume":"49","author":"HB Menz","year":"2010","unstructured":"Menz HB, Jordan KP, Roddy E, Croft PR (2010) Characteristics of primary care consultations for musculoskeletal foot and ankle problems in the UK. Rheumatology (Oxford) 49(7):1391\u20131398. https:\/\/doi.org\/10.1093\/rheumatology\/keq092","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"1233_CR75","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.joca.2014.10.007","volume":"23","author":"HB Menz","year":"2015","unstructured":"Menz HB, Roddy E, Marshall M, Thomas MJ, Rathod T, Myers H, Thomas E, Peat GM (2015) Demographic and clinical factors associated with radiographic severity of first metatarsophalangeal joint osteoarthritis: cross-sectional findings from the clinical assessment study of the foot. Osteoarthr Cartil 23(1):77\u201382. https:\/\/doi.org\/10.1016\/j.joca.2014.10.007","journal-title":"Osteoarthr Cartil"},{"key":"1233_CR76","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1502","author":"CS Chean","year":"2020","unstructured":"Chean CS, Lingham A, Rathod-Mistry T, Thomas MJ, Marshall M, Menz HB, Roddy E (2020) Identification of patterns of foot and ankle pain in the community: cross-sectional findings from the clinical assessment study of the foot. Musculoskelet Care. https:\/\/doi.org\/10.1002\/msc.1502","journal-title":"Musculoskelet Care"},{"issue":"5","key":"1233_CR77","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/RHU.0b013e3181d59d46","volume":"16","author":"A Descatha","year":"2010","unstructured":"Descatha A, Deschamps E (2010) What was the patient\u2019s occupation? J Clin Rheumatol 16(5):249. https:\/\/doi.org\/10.1097\/RHU.0b013e3181d59d46","journal-title":"J Clin Rheumatol"},{"key":"1233_CR78","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0184","author":"G Mazziotti","year":"2019","unstructured":"Mazziotti G, Lania A, Canalis E (2019) Management of endocrine disease: bone disorders associated with acromegaly: mechanisms and treatment. Eur J Endocrinol. https:\/\/doi.org\/10.1530\/EJE-19-0184","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"1233_CR79","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s11102-017-0838-2","volume":"20","author":"FF Casanueva","year":"2017","unstructured":"Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A, Pituitary Society EGoPT (2017) Criteria for the definition of pituitary tumor centers of excellence (PTCOE): a pituitary society statement. Pituitary 20(5):489\u2013498. https:\/\/doi.org\/10.1007\/s11102-017-0838-2","journal-title":"Pituitary"},{"issue":"10086","key":"1233_CR80","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/s0140-6736(17)31491-5","volume":"389","author":"GR Burmester","year":"2017","unstructured":"Burmester GR, Pope JE (2017) Novel treatment strategies in rheumatoid arthritis. Lancet 389(10086):2338\u20132348. https:\/\/doi.org\/10.1016\/s0140-6736(17)31491-5","journal-title":"Lancet"},{"issue":"3","key":"1233_CR81","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","volume":"22","author":"TE McAlindon","year":"2014","unstructured":"McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22(3):363\u2013388. https:\/\/doi.org\/10.1016\/j.joca.2014.01.003","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"1233_CR82","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","volume":"27","author":"RR Bannuru","year":"2019","unstructured":"Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, Kraus VB, Lohmander LS, Abbott JH, Bhandari M, Blanco FJ, Espinosa R, Haugen IK, Lin J, Mandl LA, Moilanen E, Nakamura N, Snyder-Mackler L, Trojian T, Underwood M, McAlindon TE (2019) OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil 27(11):1578\u20131589. https:\/\/doi.org\/10.1016\/j.joca.2019.06.011","journal-title":"Osteoarthr Cartil"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01233-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-022-01233-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01233-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T10:22:03Z","timestamp":1659435723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-022-01233-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1233"],"URL":"https:\/\/doi.org\/10.1007\/s11102-022-01233-z","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"assertion":[{"value":"12 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors have no conflict of interest or funding details to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}